T4261 |
BPR1J-097 hydrochloride (1327167-19-0(free base))
|
|
FLT
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BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo. |
T12555 |
PROTAC FLT-3 degrader 1
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|
Others
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PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-prolifera... |
T39818 |
Desmorpholinyl Quizartinib-PEG2-COOH
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|
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Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quiz... |
T25168 |
Boc-ypgflt(O-tbu)
|
Boc-tyr-pro-gly-phe-leu-thr(O-t-Bu) |
|
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Boc-ypgflt(O-tbu) is a delta-receptor-selective opioid antagonist. |
T61977 |
FLT3/D835Y-IN-1
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|
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FLT3/D835Y-IN-1 (compound 13a) is a orally active, and selective inhibitor of FLT3 and FLT3/D835Y, with IC50s of 0.26 nM... |
T61415 |
FLT3/ITD-IN-1
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|
|
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FLT3/ITD-IN-1 (Compound 1) is a potent FLT3 internal tandem duplications ( FLT3-ITD ) inhibitor with IC 50 values of 38.... |
T61101 |
FLT3-IN-13
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|
|
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FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and FLT3 dual inhibitor with IC 50 valu... |
T2272 |
BPR1J-097
|
BPR1J097 |
FLT
|
|
BPR1J-097 is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3... |
T4053 |
AST 487
|
NVP-AST 487 |
FLT
,
c-RET
,
VEGFR
,
c-Kit
,
Bcr-Abl
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|
AST 487 is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also ca... |
T5466 |
Tyrosine kinase-IN-1
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FLT
,
FGFR
,
VEGFR
,
PDGFR
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|
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM,... |
T15542 |
Hypothemycin
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Others
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Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8... |
T8326 |
BMS-2
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|
FLT
,
c-Met/HGFR
,
VEGFR
|
|
BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor. |
T6720 |
Vatalanib dihydrochloride
|
CGP-79787 dihydrochloride , ZK-222584 dihydrochloride , Vatalanib 2HCl , Vatalanib (PTK787) 2HCl , PTK787 dihydrochloride , CGP-797870 dihydrochloride |
VEGFR
,
Apoptosis
,
PDGFR
|
|
Vatalanib (PTK787) (IC50=37 nM) is an inhibitor of VEGFR2/KDR. It exhibits less effective against VEGFR1/Flt-1 and 18-fo... |
T37426 |
FIIN-1
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|
|
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Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respective... |
T1836 |
AZD2932
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|
FLT
,
VEGFR
,
c-Kit
,
PDGFR
|
|
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit. |
T19689 |
Raluridine
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DRG-0215 , FddClUrd , FCU , 935U-83 , BW-935U-83 |
|
|
Raluridine is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. 935U83 inhibited v... |
T8496 |
MAZ51
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Apoptosis
,
VEGFR
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|
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor. |
T6092 |
Sapitinib
|
AZD-8931 |
EGFR
|
|
AZD8931, a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effe... |
T1754 |
ZM 306416
|
CB 676475 |
VEGFR
,
Bcr-Abl
,
Src
|
|
ZM 306416, a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM). |
T2624 |
OSI-930
|
OSI 930 |
FLT
,
c-Fms
,
Raf
,
Apoptosis
,
VEGFR
,
CSF-1R
,
Src
,
c-Kit
|
|
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets ca... |