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Estrogen Receptor/ERR

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.There are three human estrogen related receptors:ERRα,ERRβand ERRγ .
Cat No. product name
T11399 Giredestrant Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor ac...
T12832 Amcenestrant SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM fo...
T0835 Tamoxifen Citrate Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T0168 Estradiol (cypionate) Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
T5531 GSK-4716 GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand
T8984 FLTX1 FLTX1, a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-perm...
T6404 Bazedoxifene hydrochloride Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectivel...
T0695 Avobenzone Avobenzone, an oil-soluble ingredient, is a dibenzoylmethane derivative used in sunscreen products to absorb the full spectrum of UVA rays.
T8370 GSK5182 GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T14987 CMP8 CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM...
T9455 4-hydroxyestrone-4-methyl ether 4-hydroxyestrone-4-methyl ether is the methylation of 4-OHE1, which is catalyzed by COMT.
T3913 Saikosaponin D Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T3958 WAY-200070 WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T9604 Beta-Estradiol 17-hemisuccinate beta-Estradiol 17-hemisuccinate selectively stains estrogen receptor (ER)-rich cells.
T15364 G-1 G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).
T1048 Estradiol Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
T3665 Tectoridin Tectoridin possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflamm...
T5835 PROTAC ERRα ligand 2 PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T5633 H3B-5942 H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
T6743 (E/Z)-4-Hydroxytamoxifen 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemoprevent...
T3975 AZD9496 AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T7644 DPN DPN is an selective agonist of estrogen receptor β (ERβ) .
T2231 Estradiol dipropionate Estradiol dipropionate is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
T13674 Elacestrant Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
TN1052 Lindleyin Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
T6827 Endoxifen Z-isomer hydrochloride Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T1193 Clomiphene citrate Clomifene Citrate is a selective estrogen receptor modulator.
T7389 G15 G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)
TN1148 Isopsoralenoside Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
T13542 α-Zearalenol α-Zearalenol is a Mycotoxin with a high affinity for the estrogen receptors. Due to xenoestrogen effects, it causes reproductive disorders in animals.
T2177 Kaempferol Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
T2810 (20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T5118 Brilanestrant GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
T2569 Chlorotrianisene Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wit...
T0040 Quinestrol Quinestrol is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
T4281 Endoxifen (E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-e...
T1549 Raloxifene hydrochloride Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estroge...
T7313 Enclomiphene citrate Enclomiphene citrate is a non-steroidal estrogen receptor antagonist,with antioestrogenic property
T4000 (±)-Equol Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
T6491 (-)-(S)-Equol S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with ...
T0384 Estradiol benzoate Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics...
T0593 XCT790 XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T3385 Gypenoside XVII Gypenoside XVII confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/...
T9454 4-Hydroxyestrone 4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.
T2544 Bazedoxifene acetate Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
T11200 Endoxifen (E-isomer) (Z)-Endoxifen is an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen....
T1216 Diethylstilbestrol Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
T0035 Dienestrol Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and m...
T3325 Liquiritigenin Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T1424 Ethynyl estradiol Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is of...
Giredestrant
T11399
Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor ac...
Amcenestrant
T12832
SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM fo...
Tamoxifen Citrate
T0835
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
Estradiol (cypionate)
T0168
Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
GSK-4716
T5531
GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand
FLTX1
T8984
FLTX1, a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-perm...
Bazedoxifene hydrochloride
T6404
Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectiv...
Avobenzone
T0695
Avobenzone, an oil-soluble ingredient, is a dibenzoylmethane derivative used in sunscreen products to absorb the full spectrum of UVA rays.
GSK5182
T8370
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
CMP8
T14987
CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM...
4-hydroxyestrone-4-methyl ether
T9455
4-hydroxyestrone-4-methyl ether is the methylation of 4-OHE1, which is catalyzed by COMT.
Saikosaponin D
T3913
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
WAY-200070
T3958
WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
beta-Estradiol 17-hemisuccinate
T9604
beta-Estradiol 17-hemisuccinate selectively stains estrogen receptor (ER)-rich cells.
G-1
T15364
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).
Estradiol
T1048
Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
Tectoridin
T3665
Tectoridin possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflamm...
PROTAC ERRα ligand 2
T5835
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
H3B-5942
T5633
H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
(E/Z)-4-Hydroxytamoxifen
T6743
4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemoprevent...
AZD9496
T3975
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
DPN
T7644
DPN is an selective agonist of estrogen receptor β (ERβ) .
Estradiol dipropionate
T2231
Estradiol dipropionate is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
Elacestrant
T13674
Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
Lindleyin
TN1052
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
Endoxifen Z-isomer hydrochloride
T6827
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Clomiphene citrate
T1193
Clomifene Citrate is a selective estrogen receptor modulator.
G15
T7389
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)
Isopsoralenoside
TN1148
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
α-Zearalenol
T13542
α-Zearalenol is a Mycotoxin with a high affinity for the estrogen receptors. Due to xenoestrogen effects, it causes reproductive disorders in animals.
Kaempferol
T2177
Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
(20S)-Protopanaxatriol
T2810
(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
Brilanestrant
T5118
GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
Chlorotrianisene
T2569
Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wit...
Quinestrol
T0040
Quinestrol is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
Endoxifen
T4281
(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-e...
Raloxifene hydrochloride
T1549
Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estroge...
Enclomiphene citrate
T7313
Enclomiphene citrate is a non-steroidal estrogen receptor antagonist,with antioestrogenic property
(±)-Equol
T4000
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
(-)-(S)-Equol
T6491
S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with ...
Estradiol benzoate
T0384
Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics...
XCT790
T0593
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
Gypenoside XVII
T3385
Gypenoside XVII confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2...
4-Hydroxyestrone
T9454
4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.
Bazedoxifene acetate
T2544
Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
Endoxifen (E-isomer)
T11200
(Z)-Endoxifen is an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen....
Diethylstilbestrol
T1216
Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
Dienestrol
T0035
Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and m...
Liquiritigenin
T3325
Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
Ethynyl estradiol
T1424
Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is of...
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