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Immunology / Inflammation ROS

ROS

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen. Examples include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen. The reduction of molecular oxygen (O2) produces superoxide (•O−2), which is the precursor of most other reactive oxygen species.In a biological context, ROS are formed as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically.
Cat No. product name
T0437 Inosine Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analges...
T0692 Allopurinol Allopurinol is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
T0773 Febuxostat Febuxostat is a xanthine oxidase Inhibitor.
T1363 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 1,2-Dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile was reported as xanthine oxidase inhibitor.
T1694 Oxypurinol Oxipurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
T2397 Topiroxostat Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
T2841 Plumbagin Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also c...
T2858 Baicalein Baicalein is a xanthine oxidase inhibitor.
T3061 Lorlatinib PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wi...
T3374 Dihydrotanshinone I Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
T3415 Secoisolariciresinol diglucoside Secoisolariciresinol Diglucoside was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol Diglucoside (2...
T3621 Brigatinib Brigatinib is a highly potent and selective ALK inhibitor.
T3678 Entrectinib Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and ...
T6376 Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
T6699 Tempol Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
T6917 Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf.
T6947 Piperlongumine Piperlongumine is a natural alkaloid from Piper longum L.. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T4309 CIL56 CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation...
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
T4957 Carnosic acid Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
T5518 N-acetylcysteine amide N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
T5426 DMNQ DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases RO...
T6S1255 Ophiopogonin D Ophiopogonin D(OPD) significantly inhibited the in vitro and in vivo growth of prostate cells via RIPK1, OPD may be developed as a potential anti-prostate cance...
T8255 (±)-Catechin hydrate (±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress. 
T8347 Rifamycin S Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
TN1037 Groenlandicine Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as mark...
TN1067 6'-O-Galloyl paeoniflorin 6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
TN1079 Deoxyelephantopin Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity, by inhibiting metastatic, inducing apop...
TN1141 Isodeoxyelephantopin Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apop...
TN1241 3,8'-Biapigenin 3, 8''-Biapigenin can modulate intracellular ROS production.
TN1290 5-Galloylquinic acid 5-Galloylquinic acid as an index for the baking intensity of oolong teas. It has antioxidant activity.
TN1372 alpha-Amyrin Alpha-Amyrin is trypsin and chymotrypsin inhibitor,it has antineoplastic,it induces proliferation of human keratinocytes.Alpha-Amyrin can as a hepatomodulatory ...
TN1425 Bacoside A3 Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
TN1449 Brandioside Brandioside shows strong antioxidant, and neuroprotective effects, it significantly attenuates glutamate-induced neurotoxicity at concentrations ranging from 0....
TN1548 Daidzin 6''-O-malonate Daidzin 6''-O-malonate may have anticancer activity.
TN1566 Delphinidin-3-sambubioside chloride Delphinidin-3-sambubioside chloride has antioxidant activity.
TN1624 Ethyl cinnamate Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dep...
TN1721 Gypenoside L Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also ...
TN1725 Hederacolchiside E Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by ...
TN1846 Kushenol W Kushenol W is a natural product
TN1910 Malvidin chloride Malvidin chloride has anti-spermatogenic, and antioxidant activities. It can prevent endothelial dysfunction by inhibiting ROS and XO-1.
TN1916 Matairesinol Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-induci...
TN1918 Medicarpin Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of ...
TN1919 Medioresinol Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in t...
TN1949 Moracin C Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
TN1952 Moracin P Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tu...
TN1969 N-(p-Coumaroyl) serotonin N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving vascular distensibi...
TN2243 Sugiol Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals...
TN1002 Blumeatin Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity.
TN1042 Chebulic acid Chebulic acid has effects against the progression of AGE-induced endothelial cell dysfunction, may constitute a promising intervention agent against diabetic va...
Inosine
T0437CAS 58-63-9
Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analges...
Allopurinol
T0692CAS 315-30-0
Allopurinol is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
Febuxostat
T0773CAS 144060-53-7
Febuxostat is a xanthine oxidase Inhibitor.
4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
T1363CAS 21642-98-8
1,2-Dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile was reported as xanthine oxidase inhibitor.
Oxypurinol
T1694CAS 2465-59-0
Oxipurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
Topiroxostat
T2397CAS 577778-58-6
Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
Plumbagin
T2841CAS 481-42-5
Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also c...
Baicalein
T2858CAS 491-67-8
Baicalein is a xanthine oxidase inhibitor.
Lorlatinib
T3061CAS 1454846-35-5
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wi...
Dihydrotanshinone I
T3374CAS 87205-99-0
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
Secoisolariciresinol diglucoside
T3415CAS 148244-82-0
Secoisolariciresinol Diglucoside was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol Diglucoside (2...
Brigatinib
T3621CAS 1197953-54-0
Brigatinib is a highly potent and selective ALK inhibitor.
Entrectinib
T3678CAS 1108743-60-7
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and ...
Allopurinol Sodium
T6376CAS 17795-21-0
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
Tempol
T6699CAS 2226-96-2
Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
Oleuropein
T6917CAS 32619-42-4
Oleuropein is an antioxidant polyphenol isolated from olive leaf.
Piperlongumine
T6947CAS 20069-09-4
Piperlongumine is a natural alkaloid from Piper longum L.. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
CIL56
T4309CAS 300802-28-2
CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation...
Acetylcysteine
T0875CAS 616-91-1
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
Carnosic acid
T4957CAS 3650-09-7
Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
N-acetylcysteine amide
T5518CAS 38520-57-9
N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
DMNQ
T5426CAS 6956-96-3
DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases RO...
Ophiopogonin D
T6S1255CAS 41753-55-3
Ophiopogonin D(OPD) significantly inhibited the in vitro and in vivo growth of prostate cells via RIPK1, OPD may be developed as a potential anti-prostate cance...
(±)-Catechin hydrate
T8255CAS 7295-85-4
(±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress. 
Rifamycin S
T8347CAS 13553-79-2
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
Groenlandicine
TN1037CAS 38691-95-1
Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as mark...
6'-O-Galloyl paeoniflorin
TN1067CAS 122965-41-7
6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
Deoxyelephantopin
TN1079CAS 29307-03-7
Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity, by inhibiting metastatic, inducing apop...
Isodeoxyelephantopin
TN1141CAS 38927-54-7
Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apop...
3,8'-Biapigenin
TN1241CAS 101140-06-1
3, 8''-Biapigenin can modulate intracellular ROS production.
5-Galloylquinic acid
TN1290CAS 53584-43-3
5-Galloylquinic acid as an index for the baking intensity of oolong teas. It has antioxidant activity.
alpha-Amyrin
TN1372CAS 638-95-9
Alpha-Amyrin is trypsin and chymotrypsin inhibitor,it has antineoplastic,it induces proliferation of human keratinocytes.Alpha-Amyrin can as a hepatomodulatory ...
Bacoside A3
TN1425CAS 157408-08-7
Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
Brandioside
TN1449CAS 133393-81-4
Brandioside shows strong antioxidant, and neuroprotective effects, it significantly attenuates glutamate-induced neurotoxicity at concentrations ranging from 0....
Daidzin 6''-O-malonate
TN1548CAS 124590-31-4
Daidzin 6''-O-malonate may have anticancer activity.
Delphinidin-3-sambubioside chloride
TN1566CAS 53158-73-9
Delphinidin-3-sambubioside chloride has antioxidant activity.
Ethyl cinnamate
TN1624CAS 103-36-6
Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dep...
Gypenoside L
TN1721CAS 94987-09-4
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also ...
Hederacolchiside E
TN1725CAS 33783-82-3
Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by ...
Kushenol W
TN1846CAS 254886-76-5
Kushenol W is a natural product
Malvidin chloride
TN1910CAS 643-84-5
Malvidin chloride has anti-spermatogenic, and antioxidant activities. It can prevent endothelial dysfunction by inhibiting ROS and XO-1.
Matairesinol
TN1916CAS 580-72-3
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-induci...
Medicarpin
TN1918CAS 32383-76-9
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of ...
Medioresinol
TN1919CAS 40957-99-1
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in t...
Moracin C
TN1949CAS 69120-06-5
Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
Moracin P
TN1952CAS 102841-46-3
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tu...
N-(p-Coumaroyl) serotonin
TN1969CAS 68573-24-0
N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving vascular distensibi...
Sugiol
TN2243CAS 511-05-7
Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals...
Blumeatin
TN1002CAS 118024-26-3
Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity.
Chebulic acid
TN1042CAS 23725-05-5
Chebulic acid has effects against the progression of AGE-induced endothelial cell dysfunction, may constitute a promising intervention agent against diabetic va...