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Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
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Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.
Cat. No. Product name CAS No. Purity Chemical Structure
T10821 Cirsiliol 34334-69-5 98%
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
TN1871 Ligustroside 35897-92-8 98%
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
T10719 CCT365623 hydrochloride 2126136-98-7 98%
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
T11196 Enazadrem 107361-33-1 98%
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
TN5020 (+/-)-Sigmoidin A 176046-04-1 98%
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
TN4783 Picralinal 20045-06-1 98%
Picralinal has anti-inflammatory and analgesic effects.
TN4331 Isotachioside 31427-08-4 98%
Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
T10438 AZD 4407 166882-70-8 98%
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
T34624 Setileuton 910656-27-8 98%
Setileuton is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
TN5174 Trichosanatine 169626-16-8 98%
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
TL0014 Pinusolide 31685-80-0 98%
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T4571 Balsalazide 80573-04-2 98%
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
T13764 Lycopodine 466-61-5 98%
Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive comp...
T10151 5-Lipoxygenase-In-1 125235-15-6 98%
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
T39986 LOX-IN-3 dihydrochloride 2409964-23-2 98%
LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities...
T9878 Croconazole 77175-51-0 98%
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the syn...
T21838 1-Naphthyl 3,5-dinitrobenzoate 93261-39-3 98%
1-Naphthyl 3,5-dinitrobenzoate is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.
T5759 S-(+)-Marmesin 13849-08-6
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T22054 BW 755C 66000-40-6
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.
TN1255 3-O-Acetyl-11-hydroxy-beta-boswellic acid 146019-25-2
3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
Cirsiliol
T10821
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
Ligustroside
TN1871
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
CCT365623 hydrochloride
T10719
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
Enazadrem
T11196
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
(+/-)-Sigmoidin A
TN5020
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
Picralinal
TN4783
Picralinal has anti-inflammatory and analgesic effects.
Isotachioside
TN4331
Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
AZD 4407
T10438
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
Setileuton
T34624
Setileuton is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
Trichosanatine
TN5174
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
Balsalazide
T4571
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
Lycopodine
T13764
Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive comp...
5-Lipoxygenase-In-1
T10151
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
LOX-IN-3 dihydrochloride
T39986
LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities...
Croconazole
T9878
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the syn...
1-Naphthyl 3,5-dinitrobenzoate
T21838
1-Naphthyl 3,5-dinitrobenzoate is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.
S-(+)-Marmesin
T5759
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
BW 755C
T22054
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.
3-O-Acetyl-11-hydroxy-beta-boswellic acid
TN1255
3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
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