T6525 |
GW 5074
|
Raf1 Kinase Inhibitor I , GW5074 |
Apoptosis
,
Raf
|
|
GW5074(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MK... |
T41003 |
KG5
|
|
FLT
,
Raf
,
c-Kit
,
PDGFR
|
|
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibit... |
T39738 |
ASP2453
|
|
Ras
|
|
ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits the Son of Sevenless (SOS)-mediated... |
T5172 |
AZ304
|
|
c-Fms
,
Raf
,
p38 MAPK
,
Autophagy
|
|
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (I... |
T8823 |
Locostatin
|
|
Raf
|
|
Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and a... |
T38511 |
AWL-II-38.3
|
|
Ephrin Receptor
|
|
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular ac... |
T9638 |
CCT241161
|
|
Raf
|
|
CCT241161 is an orally active pan- RAF inhibitor with IC 50 s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF a... |
T41284 |
Nalfurafine
|
TRK-820 |
Opioid Receptor
|
|
Nalfurafine is an effective and selective agonist of G protein-biased κ-opioid receptor with high translational potentia... |
T36642 |
RAS/RAS-RAF-IN-1
|
|
|
|
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYP... |
T40284 |
B-Raf IN 2
|
|
Raf
|
|
B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be... |
T60727 |
B-Raf IN 8
|
|
|
|
B-Raf IN 8 (compound 7g) is a potent inhibitor of B-Raf (IC 50 = 70.65 nM). B-Raf IN 8 shows antitumor activity which h... |
T61935 |
B-Raf IN 9
|
|
|
|
B-Raf IN 9 (compound 8b) is an effective B-Raf inhibitor (IC50=24.79 nM). B-Raf IN 9 blocks cell cycle at G2/M phase and... |
T22272 |
Lifirafenib
|
BGB-283 , Beigene-283 |
EGFR
,
Raf
|
|
Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM fo... |
T30781 |
CCT3833
|
BAL3833 , BAL 3833 , CCT 3833 , CCT-3833 , BAL-3833 |
|
|
CCT3833, also known as BAL3833, is an orally available inhibitor of the serine/threonine-protein kinase family Raf, incl... |
T18552 |
Pomalidomide-amido-C1-Br
|
|
Others
|
|
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cer... |
T12976 |
Sorafenib-d4
|
Bay 43-9006 (D4) , Sorafenib (D4) |
Others
|
|
Sorafenib D4 is the deuterium labeled Sorafenib. Sorafenib is an inhibitor of multikinase (Raf-1, B-Raf, and VEGFR-3 IC5... |
T39117 |
PLX7922
|
|
|
|
PLX7922, a RAF inhibitor, can bind with BRAF V600E . PLX7922 inhibits pERK in BRAF V600E cell lines, and activates pERK ... |
T21602 |
PF-04880594
|
|
|
|
PF-04880594 is a potent and selective RAF inhibitor. PF-04880594 inhibits both wild-type and mutant BRAF and CRAF. PF-04... |
T28510 |
REDX05358
|
REDX 05358 , REDX-05358 |
|
|
REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors... |
T32086 |
HM95573
|
HM 95573 , HM-95573 |
|
|
HM95573 is an orally available inhibitor of members of the Raf family of serine/threonine protein kinases, with potentia... |