T14912 |
CD3254
|
196961-43-0
|
98%
|
|
CD3254 a selective agonist of retinoid-X-receptor (RXR).
|
T14689 |
BMS493
|
215030-90-3
|
98%
|
|
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepres...
|
T14090 |
AC-55649
|
59662-49-6
|
98%
|
|
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
|
T14143 |
AGN 194310
|
229961-45-9
|
98%
|
|
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
|
T24240 |
K-8012
|
1346513-17-4
|
98%
|
|
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
|
T15825 |
LY 178002
|
107889-32-7
|
98%
|
|
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
|
T16425 |
PA452
|
457657-34-0
|
98%
|
|
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
|
T22920 |
LE135
|
155877-83-1
|
98%
|
|
LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly select...
|
T14089 |
AC-261066
|
870773-76-5
|
98%
|
|
AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
|
T23005 |
MM 11253
|
345952-44-5
|
98%
|
|
MM 11253 is a RARγ antagonist with IC50 of 44nM.
|
T11303 |
Fluorobexarotene
|
1190848-23-7
|
98%
|
|
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene is a potent retinoid-X-receptor (RXR) agonist,...
|
T3000 |
Magnolol
|
528-43-8
|
100%
|
|
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
|
T5854 |
AM580
|
102121-60-8
|
98%
|
|
AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
|
T7370 |
Talarozole
|
201410-53-9
|
98%
|
|
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46...
|
T4538 |
Palovarotene
|
410528-02-8
|
98.05%
|
|
Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
|
T6694 |
Tamibarotene
|
94497-51-5
|
98.2%
|
|
Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
|
T15811 |
LY2955303
|
1433497-19-8
|
98.56%
|
|
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
|
T1288 |
TTNPB
|
71441-28-6
|
98.84%
|
|
TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
|
T5341 |
WYC-209
|
2131803-90-0
|
98.91%
|
|
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
|
T6410 |
Bexarotene
|
153559-49-0
|
99%
|
|
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
|