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Chromatin/Epigenetic PARP

PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.
Cat No. product name
T2105 Veliparib dihydrochloride Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
T2124 PJ34 hydrochloride PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
T2484 AZD2461 AZD2461 is a novel PARP inhibitor.
T2591 VeliparibHOT Veliparib (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
T3015 OlaparibHOT Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 μM).
T3231 Niraparib MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-f...
T3375 Verbascoside Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T3649 BGP-15 BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
T6127 Rucaparib PhosphateHOT Rucaparib is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
T6181 UPF 1069 UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
T6197 PJ34 PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
T6224 Iniparib Iniparib (BSI-201) ,a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T6253 TalazoparibHOT Talazoparib is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).
T6329 INO-1001 INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
T6339 AG-14361 AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
T6578 ME0328 ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
T6780 Benzamide Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T6892 Niraparib tosylate MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
T6942 Picolinamide Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
T7042 1,5-Isoquinolinediol 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes w...
T9115 Vanillic Acid Vanillic acid is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.
T4463 Rucaparib Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
T5399 GeA-69 GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
T5860 CK-869 CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
T8296 4',5,7-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
T7896 BYK204165 BYK204165 is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)
TN1038 Galgravin Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
TN1153 Polyporenic acid C Polyporenic acid C shows inhibitory activity against human collagenase.
TN1642 Ferruginol Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce a...
TN1663 Ganoderic acid DM Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1...
TN1837 Kuguaglycoside C Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
TN1880 Lucidenic acid B Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal t...
TN1891 Lupiwighteone Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
TN1962 Myricetin 3-O-galactoside Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral in...
TN1023 Miltirone Miltirone is a CYPs inhibition, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
TN1416 Ayanin Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethyleth...
TN1651 Furanodiene Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
TN1728 Hellebrigenin Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. ...
TN1854 Lasiodin Lasiokaurin has anti-oxidative, and antineoplastic activities, it also shows antibacterial activity, esp. against Sarcina lutea.
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TN1458 Buddlejasaponin IV Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-k...
TN2106 Protodeltonin Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inh...
TN2329 Zingiberen newsaponin Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
T12366 PARP14 inhibitor H10 PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM
T21524 4-amino-1,8-Naphthalimide 4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM
T11992 Mefuparib hydrochloride Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, ...
T16979 Talazoparib tosylate Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1).
T2A2486 5,7,3',4',5'-Pentamethoxyflavone 3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adj...
T2S1975 Ponicidin Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...
Veliparib dihydrochloride
T2105CAS 912445-05-7
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
PJ34 hydrochloride
T2124CAS 344458-15-7
PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
AZD2461
T2484CAS 1174043-16-3
AZD2461 is a novel PARP inhibitor.
Veliparib HOT
T2591CAS 912444-00-9
Veliparib (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
Olaparib HOT
T3015CAS 763113-22-0
Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 μM).
Niraparib
T3231CAS 1038915-60-4
MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-f...
Verbascoside
T3375CAS 61276-17-3
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
BGP-15
T3649CAS 66611-37-8
BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
Rucaparib Phosphate HOT
T6127CAS 459868-92-9
Rucaparib is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
UPF 1069
T6181CAS 1048371-03-4
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
PJ34
T6197CAS 344458-19-1
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
Iniparib
T6224CAS 160003-66-7
Iniparib (BSI-201) ,a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
Talazoparib HOT
T6253CAS 1207456-01-6
Talazoparib is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).
INO-1001
T6329CAS 3544-24-9
INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
AG-14361
T6339CAS 328543-09-5
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
ME0328
T6578CAS 1445251-22-8
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
Benzamide
T6780CAS 55-21-0
Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
G007-LK
T6842CAS 1380672-07-0
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
Niraparib tosylate
T6892CAS 1038915-73-9
MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
Picolinamide
T6942CAS 1452-77-3
Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
1,5-Isoquinolinediol
T7042CAS 5154-02-9
1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes w...
Vanillic Acid
T9115CAS 121-34-6
Vanillic acid is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.
Rucaparib
T4463CAS 283173-50-2
Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
GeA-69
T5399CAS 2143475-98-1
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
CK-869
T5860CAS 388592-44-7
CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
4',5,7-Trimethoxyflavone
T8296CAS 5631-70-9
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
BYK204165
T7896CAS 1104546-89-5
BYK204165 is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)
Galgravin
TN1038CAS 528-63-2
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
Polyporenic acid C
TN1153CAS 465-18-9
Polyporenic acid C shows inhibitory activity against human collagenase.
Ferruginol
TN1642CAS 514-62-5
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce a...
Ganoderic acid DM
TN1663CAS 173075-45-1
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1...
Kuguaglycoside C
TN1837CAS 1041631-93-9
Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
Lucidenic acid B
TN1880CAS 95311-95-8
Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal t...
Lupiwighteone
TN1891CAS 104691-86-3
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
Myricetin 3-O-galactoside
TN1962CAS 15648-86-9
Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral in...
Miltirone
TN1023CAS 27210-57-7
Miltirone is a CYPs inhibition, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
Ayanin
TN1416CAS 572-32-7
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethyleth...
Furanodiene
TN1651CAS 19912-61-9
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
Hellebrigenin
TN1728CAS 465-90-7
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. ...
Lasiodin
TN1854CAS 28957-08-6
Lasiokaurin has anti-oxidative, and antineoplastic activities, it also shows antibacterial activity, esp. against Sarcina lutea.
Deoxypodophyllotoxin
TN1087CAS 19186-35-7
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
Buddlejasaponin IV
TN1458CAS 139523-30-1
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-k...
Protodeltonin
TN2106CAS 94992-08-2
Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inh...
Zingiberen newsaponin
TN2329CAS 91653-50-8
Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
PARP14 inhibitor H10
T12366CAS 2084811-68-5
PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM
4-amino-1,8-Naphthalimide
T21524CAS 1742-95-6
4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM
Mefuparib hydrochloride
T11992CAS 1449746-00-2
Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, ...
Talazoparib tosylate
T16979CAS 1373431-65-2
Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1).
5,7,3',4',5'-Pentamethoxyflavone
T2A2486CAS 53350-26-8
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adj...
Ponicidin
T2S1975CAS 52617-37-5
Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...