T0433 |
Artesunate |
Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefor...
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T0711 |
Niclosamide |
Niclosamide(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication. |
T1038 |
FludarabineHOT |
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor. |
T11449 |
Golotimod hydrochloride |
Golotimod hydrochloride inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a com...
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T11449L |
Golotimod |
Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and sp...
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T11449L2 |
Golotimod (TFA) |
Golotimod TFA inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of ...
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T12905 |
SI-109 |
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity. |
T13009 |
STAT3-IN-1 |
STAT3-IN-1 is a selective and orally active inhibitor of STAT3(IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively),and induces tumo...
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T13010 |
STAT3-IN-3 |
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator. |
T13950 |
UC-514321 |
UC-514321 is a structural analog of NSC370284, and has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. |
T14330 |
Ascochlorin |
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlo...
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T14925 |
Cenisertib |
Cenisertib (AS-703569) is a multi-kinase inhibitor and blocks the activity of Aurora-kinase-A/B, AKT, ABL1, STAT5, and FLT3. Cenisertib inhibits tumor growth in...
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T15234 |
ENMD-119 |
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells. |
T15582 |
inS3-54A18 |
inS3-54A18 is a potent inhibitor of STAT3. It has anti-cancer properties. |
T1563 |
Nifuroxazide |
Nifuroxazide is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STA...
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T2156 |
WP1066 |
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 h...
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T2168 |
2-NP |
2-NP is a STAT1 enhancer. |
T2505 |
S3I-201HOT |
S3I-201 is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5. |
T2814 |
Cryptotanshinone |
Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser72...
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T2S0501 |
Ilexgenin A |
Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib...
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T2S1040 |
Jolkinolide B |
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part,...
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T2S1975 |
Ponicidin |
Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...
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T3218 |
Napabucasin |
Napabucasin is an orally available Stat3 and Y cell stemness inhibitor. |
T3380 |
Homoharringtonine |
Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with mye...
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T3398 |
Icaritin |
Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apopt...
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T3404 |
Cucurbitacin B |
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-re...
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T3708 |
BP-1-102 |
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide intera...
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T3913 |
Saikosaponin D |
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity. |
T3971 |
CASIN |
CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM). |
T3S1775 |
Tectochrysin |
1. Tectochrysin has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apop...
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T4034 |
Solamargine |
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growt...
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T4216 |
STAT5 Inhibitor |
STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain. |
T4234 |
HJC0152 hydrochloride |
HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor. |
T4615 |
Balsalazide disodium salt dihydrate |
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing p...
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T4650 |
C188-9 |
C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM. |
T4672 |
Brevilin A |
Brevilin A is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperact...
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T4S0145 |
Corylifol A |
1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2....
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T4S2126 |
Ginkgetin |
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo again...
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T5668 |
Acetyl-trans-resveratrol |
Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pan...
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T5S0168 |
Atractylenolide II |
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation ,ERK...
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T5S0993 |
Kurarinone |
Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may amelior...
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T5S1467 |
Cucurbitacin E |
Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions, it also exhibits ...
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T5S1607 |
Morusin |
1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apop...
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T6308 |
StatticHOT |
Stattic is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 μM). |
T6537 |
HO3867 |
HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor. |
T6669 |
SH-4-54 |
SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor. |
T6S0141 |
Corylin |
Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer. |
T8476 |
RSVA 405 |
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor |
T8478 |
SC-43 |
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and...
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T8546 |
BD750 |
BD750 is a JAK3/STAT5 inhibitor and an effective immunosuppressant that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.1 μM and...
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T8597 |
ML116 |
ML116 is a potent and selective STAT3 inhibitor. |
TJS1779 |
Protosappanin A |
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infl...
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TMA1743 |
Ergosterol peroxide |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fo...
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TN1013 |
Cucurbitacin D |
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. |
TN1059 |
Ganoderic acid B |
Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards t...
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TN1620 |
Eriocalyxin B |
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a can...
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TN1775 |
Isocryptotanshinone |
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negativ...
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TN1840 |
Kurarinol |
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts vary...
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TN2511 |
1,6-O,O-Diacetylbritannilactone |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airw...
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TN2775 |
2-Methoxystypandrone |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infl...
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TN3364 |
Agrimonolide |
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation o...
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TN3410 |
Anatabine |
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
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TN3525 |
Boehmenan |
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity i...
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TN3541 |
Broussonin E |
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathw...
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TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
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TN4035 |
Eupalinolide I |
Eupalinolide I is a natural product from Eupatorium lindleyanum. |
TN4356 |
Jolkinolide A |
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly i...
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TN4489 |
Manassantin A |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
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TN4490 |
Manassantin B |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti...
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TN4604 |
Myricanone |
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferatio...
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TN4774 |
Physalin A |
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate can...
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TP1433 |
CMD178 TFA |
CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling. |
TP1856 |
Colivelin |
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN). |
TQ0052 |
SH5-07 |
SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM). |
TQ0196 |
Cucurbitacin I |
Cucurbitacin I, a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity. |