acyl

Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat . Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (UGTs).

Diclofenac Acyl Glucuronide is a major biliary metabolite of Diclofenac (GLXC-07892), a nonsteroidal antiinflammatory drug and COX inhibitor.

Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), the acyl glucuronide formation of thyroxine (T4), an endogenous metabolite.

T3 Acyl glucuronide is the acyl glucuronide formation of triiodothyronine (T3). T3 Acyl glucuronide is an endogenous metabolite

Etodolac acyl glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac .1It is formedviaglucuronidation of etodolac by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A10, and UGT2B7. 1.Kutsuno, Y., Itoh, T., Tukey, R.H., et al.Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 miceDrug Metab. Dispos.42(7)1146-1152(2014)

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan . It does not bind human serum albumin and is cleared from rat plasma with a clearance rate of 180 ml/min/kg following intravenous administration.

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

UDP-3-O-acyl-GlcNAc diammonium serves as a metabolite in E. coli, playing a critical role in the biosynthesis pathway of 3-deoxy-D-manno-octulosonate (KDO) [1].

Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor perindopril [1].

UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine), an E. coli metabolite, plays a role in the 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway [1].

Methyl-PEG4-acyl chloride is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

Acyl coenzyme A synthetase (ACS), also known as acetyl coenzyme A synthetase, plays a pivotal role in biochemical research. This enzyme catalyzes the activation of fatty acids via coenzyme A through a two-step thioesterification process, resulting in the formation of acyl coenzyme A. Subsequently, it is involved in numerous anabolic and catabolic lipid metabolism pathways and contributes to the tricarboxylic acid (TCA) cycle during aerobic respiration [1].

Dabigatran acyl-β-D-glucuronide, an active metabolite of the thrombin inhibitor dabigatran, is synthesized predominantly through the action of the UDP-glucuronosyltransferase isoform UGT2B15. This compound, at a concentration of 0.46 µM, effectively prolongs activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.

Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.

Indomethacin acyl glucuronide, a metabolite of the COX inhibitor indomethacin (1), embodies an essential byproduct formed during the metabolic processing of indomethacin.

Ferulic acid acyl-β-D-glucoside, a metabolite of Ferulic Acid, is a novel inhibitor of fibroblast growth factor receptor 1 (FGFR1). It exhibits IC50 values of 3.78 µM and 12.5 µM for FGFR1 and FGFR2, respectively.

Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.

Acyl Carrier Protein (ACP) (65-74) is an active acyl carrier protein (ACP) fragment.Acyl Carrier Protein (ACP) is a component of plastid-located plant fatty acid synthetase. It binds acyl groups covalently via the prosthetic group, 4-phosphopantetheine, d

Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent. Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole.

Aminoacyl tRNA synthetase-IN-1 is an inhibitor of bacterial aminoacyl tRNA synthetase (aaRS).

OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.

Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid (13(Z)-Docosenoic Acid) is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase, which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this, babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism.

Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.

Tetracycline (Tetracyclin) is a naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.

2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.

Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct, therefore, exist in a glycine conjugated form. Bile acids are steroid acids found predominantly in bile of mammals.

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

Digalactosyldiacylglycerol is a natural product for research related to life sciences. The catalog number is TN5814 and the CAS number is 145033-48-3.

Deacylpolymyxin B increases outer membrane permeability.

erythro-Guaiacylglycerol beta-sinapyl ether is a natural product of Sambucus, Caprifoliaceae. The catalog number is TN4007 and the CAS number is 877875-96-2. erythro-Guaiacylglycerol beta-sinapyl ether can be used as a reference standard.

threo-Guaiacylglycerol is a natural product for research related to life sciences. The catalog number is TN5145 and the CAS number is 27391-16-8.

Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1.

Erythro-guaiacylglycerol-β-ferulic acid ether, a natural product, is isolated from Gueldenstaedtia verna [1].

erythro-Guaiacylglycerol is a natural product of Eucommia, Eucommiaceae. The catalog number is TN4008 and the CAS number is 38916-91-5. erythro-Guaiacylglycerol can be used as a reference standard.

Asebotoxin V, bisdeacyl- is a biochemical.

Deacylmetaplexigenin is a pregnane glycoside isolated from Asclepias incarnate.

NITD-916 is an orally active and highly lipophilic inhibitor of Mycobacterium enoyl reductase InhA with an IC50 of 570 nM.NITD-916 is a potent 4-hydroxy-2-pyridone derivative that forms a ternary complex with InhA and NADH, preventing access to the fatty acyl substrate-binding pocket.NITD-916 exhibits antituberculosis activity.

Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.

Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT), which can be used to study diseases due to high lipids.

Eflucimibe (L0081) is an acyl coenzyme A: cholesterol acyltransferase inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, and can be used to study atherosclerosis and hyperlipidemia.

Diformylphloroglucinol (2,4,6-Trihydroxyisophthalaldehyde) is an acyl resorcinol isolated from the leaves of the Eucalyptus nigra tree and is a raw material for the synthesis of resorcinol compounds with antioxidant and antiulcer activity.

CL 277082 (Ddpmhu) is an acyl coenzyme A:cholesterol O-acyltransferase inhibitor that inhibits granuloma tissue ACAT activity.

Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) is an acyl amino acid that blocks aortic constriction and antagonizes haloperidol-induced oral motility disorders.

DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride synthesis. The discovery of transgenic mice and pharmacological studies indicate that inhibiting DGAT1 is a promising strategy for treating obesity and type 2 diabetes.

Sphingolipid ceramide N-deacylase (SCDase) is an enzyme that catalyzes the cleavage of the N-acyl linkage between fatty acids and sphingosine bases in various glycosphingolipids, converting them into lysoglycosphingolipids [1].

erythro-Guaiacylglycerol β-coniferyl ether is a useful organic compound for research related to life sciences and the catalog number is T125621.

threo-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether is a natural product for research related to life sciences. The catalog number is TN5421 and the CAS number is 844637-85-0.

Lipase, triacylglycerol is a useful organic compound for research related to life sciences. The catalog number is T65529 and the CAS number is 9001-62-1.

threo-Guaiacylglycerol β-dihydroconiferyl ether is a useful organic compound for research related to life sciences and the catalog number is T125992.