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Mitochondrial Metabolism

Mitochondrial metabolism encompasses pathways that generate ATP to drive intracellular unfavorable energetic reactions and produce the building blocks necessary for macromolecule synthesis.
Cat No. product name
TN1362 Afzelin Afzelin 具有多种细胞活性,例如 DNA 保护、抗菌、抗氧化和抗炎以及 UV 吸收活性,并且可以通过 UV 吸收和细胞活性的组合保护人体皮肤免受 UVB 引起的损伤。 Afzelin 减轻线粒体损伤,增强线粒体生物合成并降低线粒体自噬相关蛋白、parkin 和 putative kinase 1 的水平。
T7081 CCCP CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T5564 Tricarballylic acid Tricarballylic acid is an inhibitor of aconitase.
T0200 α-Lipoic Acid Thioctic acid is an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by c...
T9777 THP104c THP104c is an inhibitor of mitochondrial fission.
T2901 Daidzin Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T5363 Tempo TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
T3898 Schaftoside Schaftoside has antioxidant and anticancer activity.
T9211 Mito-LND Mito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T1768 7ACC2 7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
T36141 Boscalid Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehyd...
T8732 CTPI-2 CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose trans...
T8841 IMT1 Anticancer.
T5827 BI-6C9 BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.
T14140 Agaric acid Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus i...
T9169 MPP+ iodide MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in s...
T8500 VLX600 VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosp...
T7922 Kresoxim-Methyl Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .
T2970 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)....
T4639 Azemiglitazone MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes.
T4441 UK-5099 UK 5099 is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC5...
T0239 Lonidamine Lonidamine is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK)....
T2A2532 L-Histidine Histidine is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, Histidine is important for maintena...
T0938 Thiabendazole Thiabendazole is a benzimidazole derivative with anthelminthic property.
T15241 ER-000444793 ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
T22235 Lipoic acid Lipoic acid is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
T14497 BAM 15 BAM 15 is an uncoupler of mitochondrial protonophore.
T5645 Nerol Nerol is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian hea...
T0412 Idebenone Idebenone is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).
T1634 Glibenclamide Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T15373 Gboxin Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
T16342 KL1333 KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subseque...
T5337 IACS-010759 IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.
T2988 (-)-Epigallocatechin Gallate Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF recep...
T7487 Speract Speract is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
T6157 Devimistat CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metab...
T2607 MSDC 0160 MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
T7486 Imeglimin hydrochloride Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
T12408 Perhexiline maleate Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT 1) (rat heart and liver CPT 1 with IC50s of 77 and 148 μM , respectively).
T6834 FCCP FCCP, a potent uncoupler of oxidative phosphorylation in mitochondria, transport protons across cell membranes leading to disrupts ATP synthesis.
T4446 Tebufenpyrad Tebufenpyrad (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant rotenone.
T9031 MCU-i4 MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
T19428 Mito-TEMPO Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties.
T9372 D-Histidine D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.
T2930 α-Lipoic Acid α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoi...
T2498 Adjudin Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T9232 Mitochondrial fusion promoter M1 Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellula...
T9235 GW604714X GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate
T8366 Mitochonic acid 5 Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocy...
T8433 HQNO HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mit...
Afzelin
TN1362
CCCP
T7081
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochond...
Tricarballylic acid
T5564
Tricarballylic acid is an inhibitor of aconitase.
α-Lipoic Acid
T0200
Thioctic acid is an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by c...
THP104c
T9777
THP104c is an inhibitor of mitochondrial fission.
Daidzin
T2901
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
Tempo
T5363
TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
Schaftoside
T3898
Schaftoside has antioxidant and anticancer activity.
Mito-LND
T9211
Mito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
7ACC2
T1768
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
Boscalid
T36141
Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehyd...
CTPI-2
T8732
CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose tra...
IMT1
T8841
Anticancer.
BI-6C9
T5827
BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.
Agaric acid
T14140
Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus i...
MPP+ iodide
T9169
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in s...
VLX600
T8500
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosp...
Kresoxim-Methyl
T7922
Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .
Rotenone
T2970
Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)....
Azemiglitazone
T4639
MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes.
UK-5099
T4441
UK 5099 is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC5...
Lonidamine
T0239
Lonidamine is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK)....
L-Histidine
T2A2532
Histidine is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, Histidine is important for maintena...
Thiabendazole
T0938
Thiabendazole is a benzimidazole derivative with anthelminthic property.
ER-000444793
T15241
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
Lipoic acid
T22235
Lipoic acid is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
BAM 15
T14497
BAM 15 is an uncoupler of mitochondrial protonophore.
Nerol
T5645
Nerol is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian hea...
Idebenone
T0412
Idebenone is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).
Glibenclamide
T1634
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Gboxin
T15373
Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
KL1333
T16342
KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subseque...
IACS-010759
T5337
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.
(-)-Epigallocatechin Gallate
T2988
Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF recep...
Speract
T7487
Speract is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
Devimistat
T6157
CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial meta...
MSDC 0160
T2607
MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
Imeglimin hydrochloride
T7486
Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
Perhexiline maleate
T12408
Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT 1) (rat heart and liver CPT 1 with IC50s of 77 and 148 μM , respectively).
FCCP
T6834
FCCP, a potent uncoupler of oxidative phosphorylation in mitochondria, transport protons across cell membranes leading to disrupts ATP synthesis.
Tebufenpyrad
T4446
Tebufenpyrad (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant rotenone.
MCU-i4
T9031
MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
Mito-TEMPO
T19428
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties.
D-Histidine
T9372
D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.
α-Lipoic Acid
T2930
α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-L...
Adjudin
T2498
Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
Mitochondrial fusion promoter M1
T9232
Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellula...
GW604714X
T9235
GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate
Mitochonic acid 5
T8366
Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocy...
HQNO
T8433
HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mit...
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