T11992 |
Mefuparib hydrochloride |
Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, ...
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T12366 |
PARP14 inhibitor H10 |
PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM |
T16979 |
Talazoparib tosylate |
Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1). |
T2105 |
Veliparib dihydrochloride |
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. |
T2124 |
PJ34 hydrochloride |
PJ34 hydrochloride is a potent specific inhibitor of PARPl/2. |
T21524 |
4-amino-1,8-Naphthalimide |
4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM |
T22414 |
RBN012759 |
RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants. |
T2484 |
AZD2461 |
AZD2461 is a novel PARP inhibitor. |
T2591 |
VeliparibHOT |
Veliparib (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy. |
T2A2486 |
5,7,3',4',5'-Pentamethoxyflavone |
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adj...
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T2S1975 |
Ponicidin |
Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...
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T3015 |
OlaparibHOT |
Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 μM). |
T3231 |
Niraparib |
MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-f...
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T3375 |
Verbascoside |
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities. |
T3649 |
BGP-15 |
BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury. |
T4463 |
Rucaparib |
Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP. |
T5399 |
GeA-69 |
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays). |
T5526 |
Glycoborinine |
Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-a...
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T5860 |
CK-869 |
CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex. |
T6127 |
Rucaparib PhosphateHOT |
Rucaparib is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy. |
T6181 |
UPF 1069 |
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1. |
T6197 |
PJ34 |
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. |
T6224 |
Iniparib |
Iniparib (BSI-201) ,a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC). |
T6253 |
TalazoparibHOT |
Talazoparib is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM). |
T6329 |
INO-1001 |
INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
T6339 |
AG-14361 |
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM). |
T6578 |
ME0328 |
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. |
T6780 |
Benzamide |
Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid. |
T6842 |
G007-LK |
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively. |
T6892 |
Niraparib tosylate |
MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. |
T6942 |
Picolinamide |
Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
T7042 |
1,5-Isoquinolinediol |
1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes w...
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T7896 |
BYK204165 |
BYK204165 is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay) |
T8296 |
4',5,7-Trimethoxyflavone |
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand. |
T9113 |
Myristicin |
Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytoki...
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T9115 |
Vanillic Acid |
Vanillic acid is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid. |
TL0016 |
Sulforaphene |
Sulforaphene may be a potential anti- triple negative breast cancer natural compound and its /\''antiproliferation effects may be mediated by tumor suppressor E...
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TN1023 |
Miltirone |
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors. |
TN1038 |
Galgravin |
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
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TN1087 |
Deoxypodophyllotoxin |
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
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TN1153 |
Polyporenic acid C |
Polyporenic acid C shows inhibitory activity against human collagenase. |
TN1416 |
Ayanin |
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethyleth...
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TN1458 |
Buddlejasaponin IV |
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-k...
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TN1642 |
Ferruginol |
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce a...
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TN1651 |
Furanodiene |
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans. |
TN1663 |
Ganoderic acid DM |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1...
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TN1728 |
Hellebrigenin |
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. ...
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TN1837 |
Kuguaglycoside C |
Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis. |
TN1854 |
Lasiodin |
Lasiokaurin has anti-oxidative, and antineoplastic activities, it also shows antibacterial activity, esp. against Sarcina lutea. |
TN1880 |
Lucidenic acid B |
Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal t...
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TN1891 |
Lupiwighteone |
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells. |
TN1962 |
Myricetin 3-O-galactoside |
Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral in...
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TN2106 |
Protodeltonin |
Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inh...
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TN2329 |
Zingiberen newsaponin |
Zingiberensis newsaponin I exhibits induction effect on platelet aggregation. |
TN2511 |
1,6-O,O-Diacetylbritannilactone |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airw...
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TN3070 |
4beta-Hydroxywithanolide E |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic prog...
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TN3525 |
Boehmenan |
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity i...
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TN3614 |
Cearoin |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing th...
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TN3619 |
Cedrusin |
Cedrusin shows a cytotoxic effect on A375 and HeLa cells. |
TN3922 |
Effusanin E |
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p...
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TN4028 |
Euchrestaflavanone B |
Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavano...
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TN4046 |
Excisanin A |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pot...
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TN4271 |
Isochamaejasmine |
Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the...
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TN4340 |
Ivangustin |
Ivangustin exhibits remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines. |
TN4341 |
IVHD-valtrate |
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a...
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TN4637 |
Neogrifolin |
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS...
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TN4932 |
Sageone |
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gas...
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TN4999 |
Serratenediol |
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects b...
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TN5263 |
Xanthohumol |
Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
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