HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat No.	product name
T0835	Tamoxifen Citrate	Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T6290	Tanespimycin	Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T1501	Rifabutin	Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
T6297	Alvespimycin hydrochloride	17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
T8189	Dihydroberberine	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
T12896L	Shepherdin 79-87 acetate	Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.
T6804	Chetomin	Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
T7261	Grp94 Inhibitor-1	Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).
T3652	KRIBB11	KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T7010	VER-155008	VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
T2230	Paeoniflorin	Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.
T3293	Apoptozole	Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.
T2309	Ganetespib	Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
T2258	VER-50589	VER-50589 is a potent HSP90 inhibitor.
T2908	Palmitic acid	Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
T5350	JG-98	JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
T6210	Pifithrin-μ	Pifithrin-μ is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
T2286	BIIB021	BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).
T2179	Triptolide	Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
T3487	HSP70-IN-1	HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).
T8901	YUM70	YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length pro...
T1989	Luminespib	AUY922 (NVP-AUY922) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
T6170	Elesclomol	Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
T0756	Ethoxyquin	Ethoxyquin is an antioxidant used in animal feeds.
T6855	HA15	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
T6118	NVP-HSP990	NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).
T6343	Geldanamycin	Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
T2444	KNK437	KNK437, a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).
T2268	VER49009	VER-49009 is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
T21883	Gedunin	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
T2114	VER-82576	NVP-BEP800, a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.
T8668	HM03	HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.
T8829	2',4'-DIHYDROXYCHALCONE	2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
T8858	DTHIB	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
T9202	DDO-5936	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
T7265	HSP27 inhibitor J2	HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the H...
TN2360	Falcarinol	Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Pan...
TN1901	(-)-Maackiain	(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
T10860	Col003	Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the investig...
T13076	Tamoxifen-d5	Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
T11356	Gamitrinib TPP hexafluorophosphate	Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA...
T11355	Gamitrinib TPP	Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor.
TQ0131	Rocaglamide	Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
TQ0280	Feretoside	Feretoside is a natural product extracted from the barks of E. ulmoides. It is an HSP inducer.
TN5254	Wighteone	Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...
TP1496L	P5 Ligand for Dnak and DnaJ acetate	p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).
TN3070	4beta-Hydroxywithanolide E	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
TN3572	Calyxin H	Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
TN4604	Myricanone	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4183	Hardwickiic acid	Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic ac...