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Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.
Cat No. product name
T2S0271 Voacamine Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action i...
T19094 2,3-Butanediol 2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.
T9114 β-Caryophyllene β-Caryophyllene is a CB2 receptor agonist.
T8571 ML-184 ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
T1519L Rimonabant Rimonabant is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue ...
T8975 PSB-SB-487 PSB-SB-487 is antagonist of GPR55.
T14046 Anandamide Anandamide, an immune modulator, in the central nervous system acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55).
T4478 CID 16020046 CID16020046 is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
T0851 Pregnenolone Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T21450 AM-2232 AM-2232 is a potent and unselective agonist of the cannabinoid receptors.
T13803 N-Oleoyl glycine N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
T3736 Olivetol Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of...
T36520 COR659 COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
T14011 2-Arachidonoylglycerol In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand
T13289 EHP-101 VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
T12306 OMDM-5 OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
T1519 Rimonabant hydrochloride Rimonabant hydrochloride is a cannabinoid receptor antagonist, binding selectively to central cannabinoid receptors (CB1) with high affinity.
T3S0738 Yangonin 1. Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. 2. Yangonin could be a valuable candidate for the interv...
T1796 Otenabant hydrochloride Otenabant hydrochloride (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
T1915 AM251 AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
T2635 Org 27569 Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
T22103 ML-193 ML-193 is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the ...
T2264 AM281 AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
T7375 A-836339 A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
T7316 LY2828360 LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
T7705 GW 405833 GW 405833 is an agonist of cannabinoid-2 (CB(2)) receptor-selective
TC0019 Pregnenolone acetate Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibi...
T8511 TM38837 TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
TN2268 Tetrahydromagnolol Tetrahydromagnolol can activate cannabinoid (CB) receptors.
T10510 CB1 antagonist 1 CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and gast...
T10694 CB1 inverse agonist 1 CB1 inverse agonist 1 is an orally active, and specific inverse agonist of the CB1 receptor (IC50s: 7.5 nM and 4100 nM for CB1 and CB2 receptors) with anorexigen...
T13081 Taranabant racemate Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.
TN3575 (±)-Cannabichromene Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 ...
TN5131 Tetrahydrocannabivarin Tetrahydrocannabivarin is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, th...
TP1939L1 RVD-Hpα acetate(1193362-76-3 free base) RVD-Hpα acetate is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. Increases intracellular Ca2+ levels in cell...
TP1901L1 Hemopressin (rat) acetate(568588-77-2 free base) Hemopressin (rat) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally acti...
TP1900L1 Hemopressin (human, mouse) acetate Hemopressin (human, mouse) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is or...
T4654 (±)-Ibipinabant SLV319 has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
T4458 WIN 55,212-2 Mesylate WIN 55, 212-2 (Mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, ...
T4453 JD-5037 JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
T3699 Bay 59-3074 Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
T3530 Otenabant Otenabant has been investigated for the treatment of Obesity.
T5996 CB1-IN-1 CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T6755 AM1241 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
T6417 BML-190 BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
T6527 GW842166X GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase ...
T17027 Tedalinab Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab ...
T16928 SR144528 SR144528 is an effective and selective antagonist of the CB2 receptor (Ki: 0.6 nM).
T14302 Olorinab Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
T14204 6-Iodopravadoline 6-Iodopravadoline is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
Voacamine
T2S0271
Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action i...
2,3-Butanediol
T19094
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.
β-Caryophyllene
T9114
β-Caryophyllene is a CB2 receptor agonist.
ML-184
T8571
ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
Rimonabant
T1519L
Rimonabant is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue ...
PSB-SB-487
T8975
PSB-SB-487 is antagonist of GPR55.
Anandamide
T14046
Anandamide, an immune modulator, in the central nervous system acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55).
CID 16020046
T4478
CID16020046 is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
Pregnenolone
T0851
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
AM-2232
T21450
AM-2232 is a potent and unselective agonist of the cannabinoid receptors.
N-Oleoyl glycine
T13803
N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
Olivetol
T3736
Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of...
COR659
T36520
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
2-Arachidonoylglycerol
T14011
In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand
EHP-101
T13289
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-indu...
OMDM-5
T12306
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
Rimonabant hydrochloride
T1519
Rimonabant hydrochloride is a cannabinoid receptor antagonist, binding selectively to central cannabinoid receptors (CB1) with high affinity.
yangonin
T3S0738
1. Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. 2. Yangonin could be a valuable candidate for the interv...
Otenabant hydrochloride
T1796
Otenabant hydrochloride (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
AM251
T1915
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
Org 27569
T2635
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
ML-193
T22103
ML-193 is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the ...
AM281
T2264
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
A-836339
T7375
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
LY2828360
T7316
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM,...
GW 405833
T7705
GW 405833 is an agonist of cannabinoid-2 (CB(2)) receptor-selective
Pregnenolone acetate
TC0019
Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibi...
TM38837
T8511
TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
Tetrahydromagnolol
TN2268
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
CB1 antagonist 1
T10510
CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and gast...
CB1 inverse agonist 1
T10694
CB1 inverse agonist 1 is an orally active, and specific inverse agonist of the CB1 receptor (IC50s: 7.5 nM and 4100 nM for CB1 and CB2 receptors) with anorexigen...
Taranabant racemate
T13081
Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.
(±)-Cannabichromene
TN3575
Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 ...
Tetrahydrocannabivarin
TN5131
Tetrahydrocannabivarin is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, th...
RVD-Hpα acetate(1193362-76-3 free base)
TP1939L1
RVD-Hpα acetate is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. Increases intracellular Ca2+ levels in cel...
Hemopressin (rat) acetate(568588-77-2 free base)
TP1901L1
Hemopressin (rat) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally ac...
Hemopressin (human, mouse) acetate
TP1900L1
Hemopressin (human, mouse) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is ...
(±)-Ibipinabant
T4654
SLV319 has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
WIN 55,212-2 Mesylate
T4458
WIN 55, 212-2 (Mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, ...
JD-5037
T4453
JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
Bay 59-3074
T3699
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
Otenabant
T3530
Otenabant has been investigated for the treatment of Obesity.
CB1-IN-1
T5996
CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
AM1241
T6755
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
BML-190
T6417
BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
GW842166X
T6527
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase ...
Tedalinab
T17027
Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab ...
SR144528
T16928
SR144528 is an effective and selective antagonist of the CB2 receptor (Ki: 0.6 nM).
Olorinab
T14302
Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
6-Iodopravadoline
T14204
6-Iodopravadoline is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
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