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Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).
Cat. No. Product name CAS No. Purity Chemical Structure
T67777 Flaviviruses-IN-3 420090-97-7 98%
Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruse. Flaviviruses-IN-3 could reduce the WNV (West Nile virus) protease activity, with a inhibiti...
TN1202 (-)-α-Pinene 7785-26-4 98%

(1S)-(-)-Alpha-Pinene is a natural product

T11138L LHF-535 1450929-77-7 98%
LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
T13397 ZINC03129319 1777807-64-3 98%
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
T18928 Brilliant Black BN 2519-30-4
Brilliant black BN (E151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71...
T0220 Foscarnet sodium 63585-09-1
Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T4061 LY2334737 892128-60-8 100%
LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
T2A2498 L-Lysine 56-87-1 100%
Lysine is one of nine essential amino acids in humans required for growth and tissue repair, Lysine is supplied by many foods, especially red meats, fish, and da...
T5666 Dipotassium glycyrrhizinate 68797-35-3 89.63%
Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
T6327 Tubacin 537049-40-4 95.63%
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
T6309 AZ960 905586-69-8 96.02%
AZ 960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
T8903 Retro-2 1201652-50-7 96.08%
Retro 2 is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endos...
T3S1852 Cephaeline hydrochloride 3738-70-3 97.81%
T5779 MOSLOFLAVONE 740-33-0 98%
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
T5S1805 5,7-Dihydroxychromone 31721-94-5 98%
1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
T7366 NGI-1 790702-57-7 98%
NGI-1 is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability.
T8071 L-Lysine hydrochloride 657-27-2 98%
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, reducing diabetes-related illnesses, increasing cal...
T6S0095 Genkwanin 437-64-9 98%
1. Genkwanin exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diff...
T8371 ML188 1417700-13-0 98.04%
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
T6605 NH125 278603-08-0 98.04%
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
Flaviviruses-IN-3
T67777
Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruse. Flaviviruses-IN-3 could reduce the WNV (West Nile virus) protease activity, with a inhibiti...
(-)-α-Pinene
TN1202
<p>(1S)-(-)-Alpha-Pinene is a natural product</p>
LHF-535
T11138L
LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
ZINC03129319
T13397
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
Brilliant Black BN
T18928
Brilliant black BN (E151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71...
Foscarnet sodium
T0220
Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
LY2334737
T4061
LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
L-Lysine
T2A2498
Lysine is one of nine essential amino acids in humans required for growth and tissue repair, Lysine is supplied by many foods, especially red meats, fish, and da...
Dipotassium glycyrrhizinate
T5666
Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
Tubacin
T6327
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
AZ960
T6309
AZ 960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
Retro-2
T8903
Retro 2 is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endos...
Cephaeline hydrochloride
T3S1852
MOSLOFLAVONE
T5779
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
5,7-Dihydroxychromone
T5S1805
1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
NGI-1
T7366
NGI-1 is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability.
L-Lysine hydrochloride
T8071
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, reducing diabetes-related illnesses, increasing cal...
Genkwanin
T6S0095
1. Genkwanin exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diff...
ML188
T8371
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
NH125
T6605
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
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