[email protected] (US) / [email protected]    Tel: (781) 999-4286 / (781) 999-5354
Home > PARP

PARP

T2105 Veliparib dihydrochloride Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
T2124 PJ34 hydrochloride PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
T2484 AZD2461 AZD2461 is a novel PARP inhibitor.
T2591 Veliparib Veliparib (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
T3015 Olaparib Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 μM).
T3231 Niraparib MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-f...
T3375 Verbascoside Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T3649 BGP-15 BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
T6127 Rucaparib Phosphate Rucaparib is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
T6181 UPF 1069 UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
T6197 PJ34 PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
T6224 Iniparib Iniparib (BSI-201) ,a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T6253 Talazoparib Talazoparib is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).
T6329 INO-1001 INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
T6339 AG-14361 AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
T6578 ME0328 ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
T6780 Benzamide Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T6892 Niraparib tosylate MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
T6942 Picolinamide Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
T7042 1,5-Isoquinolinediol 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes w...
T9115 Vanillic Acid Vanillic acid is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.
T4463 Rucaparib Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
Prev 1 Next