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Ras

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
Cat No. product name
T6342 NSC 23766 trihydrochloride NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
T7131 Antineoplaston A10 Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
T16745 Rhosin hydrochloride Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
T2267 BQU57 BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.
T5418 BAY-293 BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
T5379 (Rac)-Antineoplaston A10 Antineoplaston A10 is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative...
T4306 CCG-203971 CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
T8756 KRAS inhibitor-9 KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2...
T3553 Y16 Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
T5S1261 Methylophiopogonanone B 1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.
T1931 6H05 6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
T1876 Kobe0065 Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H...
T2463 ML141 ML141 is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).
T3971 CASIN CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T6555 K-Ras(G12C) inhibitor 12 K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
T1892 Kobe2602 Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
T2700 FTI-277 hydrochloride FTI 277 hydrochloride is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely rela...
T6483 EHT 1864 EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
T11738 K-Ras G12C-IN-4 K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..
T7764 CCG-222740 CCG-222740 is an inhibitor of Rho/MRTF pathway
T6844 GGTI298 Trifluoroacetate GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
T5469 K-Ras-IN-1 K-Ras-IN-1 is a K-Ras inhibitor.
T9303 MRTX1133 MRTX1133 is a noncovalent, potent, and selective inhibitor of KRAS G12D.
T2427 EHop-016 EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.
T9407 Rasarfin Rasarfin inhibits Ras and ARF6.
T8006 Oncrasin-1 Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
T7414 ARS-853 ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
T8473 MLS000532223 MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
T15485 HJC0197 HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9...
T6462 Deltarasin Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
T6302 Lonafarnib Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
TN1413 Atranorin Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent ...
T6634 RBC8 RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
T22106 MLS-573151 MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 ...
T6163 Salirasib Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic a...
T0679 Ketoconazole Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T5597 ZT-12-037-01 Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
T1855 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor.
T8375 ML-210 ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
T8930 CID44216842 CID44216842 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding ...
T2014 CCG-1423 CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T22062 CCG-100602 CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 µM).
T22991 ML-099 pan activator of Ras-related GTPases
T12979 BI-3406 BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T22258 Sotorasib racemate AMG-510 racemate is a racemic of AMG-510 which is a potent inhibitor of KRAS G12C covalent, and leading to potential antineoplastic activity.
T22249 1588-A4 1588-A4 is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
T9198 SCH54292 SCH-54292 is a GDP exchange inhibitor.
T9184L Compound 3344 hydrochloride Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
T9184 Compound 3344 3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
T8843 APS6-45 APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
NSC 23766 trihydrochloride
T6342
NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
Antineoplaston A10
T7131
Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
Rhosin hydrochloride
T16745
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
BQU57
T2267
BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.
BAY-293
T5418
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
(Rac)-Antineoplaston A10
T5379
Antineoplaston A10 is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative...
CCG-203971
T4306
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. Th...
KRAS inhibitor-9
T8756
KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G...
Y16
T3553
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated si...
Methylophiopogonanone B
T5S1261
1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.
6H05
T1931
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
Kobe0065
T1876
Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of...
ML141
T2463
ML141 is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).
CASIN
T3971
CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
K-Ras(G12C) inhibitor 12
T6555
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
Kobe2602
T1892
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
FTI-277 hydrochloride
T2700
FTI 277 hydrochloride is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely rela...
EHT 1864
T6483
EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
K-Ras G12C-IN-4
T11738
K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..
CCG-222740
T7764
CCG-222740 is an inhibitor of Rho/MRTF pathway
GGTI298 Trifluoroacetate
T6844
GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
K-Ras-IN-1
T5469
K-Ras-IN-1 is a K-Ras inhibitor.
MRTX1133
T9303
MRTX1133 is a noncovalent, potent, and selective inhibitor of KRAS G12D.
EHop-016
T2427
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.
Rasarfin
T9407
Rasarfin inhibits Ras and ARF6.
Oncrasin-1
T8006
Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
ARS-853
T7414
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
MLS000532223
T8473
MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
HJC0197
T15485
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9...
Deltarasin
T6462
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
Lonafarnib
T6302
Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
Atranorin
TN1413
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent ...
RBC8
T6634
RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
MLS-573151
T22106
MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2...
Salirasib
T6163
Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic ...
Ketoconazole
T0679
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
ZT-12-037-01
T5597
Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
ZCL278
T1855
ZCL278 is a selective Cdc42 GTPase inhibitor.
ML-210
T8375
ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
CID44216842
T8930
CID44216842 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding...
CCG-1423
T2014
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
CCG-100602
T22062
CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 µM).
ML-099
T22991
pan activator of Ras-related GTPases
BI-3406
T12979
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
Sotorasib racemate
T22258
AMG-510 racemate is a racemic of AMG-510 which is a potent inhibitor of KRAS G12C covalent, and leading to potential antineoplastic activity.
1588-A4
T22249
1588-A4 is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
SCH54292
T9198
SCH-54292 is a GDP exchange inhibitor.
Compound 3344 hydrochloride
T9184L
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
Compound 3344
T9184
3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
APS6-45
T8843
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
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