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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN2217 Sophoflavescenol 216450-65-6 99.65%
Sophoflavescenol
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T13446 (S)-Rivastigmine D6 tartrate 194930-00-2
(S)-Rivastigmine D6 tartrate
(S)-Rivastigmine D6 tartrate is the deuterium labeled (S)-Rivastigmine, and is an inhibitor of cholinesterase.
T15949 Mahanimbine 21104-28-9 98%
Mahanimbine
Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum...
TN1428 (+)-Balanophonin 215319-47-4 98%
(+)-Balanophonin
(+)-Balanophonin is a natural phenolic compound isolated from Passiflora edulis with antioxidant, anti-inflammatory, anticancer and anti-neurodegenerative activi...
TN2131 Questin 3774-64-9 98%
Questin
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
T8306 Epiberberine chloride 889665-86-5 98%
Epiberberine chloride
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
T0204 Protriptyline hydrochloride 1225-55-4 99.98%
Protriptyline hydrochloride
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochlo...
TN1858 Leptomerine 22048-97-1 99.96%
Leptomerine
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
T1111 Pralidoxime Chloride 51-15-0 99.96%
Pralidoxime Chloride
Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcho...
T2227 Hemicholinium 3 312-45-8 99.95%
Hemicholinium 3
Hemicholinium 3 is a potent and selective choline uptake blocker.
T3819 Ursolic acid acetate 7372-30-7 99.95%
Ursolic acid acetate
Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO productio...
TN1124 Neoeriocitrin 13241-32-2 99.92%
Neoeriocitrin
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a...
T1612 Neostigmine methyl sulfate 51-60-5 99.90%
Neostigmine methyl sulfate
Neostigmine methyl sulfate (Syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myas...
T77758 AChE/BuChE-IN-4 1997158-25-4 99.89%
AChE/BuChE-IN-4
AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and...
T0998 Diazinon 333-41-5 99.89%
Diazinon
Diazinon (Dimpylate) is a thiophosphoric acid ester, functioning as a nonsystemic organophosphate insecticide that effectively targets and controls a variety of ...
T6478 Donepezil Hydrochloride 120011-70-3 99.89%
Donepezil Hydrochloride
Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T2191 Tacrine hydrochloride (hydrate) 206658-92-6 99.89%
Tacrine hydrochloride (hydrate)
Tacrine hydrochloride hydrate (Tetrahydroaminacrine) is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the eff...
T2984 Scopoletin 92-61-5 99.88%
Scopoletin
Scopoletin (Esculetin 6-methyl ether) is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
TN1091 Dehydronuciferine 7630-74-2 99.88%
Dehydronuciferine
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
T83616 SEW06622 261349-28-4 99.87%
SEW06622
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease...
Sophoflavescenol
TN2217
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
(S)-Rivastigmine D6 tartrate
T13446
(S)-Rivastigmine D6 tartrate is the deuterium labeled (S)-Rivastigmine, and is an inhibitor of cholinesterase.
Mahanimbine
T15949
Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum...
(+)-Balanophonin
TN1428
(+)-Balanophonin is a natural phenolic compound isolated from Passiflora edulis with antioxidant, anti-inflammatory, anticancer and anti-neurodegenerative activi...
Questin
TN2131
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
Epiberberine chloride
T8306
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
Protriptyline hydrochloride
T0204
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochlo...
Leptomerine
TN1858
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
Pralidoxime Chloride
T1111
Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcho...
Hemicholinium 3
T2227
Hemicholinium 3 is a potent and selective choline uptake blocker.
Ursolic acid acetate
T3819
Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO productio...
Neoeriocitrin
TN1124
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a...
Neostigmine methyl sulfate
T1612
Neostigmine methyl sulfate (Syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myas...
AChE/BuChE-IN-4
T77758
AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and...
Diazinon
T0998
Diazinon (Dimpylate) is a thiophosphoric acid ester, functioning as a nonsystemic organophosphate insecticide that effectively targets and controls a variety of ...
Donepezil Hydrochloride
T6478
Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
Tacrine hydrochloride (hydrate)
T2191
Tacrine hydrochloride hydrate (Tetrahydroaminacrine) is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the eff...
Scopoletin
T2984
Scopoletin (Esculetin 6-methyl ether) is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
Dehydronuciferine
TN1091
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
SEW06622
T83616
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease...
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TargetMol