Retinoid Receptor

Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis. Subtypes include: Retinoic acid receptors (RARs), Retinoid X receptors (RXRs), RAR-related orphan receptors (RORs).

Cat. No.	Product name	CAS No.	Purity
T14912	CD3254	196961-43-0	98%
T14912	CD3254 a selective agonist of retinoid-X-receptor (RXR).
T14689	BMS493	215030-90-3	98%
T14689	BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepres...
T14090	AC-55649	59662-49-6	98%
T14090	AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
T14143	AGN 194310	229961-45-9	98%
T14143	AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
T24240	K-8012	1346513-17-4	98%
T24240	K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
T15825	LY 178002	107889-32-7	98%
T15825	LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
T16425	PA452	457657-34-0	98%
T16425	PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
T22920	LE135	155877-83-1	98%
T22920	LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly select...
T14089	AC-261066	870773-76-5	98%
T14089	AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
T23005	MM 11253	345952-44-5	98%
T23005	MM 11253 is a RARγ antagonist with IC50 of 44nM.
T11303	Fluorobexarotene	1190848-23-7	98%
T11303	Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene is a potent retinoid-X-receptor (RXR) agonist,...
T3000	Magnolol	528-43-8	100%
T3000	Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T5854	AM580	102121-60-8	98%
T5854	AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
T7370	Talarozole	201410-53-9	98%
T7370	Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46...
T4538	Palovarotene	410528-02-8	98.05%
T4538	Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
T6694	Tamibarotene	94497-51-5	98.2%
T6694	Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
T15811	LY2955303	1433497-19-8	98.56%
T15811	LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
T1288	TTNPB	71441-28-6	98.84%
T1288	TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
T5341	WYC-209	2131803-90-0	98.91%
T5341	WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
T6410	Bexarotene	153559-49-0	99%
T6410	Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).