T14375 |
AZD3988
|
892489-52-0
|
98%
|
|
AZD3988 is an inhibitor of diacylglycerol acyl transferase-1 (DGAT-1). For human, rat, mouse, the IC50s values are 6, 5, 11 nM , respectively.
|
T6937 |
PF-04620110
|
1109276-89-2
|
98%
|
|
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
|
TN3257 |
7beta-Methoxyrosmanol
|
24703-38-6
|
98%
|
|
7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.
|
T11396 |
GGTI-2418
|
501010-06-6
|
98%
|
|
GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regress...
|
T12426 |
PF-06424439
|
1469284-78-3
|
98%
|
|
PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).
|
T13181 |
Tolcapone D7
|
T13181
|
98%
|
|
Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT.
|
T10119 |
3-O-Methyltolcapone
|
134612-80-9
|
98%
|
|
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for tre...
|
T11491 |
GSK2973980A
|
2219321-25-0
|
98%
|
|
GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM).
|
T10118 |
3-O-Methyltolcapone D7
|
T10118
|
98%
|
|
3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a poten...
|
T15109 |
DGAT1-IN-1
|
1449779-49-0
|
98%
|
|
DGAT1-IN-1 is a potent inhibitor of DGAT1 (IC50: < 10 nM in cell lysate from Hep3B cells overexpressing human DGAT1).
|
T11282 |
FGTI-2734
|
1247018-19-4
|
98%
|
|
FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. FGTI-2734...
|
T40542 |
Sinbaglustat
|
441061-33-2
|
98%
|
|
Sinbaglustat (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administere...
|
T1455 |
Nialamide
|
51-12-7
|
98%
|
|
Nialamide is an MAO inhibitor that is used as an antidepressive agent.
|
T6365 |
A 922500
|
959122-11-3
|
98%
|
|
A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel o...
|
T16398 |
Opicapone
|
923287-50-7
|
98%
|
|
Opicapone reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research ...
|
T2678 |
LB42708
|
226929-39-1
|
98%
|
|
LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).
|
T8489 |
Minodronic acid monohydrate
|
155648-60-5
|
98%
|
|
Minodronic acid monohydrate is an farnesyl diphosphate synthase inhibitor that acts as a bone resorption inhibitor.
|
T6302 |
Lonafarnib
|
193275-84-2
|
98%
|
|
Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
|
T7439 |
3-Methoxybenzamide
|
5813-86-5
|
98%
|
|
3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase.
|
T1599L |
Ibandronate sodium
|
138844-81-2
|
98%
|
|
Ibandronate Sodium is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis.
|