T2434 |
LY 303511
|
154447-38-8
|
98%
|
|
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
|
T12589 |
PI3Kα/mTOR-IN-1
|
1013098-90-2
|
98%
|
|
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTO...
|
TN4356 |
Jolkinolide A
|
37905-07-0
|
98%
|
|
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
|
TN2250 |
Syringaresinol
|
487-35-4
|
98%
|
|
(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation ...
|
TN4788 |
Pierreione B
|
1292766-21-2
|
98%
|
|
Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cy...
|
TN3218 |
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
|
100667-52-5
|
98%
|
|
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
|
TN1140 |
Onjisaponin B
|
35906-36-6
|
98%
|
|
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-sy...
|
TN3310 |
9,9'-Di-O-(E)-feruloylsecoisolariciresinol
|
56973-66-1
|
98%
|
|
1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer...
|
T16263 |
N6-Cyclopentyladenosine
|
41552-82-3
|
98%
|
|
N6-Cyclopentyladenosine (CPA) is a selective agonist of Adenosine A1 receptor (Ki: 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively).
|
TN4382 |
Kazinol A
|
99624-28-9
|
98%
|
|
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
|
TN2118 |
Lup-20(29)-en-28-oic acid
|
848784-85-0
|
98%
|
|
Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
|
T14552 |
Dactolisib Tosylate
|
1028385-32-1
|
98%
|
|
Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolisib To...
|
T11742L |
K-7174 dihydrochloride
|
191089-60-8
|
98%
|
|
K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α...
|
T6346 |
WYE-132
|
1144068-46-1
|
98%
|
|
WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG...
|
T6730 |
WAY-600
|
1062159-35-6
|
98%
|
|
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...
|
TN1245 |
3-Deoxysappanchalcone
|
112408-67-0
|
98%
|
|
3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
|
TN5050 |
Sprengerinin C
|
88861-91-0
|
98%
|
|
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
|
T12124 |
MTOR inhibitor-2
|
2219323-96-1
|
98%
|
|
mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).
|
TN4213 |
Hirsutenone
|
41137-87-5
|
98%
|
|
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
|
T11328 |
FT-1518
|
1313026-58-2
|
98%
|
|
FT-1518 ,exhibits antitumor activity, is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor.
|