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Retinoid Receptor

Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis. Subtypes include: Retinoic acid receptors (RARs), Retinoid X receptors (RXRs), RAR-related orphan receptors (RORs).
Cat. No. Product name CAS No. Purity Chemical Structure
T14912 CD3254 196961-43-0 98%
CD3254 a selective agonist of retinoid-X-receptor (RXR).
T14689 BMS493 215030-90-3 98%
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepres...
T14090 AC-55649 59662-49-6 98%
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
T14143 AGN 194310 229961-45-9 98%
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
T24240 K-8012 1346513-17-4 98%
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
T15825 LY 178002 107889-32-7 98%
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
T16425 PA452 457657-34-0 98%
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
T22920 LE135 155877-83-1 98%
LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly select...
T14089 AC-261066 870773-76-5 98%
AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
T23005 MM 11253 345952-44-5 98%
MM 11253 is a RARγ antagonist with IC50 of 44nM.
T11303 Fluorobexarotene 1190848-23-7 98%
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene  is a potent retinoid-X-receptor (RXR) agonist,...
T3000 Magnolol 528-43-8 100%
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T5854 AM580 102121-60-8 98%
AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
T7370 Talarozole 201410-53-9 98%
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46...
T4538 Palovarotene 410528-02-8 98.05%
Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
T6694 Tamibarotene 94497-51-5 98.2%
Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
T15811 LY2955303 1433497-19-8 98.56%
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
T1288 TTNPB 71441-28-6 98.84%
TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
T5341 WYC-209 2131803-90-0 98.91%
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
T6410 Bexarotene 153559-49-0 99%
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
CD3254
T14912
CD3254 a selective agonist of retinoid-X-receptor (RXR).
BMS493
T14689
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepres...
AC-55649
T14090
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
AGN 194310
T14143
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
K-8012
T24240
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
LY 178002
T15825
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
PA452
T16425
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
LE135
T22920
LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly select...
AC-261066
T14089
AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
MM 11253
T23005
MM 11253 is a RARγ antagonist with IC50 of 44nM.
Fluorobexarotene
T11303
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene  is a potent retinoid-X-receptor (RXR) agonist,...
Magnolol
T3000
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
AM580
T5854
AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
Talarozole
T7370
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46...
palovarotene
T4538
Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
Tamibarotene
T6694
Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
LY2955303
T15811
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
TTNPB
T1288
TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
WYC-209
T5341
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
Bexarotene
T6410
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
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