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Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Cat No. product name
T37621 Ezeprogind disulfate Ezeprogind disulfate 是一种神经营养诱导剂。 Ezeprogind disulfate 针对所有神经退行性变,包括 Abeta 蛋白或 tau 蛋白。 Ezeprogind disulfate 可用于神经系统疾病相关研究,包括进行性核上性麻痹(PSP)、tau蛋白病、阿尔茨海默病和帕金森病等。
T3394 Timosaponin BII Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-r...
TN6919 Methyl tridecanoate Methyl tridecanoate is a natural product.
T0795 Rutin Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
T7003 Leucomethylene blue mesylate TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
T6708 Tolcapone Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
T6125 Semagacestat Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T2639 LY2811376 LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
T22932L LPYFD-NH2 acetate LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42).
T2507 Azeliragon Azeliragon is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheim...
TN2082 Pinostrobin Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
T2873 Ginsenoside Rg2 Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
T1686 Hematoxylin Hematoxylin is a dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture o...
T3914 Saikosaponin C Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T2872 Ginsenoside Re Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
T3402 20(S)-Ginsenoside Rg3 Ginsenoside Rg3 possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the prol...
T6562 Latrepirdine dihydrochloride Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T4364 Aftin-4 Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 incre...
TP1935L1 RAGE antagonist peptide acetate RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflamm...
T3259 FPS-ZM1 FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
T22417 Rutin hydrate Rutin hydrate, a kind of glycoside, widely exists in many plants including citrus fruit.
T21825 TAE-1 TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
T2961 Notoginsenoside R1 Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
T2777 Ginsenoside Rg1 Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
T4S0350 Licochalcone B 1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (mur...
T2212 Geniposide Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activit...
T6S1918 Schisantherin B 1. Schisantherin B shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.
T1637 Deferoxamine Mesylate Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also is an inhibitor of ferroptosis.
T6202 DAPT DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T4398 LX2343 LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
T5447 Anle138b Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
T8012 Scyllo-Inositol Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease...
TN1027 β-Amyrin beta-Amyrin has antiviral, hepatoprotective, antinociceptive, anti-inflammatory, it retard acute inflammation in rat model of periodontitis.
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
T19011L Hoechst 34580 xHCl(23555-00-2(free base) Hoechst 34580 xHCl is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T19011 Hoechst 34580 Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T19013 Hoechst 34580 tetrahydrochloride Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T19892 BSBM7 BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
T2625 MK-0752 MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T2262 Itanapraced CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
TN1798 Isorosmanol Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions ...
TN1919 (+)-Medioresinol Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN1725 Hederacolchiside E Hederacolchiside E 具有抗氧化活性,并通过调节氧化应激在阿尔茨海默病 (AD) 模型中显示神经保护作用。 Hederacolchiside E 对亚油酸乳液的脂质过氧化具有抑制作用。 Hederacolchiside E 可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。
TN1653 Fustin Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN1341 8-Deoxygartanin 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it has mu...
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
TMS1461 Qingyangshengenin B Qingyangshengenin B is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by ...
T7905 PBD-150 PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
T7680 GSNKGAIIGLM(131602-53-4(free base)) GSNKGAIIGLM is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.
T7490 ARN2966 ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
Ezeprogind disulfate
T37621
Ezeprogind disulfate 是一种神经营养诱导剂。 Ezeprogind disulfate 针对所有神经退行性变,包括 Abeta 蛋白或 tau 蛋白。 Ezeprogind disu...
Timosaponin BII
T3394
Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-r...
Methyl tridecanoate
TN6919
Methyl tridecanoate is a natural product.
Rutin
T0795
Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
Leucomethylene blue mesylate
T7003
TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Tolcapone
T6708
Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
Semagacestat
T6125
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
LY2811376
T2639
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivi...
LPYFD-NH2 acetate
T22932L
LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42).
Azeliragon
T2507
Azeliragon is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheim...
Pinostrobin
TN2082
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiti...
Ginsenoside Rg2
T2873
Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
Hematoxylin
T1686
Hematoxylin is a dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture o...
Saikosaponin C
T3914
Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
Ginsenoside Re
T2872
Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
20(S)-Ginsenoside Rg3
T3402
Ginsenoside Rg3 possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the prol...
Latrepirdine dihydrochloride
T6562
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
Aftin-4
T4364
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 i...
RAGE antagonist peptide acetate
TP1935L1
RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflamm...
FPS-ZM1
T3259
FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
Rutin hydrate
T22417
Rutin hydrate, a kind of glycoside, widely exists in many plants including citrus fruit.
TAE-1
T21825
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Notoginsenoside R1
T2961
Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
Ginsenoside Rg1
T2777
Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
Licochalcone B
T4S0350
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (mur...
Geniposide
T2212
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activit...
Schisantherin B
T6S1918
1. Schisantherin B shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.
Deferoxamine Mesylate
T1637
Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also is an inhibitor of ferroptosis.
DAPT
T6202
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
LX2343
T4398
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX...
Anle138b
T5447
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
Scyllo-Inositol
T8012
Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease...
β-Amyrin
TN1027
beta-Amyrin has antiviral, hepatoprotective, antinociceptive, anti-inflammatory, it retard acute inflammation in rat model of periodontitis.
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
T19142
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
Hoechst 34580 xHCl(23555-00-2(free base)
T19011L
Hoechst 34580 xHCl is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Hoechst 34580
T19011
Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Hoechst 34580 tetrahydrochloride
T19013
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
BSBM7
T19892
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
MK-0752
T2625
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
Itanapraced
T2262
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Isorosmanol
TN1798
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions ...
(+)-Medioresinol
TN1919
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
Hederacolchiside E
TN1725
Fustin
TN1653
Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
8-Deoxygartanin
TN1341
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it ha...
Schisandrone
TN1116
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
Qingyangshengenin B
TMS1461
Qingyangshengenin B is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition b...
PBD-150
T7905
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
GSNKGAIIGLM(131602-53-4(free base))
T7680
GSNKGAIIGLM is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.
ARN2966
T7490
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
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