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ROS

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen. Examples include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen. The reduction of molecular oxygen (O2) produces superoxide (•O−2), which is the precursor of most other reactive oxygen species.In a biological context, ROS are formed as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically.
Cat No. product name
T8347 Rifamycin S Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
T4957 Carnosic acid Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
T0877 Gallic acid Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T0437 Inosine Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesi...
T8255 (±)-Catechin (±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.
T5518 N-acetylcysteine amide N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
T2864 Lycopene Lycopene is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, r...
T26288 Clovamide trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.). It possesses antioxidant ...
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
T6699 Tempol Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
TQ0288 Hexahydrocurcumin Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
T15433 GSK2795039 GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
TN1721 Gypenoside L Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also i...
TN1675 Gardenin B Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
T10668 Camalexin Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce RO...
T3061 Lorlatinib PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
T1661 Crizotinib Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
T2397 Topiroxostat Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
TN1624 Ethyl cinnamate Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
T3678 Entrectinib Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...
T1633 β-Carotene Beta-Carotene is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventiv...
TN1067 Galloylpaeoniflorin 6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
T8399 Crizotinib hydrochloride Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T3S1692 Octahydrocurcumin Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
T5426 DMNQ DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS...
TN1918 Medicarpin Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of pea...
T3834 8-Epideoxyloganic acid 8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during ...
T0692 Allopurinol Allopurinol is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
T1694 Oxypurinol Oxipurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
T23046 N-tert-butyl-α-Phenylnitrone COX-2 inhibitor
T0773 Febuxostat Febuxostat is a xanthine oxidase Inhibitor.
TN1146 8-​Prenylnaringenin 8-Prenylnaringenin is a phytoestrogen with high estrogenic activity,
T6947 Piperlongumine Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T4309 CIL56 CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation ...
T3455 Merestinib LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. LY2801653 selectively b...
T4071 Repotrectinib TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T11254 F-1 F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
T5016 Tofogliflozin (hydrate) Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
T6917 Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf.
T3374 Dihydrotanshinone I Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
T2858 Baicalein Baicalein is a xanthine oxidase inhibitor.
T9366 Pyrazoloadenine Pyrazoloadenine is the inhibitor of human xanthine oxidase.
T22318 Taletrectinib DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectiv...
T2841 Plumbagin Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also co...
TN2501 1,5,6-Trihydroxy-3-methoxyxanthone 1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
TN2511 Britannilactone diacetate 1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN2545 1-Hydroxypinoresinol 1-O-glucoside (+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/...
TN1731 Hernandezine Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
TN1725 Hederacolchiside E Hederacolchiside E 具有抗氧化活性,并通过调节氧化应激在阿尔茨海默病 (AD) 模型中显示神经保护作用。 Hederacolchiside E 对亚油酸乳液的脂质过氧化具有抑制作用。 Hederacolchiside E 可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。
Rifamycin S
T8347
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
Carnosic acid
T4957
Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
Gallic acid
T0877
Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
Inosine
T0437
Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesi...
(±)-Catechin
T8255
(±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.
N-acetylcysteine amide
T5518
N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
Lycopene
T2864
Lycopene is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, r...
Clovamide
T26288
trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.). It possesses antioxidant ...
Acetylcysteine
T0875
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
Tempol
T6699
Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
Hexahydrocurcumin
TQ0288
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
GSK2795039
T15433
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
Gypenoside L
TN1721
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also i...
Gardenin B
TN1675
Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
Camalexin
T10668
Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce RO...
Lorlatinib
T3061
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
Crizotinib
T1661
Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
Protosappanin A
TJS1779
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Topiroxostat
T2397
Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
Ethyl cinnamate
TN1624
Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
Entrectinib
T3678
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...
β-Carotene
T1633
Beta-Carotene is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventiv...
Galloylpaeoniflorin
TN1067
6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
Crizotinib hydrochloride
T8399
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
Octahydrocurcumin
T3S1692
Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
DMNQ
T5426
DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS...
Medicarpin
TN1918
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of p...
8-Epideoxyloganic acid
T3834
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during ...
Allopurinol
T0692
Allopurinol is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
Oxypurinol
T1694
Oxipurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
N-tert-butyl-α-Phenylnitrone
T23046
COX-2 inhibitor
Febuxostat
T0773
Febuxostat is a xanthine oxidase Inhibitor.
8-​Prenylnaringenin
TN1146
8-Prenylnaringenin is a phytoestrogen with high estrogenic activity,
Piperlongumine
T6947
Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
CIL56
T4309
CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation ...
Merestinib
T3455
LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. LY2801653 selectively b...
Repotrectinib
T4071
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
F-1
T11254
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppres...
Tofogliflozin (hydrate)
T5016
Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
Oleuropein
T6917
Oleuropein is an antioxidant polyphenol isolated from olive leaf.
Dihydrotanshinone I
T3374
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
Baicalein
T2858
Baicalein is a xanthine oxidase inhibitor.
Pyrazoloadenine
T9366
Pyrazoloadenine is the inhibitor of human xanthine oxidase.
Taletrectinib
T22318
DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectiv...
Plumbagin
T2841
Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also co...
1,5,6-Trihydroxy-3-methoxyxanthone
TN2501
1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
1-Hydroxypinoresinol 1-O-glucoside
TN2545
(+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/...
Hernandezine
TN1731
Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
Hederacolchiside E
TN1725
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