mTOR

The mammalian target of rapamycin (mTOR), sometimes also referred to as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
T2434	LY 303511	154447-38-8	98%
T2434	LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
T12589	PI3Kα/mTOR-IN-1	1013098-90-2	98%
T12589	PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTO...
TN4356	Jolkinolide A	37905-07-0	98%
TN4356	Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
TN2250	Syringaresinol	487-35-4	98%
TN2250	(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation ...
TN4788	Pierreione B	1292766-21-2	98%
TN4788	Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cy...
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one	100667-52-5	98%
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN1140	Onjisaponin B	35906-36-6	98%
TN1140	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-sy...
TN3310	9,9'-Di-O-(E)-feruloylsecoisolariciresinol	56973-66-1	98%
TN3310	1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer...
T16263	N6-Cyclopentyladenosine	41552-82-3	98%
T16263	N6-Cyclopentyladenosine (CPA) is a selective agonist of Adenosine A1 receptor (Ki: 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively).
TN4382	Kazinol A	99624-28-9	98%
TN4382	Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
TN2118	Lup-20(29)-en-28-oic acid	848784-85-0	98%
TN2118	Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
T14552	Dactolisib Tosylate	1028385-32-1	98%
T14552	Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolisib To...
T11742L	K-7174 dihydrochloride	191089-60-8	98%
T11742L	K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α...
T6346	WYE-132	1144068-46-1	98%
T6346	WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG...
T6730	WAY-600	1062159-35-6	98%
T6730	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...
TN1245	3-Deoxysappanchalcone	112408-67-0	98%
TN1245	3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
TN5050	Sprengerinin C	88861-91-0	98%
TN5050	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
T12124	MTOR inhibitor-2	2219323-96-1	98%
T12124	mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).
TN4213	Hirsutenone	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T11328	FT-1518	1313026-58-2	98%
T11328	FT-1518 ,exhibits antitumor activity, is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor.