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MAPK Ras

Ras

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
Cat No. product name
T6163 Salirasib Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic...
T6302 Lonafarnib Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
T4619 ML-098 ML-098 is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).
T5379 Antineoplaston A10 Antineoplaston A10 is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferativ...
T7131 Antineoplaston A10 Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
T7328 AMG-510 AMG-510 is a potent KRAS G12C covalent inhibitor, treatment with AMG 510 led to the regression of KRASG12C tumours and improved the anti-tumour efficacy of chem...
T7326 6H05 6H05 is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
T7609 ARS-1620 ARS-1620 is a covalent inhibitor of K-RASG12C.
T7558 CID-1067700 CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).
T8006 Oncrasin 1 Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
T8375  ML-210 ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
T8369 MRTX849 MRTX849 is a potent, selective, and covalent KRASG12C inhibitor with potential antineoplastic activity.selectively modifies mutant cysteine 12 in GDP-bound KRAS...
T13844 PROTAC K-Ras Degrader-1 PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
T10375 ARS-1323 ARS-1323 (the racemate of ARS-1620) is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1.
T10374 ARS-1323-alkyne ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
T10376 ARS-1630 ARS-1630 is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1. It is a less active enantiomer of ARS-1620.
T12979 BI-3406 BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 of 6 nM),with anticancer activit...
T10533 BI-2852 BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an a...
T11744 KB-5246 KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
T16023 MC 976 MC 976 is a derivative of Vitamin D3.
T11767 KRAS G12C inhibitor 13 KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
T11768 KRAS G12C inhibitor 14 KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor . 
T11769 KRAS G12C inhibitor 15 KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
T11770 KRAS G12C inhibitor 16 KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
T11771 KRAS G12C inhibitor 17 KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor. 
T11773 KRAS inhibitor-6 KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
T11774 KRAS inhibitor-7 KRAS inhibitor-7 is a potent KRAS G12C inhibitor.
T11775 KRAS inhibitor-8 KRAS inhibitor-8 is a potent KRAS G12C inhibitor.
T11776 KRas G12C inhibitor 1 KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
T11777 KRas G12C inhibitor 2 KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
T11778 KRas G12C inhibitor 3 KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.
T11779 KRas G12C inhibitor 4 KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
T11780 KRAS G12C inhibitor 5 KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
T8684 AMG-510 AMG-510 is a selective and orally bioavailable KRAS G12C covalent inhibitor.
Salirasib
T6163CAS 162520-00-5
Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic...
Lonafarnib
T6302CAS 193275-84-2
Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
ML-098
T4619CAS 878978-76-8
ML-098 is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).
Antineoplaston A10
T5379CAS 77658-84-5
Antineoplaston A10 is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferativ...
Antineoplaston A10
T7131CAS 91531-30-5
Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
AMG-510
T7328CAS T7328
AMG-510 is a potent KRAS G12C covalent inhibitor, treatment with AMG 510 led to the regression of KRASG12C tumours and improved the anti-tumour efficacy of chem...
6H05
T7326CAS 2061344-88-3
6H05 is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
ARS-1620
T7609CAS 1698055-85-4
ARS-1620 is a covalent inhibitor of K-RASG12C.
CID-1067700
T7558CAS 314042-01-8
CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).
Oncrasin 1
T8006CAS 75629-57-1
Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
ML-210
T8375 CAS 1360705-96-9
ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
MRTX849
T8369CAS 2326521-71-3
MRTX849 is a potent, selective, and covalent KRASG12C inhibitor with potential antineoplastic activity.selectively modifies mutant cysteine 12 in GDP-bound KRAS...
PROTAC K-Ras Degrader-1
T13844CAS 2378258-52-5
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
ARS-1323
T10375CAS 1698024-73-5
ARS-1323 (the racemate of ARS-1620) is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1.
ARS-1323-alkyne
T10374CAS
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
ARS-1630
T10376CAS 1698055-86-5
ARS-1630 is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1. It is a less active enantiomer of ARS-1620.
BI-3406
T12979CAS 2230836-55-0
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 of 6 nM),with anticancer activit...
BI-2852
T10533CAS 2375482-51-0
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an a...
KB-5246
T11744CAS 119474-55-4
KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
MC 976
T16023CAS 129831-99-8
MC 976 is a derivative of Vitamin D3.
KRAS G12C inhibitor 13
T11767CAS 2241719-75-3
KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
KRAS G12C inhibitor 14
T11768CAS
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor . 
KRAS G12C inhibitor 15
T11769CAS 2349393-21-9
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
KRAS G12C inhibitor 16
T11770CAS 2349392-79-4
KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
KRAS G12C inhibitor 17
T11771CAS 2349393-04-8
KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor. 
KRAS inhibitor-6
T11773CAS 2022986-61-2
KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
KRAS inhibitor-7
T11774CAS 2022986-68-9
KRAS inhibitor-7 is a potent KRAS G12C inhibitor.
KRAS inhibitor-8
T11775CAS 2022986-70-3
KRAS inhibitor-8 is a potent KRAS G12C inhibitor.
KRas G12C inhibitor 1
T11776CAS 2158297-28-8
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
KRas G12C inhibitor 2
T11777CAS 2206735-61-5
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
KRas G12C inhibitor 3
T11778CAS 2206735-75-1
KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.
KRas G12C inhibitor 4
T11779CAS 2206736-07-2
KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
KRAS G12C inhibitor 5
T11780CAS 2158297-63-1
KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
AMG-510
T8684CAS 2296729-00-3
AMG-510 is a selective and orally bioavailable KRAS G12C covalent inhibitor.