TN1631 |
Eupalinolide K
|
108657-10-9
|
|
|
Eupalinolide K is a natural product
|
TN1840 |
Kurarinol
|
855746-98-4
|
98%
|
|
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
|
T78983 |
STAT3 degrader-2
|
2497583-03-4
|
98%
|
|
STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseas...
|
T79185 |
STAT6-IN-2
|
1355594-85-2
|
98%
|
|
STAT6-IN-2 (Comp R-84) serves as a STAT6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltrati...
|
T79186 |
STAT6-IN-3
|
371919-80-1
|
98%
|
|
STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain. It is utilized in ...
|
T79662 |
STAT3-IN-20
|
2768427-54-7
|
98%
|
|
STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear tra...
|
T80639 |
HJC0152 free base
|
1420290-88-5
|
98%
|
|
HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograft ...
|
T80847 |
W1131 TFA
|
|
98%
|
|
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric...
|
T81690 |
Neocucurbitacin A
|
352359-53-6
|
98%
|
|
Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].
|
T14925 |
Cenisertib
|
871357-89-0
|
98%
|
|
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
|
TN4035 |
Eupalinolide I
|
1402067-84-8
|
98%
|
|
Eupalinolide I is a natural product from Eupatorium lindleyanum.
|
TN3587 |
Capillarisin
|
56365-38-9
|
98%
|
|
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
|
T13010 |
STAT3-IN-3
|
2361304-26-7
|
98%
|
|
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
|
TN3410 |
Anatabine
|
581-49-7
|
98%
|
|
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
TN2511 |
Britannilactone diacetate
|
1286694-67-4
|
98%
|
|
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
|
T11449L2 |
Golotimod (TFA) (229305-39-9 free base)
|
T11449L2
|
98%
|
|
Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and...
|
TN4774 |
Physalin A
|
23027-91-0
|
98%
|
|
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
|
T12905 |
SI-109
|
T12905
|
98%
|
|
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
|
T19886 |
Cirsilineol
|
41365-32-6
|
98%
|
|
Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineo...
|