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Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Cat No. product name
Fr13756 Isonicotinic acid Isonicotinic acid is a metabolite of Isoniazid.Isonicotinic acid is a useful isomer of nicotinic acid. Isoniazid is converted to Isonicotinic acid by hydrazinoly...
T6619 Desmethyl Erlotinib hydrochloride OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM fo...
T0249 N-Acetylprocainamide N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
T24047 Etilevodopa hydrochloride Etilevodopa HCl is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
T7440 P,p'-DDE 4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
T8547 DCBA DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T0150 Hydroxyhexamide Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.
T8945L AST5902 mesylate(2412155-74-7 free base) AST5902 mesylate is principal metabolite of Alflutinib in vivo. AST5902 mesylate exerts antineoplastic activity.
T5420 Cycloguanil hydrochloride Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodiu...
T6328 Desmethyl Erlotinib OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
T13808 P-Coumaric Acid Ethyl Ester p-Coumaric Acid Ethyl Ester is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a potential immunosuppressive agent in treating autoimmune inflammatory dis...
T10157 Regorafénib N-oxyde (M2) Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
T8183 Deslanoside Deslanoside is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside ...
TN1740 Homoeriodictyol Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
T2149 Vinburnine Eburnalritardo is a vasodilator. Eburnalritardo is a vinca alkaloid and a metabolite of vincamine.
T5186 Oseltamivir acid Oseltamivir acid (GS4071) is a potent influenza virus neuraminidase inhibitor and the prodrug of GS4071.
T4282 S-methyl-KE-298 S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
T12095 Monomethyl fumarate Monomethyl fumarate is a potent agonist of GPR109A .
T5539 GS-443902 GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T4494 CLOZAPINE N-OXIDE Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produ...
T10152 4-Methylamino antipyrine 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methy...
T4281 Endoxifen (E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-e...
T5320 Tulipalin A Tulipalin A (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
T4000 (±)-Equol Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
T8339 16α-Hydroxyprednisolone 16alpha-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide
TN1742 Homovanillyl alcohol Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
T2687 Omeprazole sulfide Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
T4710 3-Methoxytyramine hydrochloride 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be foun...
T11641 N-Desmethyl imatinib N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T16045 Methotrexate metabolite Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent. Methotrexate is the active metabolite of Methotre...
T5158 N-Desmethylclozapine N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
T16339 Norverapamil hydrochloride Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glyc...
T6293 Mycophenolate Mofetil Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydroge...
T13621 CNDAC hydrochloride CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
T0617 Nicotinamide N-oxide Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzy...
T0061 Clofibric acid Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T8175 DL-Laudanosine Laudanosine is a recognized metabolite of atracurium and cisatracurium.
T3540 IMR-1A IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T16338 Norgestimate metabolite Norelgestromin Norelgestromin is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen...
T4350 Palifosfamide Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, ...
T37514 Hydroxy Dimetridazole Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections ...
T8217 Enzalutamide carboxylic acid Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
T13564 AZ7550 AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T0050 Ampyrone 4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
T10138 4-Desmethoxy Omeprazole 4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole is a proton pump inhibitor (PPI). Omeprazole shows competitive inhibition of CYP2C19 a...
T20723 LGE-899 LGE-899 是 Sonidegib 的主要代谢物,是一种刺猬通路抑制剂。 LGE-899 (60 h) 的 Tmax 比 Sonidegib 长得多。
T13539 Allopurinol riboside Allopurinol riboside 是别嘌醇的代谢产物,具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用,Ki 为 277 μM。
Isonicotinic acid
Fr13756
Isonicotinic acid is a metabolite of Isoniazid.Isonicotinic acid is a useful isomer of nicotinic acid. Isoniazid is converted to Isonicotinic acid by hydrazinoly...
Desmethyl Erlotinib hydrochloride
T6619
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM fo...
N-Acetylprocainamide
T0249
N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
Etilevodopa hydrochloride
T24047
Etilevodopa HCl is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
p,p'-DDE
T7440
4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
DCBA
T8547
DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
Urolithin A
T7174
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Hydroxyhexamide
T0150
Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.
AST5902 mesylate(2412155-74-7 free base)
T8945L
AST5902 mesylate is principal metabolite of Alflutinib in vivo. AST5902 mesylate exerts antineoplastic activity.
Cycloguanil hydrochloride
T5420
Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodiu...
Desmethyl Erlotinib
T6328
OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
p-Coumaric Acid Ethyl Ester
T13808
p-Coumaric Acid Ethyl Ester is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a potential immunosuppressive agent in treating autoimmune inflammatory dis...
Regorafénib N-oxyde (M2)
T10157
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4...
Deslanoside
T8183
Deslanoside is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside ...
Homoeriodictyol
TN1740
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
Vinburnine
T2149
Eburnalritardo is a vasodilator. Eburnalritardo is a vinca alkaloid and a metabolite of vincamine.
Oseltamivir acid
T5186
Oseltamivir acid (GS4071) is a potent influenza virus neuraminidase inhibitor and the prodrug of GS4071.
S-methyl-KE-298
T4282
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
Monomethyl fumarate
T12095
Monomethyl fumarate is a potent agonist of GPR109A .
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
CLOZAPINE N-OXIDE
T4494
Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produ...
4-Methylamino antipyrine
T10152
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methy...
Endoxifen
T4281
(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-e...
Tulipalin A
T5320
Tulipalin A (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
(±)-Equol
T4000
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
16α-Hydroxyprednisolone
T8339
16alpha-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide
Homovanillyl alcohol
TN1742
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
Omeprazole sulfide
T2687
Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
3-Methoxytyramine hydrochloride
T4710
3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be foun...
N-Desmethyl imatinib
T11641
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
Methotrexate metabolite
T16045
Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent. Methotrexate is the active metabolite of Methotre...
N-Desmethylclozapine
T5158
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
Norverapamil hydrochloride
T16339
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-gly...
Mycophenolate Mofetil
T6293
Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydroge...
CNDAC hydrochloride
T13621
CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
Nicotinamide N-oxide
T0617
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzy...
Clofibric acid
T0061
Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
DL-Laudanosine
T8175
Laudanosine is a recognized metabolite of atracurium and cisatracurium.
IMR-1A
T3540
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Norgestimate metabolite Norelgestromin
T16338
Norelgestromin is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen...
Palifosfamide
T4350
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
Nortriptyline hydrochloride
T1327
Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, ...
Hydroxy Dimetridazole
T37514
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections ...
Enzalutamide carboxylic acid
T8217
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Ampyrone
T0050
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
4-Desmethoxy Omeprazole
T10138
4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole is a proton pump inhibitor (PPI). Omeprazole shows competitive inhibition of CYP2C19 a...
LGE-899
T20723
LGE-899 是 Sonidegib 的主要代谢物,是一种刺猬通路抑制剂。 LGE-899 (60 h) 的 Tmax 比 Sonidegib 长得多。
Allopurinol riboside
T13539
Allopurinol riboside 是别嘌醇的代谢产物,具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用,K...