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Search Result

Search Results for " flt3 "

Targets

FLT

218

Compounds

3

Natural Products

15

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11299 FLT3-IN-4 FLT3 inhibitor 9u FLT
FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.
T27011 CHMFL-FLT3-122 CHMFLFLT3122,CHMFL FLT3 122 FLT
CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft m...
T1938 FLT3-IN-2 FLT
FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).
T11298 FLT3-IN-3 FLT
FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.
T9843 FLT3-IN-16
FLT3-IN-16 exhibits potent inhibitory activity against FLT3 tyrosine kinase with an IC 50 of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia [1].
T9856 FLT3-IN-10 2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl- FLT
FLT3-IN-10 (compound 7c) is a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3). FLT3-IN-10 shows the potential for the treatment of FLT3-mutated acute myeloid leukemia (AML).
T2051 SKLB4771 FLT3-​IN-​1,FLT3-IN-1 FLT
SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.
T24067 Flt3 Inhibitor IV Flt3 Inhibitor-IV,Flt3-IN-IV
Flt3 Inhibitor IV is a potent ATP-competitive Flt3 inhibitor.
T6138 TCS 359 FLT3 Inhibitor FLT
TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.
T11300 FLT3-IN-6 Others
FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.
T11707 JAK2/FLT3-IN-1 JNK
JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, F...
T78176 FLT3-IN-19
FLT3-IN-19 (Comp 50) is a potent, selective inhibitor of FLT3, demonstrating an IC50 value of 0.213 nM, and is applicable in research pertaining to acute myeloid leukemia (AML) [1].
T63058 FLT3-IN-14
FLT3-IN-14 is a potent inhibitor of FLT3, acting on FLT3-WT (IC50: 5.6 nM) and FLT3-ITD (IC50: 1.4 nM). FLT3-IN-14 inhibits FLT3 (Y591) phosphorylation, arrests the cell cycle in G1 phase and induces apoptosis.
T62607 FLT3-IN-15
FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).
T62412 FLT3-IN-12
FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM). FLT3-IN-12 is more selective than c-KIT (>1000-fold). FLT3-IN-12 showed signific...
T82392 FLT3-IN-23
FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effects against BaF3 cells harboring diverse FLT3-TKD and FLT3-ITD-...
T61101 FLT3-IN-13
FLT3-IN-13 (compound 20) is a highly effective inhibitor targeting both topoisomerase II and FLT3 proteins in leukemic cells. It exhibits potent activity against these targets, with IC50 values of 2.26 μM for both. Moreo...
T79420 FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant. This compound displays significant antiproliferative effects against MV4-11 ...
T62260 FLT3-IN-11
FLT3-IN-11 (compound 30) is an orally active, potent and selective inhibitor of FLT3 kinase, acting on wild-type FLT3 (IC50: 7.22 nM) and FLT3-D835Y (IC50: 4.95 nM). FLT3-IN-11 exhibited significant anti-AML effects with...
T63174 FLT3-IN-17
FLT3-IN-17 is an FAK inhibitor (IC50: 12 nM). FLT3-IN-17 inhibits the activity of CYPs and FLT3 mutants and has an IC50 of <0.5 nM for D835Y. FLT3-IN-17 can be used in cancer research.
T79596 FLT3-IN-20
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor, demonstrating IC50 values of 1 nM for FLT3-D835Y and 4 nM for FLT3-ITD. It exhibits anti-proliferative effects on FLT3-ITD-positive AML cell lines, with IC50s of 7 nM...
T73142 FLT3-IN-18
FLT3-IN-18, a potent and selective FLT3 inhibitor, exhibits an IC50 value of 0.003 μM. It effectively induces apoptosis and G1 phase cell cycle arrest, while inhibiting FLT3 and STAT5 phosphorylation. This compound holds...
T79391 FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase. It effectively inhibits the proliferation of FLT3-ITD-positive AML cells MV-...
T62863 FLT3/ITD-IN-4
FLT3/ITD-IN-4 (Compound 16) is a selective inhibitor of FLT3 internal tandem repeat mutations (FLT3-ITD) (IC50: 2.3 nM). FLT3/ITD-IN-4 can be used to study acute myeloid leukaemia.
T61977 FLT3/D835Y-IN-1
FLT3/D835Y-IN-1 (compound 13a) is a orally active, and selective inhibitor of FLT3 and FLT3/D835Y, with IC50s of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 has anticancer efficacy, and has research value in AML (...
T82393 FLT3/CHK1-IN-1
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr...
T61415 FLT3/ITD-IN-1
FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD). It exhibits remarkable inhibitory effects against FLT3 and FLT3-ITD, with impressive IC50 values of 38.2 nM and 144...
T62801 FLT3/TrKA-IN-1
FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor, capable of acting on FLT3 (IC50: 43.8 nM), FLT3-ITD (IC50: 97.2 nM), FLT3-TKD (IC50: 92.5 nM) and TrKA (IC50: 23.6 nM). -FLT3/TrKA-IN-1 has potential for acute ...
T63135 FLT3/CDK4-IN-1
FLT3/CDK4-IN-1 is a highly selective, potent, orally active dual inhibitor of FLT3/CDK4, acting on FLT3 (IC50: 7 nM) and CDK4 (IC50: 11 nM).FLT3/CDK4-IN-1 has good anti-tumour effects in vivo, showing anti-proliferative ...
T62824 FLT3/ITD-IN-3
FLT3/ITD-IN-3 (Compound 19) is a potent inhibitor of FLT3-ITD, acting on FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM) and FLT3-ITD (IC50: 0.9 nM). FLT3/ITD-IN-3 showed potent inhibition of FLT3 phosphorylation and was e...
T63274 FLT3/ITD-IN-2
FLT3/ITD-IN-2 is a potent inhibitor of FLT3-ITD and is able to act on FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM) and FLT3-ITD (IC50: 1.0 nM).FLT3/ITD-IN-2 effectively inhibits the phosphorylation of FLT3 and is able t...
T64104 JAK2/FLT3-IN-1 TFA
JAK2/FLT3-IN-1 (TFA) is an orally active dual inhibitor of JAK2/FLT3 that exhibits anticancer effects, acting on JAK2 (IC50: 0.7 nM), FLT3 (IC50: 4 nM), JAK1 (IC50: 26 nM) and JAK3 (IC50: 39 nM).
T24438 MDK5466 MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III
MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.
T74707 PROTAC FLT3/CDK9 degrader-1
PROTAC FLT3/CDK9 degrader-1, a potent dual degrader of FLT3 and CDK9, effectively induces apoptosis and targets protein degradation of FLT3 and CDK9. This compound holds research potential for FLT3-ITD mutated AML [1].
T63629 PDGFRα/FLT3-ITD-IN-2
PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM). PDGFRα/FLT3-ITD-IN-2 has shown investigational potential in acute myeloid leukemia or chronic eosinophilic leukemia.
T63454 PDGFRα/FLT3-ITD-IN-1
PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 exhibits investigational potential in acute myeloid leukemia or chr...
T63127 PDGFRα/FLT3-ITD-IN-3
PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be studied in acute myeloid leukaemia or chronic eosinophilic leuk...
T38562 AKN-028 FLT
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
T2340 AC1NS4RE Tyrosinase
It is a tyrosine kinase inhibitor.
T2066 Quizartinib AC220 Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T4428 CCT241736 FLT , Aurora Kinase
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica...
T6756 AMG 925 FLT , CDK
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.
T15335 FN-1501 FLT , CDK
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.
T2272 BPR1J-097 BPR1J097 FLT
BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).
T3065 TG101209 Apoptosis , FLT , c-RET , JAK , Autophagy
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.
T7673 ATH686 ATH 686 Apoptosis , FLT
ATH686 is an potent and selective Inhibitor of FLT3.
T9473 4SC-203 FLT
4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG...
T6020 Pacritinib SB1518 FLT , Tyrosine Kinases , JAK
Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).
T8317 5'-Fluoroindirubinoxime 5'-FIO FLT
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).
T1667 Tandutinib MLN518,CT53518,NSC726292 Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu...

Compounds

FLT3-IN-4
T11299
Synonym: FLT3 inhibitor 9u
Target: FLT
CHMFL-FLT3-122
T27011
Synonym: CHMFLFLT3122,CHMFL FLT3 122
Target: FLT
FLT3-IN-2
T1938
Synonym:
Target: FLT
FLT3-IN-3
T11298
Synonym:
Target: FLT
FLT3-IN-16
T9843
Synonym:
Target:
FLT3-IN-10
T9856
Synonym: 2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl-
Target: FLT
SKLB4771
T2051
Synonym: FLT3-​IN-​1,FLT3-IN-1
Target: FLT
Flt3 Inhibitor IV
T24067
Synonym: Flt3 Inhibitor-IV,Flt3-IN-IV
Target:
TCS 359
T6138
Synonym: FLT3 Inhibitor
Target: FLT
FLT3-IN-6
T11300
Synonym:
Target: Others
JAK2/FLT3-IN-1
T11707
Synonym:
Target: JNK
FLT3-IN-19
T78176
Synonym:
Target:
FLT3-IN-14
T63058
Synonym:
Target:
FLT3-IN-15
T62607
Synonym:
Target:
FLT3-IN-12
T62412
Synonym:
Target:
FLT3-IN-23
T82392
Synonym:
Target:
FLT3-IN-13
T61101
Synonym:
Target:
FLT3-IN-22
T79420
Synonym:
Target:
FLT3-IN-11
T62260
Synonym:
Target:
FLT3-IN-17
T63174
Synonym:
Target:
FLT3-IN-20
T79596
Synonym:
Target:
FLT3-IN-18
T73142
Synonym:
Target:
FLT3-IN-21
T79391
Synonym:
Target:
FLT3/ITD-IN-4
T62863
Synonym:
Target:
FLT3/D835Y-IN-1
T61977
Synonym:
Target:
FLT3/CHK1-IN-1
T82393
Synonym:
Target:
FLT3/ITD-IN-1
T61415
Synonym:
Target:
FLT3/TrKA-IN-1
T62801
Synonym:
Target:
FLT3/CDK4-IN-1
T63135
Synonym:
Target:
FLT3/ITD-IN-3
T62824
Synonym:
Target:
FLT3/ITD-IN-2
T63274
Synonym:
Target:
JAK2/FLT3-IN-1 TFA
T64104
Synonym:
Target:
MDK5466
T24438
Synonym: MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III
Target:
PROTAC FLT3/CDK9 degrader-1
T74707
Synonym:
Target:
PDGFRα/FLT3-ITD-IN-2
T63629
Synonym:
Target:
PDGFRα/FLT3-ITD-IN-1
T63454
Synonym:
Target:
PDGFRα/FLT3-ITD-IN-3
T63127
Synonym:
Target:
AKN-028
T38562
Synonym:
Target: FLT
AC1NS4RE
T2340
Synonym:
Target: Tyrosinase
Quizartinib
T2066
Synonym: AC220
Target: Apoptosis, FLT, Autophagy, Ligands for Target Protein for PROTAC
CCT241736
T4428
Synonym:
Target: FLT, Aurora Kinase
AMG 925
T6756
Synonym:
Target: FLT, CDK
FN-1501
T15335
Synonym:
Target: FLT, CDK
BPR1J-097
T2272
Synonym: BPR1J097
Target: FLT
TG101209
T3065
Synonym:
Target: Apoptosis, FLT, c-RET, JAK, Autophagy
ATH686
T7673
Synonym: ATH 686
Target: Apoptosis, FLT
4SC-203
T9473
Synonym:
Target: FLT
Pacritinib
T6020
Synonym: SB1518
Target: FLT, Tyrosine Kinases, JAK
5'-Fluoroindirubinoxime
T8317
Synonym: 5'-FIO
Target: FLT
Tandutinib
T1667
Synonym: MLN518,CT53518,NSC726292
Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit
1 2 3 4 5
Cat No. Product Name Synonyms Targets
T6S0033 Crotonoside Isoguanosine,2-HYDROXYADENOSINE Others , FLT , HDAC
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim...
T14055 5Z-7-Oxozeaenol FR148083,L783279,LL-Z 1640-2 VEGFR , FLT , MEK , MAPK , PDGFR , Antibiotic , Src
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is ...
T15542 Hypothemycin Others
Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).

Natural Products

Crotonoside
T6S0033
Synonym: Isoguanosine,2-HYDROXYADENOSINE
Target: Others, FLT, HDAC
5Z-7-Oxozeaenol
T14055
Synonym: FR148083,L783279,LL-Z 1640-2
Target: VEGFR, FLT, MEK, MAPK, PDGFR, Antibiotic, Src
Hypothemycin
T15542
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (9)
Mouse (4)
Cynomolgus (1)
Rat (1)
Expression System：
HEK293 (8)
E. coli (3)
Baculovirus-Insect Cells (2)
CHO (1)
Human Cells (1)
Tag：
His (5)
C-hFc (3)
hFc (2)
C-6His (1)
C-His-Avi (1)
N-terminal GST-tagged (1)
Tag Free (1)
hFc,AVI (1)
Cat No. Product Name Species Expression System
TMPY-06873 FLT3 Ligand Protein, Human, Recombinant Human E. coli
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th...
TMPY-03215 FLT3 Ligand Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th...
TMPK-00929 FLT3 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synerg...
TMPK-00125 FLT3 Ligand Protein, Human, Recombinant (hFc) Human HEK293
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synerg...
TMPY-01247 FLT3 Protein, Human, Recombinant (T227M, His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-03066 FLT3 Ligand Protein, Mouse, Recombinant (hFc) Mouse HEK293
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th...
TMPK-00523 FLT3 Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPK-00416 FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated Human CHO
The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPY-03704 FLT3 Protein, Mouse, Recombinant (His) Mouse HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-05738 FLT3 Protein, Human, Recombinant (hFc) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-05332 FLT3 Ligand Protein, Rat, Recombinant (His) Rat Baculovirus-Insect Cells
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th...
TMPY-06938 FLT3 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPJ-00123 FLT3LG Protein, Mouse, Recombinant (His) Mouse Human Cells
Fms-related tyrosine kinase 3 ligand(Flt3L) is a single-pass type I membrane protein and consists of 232 amino acids. Flt3L is a hematopoietic four helical bundle cytokine, structurally homologous to stem cell factor and...
TMPY-02842 UBE2L6 Protein, Human, Recombinant (His) Human E. coli
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain....
TMPH-01268 SIAH1 Protein, Human, Recombinant (GST) Human E. coli
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester...
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