AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.

Cat No.	product name
T9862	Pseudocoptisine chloride	Pseudocoptisine chloride 是从 Corydalis Tuber 中分离出来的，具有抗炎和抗健忘的作用。 Pseudocoptisine chloride 抑制乙酰胆碱酯酶 (AChE) 活性 (IC50 = 12.8 μM)。
TN6919	Methyl tridecanoate	Methyl tridecanoate is a natural product.
T6478	Donepezil Hydrochloride	Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T7640	Aldicarb sulfone	Aldicarb sulfone is a cholinesterase inhibitor .
T5855	Edrophonium chloride	Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specific...
T6S0653	Linarin	1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver i...
T3872	Nodakenin	Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
T5S1025	Picfeltarraenin IA	1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
T4S1024	Picfeltarraenin IB	1. Picfeltarraenin IB and Picfeltarraenin IA displayes no cytotoxic activity in vitro human tumor cell line panel.
TN2217	Sophoflavescenol	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T2S1200	Sinapine	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
T6S2356	Corynoline	1. Corynoline is an acetylcholinesterase inhibitor.
T1575	Nizatidine	Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
T0780	Pyridostigmine bromide	Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis...
T0086	Galanthamine hydrobromide	Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
TN1011	Rhodionin	Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
T3769	Tenuifolin	Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
Fr14127	Coumaran	2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzofura...
T0204	Protriptyline hydrochloride	Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochlo...
T4852	Trimyristin	Within the cell, glyceryl trimyristate is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ...
T4466	Pitofenone hydrochloride	Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36...
T7465	4-Methylbenzylidene camphor	4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activi...
T2S0491	Isoeugenol acetate	1. Acetylisoeugenol shows good antifungal activities against R. solani and F. oxysporum. 2. Acetylisoeugenol is a mild sensitizer in vivo.
TN6786	O-Desmethyl Galanthamine	Sanguinine (O-Desmethyl galanthamine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
T13301	Violanthin	Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxid...
T8585	TA-03	TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
T5S2254	Swertianolin	1. Swertianolin, mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentian...
T1111	Pralidoxime Chloride	Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve age...
T20847	Thiobencarb	Thiobencarb, a thiocarbamate cholinesterase inhibitor, is used as a pre-emergence herbicide.
T2227	Hemicholinium 3	Hemicholinium-3 is a potent and selective choline uptake blocker.
T2979	DL-Menthol	DL-Menthol is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-m...
T2845	Imperatorin	Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2571	Benactyzine hydrochloride	Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to invest...
T0338	Minaprine	Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T3026	(-)-Huperzine A	Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
TN6783	Corysamine chloride	Corysamine chloride was identified to inhibit the activity of ACHE.
T3392	Sinapine thiocyanate	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
T7114	GALANTHAMINONE	Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
T2984	Scopoletin	Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
TN1091	Dehydronuciferine	Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
T3395	Timosaponin AIII	Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibitio...
T3819	Ursolic acid acetate	Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities...
TN1899	Lycoramine	Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
T2846	Isoimperatorin	Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
T1612	Neostigmine methyl sulfate	Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
TN1786	Isomerazin	Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
T5S2361	Epiberberine	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
T0269	Dichlorisone Acetate	Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
T0713	Drofenine hydrochloride	Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
T11366	Garcinol	Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...