STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat No.	product name
T28865	STAT3-IN-B9	STAT3-IN-B9 是异常 STAT3 激活的抑制剂，可抑制 MDA-MB-468、MDA-MB-231 和 DU145 等肿瘤细胞的增殖。
T4034	Solamargine	Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
T35544	ML115	Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxaz...
T13009	STAT3-IN-1	STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor ap...
T3404	Cucurbitacin B	Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-reg...
T6S1966	Curculigoside	1. Curculigoside can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic...
T3913	Saikosaponin D	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T6838	FLLL32	FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
T6S0141	Corylin	Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer.
T4234	HJC0152 hydrochloride	HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
TN1059	Ganoderic acid B	Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards th...
T6S0071	Fraxinellone	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
T3971	CASIN	CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T2814	Cryptotanshinone	Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727,...
T9339	Stafia-1	Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
T2156	WP1066	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has ...
T3049	TPCA-1	TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzy...
T2896	Alantolactone	Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transdu...
T11807	L002	L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
TN1631	Eupalinolide K	Eupalinolide K is a natural product
T6995	Ochromycinone	STA-21 is a selective STAT3 inhibitor.
T2S1975	Ponicidin	Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
T6537	HO-3867	HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
TJS1779	Protosappanin A	Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammat...
T2787	Picroside I	Picroside I, a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may...
T8719	SC99	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation...
T6677	Sophocarpine	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
TN1674	Garcinone D	Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
T3398	Icaritin	Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apopto...
T2789	Scutellarin	Scutellarin, an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regula...
T5668	Triacetylresveratrol	Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancr...
T2600	AG490	AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, L...
T6308	Stattic	Stattic is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 μM).
T4S2126	Ginkgetin	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
TN1405	Arnicolide D	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T4605	NT157	NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal c...
T1563	Nifuroxazide	Nifuroxazide is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT...
T5S1607	Morusin	1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopto...
T0711	Niclosamide	Niclosamide(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
T8476	RSVA405	RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
TN1620	Eriocalyxin B	Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
T1038	Fludarabine	Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T0433	Artesunate	Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore...
T5S0167	Atractylenolide I	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T4650	C188-9	C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
T13950	UC-514321	UC-514321 is a structural analog of NSC370284 and has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
T4571	Balsalazide	Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
T22424	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea	SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation...
T4615	Balsalazide sodium hydrate	Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing pr...
T5S0761	Nitidine chloride	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...