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Search Result

Search Results for " mdm2 "

Targets

Mdm2 Mdm2 p53

114

Compounds

6

Natural Products

21

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T72026 P53-MDM2-IN-1 Mdm2 , p53
p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM. This compound holds potential for applications in anti-tumor research.
T67698 P53-Mdm2 inhibitor 4 Mdm2 , p53
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
T41084 MDM2-IN-21 MDM2-IN-21
MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.
T24440 MDM2-p53-IN-1b MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b
MDM2-p53-IN-1b is the MDM2-p53 interaction inhibitor.
T12351 P53 and MDM2 proteins-interaction-inhibitor (racemic) p53-and-mdm2-proteins-interaction-inhibitor-racemic Others
p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.
T18633 PROTAC MDM2 Degrader-3 Others
PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T11982 MDM2-IN-1 Others
MDM2-IN-1 is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration.
T18632 PROTAC MDM2 Degrader-2 Others
PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2, a linker, and the MDM2 ligand for E3 ubiquitin ligase, thi...
T18634 PROTAC MDM2 Degrader-4 Others
PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T18631 PROTAC MDM2 Degrader-1 Others
PROTAC MDM2 Degrader-1 is a chemical compound that utilizes PROTAC technology to degrade MDM2. This compound is comprised of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T12350 P53 and MDM2 proteins-interaction-inhibitor dihydrochloride Others
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.
T79483 MDM2/XIAP-IN-3
MDM2/XIAP-IN-3 (compound 3e), a dual inhibitor of MDM2/XIAP, diminishes MDM2 and XIAP protein levels while augmenting p53 expression, consequently suppressing cancer cell proliferation and inducing apoptosis [1].
T82179 HOXB7 8–25 MDM2 32-46
HOXB7 8–25 (MDM2 32-46) is a peptide epitope derived from MDM2 that can induce both antigen-specific and tumor-reactive CD4+ T cell responses [1].
T78699 MDMX/MDM2-IN-2
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX. It effectively disrupts the interaction between p53 and MDM2 proteins, ther...
T72832 MDM2-p53-IN-16
MDM2-p53-IN-16 is a potent inhibitor of the MDM2-p53 complex, exhibiting an IC 50 value of 4.3 nM for the dissociation of the human p53/MDM2 complex. It effectively reactivates p53, leading to apoptosis and cell-cycle ar...
T81830 MDM2/XIAP-IN-1
MDM2/XIAP-IN-1 (compound 14) is an orally active dual inhibitor of MDM2 and XIAP, exhibiting anti-cancer activity with an IC50 of 0.3 μM and potential applications in cancer research [1].
T79012 MDM2/XIAP-IN-2
MDM2/XIAP-IN-2 is a dual inhibitor targeting murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). It promotes the degradation of MDM2 and impedes translation of XIAP mRNA, effectively inhibit...
T74936 MDM2/4-p53-IN-3
MDM2/4-p53-IN-3, an inhibitor of MDM2/4-p53 protein-protein interactions (PPIs), exhibits potent activity with IC50 values of 18.5 nM for MDM2-p53 and 14.8 nM for MDM4-p53. This compound is applicable in cancer research,...
T74935 MDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a potent dual inhibitor of MDM2/MDM4 and activator of p53, demonstrating IC50 values of 70.7 nM for MDM2-p53 and 81.4 nM for MDM4-p53 complexes. It facilitates cell cycle regulation, promotes apop...
T63438 Rel-MDM2/4-p53-IN-3
rel-MDM2/4-p53-IN-3 is an MDM2/4-p53 protein-protein interaction (PPI) inhibitor that acts on MDM2-p53 and MDM4-p53 with IC50 values of 18.5 nM and 14.8 nM, respectively. rel-MDM2/4-p53-IN-3 can be used to study cancers,...
T63748 Rel-MDM2/4-p53-IN-2
rel-MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/MDM4 inhibitor and p53 activator that acts on both the MDM2-p53 complex (IC50: 70.7 nM) and the MDM4-p53 complex (IC50: 81.4 nM). rel-MDM2/4-p53-IN-2 is capable of regulatin...
T17874 Nutlin carboxylic acid MDM2 ligand 1,E3 ligase Ligand 16 Others
Nutlin Carboxylic Acid (MDM2 ligand 1), derived from Nutlin 3, serves as an MDM2 ligand. It can be attached to a protein ligand via a linker to create PROTACs[1].
T17873 (4R,5S)-nutlin carboxylic acid E3 ligase Ligand 15,MDM2 ligand 2 Others
(4R,5S)-Nutlin Carboxylic Acid (MDM2 Ligand 2), a Nutlin 3-based MDM2 ligand, can be conjugated to a protein-binding ligand via a linker to create PROTACs[1].
T21578 NSC 66811 Mdm2
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53...
T17902 Nutlin-C1-amido-PEG4-C2-N3 E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1 Others
Nutlin-C1-amido-PEG4-C2-N3 is a novel compound that functions as a ligand-linker conjugate for the E3 ligase. It is a synthesized molecule incorporating the MDM2 ligand derived from Nutlin 3, and a 4-unit PEG linker. Thi...
T6610 XI-006 NSC 207895 Mdm2 , p53
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
T1919 Tenovin-1 Tenovin 1 Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T1818 Tenovin-6 Tenovin 6 Dehydrogenase , Sirtuin , Autophagy
Tenovin-6 is a p53 transcriptional activity agonist.
T8480 Tenovin-6 Hydrochloride Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
T3653 MX69 Mdm2 , E1/E2/E3 Enzyme , IAP
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
T6614 Nutlin-3b (+)-Nutlin-3 Mdm2 , E1/E2/E3 Enzyme
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
TQ0127 Navtemadlin AMG232,CS-1300 Mdm2 , E1/E2/E3 Enzyme
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T2158 Nutlin-3 Nutlin3 E1/E2/E3 Enzyme
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.
T11980 MD-224 Mdm2 , E1/E2/E3 Enzyme , PROTACs
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
TQ0231 NVP-CGM097 CGM097 Mdm2 , E1/E2/E3 Enzyme
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
T6585 SAR405838 MI773,MI 773,MI-77301,MI-773 Mdm2 , E1/E2/E3 Enzyme
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
T6254 Idasanutlin RG7388,Ro 5503781 Mdm2 , E1/E2/E3 Enzyme
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T14303 Alrizomadlin APG-115,AA-115 Mdm2
Alrizomadlin (APG-115) is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-d...
T6965 RG7112 RG-7112,RG 7112,RO5045337 Mdm2 , E1/E2/E3 Enzyme
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
T6023 Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 Apoptosis , E1/E2/E3 Enzyme , Autophagy
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
T3517 RO8994 Mdm2 , E1/E2/E3 Enzyme , p53
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
T16771 RO-5963 Mdm2 , p53
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
T21773 SP-141 SP 141 Mdm2
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
T28509 RDR03871 RDR 03871,ZINC20458540,RDR-03871 Mdm2
RDR03871 is an MDM2 inhibitor.
T28078 MMRi64 Apoptosis , Mdm2 , p53
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2...
T5461 GNE-6640 DUB
GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23...
T5555 Siremadlin NVP-HDM 201 E1/E2/E3 Enzyme
Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.
T6149 YH239-EE Apoptosis , E1/E2/E3 Enzyme
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
T1493 BH3I-1 BHI1 BCL , E1/E2/E3 Enzyme
BH3I-1 (BHI1) is a Bcl-2 antagonist.
T12040 Milademetan RAIN-32,DS-3032,DS3032b Mdm2 , Others
Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and soli...

Compounds

p53-MDM2-IN-1
T72026
Synonym:
Target: Mdm2, p53
p53-Mdm2 inhibitor 4
T67698
Synonym:
Target: Mdm2, p53
MDM2-IN-21
T41084
Synonym: MDM2-IN-21
Target:
MDM2-p53-IN-1b
T24440
Synonym: MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b
Target:
p53 and MDM2 proteins-interaction-inhibitor (racemic)
T12351
Synonym: p53-and-mdm2-proteins-interaction-inhibitor-racemic
Target: Others
PROTAC MDM2 Degrader-3
T18633
Synonym:
Target: Others
MDM2-IN-1
T11982
Synonym:
Target: Others
PROTAC MDM2 Degrader-2
T18632
Synonym:
Target: Others
PROTAC MDM2 Degrader-4
T18634
Synonym:
Target: Others
PROTAC MDM2 Degrader-1
T18631
Synonym:
Target: Others
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
T12350
Synonym:
Target: Others
MDM2/XIAP-IN-3
T79483
Synonym:
Target:
HOXB7 8–25
T82179
Synonym: MDM2 32-46
Target:
MDMX/MDM2-IN-2
T78699
Synonym:
Target:
MDM2-p53-IN-16
T72832
Synonym:
Target:
MDM2/XIAP-IN-1
T81830
Synonym:
Target:
MDM2/XIAP-IN-2
T79012
Synonym:
Target:
MDM2/4-p53-IN-3
T74936
Synonym:
Target:
MDM2/4-p53-IN-2
T74935
Synonym:
Target:
rel-MDM2/4-p53-IN-3
T63438
Synonym:
Target:
rel-MDM2/4-p53-IN-2
T63748
Synonym:
Target:
Nutlin carboxylic acid
T17874
Synonym: MDM2 ligand 1,E3 ligase Ligand 16
Target: Others
(4R,5S)-nutlin carboxylic acid
T17873
Synonym: E3 ligase Ligand 15,MDM2 ligand 2
Target: Others
NSC 66811
T21578
Synonym:
Target: Mdm2
Nutlin-C1-amido-PEG4-C2-N3
T17902
Synonym: E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1
Target: Others
XI-006
T6610
Synonym: NSC 207895
Target: Mdm2, p53
Tenovin-1
T1919
Synonym: Tenovin 1
Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy
Tenovin-6
T1818
Synonym: Tenovin 6
Target: Dehydrogenase, Sirtuin, Autophagy
Tenovin-6 Hydrochloride
T8480
Synonym:
Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy
MX69
T3653
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, IAP
Nutlin-3b
T6614
Synonym: (+)-Nutlin-3
Target: Mdm2, E1/E2/E3 Enzyme
Navtemadlin
TQ0127
Synonym: AMG232,CS-1300
Target: Mdm2, E1/E2/E3 Enzyme
Nutlin-3
T2158
Synonym: Nutlin3
Target: E1/E2/E3 Enzyme
MD-224
T11980
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, PROTACs
NVP-CGM097
TQ0231
Synonym: CGM097
Target: Mdm2, E1/E2/E3 Enzyme
SAR405838
T6585
Synonym: MI773,MI 773,MI-77301,MI-773
Target: Mdm2, E1/E2/E3 Enzyme
Idasanutlin
T6254
Synonym: RG7388,Ro 5503781
Target: Mdm2, E1/E2/E3 Enzyme
Alrizomadlin
T14303
Synonym: APG-115,AA-115
Target: Mdm2
RG7112
T6965
Synonym: RG-7112,RG 7112,RO5045337
Target: Mdm2, E1/E2/E3 Enzyme
Nutlin-3a
T6023
Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3
Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy
RO8994
T3517
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, p53
RO-5963
T16771
Synonym:
Target: Mdm2, p53
SP-141
T21773
Synonym: SP 141
Target: Mdm2
RDR03871
T28509
Synonym: RDR 03871,ZINC20458540,RDR-03871
Target: Mdm2
MMRi64
T28078
Synonym:
Target: Apoptosis, Mdm2, p53
GNE-6640
T5461
Synonym:
Target: DUB
Siremadlin
T5555
Synonym: NVP-HDM 201
Target: E1/E2/E3 Enzyme
YH239-EE
T6149
Synonym:
Target: Apoptosis, E1/E2/E3 Enzyme
BH3I-1
T1493
Synonym: BHI1
Target: BCL, E1/E2/E3 Enzyme
Milademetan
T12040
Synonym: RAIN-32,DS-3032,DS3032b
Target: Mdm2, Others
1 2 3
Cat No. Product Name Synonyms Targets
T6S1780 Protosappanin B Q-100961,FT-0689654 Apoptosis
1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, vi...
T2140 Parthenolide (-)-Parthenolide Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T6717 Vanillin Lioxin,m-Methoxy-p-hydroxybenzaldehyde,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,FEMA 3107 Others , Endogenous Metabolite
Vanillin (Zimco) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.Vanillin can reversibly and non-competitively inhibit the cellulase activity at appropr...
T22857 Illudin S Apoptosis , DNA Alkylator/Crosslinker , Antifungal
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties.
T2179 Triptolide PG490,NSC 163062 Apoptosis , Mdm2 , HSP , NF-κB
Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and ...
TN4107 Ganoderic acid X ERK , Mdm2 , MAPK , Caspase , Topoisomerase , JNK , p53
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.

Natural Products

Protosappanin B
T6S1780
Synonym: Q-100961,FT-0689654
Target: Apoptosis
Parthenolide
T2140
Synonym: (-)-Parthenolide
Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy
Vanillin
T6717
Synonym: Lioxin,m-Methoxy-p-hydroxybenzaldehyde,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,FEMA 3107
Target: Others, Endogenous Metabolite
Illudin S
T22857
Synonym:
Target: Apoptosis, DNA Alkylator/Crosslinker, Antifungal
Triptolide
T2179
Synonym: PG490,NSC 163062
Target: Apoptosis, Mdm2, HSP, NF-κB
Ganoderic acid X
TN4107
Synonym:
Target: ERK, Mdm2, MAPK, Caspase, Topoisomerase, JNK, p53

Recombinant Proteins

Species：
Human (15)
Mouse (4)
Cynomolgus (1)
HAdV-5 (1)
Expression System：
E. coli (13)
Baculovirus-Insect Cells (8)
Tag：
His,GST (4)
Tag Free (4)
His (3)
N-terminal 6xHis-SUMO-tagged (2)
N-terminal 6xHis-tagged (2)
C-terminal 6xHis-tagged (1)
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-tagged and C-terminal Myc-tagged (1)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPH-02630 MDM2 Protein, Mouse, Recombinant (His) Mouse E. coli
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional ...
TMPY-04753 IRE1 Protein, Human, Recombinant (aa 465-977) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04413 IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-01463 USP7 Protein, Human, Recombinant (aa 208-560, His & GST) Human Baculovirus-Insect Cells
Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein...
TMPH-01855 PEX19 Protein, Human, Recombinant (GST) Human E. coli
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacti...
TMPY-01464 USP7 Protein, Human, Recombinant (aa 208-560) Human Baculovirus-Insect Cells
Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein...
TMPY-01465 USP7 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein...
TMPH-02286 USP7 Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M...
TMPJ-00703 Gankyrin Protein, Human, Recombinant Human E. coli
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblast...
TMPH-02899 VRK1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream targe...
TMPH-00900 Human adenovirus C serotype 5 Early E1A protein (His & SUMO) HAdV-5 E. coli
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPY-02391 SUMO1 Protein, Human, Recombinant (His) Human E. coli
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific pro...
TMPY-02228 P53 Protein, Cynomolgus, Recombinant Cynomolgus E. coli
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and...
TMPY-01125 MDMX Protein, Human, Recombinant (His) Human E. coli
MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows str...
TMPH-02549 FHIT Protein, Mouse, Recombinant (His) Mouse E. coli
Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely ...
TMPY-04560 VRK1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family me...
TMPY-04751 VRK1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family me...
TMPY-02211 USP5 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a member of the peptidase C19 famil...
TMPH-02855 PML Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and vi...
TMPH-00855 RPS3 Protein, Human, Recombinant (His) Human E. coli
Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad spe...
TMPH-02288 UBE2D3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11)...
MDM2 Protein, Mouse, Recombinant (His)
TMPH-02630
Species: Mouse
Expression System: E. coli
IRE1 Protein, Human, Recombinant (aa 465-977)
TMPY-04753
Species: Human
Expression System: Baculovirus-Insect Cells
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
TMPY-04413
Species: Human
Expression System: Baculovirus-Insect Cells
USP7 Protein, Human, Recombinant (aa 208-560, His & GST)
TMPY-01463
Species: Human
Expression System: Baculovirus-Insect Cells
PEX19 Protein, Human, Recombinant (GST)
TMPH-01855
Species: Human
Expression System: E. coli
USP7 Protein, Human, Recombinant (aa 208-560)
TMPY-01464
Species: Human
Expression System: Baculovirus-Insect Cells
USP7 Protein, Human, Recombinant (His & GST)
TMPY-01465
Species: Human
Expression System: Baculovirus-Insect Cells
USP7 Protein, Human, Recombinant (His & Myc & SUMO)
TMPH-02286
Species: Human
Expression System: E. coli
Gankyrin Protein, Human, Recombinant
TMPJ-00703
Species: Human
Expression System: E. coli
VRK1 Protein, Mouse, Recombinant (His & Myc)
TMPH-02899
Species: Mouse
Expression System: E. coli
Human adenovirus C serotype 5 Early E1A protein (His & SUMO)
TMPH-00900
Species: HAdV-5
Expression System: E. coli
SUMO1 Protein, Human, Recombinant (His)
TMPY-02391
Species: Human
Expression System: E. coli
p53 Protein, Cynomolgus, Recombinant
TMPY-02228
Species: Cynomolgus
Expression System: E. coli
MDMX Protein, Human, Recombinant (His)
TMPY-01125
Species: Human
Expression System: E. coli
FHIT Protein, Mouse, Recombinant (His)
TMPH-02549
Species: Mouse
Expression System: E. coli
VRK1 Protein, Human, Recombinant (His & GST)
TMPY-04560
Species: Human
Expression System: Baculovirus-Insect Cells
VRK1 Protein, Human, Recombinant
TMPY-04751
Species: Human
Expression System: Baculovirus-Insect Cells
USP5 Protein, Human, Recombinant (His)
TMPY-02211
Species: Human
Expression System: Baculovirus-Insect Cells
PML Protein, Mouse, Recombinant (His & Myc)
TMPH-02855
Species: Mouse
Expression System: E. coli
RPS3 Protein, Human, Recombinant (His)
TMPH-00855
Species: Human
Expression System: E. coli
UBE2D3 Protein, Human, Recombinant (His & SUMO)
TMPH-02288
Species: Human
Expression System: E. coli
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