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Retinoid Receptor

Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis. Subtypes include: Retinoic acid receptors (RARs), Retinoid X receptors (RXRs), RAR-related orphan receptors (RORs).
Cat No. product name
TP1313L Cecropin B acetate Cecropin B acetate 通过破坏 PXR/类视黄醇 X 受体 α (RXR-α) 复合物与 DNA 序列的结合来诱导 NF-κB 活化并抑制 CYP3A29。 Cecropin B acetate 具有很强的抗菌活性。
T15811 LY2955303 LY2955303 是一种有效的特异性视黄酸受体 γ 拮抗剂(RARγ,Ki = 1.09 nM)。
T6694 Tamibarotene Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
T5854 AM580 AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
T11847L Liarozole Liarozole is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular a...
TQ0064 Peretinoin Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T6696 Tazarotene Tazarotene is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazaro...
T5341 WYC-209 WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
T1051 Retinoic acid Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell pr...
T1093 Adapalene Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
TN6735 Bigelovin Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pat...
T1611 Isotretinoin Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and a...
T4371 CD437 CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
T7586 Trifarotene trifarotene is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM...
T5843 Tarenflurbil R-flurbiprofen is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alz...
T4538 Palovarotene Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
T1288 TTNPB TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
T11844 LG-100064 LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T1872 Fenretinide Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T0499 Oxybenzone Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
T22843 HX 531 RXR antagonist
T7370 Talarozole Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46...
T6410 Bexarotene Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
TQ0097 AGN 193109 AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).
T1330 Acitretin Acitretin is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
T21714 BMS453 BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through t...
T1002 Etodolac Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, a...
T3955 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.
T15825 LY 178002 LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
T16425 PA452 PA452 is a retinoic X receptor (RXR) specific antagonist. PA452 suppresses the effect of Retinoic acid (RA) on Th1/Th2 development.
T17209 UVI 3003 UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respective...
T14143 AGN 194310 AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
T14946 Ch55 Ch55 is a potent inducer of the differentiation of HL60 cells (EC50: 200 nM). Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 shows a low affini...
T14912 CD3254 CD3254 a selective agonist of retinoid-X-receptor (RXR).
T14911 CD2665 CD2665 is an antagonist of RAR-beta/gamma (Ki: 110 nM and 306 nM for RARγ and RARβ).
T14689 BMS493 BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepres...
Cecropin B acetate
TP1313L
Cecropin B acetate 通过破坏 PXR/类视黄醇 X 受体 α (RXR-α) 复合物与 DNA 序列的结合来诱导 NF-κB 活化并抑制 CYP3A29。 Cecropin B acet...
LY2955303
T15811
LY2955303 是一种有效的特异性视黄酸受体 γ 拮抗剂(RARγ,Ki = 1.09 nM)。
Tamibarotene
T6694
Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
AM580
T5854
AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
Liarozole
T11847L
Liarozole is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular a...
Peretinoin
TQ0064
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
Tazarotene
T6696
Tazarotene is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazaro...
WYC-209
T5341
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
Retinoic acid
T1051
Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell pr...
Adapalene
T1093
Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
Bigelovin
TN6735
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pa...
Isotretinoin
T1611
Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and a...
CD437
T4371
CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
trifarotene
T7586
trifarotene is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=12...
Tarenflurbil
T5843
R-flurbiprofen is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alz...
palovarotene
T4538
Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
TTNPB
T1288
TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
LG-100064
T11844
LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
Magnolol
T3000
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
Fenretinide
T1872
Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
Oxybenzone
T0499
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
HX 531
T22843
RXR antagonist
Talarozole
T7370
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46...
Bexarotene
T6410
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
AGN 193109
TQ0097
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).
Acitretin
T1330
Acitretin is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
BMS453
T21714
BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through ...
Etodolac
T1002
Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, a...
AR7
T3955
AR7 is a retinoic acid receptor α (RARα) antagonist.
LY 178002
T15825
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production o...
PA452
T16425
PA452 is a retinoic X receptor (RXR) specific antagonist. PA452 suppresses the effect of Retinoic acid (RA) on Th1/Th2 development.
UVI 3003
T17209
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respecti...
AGN 194310
T14143
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
Ch55
T14946
Ch55 is a potent inducer of the differentiation of HL60 cells (EC50: 200 nM). Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 shows a low affi...
CD3254
T14912
CD3254 a selective agonist of retinoid-X-receptor (RXR).
CD2665
T14911
CD2665 is an antagonist of RAR-beta/gamma (Ki: 110 nM and 306 nM for RARγ and RARβ).
BMS493
T14689
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepres...