Home Tools
Log in
Cart

Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).
Cat No. product name
T2875 Angelicin Angelicin, is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
T5429 Theaflavin 3,3'-digallate 8-Gingerol (TFDG), a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it re...
T2432 PD 169316 PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
T0495 Aminothiazole Aminothiazole, a thyroid inhibitor, displays antibacterial activity.
TMO2787 Anthraquinone Anthraquinones are the main active constituents in herbs often used to relieve constipation.
T6S0095 Genkwanin 1. Genkwanin exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diff...
T1717 Alpha-Mangostin Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
T4S0999 (2S)-Isoxanthohumol 1. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphenol wi...
T2732 (-)-Epicatechin gallate One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicid...
T1583 Vorinostat Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).
T6309 AZ960 AZ 960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
T2A2498 L-Lysine Lysine is one of nine essential amino acids in humans required for growth and tissue repair, Lysine is supplied by many foods, especially red meats, fish, and da...
T2741 Glycyrrhizic acid Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
T4061 LY2334737 LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
T0939 Phenytoin Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux fr...
T6516 Golgicide A Golgicide A is a potent and rapidly reversible GBF1 inhibitor.
T11138L LHF-535 LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
T5666 Dipotassium glycyrrhizinate Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
T5S1923 Schisandrin C Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
T2616 PIK-93 PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T0220 Foscarnet sodium Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T0825 Ebselen Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is th...
T6S1315 Oroxylin A 1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting th...
T6377 Aloperine Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
TN2111 Prunin Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-re...
T3345 Hederasaponin B Hederasaponin B has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.
T12711 Retro-2 cycl Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 1...
T1750 Pirodavir Pirodavir (R 77975), the prototype of broad-spectrum anti-picornavirus compounds, is a potent human rhinovirus (HRV) capsid-binding inhibitor.
T4492 Pocapavir Pocapavir is an investigational enterovirus (EV) capsid inhibitor.
T2926 Schizandrin A
T1848 Dynasore Dynasore, a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhi...
T5013 Brequinar Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
T13006 ST-193 ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively)...
T0188 Fluticasone (propionate) Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
T2774 Lycorine hydrochloride Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.
T6605 NH125 NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T8071 L-Lysine hydrochloride L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-re...
T8205 Norwogonin Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).
T0122 Bergenin Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T1307 Carmofur Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
T13397 ZINC03129319 ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
T4536 Pleconaril Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).
T0800 Danthron Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T18928 Brilliant Black BN Brilliant black BN (E151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71...
T0254 Probucol Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
T5158 N-Desmethylclozapine N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
T8903 Retro-2 Retro 2 is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endos...
T1954 SRPIN340 SRPIN340, a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).
T1670 Lanatoside C Lanatoside C is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). L...
T5S1805 5,7-Dihydroxychromone 1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
Angelicin
T2875
Angelicin, is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
Theaflavin 3,3'-digallate
T5429
8-Gingerol (TFDG), a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it re...
PD 169316
T2432
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
Aminothiazole
T0495
Aminothiazole, a thyroid inhibitor, displays antibacterial activity.
Anthraquinone
TMO2787
Anthraquinones are the main active constituents in herbs often used to relieve constipation.
Genkwanin
T6S0095
1. Genkwanin exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diff...
alpha-Mangostin
T1717
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
(2S)-Isoxanthohumol
T4S0999
1. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphenol wi...
(-)-Epicatechin gallate
T2732
One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicid...
Vorinostat
T1583
Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).
AZ960
T6309
AZ 960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
L-Lysine
T2A2498
Lysine is one of nine essential amino acids in humans required for growth and tissue repair, Lysine is supplied by many foods, especially red meats, fish, and da...
Glycyrrhizic acid
T2741
Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
LY2334737
T4061
LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
Phenytoin
T0939
Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux fr...
Golgicide A
T6516
Golgicide A is a potent and rapidly reversible GBF1 inhibitor.
LHF-535
T11138L
LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
Dipotassium glycyrrhizinate
T5666
Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
Schisandrin C
T5S1923
Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
PIK-93
T2616
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
Foscarnet sodium
T0220
Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
Ebselen
T0825
Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is th...
Oroxylin A
T6S1315
1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting th...
Aloperine
T6377
Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
Prunin
TN2111
Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-re...
Hederasaponin B
T3345
Hederasaponin B has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.
Retro-2 cycl
T12711
Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and ...
Pirodavir
T1750
Pirodavir (R 77975), the prototype of broad-spectrum anti-picornavirus compounds, is a potent human rhinovirus (HRV) capsid-binding inhibitor.
pocapavir
T4492
Pocapavir is an investigational enterovirus (EV) capsid inhibitor.
Schizandrin A
T2926
Dynasore
T1848
Dynasore, a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inh...
Brequinar
T5013
Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
ST-193
T13006
ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively)...
Fluticasone (propionate)
T0188
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
Lycorine hydrochloride
T2774
Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.
NH125
T6605
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
L-Lysine hydrochloride
T8071
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-re...
Norwogonin
T8205
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).
Bergenin
T0122
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Carmofur
T1307
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
ZINC03129319
T13397
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
Pleconaril
T4536
Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).
Danthron
T0800
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
Brilliant Black BN
T18928
Brilliant black BN (E151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71...
Probucol
T0254
Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
N-Desmethylclozapine
T5158
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
Retro-2
T8903
Retro 2 is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endos...
SRPIN340
T1954
SRPIN340, a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).
Lanatoside C
T1670
Lanatoside C is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). L...
5,7-Dihydroxychromone
T5S1805
1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
1 2