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Cat No. | Product Name | Synonyms | Targets |
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T11299 | FLT3-IN-4 | FLT3 inhibitor 9u | FLT |
FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia. | |||
T27011 | CHMFL-FLT3-122 | CHMFLFLT3122,CHMFL FLT3 122 | FLT |
CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft m... | |||
T1938 | FLT3-IN-2 | FLT | |
FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM). | |||
T11298 | FLT3-IN-3 | FLT | |
FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively. | |||
T9843 | FLT3-IN-16 | ||
FLT3-IN-16 exhibits potent inhibitory activity against FLT3 tyrosine kinase with an IC 50 of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia [1]. | |||
T9856 | FLT3-IN-10 | 2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl- | FLT |
FLT3-IN-10 (compound 7c) is a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3). FLT3-IN-10 shows the potential for the treatment of FLT3-mutated acute myeloid leukemia (AML). | |||
T2051 | SKLB4771 | FLT3-IN-1,FLT3-IN-1 | FLT |
SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor. | |||
T24067 | Flt3 Inhibitor IV | Flt3 Inhibitor-IV,Flt3-IN-IV | |
Flt3 Inhibitor IV is a potent ATP-competitive Flt3 inhibitor. | |||
T6138 | TCS 359 | FLT3 Inhibitor | FLT |
TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM. | |||
T11300 | FLT3-IN-6 | Others | |
FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM. | |||
T11707 | JAK2/FLT3-IN-1 | JNK | |
JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, F... | |||
T78176 | FLT3-IN-19 | ||
FLT3-IN-19 (Comp 50) is a potent, selective inhibitor of FLT3, demonstrating an IC50 value of 0.213 nM, and is applicable in research pertaining to acute myeloid leukemia (AML) [1]. | |||
T63058 | FLT3-IN-14 | ||
FLT3-IN-14 is a potent inhibitor of FLT3, acting on FLT3-WT (IC50: 5.6 nM) and FLT3-ITD (IC50: 1.4 nM). FLT3-IN-14 inhibits FLT3 (Y591) phosphorylation, arrests the cell cycle in G1 phase and induces apoptosis. | |||
T62607 | FLT3-IN-15 | ||
FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM). | |||
T62412 | FLT3-IN-12 | ||
FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM). FLT3-IN-12 is more selective than c-KIT (>1000-fold). FLT3-IN-12 showed signific... | |||
T82392 | FLT3-IN-23 | ||
FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effects against BaF3 cells harboring diverse FLT3-TKD and FLT3-ITD-... | |||
T61101 | FLT3-IN-13 | ||
FLT3-IN-13 (compound 20) is a highly effective inhibitor targeting both topoisomerase II and FLT3 proteins in leukemic cells. It exhibits potent activity against these targets, with IC50 values of 2.26 μM for both. Moreo... | |||
T79420 | FLT3-IN-22 | ||
FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant. This compound displays significant antiproliferative effects against MV4-11 ... | |||
T62260 | FLT3-IN-11 | ||
FLT3-IN-11 (compound 30) is an orally active, potent and selective inhibitor of FLT3 kinase, acting on wild-type FLT3 (IC50: 7.22 nM) and FLT3-D835Y (IC50: 4.95 nM). FLT3-IN-11 exhibited significant anti-AML effects with... | |||
T63174 | FLT3-IN-17 | ||
FLT3-IN-17 is an FAK inhibitor (IC50: 12 nM). FLT3-IN-17 inhibits the activity of CYPs and FLT3 mutants and has an IC50 of <0.5 nM for D835Y. FLT3-IN-17 can be used in cancer research. | |||
T79596 | FLT3-IN-20 | ||
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor, demonstrating IC50 values of 1 nM for FLT3-D835Y and 4 nM for FLT3-ITD. It exhibits anti-proliferative effects on FLT3-ITD-positive AML cell lines, with IC50s of 7 nM... | |||
T73142 | FLT3-IN-18 | ||
FLT3-IN-18, a potent and selective FLT3 inhibitor, exhibits an IC50 value of 0.003 μM. It effectively induces apoptosis and G1 phase cell cycle arrest, while inhibiting FLT3 and STAT5 phosphorylation. This compound holds... | |||
T79391 | FLT3-IN-21 | ||
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase. It effectively inhibits the proliferation of FLT3-ITD-positive AML cells MV-... | |||
T62863 | FLT3/ITD-IN-4 | ||
FLT3/ITD-IN-4 (Compound 16) is a selective inhibitor of FLT3 internal tandem repeat mutations (FLT3-ITD) (IC50: 2.3 nM). FLT3/ITD-IN-4 can be used to study acute myeloid leukaemia. | |||
T61977 | FLT3/D835Y-IN-1 | ||
FLT3/D835Y-IN-1 (compound 13a) is a orally active, and selective inhibitor of FLT3 and FLT3/D835Y, with IC50s of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 has anticancer efficacy, and has research value in AML (... | |||
T82393 | FLT3/CHK1-IN-1 | ||
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr... | |||
T61415 | FLT3/ITD-IN-1 | ||
FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD). It exhibits remarkable inhibitory effects against FLT3 and FLT3-ITD, with impressive IC50 values of 38.2 nM and 144... | |||
T62801 | FLT3/TrKA-IN-1 | ||
FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor, capable of acting on FLT3 (IC50: 43.8 nM), FLT3-ITD (IC50: 97.2 nM), FLT3-TKD (IC50: 92.5 nM) and TrKA (IC50: 23.6 nM). -FLT3/TrKA-IN-1 has potential for acute ... | |||
T63135 | FLT3/CDK4-IN-1 | ||
FLT3/CDK4-IN-1 is a highly selective, potent, orally active dual inhibitor of FLT3/CDK4, acting on FLT3 (IC50: 7 nM) and CDK4 (IC50: 11 nM).FLT3/CDK4-IN-1 has good anti-tumour effects in vivo, showing anti-proliferative ... | |||
T62824 | FLT3/ITD-IN-3 | ||
FLT3/ITD-IN-3 (Compound 19) is a potent inhibitor of FLT3-ITD, acting on FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM) and FLT3-ITD (IC50: 0.9 nM). FLT3/ITD-IN-3 showed potent inhibition of FLT3 phosphorylation and was e... | |||
T63274 | FLT3/ITD-IN-2 | ||
FLT3/ITD-IN-2 is a potent inhibitor of FLT3-ITD and is able to act on FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM) and FLT3-ITD (IC50: 1.0 nM).FLT3/ITD-IN-2 effectively inhibits the phosphorylation of FLT3 and is able t... | |||
T64104 | JAK2/FLT3-IN-1 TFA | ||
JAK2/FLT3-IN-1 (TFA) is an orally active dual inhibitor of JAK2/FLT3 that exhibits anticancer effects, acting on JAK2 (IC50: 0.7 nM), FLT3 (IC50: 4 nM), JAK1 (IC50: 26 nM) and JAK3 (IC50: 39 nM). | |||
T24438 | MDK5466 | MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III | |
MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death. | |||
T74707 | PROTAC FLT3/CDK9 degrader-1 | ||
PROTAC FLT3/CDK9 degrader-1, a potent dual degrader of FLT3 and CDK9, effectively induces apoptosis and targets protein degradation of FLT3 and CDK9. This compound holds research potential for FLT3-ITD mutated AML [1]. | |||
T63629 | PDGFRα/FLT3-ITD-IN-2 | ||
PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM). PDGFRα/FLT3-ITD-IN-2 has shown investigational potential in acute myeloid leukemia or chronic eosinophilic leukemia. | |||
T63454 | PDGFRα/FLT3-ITD-IN-1 | ||
PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 exhibits investigational potential in acute myeloid leukemia or chr... | |||
T63127 | PDGFRα/FLT3-ITD-IN-3 | ||
PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be studied in acute myeloid leukaemia or chronic eosinophilic leuk... | |||
T38562 | AKN-028 | FLT | |
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation. | |||
T2340 | AC1NS4RE | Tyrosinase | |
It is a tyrosine kinase inhibitor. | |||
T2066 | Quizartinib | AC220 | Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC |
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. | |||
T4428 | CCT241736 | FLT , Aurora Kinase | |
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica... | |||
T6756 | AMG 925 | FLT , CDK | |
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. | |||
T15335 | FN-1501 | FLT , CDK | |
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity. | |||
T2272 | BPR1J-097 | BPR1J097 | FLT |
BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM). | |||
T3065 | TG101209 | Apoptosis , FLT , c-RET , JAK , Autophagy | |
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM. | |||
T7673 | ATH686 | ATH 686 | Apoptosis , FLT |
ATH686 is an potent and selective Inhibitor of FLT3. | |||
T9473 | 4SC-203 | FLT | |
4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG... | |||
T6020 | Pacritinib | SB1518 | FLT , Tyrosine Kinases , JAK |
Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays). | |||
T8317 | 5'-Fluoroindirubinoxime | 5'-FIO | FLT |
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM). | |||
T1667 | Tandutinib | MLN518,CT53518,NSC726292 | Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit |
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S0033 | Crotonoside | Isoguanosine,2-HYDROXYADENOSINE | Others , FLT , HDAC |
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim... | |||
T14055 | 5Z-7-Oxozeaenol | FR148083,L783279,LL-Z 1640-2 | VEGFR , FLT , MEK , MAPK , PDGFR , Antibiotic , Src |
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is ... | |||
T15542 | Hypothemycin | Others | |
Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively). |
Cat No. | Product Name | Species | Expression System |
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TMPY-06873 | FLT3 Ligand Protein, Human, Recombinant | Human | E. coli |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPY-03215 | FLT3 Ligand Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPK-00929 | FLT3 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synerg... | |||
TMPK-00125 | FLT3 Ligand Protein, Human, Recombinant (hFc) | Human | HEK293 |
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synerg... | |||
TMPY-01247 | FLT3 Protein, Human, Recombinant (T227M, His) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-03066 | FLT3 Ligand Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPK-00523 | FLT3 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re... | |||
TMPK-00416 | FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | CHO |
The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re... | |||
TMPY-03704 | FLT3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-05738 | FLT3 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-05332 | FLT3 Ligand Protein, Rat, Recombinant (His) | Rat | Baculovirus-Insect Cells |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPY-06938 | FLT3 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPJ-00123 | FLT3LG Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Fms-related tyrosine kinase 3 ligand(Flt3L) is a single-pass type I membrane protein and consists of 232 amino acids. Flt3L is a hematopoietic four helical bundle cytokine, structurally homologous to stem cell factor and... | |||
TMPY-02842 | UBE2L6 Protein, Human, Recombinant (His) | Human | E. coli |
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain.... | |||
TMPH-01268 | SIAH1 Protein, Human, Recombinant (GST) | Human | E. coli |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester... |