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Cytoskeletal Signaling HSP

HSP

Henoch–Schönlein purpura (HSP), also known as IgA vasculitis, is a disease of the skin, mucous membranes, and sometimes other organs that most commonly affects children. In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain and abdominal pain. With kidney involvement, there may be a loss of small amounts of blood and protein in the urine (hematuria and proteinuria), but this usually goes unnoticed; in a small proportion of cases, the kidney involvement proceeds to chronic kidney disease. HSP is often preceded by an infection, such as a throat infection.
Cat No. product name
T1501 Rifabutin Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
T1989 LuminespibHOT AUY922 (NVP-AUY922) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
T2114 NVP-BEP800 NVP-BEP800, a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.
T2179 Triptolide Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
T2258 VER-50589 VER-50589 is a potent HSP90 inhibitor.
T2268 VER-49009 VER-49009 is an effective HSP90 inhibitor(IC50 =25 nM,Kd=78 nM).
T2286 BIIB-021 BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7nM,EC50=38nM).
T2309 Ganetespib Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
T2444 KNK437 KNK437, a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).
T3293 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70,and can induce apoptosis.
T3527 TRC 051384 Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates hea...
T3594 ML346 ML346 is a novel activator of Hsp70.
T6118 HSP990 NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).
T6170 Elesclomol Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
T6248 XL888 XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins ...
T6284 Onalespib Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selec...
T6290 TanespimycinHOT Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T6297 Alvespimycin hydrochloride 17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
T6305 SNX-2112 SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
T6341 PF-04929113 SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positione...
T6343 Geldanamycin Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
T6558 KW-2478 KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
T6855 HA15 HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells ...
T7010 VER155008 VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fol...
T4125 HSF1A HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T4342 PF-04929113 Mesylate PF-04929113 Mesylate, a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM).
T5008 Teprenone Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
T5152 MKT-077 MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability ...
T5350 JG-98 JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
T7265 HSP27 inhibitor J2 HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the...
T5826 Eupalinolide B Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.
TQ0280 Feretoside Feretoside is a natural product extracted from the barks of E. ulmoides. It is an HSP inducer.
T3487 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).
T8189 Dihydroberberine Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channe...
TN1901 (-)-Maackiain (-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
TN2360 Falcarinol,Panaxynol Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Pa...
T13547 AMP-PCP AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
T13547L AMP-PCP disodium AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp...
T14905 CCT251236 CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induct...
T15088 Debio 0932 Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
T13076 Tamoxifen-​d5 Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enha...
T11355 Gamitrinib TPP Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a  Gamitrinib (GA) mitochondrial matrix inhibitor. 
T11356 Gamitrinib TPP hexafluorophosphate Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a  Gamitrinib ...
T15671 KU-32 KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
T16719 Radicicol Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50:...
T16994 TAS-116 TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
TN3070 4beta-Hydroxywithanolide E 4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic prog...
TN3572 Calyxin H Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
TN4160 Goniothalamin Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cel...
TN4183 Hardwickiic acid Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic a...
Rifabutin
T1501CAS 72559-06-9
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
Luminespib HOT
T1989CAS 747412-49-3
AUY922 (NVP-AUY922) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
NVP-BEP800
T2114CAS 847559-80-2
NVP-BEP800, a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.
Triptolide
T2179CAS 38748-32-2
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
VER-50589
T2258CAS 747413-08-7
VER-50589 is a potent HSP90 inhibitor.
VER-49009
T2268CAS 940289-57-6
VER-49009 is an effective HSP90 inhibitor(IC50 =25 nM,Kd=78 nM).
BIIB-021
T2286CAS 848695-25-0
BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7nM,EC50=38nM).
Ganetespib
T2309CAS 888216-25-9
Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
KNK437
T2444CAS 218924-25-5
KNK437, a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).
Apoptozole
T3293CAS 1054543-47-3
Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70,and can induce apoptosis.
TRC 051384
T3527CAS 867164-40-7
Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates hea...
ML346
T3594CAS 100872-83-1
ML346 is a novel activator of Hsp70.
HSP990
T6118CAS 934343-74-5
NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).
Elesclomol
T6170CAS 488832-69-5
Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
XL888
T6248CAS 1149705-71-4
XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins ...
Onalespib
T6284CAS 912999-49-6
Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selec...
Tanespimycin HOT
T6290CAS 75747-14-7
Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
Alvespimycin hydrochloride
T6297CAS 467214-21-7
17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
SNX-2112
T6305CAS 908112-43-6
SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
PF-04929113
T6341CAS 908115-27-5
SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positione...
Geldanamycin
T6343CAS 30562-34-6
Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
KW-2478
T6558CAS 819812-04-9
KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
HA15
T6855CAS 1609402-14-3
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells ...
VER155008
T7010CAS 1134156-31-2
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fol...
HSF1A
T4125CAS 1196723-93-9
HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
PF-04929113 Mesylate
T4342CAS 1173111-67-5
PF-04929113 Mesylate, a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM).
Teprenone
T5008CAS 6809-52-5
Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
MKT-077
T5152CAS 147366-41-4
MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability ...
JG-98
T5350CAS 1456551-16-8
JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
HSP27 inhibitor J2
T7265CAS 2133499-85-9
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the...
Eupalinolide B
T5826CAS 877822-41-8
Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.
Feretoside
TQ0280CAS 27530-67-2
Feretoside is a natural product extracted from the barks of E. ulmoides. It is an HSP inducer.
HSP70-IN-1
T3487CAS 1268273-90-0
HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).
Dihydroberberine
T8189CAS 483-15-8
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channe...
(-)-Maackiain
TN1901CAS 2035-15-6
(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
Falcarinol,Panaxynol
TN2360CAS 21852-80-2
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Pa...
AMP-PCP
T13547CAS 3469-78-1
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
AMP-PCP disodium
T13547LCAS 7414-56-4
AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp...
CCT251236
T14905CAS 1693731-40-6
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induct...
Debio 0932
T15088CAS 1061318-81-7
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
Tamoxifen-​d5
T13076CAS 157698-32-3
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enha...
Gamitrinib TPP
T11355CAS 1131626-46-4
Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a  Gamitrinib (GA) mitochondrial matrix inhibitor. 
Gamitrinib TPP hexafluorophosphate
T11356CAS 1131626-47-5
Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a  Gamitrinib ...
KU-32
T15671CAS 956498-70-7
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
Radicicol
T16719CAS 12772-57-5
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50:...
TAS-116
T16994CAS 1260533-36-5
TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
4beta-Hydroxywithanolide E
TN3070CAS 54334-04-2
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic prog...
Calyxin H
TN3572CAS 202596-22-3
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
Goniothalamin
TN4160CAS 17303-67-2
Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cel...
Hardwickiic acid
TN4183CAS 1782-65-6
Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic a...