PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Cat No.	product name
T9891	PARP1-IN-8	PARP1-IN-8是PARP1的有效抑制剂（IC50 = 97 nM）。
T3015	Olaparib	Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 µM).
T8296	5,7,4'-Trimethoxyflavone	5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
T9497	Niraparib tosylate monohyrate	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, en...
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one	Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
T3168	MN-64	MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
T6842	G007-LK	G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T3353	Niraparib hydrochloride	Niraparib (MK-4827) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the a...
T3375	Verbascoside	Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T22988	MK-4827 Racemate	MK-4827 racemate is a selective inhibitor of PARP1/2 (IC50: 3.8 nM/2.1 nM). It >330-fold selective against PARP3, V-PARP and Tank1.
T6780	Benzamide	Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
T6768	AZ6102	AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 c...
T9024	OUL35	OUL35 is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
T6224	Iniparib	Iniparib (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T8150	Nudifloramide	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).
T2S2362	Dehydrocorydaline nitrate	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
TN1891	Lupiwighteone	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T2105	Veliparib dihydrochloride	Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
TN1651	Furanodiene	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3062	WIKI4	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T6892	Niraparib tosylate	MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
T4085	Paris saponin VII	Chonglou saponin VII shows inhibitory effects on cell proliferation.
T16761	RK-287107	RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).
T8184	Fucosterol	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
T3261	NVP-TNKS656	NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T2591	Veliparib	Veliparib (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
T5S1805	5,7-Dihydroxychromone	1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
T5S2358	Dehydrocorydaline	1. Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. 2. Dehydrocorydaline stimulates p38 MAPK activa...
T9430	Venadaparib	Venadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is ...
T9113	Myristicin	Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also h...
T9593	Senaparib	Senaparib is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.
T7439	3-Methoxybenzamide	3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase.
TN1153	Polyporenic acid C	Polyporenic acid C shows inhibitory activity against human collagenase.
T4241	Rubiadin	Rubiadin possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.
T4471	E7449	E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ∼50 and ∼50 nM for PARP1, PARP2, TNKS1 and TNKS2, respecti...
T1807	JW 55	JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T3231	Niraparib	MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fo...
T1878	XAV-939	XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
T10990	Dehydrocorydaline chloride	Dehydrocorydaline chloride is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.
T7443	4'-Methoxychalcone	4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
T50098	TIQ-A	TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excess...
T50044	5-amino-1,2-dihydroisoquinolin-1-one	5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.
T2A2486	3',4',5',5,7-Pentamethoxyflavone	3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adju...
T22749	DR2313	DR 2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.
T22414	RBN012759	RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.
T22264	AZ9482	AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centro...
T2484	AZD-2461	AZD2461 is a novel PARP inhibitor.
T2124	PJ34 hydrochloride	PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
T21524	4-amino-1,8-Naphthalimide	4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM
TN2511	Britannilactone diacetate	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...