antibodies

Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model of AAV.

Cy3 NHS ester (Cyanine3 NHS ester) is a fluorescent dye for labeling amino groups in proteins, peptides, antibodies, and oligonucleotides.

Rhodopsin Epitope Tag acetate is a 9-amino acid peptide representing C terminus of bovine rhodopsin widely used as an epitope tag. A number of anti-rhodopsin antibodies can recognize this epitope.

fmoc-L-2-cyanophenylalanine is a derivative of the amino acid phenylalanine. Due to its excellent reactivity and stability, it is widely used in peptide synthesis, as well as in the synthesis of a variety of other biologically active molecules, such as peptide hormones, enzymes and antibodies.

Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable linker vital in ADC synthesis. Fmoc-Ala-Ala-Asn(Trt)-OH joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Macropa-NH2 is a bifunctional analog of macropa, a carrier molecule that is often coupled to antibodies and is often used as a chelator in cancer research.

VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.

B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.

Tyvelose is an unusual 3,6-dideoxyhexose terminal sugar and the immunodominant component of glycoprotein antigens in the parasitic helminth T. spiralis, which is responsible for trichinosis in humans. It is produced in high amounts by the infective larva and is immunodominant during the muscle stage of infection. Mice immunized with tyvelose-BSA produce IgG1 antibodies to tyvelose but are not resistant to infection by T. spiralis. Tyvelose-specific antibodies (2.5 mg/20 g) administered to rat pups leads to expulsion of first stage larvae from the intestine within one hour.

Mouse IgG3 kappa Isotype Control is a monoclonal antibody serving as an isotype control specifically for mouse IgG3κ antibodies.

Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].

MC-VC-PAB-NH2 is a cleavable linker vital in ADC synthesis. MC-VC-PAB-NH2 joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

RS 09 TFA, a TLR4 agonist, promotes NF-κB nuclear translocation and induces the secretion of inflammatory cytokines in RAW264.7 macrophages in vitro. Additionally, as an adjuvant in vivo, RS 09 TFA enhances serum concentrations of X-15 specific antibodies when co-administered with X-15-KLH in mice.

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate, an ADC linker, is a glutathione cleavable compound used for the attachment of monoclonal antibodies (mAb) in antibody-drug conjugates (ADCs). It specifically refers to the Alkyl-Chain composition of the linker portion of these molecules [1].

Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development.

Human IgG3 kappa Isotype Control is a chimeric monoclonal antibody comprising human and mouse components, serving as an isotype control for human IgG3κ antibodies.

Reslizumab is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma.

MC-VAL-CIT-PAB-VX765 or MC-VAL-CIT-PABC-VX765 is a VX765 derivative that can be conjugated to antibodies, proteins, or polymers for targeted drug delivery. MC-Val- CIT -PAB is a cathepsin cleavable ADC connector, which has been widely used in the preparat

m-PEG8-Amine is a cleavable linker vital in ADC synthesis. m-PEG8-Amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable linker for antibody-drug conjugate (ADC) synthesis that facilitates the attachment of therapeutic agents to antibodies [1].

Zamerovimab (CTB011; SYN023), a composite of human monoclonal antibodies CTB011 and CTB012, targets distinct, non-overlapping epitopes on the rabies virus (RABV) glycoprotein, with CTB011 specifically binding to antigenic site III. This compound is applicable in rabies research [1].

Tilogotamab (GEN-1029) is an enhanced hexameric mixture of two agonistic antibodies that bind to distinct epitopes on death receptor type 5 (DR5), specifically activating it. This compound is utilized in the research of multiple myeloma (MM) [1].

Sulfo-MBS Crosslinker is a non-cleavable, water-soluble, heterobifunctional protein crosslinking reagent. It is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies.

SPDP-sulfo is a cleavable linker vital in ADC synthesis. SPDP-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Bifikafusp alfa (L19-IL2) is an immunotherapeutic fusion protein that combines human L19 antibodies with the cytokine interleukin 2 (IL2), targeting the extra domain B (EDB) of fibronectin with demonstrated anticancer activity [1].

DBCO-SS-amine is a cleavable linker vital in ADC synthesis. DBCO-SS-amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Mouse IgG1 kappa Isotype Control is a mouse monoclonal antibody that serves as an isotype control for mouse IgG1κ antibodies.

BS3 Crosslinker is a non-cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs)[1]. It is utilized specifically for its proficiency in connecting antibodies with drugs, enhancing the overall efficiency and effectiveness of the resulting ADC.

Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable linker composed of two PEG units, primarily employed for the synthesis of antibody-drug conjugates (ADCs). This compound serves as an essential constituent that facilitates the conjugation of antibodies to drugs, enabling the targeted delivery of therapeutic agents.

c-Myc Peptide is a useful displacement of c-Myc-tagged fusion proteins bound to anti-c-Myc antibodies in immunoassays. The successful inhibition of antibody binding by c-Myc peptide demonstrates binding is specific. c-Myc peptide participates in the regul

Tomaymycin DM, a derivative of Tomaymycin, functions as a DNA alkylator and PBD dimer. It is utilized to formulate antibody-drug conjugates (ADCs) by attaching to tumor-targeting antibodies.

Mouse IgG1 kappa (N297A) Isotype Control is a mouse monoclonal antibody serving as an isotype control specifically for Mouse IgG1(N297A)κ antibodies.

3x FLAG-DYKDDDDK Tag is a versatile tool utilized for studying protein function and localization when specific antibodies (Abs) are unavailable. It is frequently employed in its 3x FLAG format to facilitate the purification of proteins present in low quantities [1] [2].

Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.1It induces TNF-α release in THP-1 cells (EC50= 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but notTLR2-/-, mice sensitized to ovalbumin.2It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model. 1.Morin, M.D., Wang, Y., Jones, B.T., et al.Diprovocims: A new and exceptionally potent class of toll-like receptor agonistsJ. Am. Chem. Soc.140(43)14440-14454(2018) 2.Wang, Y., Su, L., Morin, M.D., et al.Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in miceProc. Natl. Acad. Sci. U.S.A.115(37)E8698-E8706(2018)

p-SCN-Bn-TCMC is a bifunctional chelator, it contains a powerful chelator TCMC and reactive tioisocyante linker. TCMC is a powerful chelator with capability to strongly bind radio-isotopic heavy metal ion, which are widely used for radio-diagnostic/imagin

sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

NHS-SS-biotin is a cleavable linker vital in ADC synthesis. NHS-SS-biotin joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is an immunogenic derivative of cAMP that has been used to generate anti-cAMP antisera and antibodies.1,2

Cy5.5-SE (Cyanine5.5 NHS ester) DIPEA, a cyanine (CY) dye, comprises two nitrogen atoms linked by an odd number of methyl units. Characterized by long wavelength, tunable absorption and emission, high extinction coefficient, and good water solubility, alongside relatively straightforward synthesis [1], CY dyes are frequently utilized for labeling proteins, antibodies, and small molecular compounds. Their application in protein antibody labeling is achieved through a simple mixing reaction, providing a method of notable reference significance [2]. Storage instructions include protection from light.

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable linker employed in ADC synthesis for conjugation with antibodies, ultimately producing antibody-drug conjugates (ADCs).

NO2-SPDMV-sulfo is a cleavable linker vital in ADC synthesis. NO2-SPDMV-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Biotin-sar-oh is a cleavable linker vital in ADC synthesis. Biotin-sar-oh joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

N-trifluoroacetyl-β-alanyl chloride is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs), which are bioconjugates formed by attaching drug molecules to antibodies.

Biotin-LC-LC-NHS is a SMCC cross-linking reagent, which serves as a labeling agent for antibodies and small molecules, like Paclitaxel.

Biotin Hydrazide is a carbonyl-reactive biotinylation reagent, which is a carbonyl probe. Biotin Hydrazide is a great choice for labeling mouse monoclonal antibodies, lectins, sugars, unpaired cytosine residues in nucleic acids, and glycoprotiens.

Propargyl-O-C1-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

The COVID-19 Spike Protein mRNA, responsible for expressing the COVID-19 spike protein, is crucial for evaluating RNA delivery, translation efficiency, and cell viability. Positioned on the membrane surface, this spike protein facilitates virus entry into cells by binding to host cell membrane receptors and promoting membrane fusion. It serves as a significant action site for neutralizing antibodies and represents a primary focus in vaccine development [1].

Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs), which are innovative therapeutic agents that combine the targeting ability of antibodies with potent cytotoxic drugs.

PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate cancer cells. When conjugated with STEAP1 and CLL1 antibodies, PROTAC BRD4 Degrader-9 exhibits potent activity, with respective DC50 values of 0.86 nM and 7.6 nM.