HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product name	CAS No.	Purity
TN5254	Wighteone	51225-30-0	98%
TN5254	Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...
TN1901	(-)-Maackiain	2035-15-6	98%
TN1901	(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
T67836	AT-533	908112-37-8	98%
T67836	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533...
T14905	CCT251236	1693731-40-6	98%
T14905	CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
T15671	KU-32	956498-70-7	98%
T15671	KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
TN3572	Calyxin H	202596-22-3	98%
TN3572	Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
TN4604	Myricanone	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T18018	HS-27	1562024-11-6	98%
T18018	HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
T6442	CH5138303	959763-06-5	98%
T6442	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
TN2360	Falcarinol	21852-80-2	98%
TN2360	Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Pan...
T67897	GRP78-IN-3	2707510-30-1	98%
T67897	GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN...
T16719	Radicicol	12772-57-5	98%
T16719	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: ...
TN4183	Hardwickiic acid	1782-65-6	98%
TN4183	Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic ac...
T6960	PU-H71	873436-91-0	98%
T6960	PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
T11356	Gamitrinib TPP hexafluorophosphate	1131626-47-5	98%
T11356	Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA...
T15088	Debio 0932	1061318-81-7	98%
T15088	Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
T13547	AMP-PCP	3469-78-1	98%
T13547	AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
T11355	Gamitrinib TPP	1131626-46-4	98%
T11355	Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor.
T13076	Tamoxifen-d5	157698-32-3	98%
T13076	Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
TN3070	4beta-Hydroxywithanolide E	54334-04-2	98%
TN3070	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...