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JAK/STAT signaling STAT

STAT

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK). Dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis which enhances the survival of tumors and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.
Cat No. product name
T0433 Artesunate Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefor...
T0711 Niclosamide Niclosamide(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
T1038 FludarabineHOT Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T1563 Nifuroxazide Nifuroxazide is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STA...
T2156 WP1066 WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 h...
T2168 2-NP 2-NP is a STAT1 enhancer.
T2505 S3I-201HOT S3I-201 is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
T2814 Cryptotanshinone Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser72...
T3218 Napabucasin Napabucasin is an orally available Stat3 and Y cell stemness inhibitor.
T3380 Homoharringtonine Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with mye...
T3398 Icaritin Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apopt...
T3404 Cucurbitacin B Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-re...
T3708 BP-1-102 BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide intera...
T3913 Saikosaponin D Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T3971 CASIN CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T4034 Solamargine Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growt...
T4216 STAT5 Inhibitor STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
T4234 HJC0152 hydrochloride HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
T6308 StatticHOT Stattic is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 μM).
T6537 HO-3867 HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
T6669 SH-4-54 SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.
T3S1775 Tectochrysin 1. Tectochrysin has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apop...
T4S2126 Ginkgetin 1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo again...
T5S0168 Atractylenolide II 1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation ,ERK...
T5S1607 Morusin 1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apop...
T4615 Balsalazide disodium salt dihydrate Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing p...
T4650 C188-9 C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
T5668 Acetyl-trans-resveratrol Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pan...
TQ0052 SH5-07 SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
TQ0196 Cucurbitacin I Cucurbitacin I, a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
T4S0145 Corylifol A 1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2....
T6S0141 Corylin Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer.
TN1620 Eriocalyxin B Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a can...
TN1775 Isocryptotanshinone Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negativ...
TN1840 Kurarinol Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts vary...
TN1059 Ganoderic acid B Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards t...
TN1013 Cucurbitacin D Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
T13009 STAT3-IN-1 STAT3-IN-1 is a selective and orally active inhibitor of STAT3(IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively),and induces tumo...
T14330 Ascochlorin Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlo...
T8476 RSVA 405 RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T14925 Cenisertib Cenisertib (AS-703569) is a multi-kinase inhibitor and blocks the activity of Aurora-kinase-A/B, AKT, ABL1, STAT5, and FLT3. Cenisertib inhibits tumor growth in...
T15234 ENMD-119 ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T11449L Golotimod Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and sp...
T12905 SI-109 SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T13010 STAT3-IN-3 STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
T11449 Golotimod hydrochloride  Golotimod hydrochloride  inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a com...
T11449L2 Golotimod (TFA) Golotimod TFA  inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of ...
T13950 UC-514321 UC-514321 is a structural analog of NSC370284, and has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
T15582 inS3-54A18 inS3-54A18 is a potent inhibitor of STAT3. It has anti-cancer properties.
T8478 SC-43 SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and...
Artesunate
T0433CAS 88495-63-0
Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefor...
Niclosamide
T0711CAS 50-65-7
Niclosamide(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
Fludarabine HOT
T1038CAS 21679-14-1
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
Nifuroxazide
T1563CAS 965-52-6
Nifuroxazide is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STA...
WP1066
T2156CAS 857064-38-1
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 h...
2-NP
T2168CAS 65182-56-1
2-NP is a STAT1 enhancer.
S3I-201 HOT
T2505CAS 501919-59-1
S3I-201 is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
Cryptotanshinone
T2814CAS 35825-57-1
Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser72...
Napabucasin
T3218CAS 83280-65-3
Napabucasin is an orally available Stat3 and Y cell stemness inhibitor.
Homoharringtonine
T3380CAS 26833-87-4
Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with mye...
Icaritin
T3398CAS 118525-40-9
Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apopt...
Cucurbitacin B
T3404CAS 6199-67-3
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-re...
BP-1-102
T3708CAS 1334493-07-0
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide intera...
Saikosaponin D
T3913CAS 20874-52-6
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
CASIN
T3971CAS 425399-05-9
CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
Solamargine
T4034CAS 20311-51-7
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growt...
STAT5 Inhibitor
T4216CAS 285986-31-4
STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
HJC0152 hydrochloride
T4234CAS 1420290-99-8
HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
Stattic HOT
T6308CAS 19983-44-9
Stattic is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 μM).
HO-3867
T6537CAS 1172133-28-6
HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
SH-4-54
T6669CAS 1456632-40-8
SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.
Tectochrysin
T3S1775CAS 520-28-5
1. Tectochrysin has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apop...
Ginkgetin
T4S2126CAS 481-46-9
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo again...
Atractylenolide II
T5S0168CAS 73069-14-4
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation ,ERK...
Morusin
T5S1607CAS 62596-29-6
1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apop...
Balsalazide disodium salt dihydrate
T4615CAS 150399-21-6
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing p...
C188-9
T4650CAS 432001-19-9
C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
Acetyl-trans-resveratrol
T5668CAS 42206-94-0
Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pan...
SH5-07
TQ0052CAS 1456632-41-9
SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
Cucurbitacin I
TQ0196CAS 2222-07-3
Cucurbitacin I, a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
Corylifol A
T4S0145CAS 775351-88-7
1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2....
Corylin
T6S0141CAS 53947-92-5
Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer.
Eriocalyxin B
TN1620CAS 84745-95-9
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a can...
Isocryptotanshinone
TN1775CAS 22550-15-8
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negativ...
Kurarinol
TN1840CAS 855746-98-4
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts vary...
Ganoderic acid B
TN1059CAS 81907-61-1
Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards t...
Cucurbitacin D
TN1013CAS 3877-86-9
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
STAT3-IN-1
T13009CAS 2059952-75-7
STAT3-IN-1 is a selective and orally active inhibitor of STAT3(IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively),and induces tumo...
Ascochlorin
T14330CAS 26166-39-2
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlo...
RSVA 405
T8476CAS 140405-36-3
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
Cenisertib
T14925CAS 871357-89-0
Cenisertib (AS-703569) is a multi-kinase inhibitor and blocks the activity of Aurora-kinase-A/B, AKT, ABL1, STAT5, and FLT3. Cenisertib inhibits tumor growth in...
ENMD-119
T15234CAS 864668-87-1
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
Golotimod
T11449LCAS 229305-39-9
Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and sp...
SI-109
T12905CAS
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
STAT3-IN-3
T13010CAS 2361304-26-7
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
Golotimod hydrochloride
T11449CAS
 Golotimod hydrochloride  inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a com...
Golotimod (TFA)
T11449L2CAS
Golotimod TFA  inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of ...
UC-514321
T13950CAS 299420-83-0
UC-514321 is a structural analog of NSC370284, and has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
inS3-54A18
T15582CAS 328998-53-4
inS3-54A18 is a potent inhibitor of STAT3. It has anti-cancer properties.
SC-43
T8478CAS 1400989-25-4
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and...