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Neurokinin receptor

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins.
Cat No. product name
T22811L GR 94800 acetate GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.
T24697 R 396 R 396 is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.
T3034 Eprazinone dihydrochloride Eprazinone is a mucolytic with antitussive and mucolytic effect.
T24446L MEN 10207 acetate MEN 10207 acetate is a selective antagonist for NK-2 tachykinin receptor.
T1743 Aprepitant Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhi...
T7554 Substance P (7-11) Substance P 7-11(TFA) is a C-terminal fragment of Substance P .
T7631 Eledoisin Related Peptide Eledoisin Related Peptide(2TFA) is a tachykinin receptor ligand.
T7396 Substance P(1-7) Substance P 1-7 is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptiv...
T7559 Neurokinin A(4-10) Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .
T19518L Physalaemin acetate Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor.
T7631L Eledoisin Related Peptide 2TFA Eledoisin Related Peptide(2TFA) is a tachykinin receptor ligand.
T38144 Elinzanetant Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia[1]. [1]. Alvaro, Giuseppe; Andreotti, Daniele; Belvedere, Sandro; Di Fab...
TP1851L Scyliorhinin II acetate Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.
T35344 Maropitant citrate Maropitant citrate 是一种新型神经激肽 1 型 (neurokinin type-1, NK1) 受体拮抗剂,具有抗炎和镇痛特性。
TQ0087 NKP608 NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.
TP1177 Eledoisin Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.
T1790 Fosaprepitant dimeglumine Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upo...
T19518 Physalaemin Physalaemin is a non-mammalian tachykinin.
T7209 Maropitant Maropitant is a selective neurokinin (NK1) receptor antagonist.
T7549 Talnetant Talnetant is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmi...
T7828 [Sar9,Met(O2)11]-Substance P Bhsar-sp is an agonist of NK1 receptor.
T7633 Senktide Senktide is an agonist of tachykinin NK3 receptor.
T8789 N-Acetyl-L-tryptophan N-Acetyl-L-tryptophan is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).
T8235 L-732138 L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
T13329L Vofopitant dihydrochloride Vofopitant dihydrochloride is a selective and orally available antagonist of tachykinin neurokinin 1(NK1) receptor (pKi: 9.5 and 10.6 in rat and human membranes ...
T13329 Vofopitant Vofopitant is a potent antagonist of the tachykinin NK1 receptor (pKis: 10.6, 9.5, and 9.8 for the human, rat, and ferret NK1 receptor, respectively).
T13306L Vapreotide acetate Vapreotide acetate is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).
T10892 CS-003 Free base CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 ...
T10688 Casopitant mesylate Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
TP1385 Neurokinin A(4-10) TFA(97559-35-8 free base) Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1].
TP1363L Neurokinin B acetate(86933-75-7 free base) Neurokinin B acetate is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R...
TP1369L [Sar9,Met(O2)11]-Substance P acetate [Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor ...
TP1572 GR-73632 Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
TP1772L Hemokinin 1 (mouse) acetate(208041-90-1 free base) Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 recep...
TP1738L Kassinin acetate(63968-82-1 free base) Kassinin acetate is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.
TP1899L1 Hemokinin 1 (human) acetate(491851-53-7 free base) Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM ...
TP1862L [Sar9] Substance P acetate(77128-75-7 free base) [Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)1...
TP1883 [Lys5,MeLeu9,Nle10]-NKA(4-10) Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
TP1087 Substance P Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
TP1086 Men 10376 TFA(135306-85-3,free) Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
TP1008 Neurokinin A Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
TP2227L C14TKL-1 acetate C14TKL-1 acetate is a NK1 receptor agonist.
T6905 Netupitant Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
T3724 Rolapitant hydrochloride Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) ...
T3716 Rolapitant Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) ...
T16849 SB-222200 SB-222200 is a selective, reversible, and competitive antagonist of the human NK-3 receptor(Ki=4.4 nM).
T16406 Orvepitant maleate Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant...
T15278 Fezolinetant Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
GR 94800 acetate
T22811L
GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.
R 396
T24697
R 396 is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.
Eprazinone dihydrochloride
T3034
Eprazinone is a mucolytic with antitussive and mucolytic effect.
MEN 10207 acetate
T24446L
MEN 10207 acetate is a selective antagonist for NK-2 tachykinin receptor.
Aprepitant
T1743
Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhi...
Substance P (7-11)
T7554
Substance P 7-11(TFA) is a C-terminal fragment of Substance P .
Eledoisin Related Peptide
T7631
Eledoisin Related Peptide(2TFA) is a tachykinin receptor ligand.
Substance P(1-7)
T7396
Substance P 1-7 is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptiv...
Neurokinin A(4-10)
T7559
Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .
Physalaemin acetate
T19518L
Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor.
Eledoisin Related Peptide 2TFA
T7631L
Eledoisin Related Peptide(2TFA) is a tachykinin receptor ligand.
Elinzanetant
T38144
Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia[1]. [1]. Alvaro, Giuseppe; Andreotti, Daniele; Belvedere, Sandro; Di Fab...
Scyliorhinin II acetate
TP1851L
Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.
Maropitant citrate
T35344
Maropitant citrate 是一种新型神经激肽 1 型 (neurokinin type-1, NK1) 受体拮抗剂,具有抗炎和镇痛特性。
NKP608
TQ0087
NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.
Eledoisin
TP1177
Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.
Fosaprepitant dimeglumine
T1790
Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upo...
Physalaemin
T19518
Physalaemin is a non-mammalian tachykinin.
Maropitant
T7209
Maropitant is a selective neurokinin (NK1) receptor antagonist.
Talnetant
T7549
Talnetant is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmi...
[Sar9,Met(O2)11]-Substance P
T7828
Bhsar-sp is an agonist of NK1 receptor.
Senktide
T7633
Senktide is an agonist of tachykinin NK3 receptor.
N-Acetyl-L-tryptophan
T8789
N-Acetyl-L-tryptophan is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).
L-732138
T8235
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
Vofopitant dihydrochloride
T13329L
Vofopitant dihydrochloride is a selective and orally available antagonist of tachykinin neurokinin 1(NK1) receptor (pKi: 9.5 and 10.6 in rat and human membranes ...
Vofopitant
T13329
Vofopitant is a potent antagonist of the tachykinin NK1 receptor (pKis: 10.6, 9.5, and 9.8 for the human, rat, and ferret NK1 receptor, respectively).
Vapreotide acetate
T13306L
Vapreotide acetate is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).
CS-003 Free base
T10892
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 ...
Casopitant mesylate
T10688
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
Neurokinin A(4-10) TFA(97559-35-8 free base)
TP1385
Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1].
Neurokinin B acetate(86933-75-7 free base)
TP1363L
Neurokinin B acetate is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R...
[Sar9,Met(O2)11]-Substance P acetate
TP1369L
[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor ...
GR-73632
TP1572
Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
TP1772L
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 recep...
Kassinin acetate(63968-82-1 free base)
TP1738L
Kassinin acetate is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.
Hemokinin 1 (human) acetate(491851-53-7 free base)
TP1899L1
Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM ...
[Sar9] Substance P acetate(77128-75-7 free base)
TP1862L
[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)1...
[Lys5,MeLeu9,Nle10]-NKA(4-10)
TP1883
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
Substance P
TP1087
Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
Men 10376 TFA(135306-85-3,free)
TP1086
Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
Neurokinin A
TP1008
Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
C14TKL-1 acetate
TP2227L
C14TKL-1 acetate is a NK1 receptor agonist.
Netupitant
T6905
Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
Rolapitant hydrochloride
T3724
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) ...
Rolapitant
T3716
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) ...
SB-222200
T16849
SB-222200 is a selective, reversible, and competitive antagonist of the human NK-3 receptor(Ki=4.4 nM).
Orvepitant maleate
T16406
Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant...
Fezolinetant
T15278
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.