T0756 |
Ethoxyquin |
Ethoxyquin is an antioxidant used in animal feeds. |
T10860 |
Col003 |
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the invest...
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T11355 |
Gamitrinib TPP |
Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. |
T11356 |
Gamitrinib TPP hexafluorophosphate |
Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a Gamitrinib ...
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T13076 |
Tamoxifen-d5 |
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enha...
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T13547 |
AMP-PCP |
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90. |
T13547L |
AMP-PCP disodium |
AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp...
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T13554 |
Arimoclomol maleate |
Arimoclomol maleate (BRX-220) is a heat shock protein (HSP) co-inducer. |
T14905 |
CCT251236 |
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induct...
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T1501 |
Rifabutin |
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
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T15088 |
Debio 0932 |
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively). |
T15671 |
KU-32 |
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death. |
T16719 |
Radicicol |
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50:...
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T16994 |
TAS-116 |
TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively). |
T1989 |
LuminespibHOT |
AUY922 (NVP-AUY922) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay). |
T2114 |
NVP-BEP800 |
NVP-BEP800, a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94. |
T2179 |
Triptolide |
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii. |
T2258 |
VER50589 |
VER-50589 is a potent HSP90 inhibitor. |
T2268 |
VER49009 |
VER-49009 is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM). |
T2286 |
BIIB021 |
BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM). |
T2309 |
Ganetespib |
Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. |
T2444 |
KNK437 |
KNK437, a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40). |
T3293 |
Apoptozole |
Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis. |
T3487 |
HSP70-IN-1 |
HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM). |
T3527 |
TRC 051384 |
Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates hea...
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T3594 |
ML346 |
ML346 is a novel activator of Hsp70. |
T3652 |
KRIBB11 |
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor. |
T4125 |
HSF1A |
HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis. |
T4342 |
PF-04929113 Mesylate |
PF-04929113 Mesylate, a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM). |
T5008 |
Teprenone |
Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). |
T5152 |
MKT077 |
MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 µM in vitro) through its ability ...
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T5350 |
JG98 |
JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM). |
T5826 |
Eupalinolide A |
Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. |
T6118 |
HSP990 |
NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM). |
T6170 |
Elesclomol |
Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells. |
T6248 |
XL888 |
XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins ...
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T6284 |
Onalespib |
Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selec...
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T6290 |
TanespimycinHOT |
Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM). |
T6297 |
Alvespimycin hydrochloride |
17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2. |
T6305 |
SNX2112 |
SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM. |
T6341 |
PF04929113 |
SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positione...
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T6343 |
Geldanamycin |
Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association. |
T6558 |
KW2478 |
KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
T6855 |
HA15 |
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells ...
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T7010 |
VER155008 |
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fol...
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T7265 |
HSP27 inhibitor J2 |
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the ...
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T8189 |
Dihydroberberine |
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channe...
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T8668 |
HM03 |
HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity. |
T8829 |
2',4'-DIHYDROXYCHALCONE |
2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects |
T8858 |
DTHIB |
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation. |
TN1901 |
(-)-Maackiain |
(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene. |
TN2360 |
Falcarinol,Panaxynol |
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Pa...
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TN3070 |
4beta-Hydroxywithanolide E |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic prog...
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TN3572 |
Calyxin H |
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer. |
TN4160 |
Goniothalamin |
Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cel...
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TN4183 |
Hardwickiic acid |
Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic a...
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TN4604 |
Myricanone |
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferatio...
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TN5254 |
Wighteone |
Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL...
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TQ0280 |
Feretoside |
Feretoside is a natural product extracted from the barks of E. ulmoides. It is an HSP inducer. |