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Retinoid Receptor

Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis. Subtypes include: Retinoic acid receptors (RARs), Retinoid X receptors (RXRs), RAR-related orphan receptors (RORs).
Cat. No. Product name CAS No. Purity Chemical Structure
T22767 ER 50891 187400-85-7 98%
ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast d...
T68104 Mofarotene 125533-88-2 98%
Mofarotene is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and resp...
T77499 MSU-42011 2456434-36-7 98%
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
T24240 K-8012 1346513-17-4 98%
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
T14912 CD3254 196961-43-0 98%
CD3254 a selective agonist of retinoid-X-receptor (RXR).
T14689 BMS493 215030-90-3 98%
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR), inhibiting retinoic acid-induced differentiation. It can enhance nuclear corepressor intera...
T67921 Retinoic acid-d5 78996-15-3 98%
Retinoic acid-d5 is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 1...
T14143 AGN 194310 229961-45-9 98%
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
T15825 LY 178002 107889-32-7 98%
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
T17209 UVI 3003 847239-17-2 98%
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respective...
T1093 Adapalene 106685-40-9 98%
Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
TQ0064 Peretinoin 81485-25-8 98%
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T14090 AC-55649 59662-49-6 98%
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
T11844 LG-100064 153559-46-7 98%
LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
T21714 BMS453 166977-43-1 98%
BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through t...
T1872 Fenretinide 65646-68-6 98%
Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T14911 CD2665 170355-78-9 98%
CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
T4371 CD437 125316-60-1 98%
CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
T1611 Isotretinoin 4759-48-2 98%
Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and a...
T3955 AR7 80306-38-3 98%
AR7 is a retinoic acid receptor α (RARα) antagonist.
ER 50891
T22767
ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast d...
Mofarotene
T68104
Mofarotene is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and resp...
MSU-42011
T77499
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
K-8012
T24240
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
CD3254
T14912
CD3254 a selective agonist of retinoid-X-receptor (RXR).
BMS493
T14689
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR), inhibiting retinoic acid-induced differentiation. It can enhance nuclear corepressor intera...
Retinoic acid-d5
T67921
Retinoic acid-d5 is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 1...
AGN 194310
T14143
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
LY 178002
T15825
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
UVI 3003
T17209
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respective...
Adapalene
T1093
Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
Peretinoin
TQ0064
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
AC-55649
T14090
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
LG-100064
T11844
LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
BMS453
T21714
BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through t...
Fenretinide
T1872
Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
CD2665
T14911
CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
CD437
T4371
CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
Isotretinoin
T1611
Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and a...
AR7
T3955
AR7 is a retinoic acid receptor α (RARα) antagonist.
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