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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Cat No. product name
T9862 Pseudocoptisine chloride Pseudocoptisine chloride 是从 Corydalis Tuber 中分离出来的,具有抗炎和抗健忘的作用。 Pseudocoptisine chloride 抑制乙酰胆碱酯酶 (AChE) 活性 (IC50 = 12.8 μM)。
TN6919 Methyl tridecanoate Methyl tridecanoate is a natural product.
T6478 Donepezil Hydrochloride Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T7640 Aldicarb sulfone Aldicarb sulfone is a cholinesterase inhibitor .
T5855 Edrophonium chloride Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specific...
T6S0653 Linarin 1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver i...
T3872 Nodakenin Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
T5S1025 Picfeltarraenin IA 1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
T4S1024 Picfeltarraenin IB 1. Picfeltarraenin IB and Picfeltarraenin IA displayes no cytotoxic activity in vitro human tumor cell line panel.
TN2217 Sophoflavescenol Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T2S1200 Sinapine 1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
T6S2356 Corynoline 1. Corynoline is an acetylcholinesterase inhibitor.
T1575 Nizatidine Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
T0780 Pyridostigmine bromide Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis...
T0086 Galanthamine hydrobromide Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
TN1011 Rhodionin Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
T3769 Tenuifolin Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
Fr14127 Coumaran 2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzofura...
T0204 Protriptyline hydrochloride Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochlo...
T4852 Trimyristin Within the cell, glyceryl trimyristate is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ...
T4466 Pitofenone hydrochloride Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36...
T7465 4-Methylbenzylidene camphor 4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activi...
T2S0491 Isoeugenol acetate 1. Acetylisoeugenol shows good antifungal activities against R. solani and F. oxysporum. 2. Acetylisoeugenol is a mild sensitizer in vivo.
TN6786 O-Desmethyl Galanthamine Sanguinine (O-Desmethyl galanthamine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
T13301 Violanthin Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxid...
T8585 TA-03 TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
T5S2254 Swertianolin 1. Swertianolin, mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentian...
T1111 Pralidoxime Chloride Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve age...
T20847 Thiobencarb Thiobencarb, a thiocarbamate cholinesterase inhibitor, is used as a pre-emergence herbicide.
T2227 Hemicholinium 3 Hemicholinium-3 is a potent and selective choline uptake blocker.
T2979 DL-Menthol DL-Menthol is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-m...
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2571 Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to invest...
T0338 Minaprine Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T3026 (-)-Huperzine A Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
TN6783 Corysamine chloride Corysamine chloride was identified to inhibit the activity of ACHE.
T3392 Sinapine thiocyanate Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
T7114 GALANTHAMINONE Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
T2984 Scopoletin Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
TN1091 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
T3395 Timosaponin AIII Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibitio...
T3819 Ursolic acid acetate Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities...
TN1899 Lycoramine Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
T2846 Isoimperatorin Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
T1612 Neostigmine methyl sulfate Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
TN1786 Isomerazin Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
T5S2361 Epiberberine 1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
T0269 Dichlorisone Acetate Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
T0713 Drofenine hydrochloride Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
T11366 Garcinol Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
Pseudocoptisine chloride
T9862
Pseudocoptisine chloride 是从 Corydalis Tuber 中分离出来的,具有抗炎和抗健忘的作用。 Pseudocoptisine chloride 抑制乙酰胆碱酯酶 (AChE...
Methyl tridecanoate
TN6919
Methyl tridecanoate is a natural product.
Donepezil Hydrochloride
T6478
Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
Aldicarb sulfone
T7640
Aldicarb sulfone is a cholinesterase inhibitor .
Edrophonium chloride
T5855
Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specific...
Linarin
T6S0653
1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver ...
Nodakenin
T3872
Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
Picfeltarraenin IA
T5S1025
1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
Picfeltarraenin IB
T4S1024
1. Picfeltarraenin IB and Picfeltarraenin IA displayes no cytotoxic activity in vitro human tumor cell line panel.
Sophoflavescenol
TN2217
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
Sinapine
T2S1200
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
Corynoline
T6S2356
1. Corynoline is an acetylcholinesterase inhibitor.
Nizatidine
T1575
Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
Pyridostigmine bromide
T0780
Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis...
Galanthamine hydrobromide
T0086
Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Rhodionin
TN1011
Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
Tenuifolin
T3769
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
Coumaran
Fr14127
2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzofura...
Protriptyline hydrochloride
T0204
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochlo...
Trimyristin
T4852
Within the cell, glyceryl trimyristate is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ...
Pitofenone hydrochloride
T4466
Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36...
4-Methylbenzylidene camphor
T7465
4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activi...
Isoeugenol acetate
T2S0491
1. Acetylisoeugenol shows good antifungal activities against R. solani and F. oxysporum. 2. Acetylisoeugenol is a mild sensitizer in vivo.
O-Desmethyl Galanthamine
TN6786
Sanguinine (O-Desmethyl galanthamine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
Violanthin
T13301
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxi...
TA-03
T8585
TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
Swertianolin
T5S2254
1. Swertianolin, mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentian...
Pralidoxime Chloride
T1111
Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve age...
Thiobencarb
T20847
Thiobencarb, a thiocarbamate cholinesterase inhibitor, is used as a pre-emergence herbicide.
Hemicholinium 3
T2227
Hemicholinium-3 is a potent and selective choline uptake blocker.
DL-Menthol
T2979
DL-Menthol is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (...
Imperatorin
T2845
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Benactyzine hydrochloride
T2571
Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to invest...
Minaprine
T0338
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
(-)-Huperzine A
T3026
Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
Corysamine chloride
TN6783
Corysamine chloride was identified to inhibit the activity of ACHE.
Sinapine thiocyanate
T3392
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
GALANTHAMINONE
T7114
Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
Scopoletin
T2984
Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
Dehydronuciferine
TN1091
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
Timosaponin AIII
T3395
Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibiti...
Ursolic acid acetate
T3819
Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities...
Lycoramine
TN1899
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
Isoimperatorin
T2846
Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
Neostigmine methyl sulfate
T1612
Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
Isomerazin
TN1786
Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
Epiberberine
T5S2361
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
Dichlorisone Acetate
T0269
Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
Drofenine hydrochloride
T0713
Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
Garcinol
T11366
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and ant...
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