TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
TN2995 |
4,10-Aromadendranediol
|
70051-38-6
|
98%
|
|
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
|
T13345 |
Wnt pathway activator 2
|
1360540-82-4
|
98%
|
|
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
|
TQ0215 |
Salinomycin sodium salt
|
55721-31-8
|
98%
|
|
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
|
T9662 |
SRI 37892
|
1030769-75-5
|
98%
|
|
SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
|
T2161 |
Cardiogenol C
|
671225-39-1
|
98%
|
|
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
|
T13078 |
Tankyrase-IN-2
|
1588870-36-3
|
98%
|
|
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
|
T15469 |
Hematein
|
475-25-2
|
98%
|
|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
|
TMA1743 |
Ergosterol peroxide
|
2061-64-5
|
98%
|
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
|
TN2775 |
2-Methoxystypandrone
|
85122-21-0
|
98%
|
|
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
|
TN3319 |
9-Hydroxycanthin-6-one
|
138544-91-9
|
98%
|
|
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
|
T12537 |
β-catenin/CBP-IN-1
|
1198780-38-9
|
98%
|
|
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
|
TN3468 |
Atractylochromene
|
203443-33-8
|
98%
|
|
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
|
T17256 |
Wnt pathway activator 1
|
1360540-81-3
|
98%
|
|
Wnt pathway activator 1 is a potent Wnt activator (IC50s: 28-29 nM).
|
T11793 |
KY-05009
|
1228280-29-2
|
98%
|
|
KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein e...
|
TN4583 |
Moringin
|
73255-40-0
|
98%
|
|
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
|
T9557 |
TNIK-IN-2
|
2754265-76-2
|
98%
|
|
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
|
TN7036 |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
|
883715-23-9
|
98%
|
|
N-3-methoxylBenzyllinolenicamide induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-cat...
|
T35610 |
2,5-dimethyl Celecoxib
|
457639-26-8
|
98%
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
|
T9696 |
β-catenin-IN-2
|
1458664-10-2
|
98%
|
|
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
|