T1931 |
6H05
|
1469338-01-9
|
99.02%
|
|
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
|
T10374 |
ARS-1323-alkyne
|
2436544-27-1
|
98.00%
|
|
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
|
T78651 |
Glecirasib
|
2657613-87-9
|
98%
|
|
Glecirasib (KRAS G12C inhibitor 36) is a potent inhibitor targeting the oncogenic KRAS G12C mutation, a key signaling molecule within the Ras protein family that...
|
T78661 |
TH-Z835
|
2766209-50-9
|
98%
|
|
TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM. It effectively hampers both mantGMPPNP...
|
T79057 |
KRAS G12C inhibitor 58
|
2915599-52-7
|
98%
|
|
KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].
|
T79072 |
KRAS G12D modulator-1
|
2883034-05-5
|
98%
|
|
KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is ...
|
T79092 |
TH-Z827
|
2847881-81-4
|
98%
|
|
TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Addition...
|
T79148 |
PROTAC KRAS G12C degrader-3
|
2768099-51-8
|
98%
|
|
PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].
|
T79150 |
KRAS G12C inhibitor 59
|
2914919-88-1
|
98%
|
|
KRAS G12C Inhibitor 59, a compound with anticancer properties, is characterized as compound II in WO2023036282A1 [1].
|
T79162 |
SOS1/KRAS-IN-1
|
2836330-34-6
|
98%
|
|
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].
|
T79166 |
KRAS G12C inhibitor 60
|
|
98%
|
|
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and pancreati...
|
T79183 |
SOS1-IN-16
|
2930763-85-0
|
98%
|
|
SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of ...
|
T79673 |
LUNA18
|
2676177-63-0
|
98%
|
|
LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation. It is ut...
|
T79799 |
Pan-KRAS-IN-4
|
2885961-55-5
|
98%
|
|
Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].
|
T79800 |
Pan-KRAS-IN-2
|
2882825-14-9
|
98%
|
|
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D,...
|
T79814 |
Pan-KRAS-IN-3
|
2875116-29-1
|
98%
|
|
Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].
|
T79869 |
Rac1-IN-3
|
380470-06-4
|
98%
|
|
Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].
|
T79870 |
RMC-4998
|
2642037-07-6
|
98%
|
|
RMC-4998 is a molecular glue compound exhibiting potent antitumor activity, capable of forming a ternary complex with CYPA and an activated KRAS G12C mutation. B...
|
T81263 |
RMC-7977
|
2765082-12-8
|
98%
|
|
RMC-7977 is a reversible, tri-complex RAS inhibitor that demonstrates broad-spectrum activity against mutant and wild-type (WT) KRAS, NRAS, and HRAS variants. Th...
|
T11770 |
KRAS G12C inhibitor 16
|
2349392-79-4
|
98%
|
|
KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
|