Search Result

Search Results for "raf"

Targets

Libraries

Anti-Pancreatic Cancer Compound Library FDA-Approved Kinase Inhibitor Library Kinase Inhibitor Library DGK Inhibitors Library

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Compounds

Cat No.	Product Name
T6525	GW 5074	Raf1 Kinase Inhibitor I , GW5074	Apoptosis , Raf
	GW5074(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MK...		Apoptosis , Raf
T41003	KG5		FLT , Raf , c-Kit , PDGFR
	KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibit...		FLT , Raf , c-Kit , PDGFR
T39738	ASP2453		Ras
	ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits the Son of Sevenless (SOS)-mediated...		Ras
T5172	AZ304		c-Fms , Raf , p38 MAPK , Autophagy
	AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (I...		c-Fms , Raf , p38 MAPK , Autophagy
T8823	Locostatin		Raf
	Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and a...		Raf
T38511	AWL-II-38.3		Ephrin Receptor
	AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular ac...		Ephrin Receptor
T9638	CCT241161		Raf
	CCT241161 is an orally active pan- RAF inhibitor with IC 50 s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF a...		Raf
T41284	Nalfurafine	TRK-820	Opioid Receptor
	Nalfurafine is an effective and selective agonist of G protein-biased κ-opioid receptor with high translational potentia...		Opioid Receptor
T36642	RAS/RAS-RAF-IN-1
	RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYP...
T40284	B-Raf IN 2		Raf
	B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be...		Raf
T60727	B-Raf IN 8
	B-Raf IN 8 (compound 7g) is a potent inhibitor of B-Raf (IC 50 = 70.65 nM). B-Raf IN 8 shows antitumor activity which h...
T61935	B-Raf IN 9
	B-Raf IN 9 (compound 8b) is an effective B-Raf inhibitor (IC50=24.79 nM). B-Raf IN 9 blocks cell cycle at G2/M phase and...
T22272	Lifirafenib	BGB-283 , Beigene-283	EGFR , Raf
	Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM fo...		EGFR , Raf
T30781	CCT3833	BAL3833 , BAL 3833 , CCT 3833 , CCT-3833 , BAL-3833
	CCT3833, also known as BAL3833, is an orally available inhibitor of the serine/threonine-protein kinase family Raf, incl...
T18552	Pomalidomide-amido-C1-Br		Others
	Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cer...		Others
T12976	Sorafenib-d4	Bay 43-9006 (D4) , Sorafenib (D4)	Others
	Sorafenib D4 is the deuterium labeled Sorafenib. Sorafenib is an inhibitor of multikinase (Raf-1, B-Raf, and VEGFR-3 IC5...		Others
T39117	PLX7922
	PLX7922, a RAF inhibitor, can bind with BRAF V600E . PLX7922 inhibits pERK in BRAF V600E cell lines, and activates pERK ...
T21602	PF-04880594
	PF-04880594 is a potent and selective RAF inhibitor. PF-04880594 inhibits both wild-type and mutant BRAF and CRAF. PF-04...
T28510	REDX05358	REDX 05358 , REDX-05358
	REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors...
T32086	HM95573	HM 95573 , HM-95573
	HM95573 is an orally available inhibitor of members of the Raf family of serine/threonine protein kinases, with potentia...