PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Cat No.	product name
T2105	Veliparib dihydrochloride	Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
T2124	PJ34 hydrochloride	PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
T2484	AZD2461	AZD2461 is a novel PARP inhibitor.
T2591	VeliparibHOT	Veliparib (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
T3015	OlaparibHOT	Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 μM).
T3231	Niraparib	MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-f...
T3375	Verbascoside	Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T3649	BGP-15	BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
T6127	Rucaparib PhosphateHOT	Rucaparib is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
T6181	UPF 1069	UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
T6197	PJ34	PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
T6224	Iniparib	Iniparib (BSI-201) ，a PARP1 inhibitor， exhibits potency in triple-negative breast Y (TNBC).
T6253	TalazoparibHOT	Talazoparib is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).
T6329	INO-1001	INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
T6339	AG-14361	AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
T6578	ME0328	ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
T6780	Benzamide	Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
T6842	G007-LK	G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T6892	Niraparib tosylate	MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
T6942	Picolinamide	Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
T7042	1,5-Isoquinolinediol	1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes w...
T9115	Vanillic Acid	Vanillic acid is used as a condiment in food，which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.
T4463	Rucaparib	Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
T5399	GeA-69	GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
T5860	CK-869	CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
T8296	4',5,7-Trimethoxyflavone	5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
T7896	BYK204165	BYK204165 is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)
TN1038	Galgravin	Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
TN1153	Polyporenic acid C	Polyporenic acid C shows inhibitory activity against human collagenase.
TN1642	Ferruginol	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce a...
TN1663	Ganoderic acid DM	Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1...
TN1837	Kuguaglycoside C	Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
TN1880	Lucidenic acid B	Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal t...
TN1891	Lupiwighteone	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
TN1962	Myricetin 3-O-galactoside	Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral in...
TN1023	Miltirone	Miltirone is a CYPs inhibition, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
TN1416	Ayanin	Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethyleth...
TN1651	Furanodiene	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
TN1728	Hellebrigenin	Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. ...
TN1854	Lasiodin	Lasiokaurin has anti-oxidative, and antineoplastic activities, it also shows antibacterial activity, esp. against Sarcina lutea.
TN1087	Deoxypodophyllotoxin	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TN1458	Buddlejasaponin IV	Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-k...
TN2106	Protodeltonin	Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inh...
TN2329	Zingiberen newsaponin	Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
T12366	PARP14 inhibitor H10	PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM
T21524	4-amino-1,8-Naphthalimide	4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM
T11992	Mefuparib hydrochloride	Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, ...
T16979	Talazoparib tosylate	Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1).
T2A2486	5,7,3',4',5'-Pentamethoxyflavone	3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adj...
T2S1975	Ponicidin	Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...