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BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2775 2-Methoxystypandrone 85122-21-0 98%
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
T11968 MCL-1/BCL-2-IN-1 T11968 98%
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].
T16694 Pyridoclax 1651890-44-6 98%
Pyridoclax is an inhibitor of potential Mcl-1.
T16089 MK-0674 887781-62-6 98%
MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
TN3653 Cimidahurinine 142542-89-0 98%
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
TN3708 Coronarin D 119188-37-3 98%
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
TN4490 Manassantin B 88497-88-5 98%
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
TN2149 Reynosin 28254-53-7 98%
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
T10434L AZD-5991 Racemate 2143010-83-5 98%
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is an Mcl-1 inhibitor (IC50: <3 nM in FRET assay).
TMA0153 Safflor Yellow A 85532-77-0 98%
Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
TN3618 Cedrin 75513-81-4 98%
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN2691 2',3'-Dehydrosalannol 97411-50-2 98%
2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits ca...
T10577 BM 957 1391107-54-2 98%
BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).
TN3681 Clerosterol 2364-23-0 98%
Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots. Clerosterol exerts its cy...
T13454 (S)-Purvalanol B T13454 98%
(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.
TN4999 Serratenediol 2239-24-9 98%
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
T12629L MIK665 1799631-75-6 98%
MIK665 (S-64315) has an inhibitory effect on myeloid leukemia.
T13337 WEHI-539 hydrochloride 2070018-33-4 98%
WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
TN2191 Scutebarbatine A 176520-13-1 98%
Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspa...
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 57719-81-0 98%
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
MCL-1/BCL-2-IN-1
T11968
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].
Pyridoclax
T16694
Pyridoclax is an inhibitor of potential Mcl-1.
MK-0674
T16089
MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
Cimidahurinine
TN3653
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
Coronarin D
TN3708
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
Manassantin B
TN4490
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
Reynosin
TN2149
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
AZD-5991 Racemate
T10434L
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is an Mcl-1 inhibitor (IC50: <3 nM in FRET assay).
Safflor Yellow A
TMA0153
Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
Cedrin
TN3618
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
2',3'-Dehydrosalannol
TN2691
2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits ca...
BM 957
T10577
BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).
Clerosterol
TN3681
Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots. Clerosterol exerts its cy...
(S)-Purvalanol B
T13454
(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.
Serratenediol
TN4999
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
MIK665
T12629L
MIK665 (S-64315) has an inhibitory effect on myeloid leukemia.
WEHI-539 hydrochloride
T13337
WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
Scutebarbatine A
TN2191
Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspa...
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
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