Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No.	Product name	CAS No.	Purity
T11986	Mebeverine acid	475203-77-1	99.66%
T11986	Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine and can be used as a marker of oral exposure to Mebeverine.
T35688	MTIC	3413-72-7	99.51%
T35688	MTIC is the active metabolite of Temozolomide (TMZ) with anticancer and antitumor activity and is used in the study of melanoma.3'-Sialyllactose (3'-SL) sodium i...
TQ0045	2-Hydroxy atorvastatin calcium salt	265989-46-6	97.06%
TQ0045	2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
T5539	GS-443902	1355149-45-9
T5539	GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T78069	RPR132595A hydrochloride		98%
T78069	RPR132595A (NPC) hydrochloride, an active metabolite of CPT-11, is produced via cytochrome P-450 3A4 (CYP3A4) metabolism and is ultimately eliminated via urinary...
T78130	N-Methyl Palbociclib	571189-51-0	98%
T78130	N-Methyl Palbociclib is an impurity of the orally active selective CDK4 and CDK6 inhibitor Palbociclib (PD 0332991).
T78136	Perindopril acyl-β-D-glucuronide	120398-66-5	98%
T78136	Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor perindopril [1].
T78547	2-Phenyl-2-(2-pyridyl)acetonitrile	5005-36-7	98%
T78547	2-Phenyl-2-(2-pyridyl)acetonitrile represents the principal metabolite of the antigastric agent SC 15396, produced by the supernatant fraction of rat liver homog...
T78589	3-Hydroxycarbofuran	16655-82-6	98%
T78589	3-Hydroxycarbofuran, a principal metabolite of Carbofuran, acts as a reversible inhibitor of acetylcholinesterase (AChE) [1].
T78595	3-Hydroxyphenazepam	70030-11-4	98%
T78595	3-Hydroxyphenazepam, an active metabolite of Cinazepam, acts as a GABAA receptor agonist. This compound has the ability to inhibit synaptosomal transporter-media...
T80022	(R)-tert-OMe-byakangelicin	89560-97-4	98%
T80022	(R)-tert-OMe-byakangelicin, a furanocoumarin, exhibits inhibitory effects on liver drug metabolizing enzyme (DME) activity and can be isolated from the immature ...
T80635	Gentisuric acid	25351-24-0	98%
T80635	Gentisuric acid, an Aspirin metabolite and a substrate of α-amidating monooxygenase (PAM), mitigates DNA damage induced by Mitomycin C. [1] [2]
T80658	Quercetin 7-glucuronide	38934-20-2	98%
T80658	Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a Quercetin metabolite found in Madagascarian Uncarina species, has the capability to inhibit LDL oxidatio...
T82599	DDC 3′-O-β-D glucuronide		98%
T82599	Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential ...
T37308	Desmethylene Paroxetine hydrochloride	1394861-12-1	98%
T37308	Desmethylene Paroxetine hydrochloride is a non-conjugated metabolite of Paroxetine, a catechol intermediate.
T36896	6α-hydroxy Paclitaxel	153212-75-0	98%
T36896	6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.
TN1740	Homoeriodictyol	446-71-9	99.96%
TN1740	Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
T0617	Nicotinamide N-oxide	1986-81-8	99.9%
T0617	Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD...
T8183	Deslanoside	17598-65-1	99.89%
T8183	Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry ...
T2149	Vinburnine	4880-88-0	99.86%
T2149	Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.