ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product name	CAS No.	Purity
TN3486	Bakkenolide IIIa	915289-60-0	98%
TN3486	Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-ÎºB...
TN3806	Dehydroglyasperin C	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN1889	Lupalbigenin	76754-24-0	98%
TN1889	Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN1793	Isorhamnetin 3-O-galactoside	6743-92-6	98%
TN1793	Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
T4082	Astragaloside	T4082	98%
T4082	Astragaloside, one of the main active ingredients in Astragalus membranaceus.
TN3541	Broussonin E	90902-21-9	98%
TN3541	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
TN4469	(+)-Lyoniresinol	14464-90-5	98%
TN4469	Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activat...
TN4374	Kaerophyllin	75590-33-9	98%
TN4374	Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
T12410	PERK-IN-3	1337532-08-7	98%
T12410	PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).
TN5100	Taspine	602-07-3	98%
TN5100	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN1996	Nothofagin	11023-94-2	98%
TN1996	Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
TN1211	2-Hydroxy-3-methylanthraquinone	17241-40-6	98%
TN1211	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
TN4683	Nyasol	96895-25-9	98%
TN4683	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
TN3614	Cearoin	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN3525	Boehmenan	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T10809L	CHPG hydrochloride	T10809L	98%
T10809L	CHPG hydrochloride is a selective agonist of mGluR5.
TN3003	4-(3,4-Dimethoxyphenyl)-3-buten-1-ol	69768-97-4	98%
TN3003	(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypop...
T10299	AMG PERK 44	1883548-84-2	98%
T10299	AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 ...
TL0014	Pinusolide	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T16390	Omtriptolide	195883-06-8	98%
T16390	Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.