ropa

ROPA, a potent PKCalpha and PKCgamma activator, promotes tumor growth through PKC-activation.

O-Propargyl-Puromycin (OP-puro) is a potent protein synthesis inhibitor, a puromycin acetylene analog.

(R)-Naroparcil is an isomer of Naroparcil. Naroparcil, a 4-methylumbelliferyl beta-D-xyloside analog, is associated with vascular smooth muscle cell proliferation and inhibits thrombus formation in the Wessler slough model.

Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is the R-isomer of Aleglitazar.

Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure.

Macropa-NCS is a macropa bifunctional analog with antitumor activity and can be used to study prostate cancer.

3-Phenylpropanal (Phenylpropyl aldehyde) is a RIFM flavor ingredient and can be used to make perfume.3-Phenylpropanal is the main ingredient in acaricides.3-Phenylpropanal can be used as a fly attractant.3-Phenylpropanal can be used as an insecticide.

3-Diethylamino-1-propanol exhibits anticonvulsant effects.

L-(R,S)-Tetrahydropalmatine (Rotundine) is extracted from Corydalis yanhusuo W. T. Wang.

3-Ethoxy-3-oxopropanoic acid (Monoethyl malonic acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. 3-Ethoxy-3-oxopropanoic acid exists as a solid, soluble (in water), and a weakly acidic compound (based on its pKa). 3-Ethoxy-3-oxopropanoic acid has been primarily detected in blood. Within the cell, monoethyl malonic acid is primarily located in the cytoplasm.

(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via lactate dehydrogenase. The D-form is derived from bacterial sources, while the L-form is endogenous. Phenyllactate levels are normally very low in blood or urine, but high levels indicate phenylketonuria (PKU) and hyperphenylalaninemia (HPA). PKU is due to a deficiency of phenylalanine hydroxylase (PAH), causing phenylalanine to convert to phenylpyruvic acid rather than tyrosine.

Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of glucose reabsorption in the kidney.

Propargyl-PEG3-amine (Propargyl-PEG3-NH2) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

1,3-Propanediol is a natural product produced by microbial fermentation of glycerol.

2-Amino-3-(2-chlorophenyl)propanoic acid (2-Chloro-DL-Phenylalanine) is a phenylalanine derivative involved in biometabolism.

Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.

Methyl 3-aminopropanoate hydrochloride (β-Alanine methyl ester hydrochloride) is the ethyl ester of the non-essential amino acid β-alanine.

Cyclopropanecarbonitrile (Cyclopropylnitrile) is the minimum carbon ring molecule with a cyanide group attached. It has mainly used in experiments with microwave spectroscopy, photodissociation, and rotational spectroscopy.

Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.

Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others

3-(3,4-Dimethoxyphenyl)propanoic acid (3,4-Dimethoxyhydrocinnamic acid) is an orally active short-chain fatty acid (SCFAs) that promotes γ-globin gene expression and erythropoiesis in vivo, making it useful in treating beta hemoglobinopathies and other anemias.

1-Phenylpropane-1,2-dione (Acetyl benzoyl) is a eukaryotic metabolite produced in plant metabolic reactions.

Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease.

Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.

BIS-TRIS propane (BTP), a novel multidentate ligand of nickel- and cobalt-based spin clusters, is a metal chelator. BIS-TRIS propane is often used as a zwitterionic buffer for PCR and protein crystallization studies.

L-Propargylglycine ((S)-Propargylglycine) is an inhibitor of the enzyme.

2,3-Diaminopropanoic acid hydrochloride (3-Amino-DL-alanine monohydrochloride) is an amino acid amide used as a substrate for studying the action of aminopeptidase enzyme.

Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.

2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human)

Propan-2-yl octanoate (Isopropyl n-Octanoate) is a food fragrance that can be used to adjust the aroma of wine.

(±)-1,2-Propanediol is an aliphatic alcohol that has a variety of roles as a preservative and antifreeze, and has a wide range of applications in the food industry and skin care industry. (±)-1,2-Propanediol is a natural bacteriostatic agent that inhibits the growth and multiplication of bacteria to a certain extent.

3-(3,4,5-Trimethoxyphenyl)propanoic acid, a constituent of Piper retrofractum and Piper longum, is found in herbs and spices.

Methyl 3-phenylpropanoate (3-Phenylpropionic acid methyl ester) is a huamn endogenous metabolite.

Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) is a triacylglycerol found in dietary fats. In hamsters fed a diet enriched with it, Tripalmitin increases body weight, elevates plasma LDL levels, and reduces hepatic LDL receptor mRNA levels. It inhibits glucose-stimulated insulin secretion and decreases the viability of INS1 cells dose-dependently. Tripalmitin is used in cosmetic products for skin conditioning and as a thickening agent, and it forms lipid matrices of nanoparticles for drug delivery.

Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride (Proparacaine HCl) stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid is a potential SSTR4 agonist.

Propargyl-PEG12-bromide, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

(2S,3S)-3-Hydroxy-2-methyl-3-phenylpropanoic acid is a chemical synthesis intermediate.

3-Sulfopropanoic acid, a major metabolite of treprostinil and its prodrug ALZ-801, is an endogenous molecule present in the cerebrospinal fluid (CSF) of AD patients that inhibits the formation of Aβ42 oligomers.

1-methoxycyclopropanecarboxylic acid is an agonist of free fatty acid receptor 3 (FFAR3, human).

1,2-Diphenylpropan-2-amine is the monohydrochloride metabolite of the (S,R)-isomer of Remacemide.1,2-Diphenylpropan-2-amine has anticonvulsant properties.

3-(Dodecylamino)propane-1,2-diol (3-(Dodecylamino)propane-1,2-diol) is a surfactant that can be used to prepare nanomicelles.

Propargyl-PEG11-methane is a PEG-based PROTAC linker utilized for the synthesis of PROTACs [1].

Propargyl-PEG5-Ms (Propargyl-PEG6-Ms) is a PEG-based PROTAC linker. Propargyl-PEG5-Ms can be used in the synthesis of PROTACs.

3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid (DCPPA) is an ASIC3 inhibitor that effectively blocks ASIC3-mediated pain and inflammation. It has been shown to have potential applications in the treatment of other diseases such as stroke, epilepsy and cancer.

Propagermanium (Ge132), an organometallic compound of germanium, has been used as a therapeutic agent against chronic hepatitis B in Japan.

Naroparcil, an orally available thioglycoside analog of 4-methylumbelliferyl β-D-xyloside, showed antithrombotic effects in the Wessler sludge model of venous thrombosis (jugular vein).Naroparcil enhanced the formation of the thrombin heparin cofactor II complex, induced dermatophyte sulfate-like substances in plasma from treated rabbits appearance, but reduced the formation of thrombin antithrombin III complexes in plasma incubated with (125I)-human alpha-thrombin.

(4R)-3-[2-(4-chlorophenoxy)-2-methylpropanoyl]-1,3-thiazolidine-4-carboxylic acid can be used in research in the fields of chemistry and life sciences.