T3066 |
S-Ruxolitinib
|
1160597-27-2
|
99.75%
|
|
Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivi...
|
T22319 |
DTP3
|
1809784-29-9
|
99.57%
|
|
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
|
T2460 |
JAK 3 inhibitor IV
|
58753-54-1
|
98%
|
|
JAK 3 inhibitor IV is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutam...
|
T2653 |
SB1317
|
1204918-72-8
|
100%
|
|
SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
|
T11710L |
JAK-IN-5 hydrochloride
|
2751323-21-2
|
|
|
JAK-IN-5 hydrochloride is a JAK inhibitor [1].
|
T11709 |
JAK3 covalent inhibitor-1
|
2300106-50-5
|
98%
|
|
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.
|
T11713 |
JBJ-02-112-05
|
2748162-29-8
|
98%
|
|
JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].
|
T16995 |
TAS05567
|
1429038-15-2
|
98%
|
|
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
|
T9814 |
JAK3/BTK-IN-1
|
2674036-91-8
|
98%
|
|
JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important target...
|
T15606 |
JAK1-IN-4
|
2091134-35-7
|
98%
|
|
JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively). JAK1-IN-4 inhibits STAT3 phosphorylation in NC...
|
TN2511 |
Britannilactone diacetate
|
1286694-67-4
|
98%
|
|
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
|
T11721L |
JDTic dihydrochloride
|
785835-79-2
|
98%
|
|
JDTic is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
|
TN4774 |
Physalin A
|
23027-91-0
|
98%
|
|
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
|
T11708 |
JAK2-IN-4
|
1438284-00-4
|
98%
|
|
JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.
|
T5049 |
NVP-BSK805
|
1092499-93-8
|
98%
|
|
NVP-BSK805 is an ATP-competitive JAK2 inhibitor.
|
TMA1743 |
Ergosterol peroxide
|
2061-64-5
|
98%
|
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
|
T15037 |
Momelotinib Mesylate
|
1056636-07-7
|
98%
|
|
Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.
|
T10009 |
JAK3-IN-7
|
1263774-57-7
|
98%
|
|
JAK3-IN-7 is an effective and selective JAK3 inhibitor (IC50 <0.01 μM) extracted from patent WO2011013785A1.
|
T4S1499 |
Ginsenoside Rk1
|
494753-69-4
|
98%
|
|
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the acti...
|
TQ0061 |
CHZ868
|
1895895-38-1
|
98%
|
|
CHZ868 is a type II JAK2 inhibitor (IC50: 0.17 μM in EPOR JAK2 WT Ba/F3 cell).
|