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Caspase

T1772	Apoptosis Activator 2	Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
T2503	PAC1	PAC-1 has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.
T2A2481	Taurochenodeoxycholic Acid	Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T3519	Polyphyllin B	Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal system...
T3600	Licochalcone A	Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
T3907	Senegenin	Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
T3914	Saikosaponin C	Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T3S0335	Soyasaponin Bb	1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-...
T3S1227	Aristololactam I	1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I ma...
T4S0498	Glaucocalyxin A	1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreas...
T4S1335	Daphnoretin	1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcom...
T4S2012	Dihydro Sanguinarine	Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity.
T5558	Chelidonic acid	Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sh...
T5574	Guggulsterone E&Z	Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T5S1632	8-O-Acetylshanzhiside methyl ester	8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
T5S2083	Puerarin 6''-O-Xyloside	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relat...
T5S2283	Sesamolin	1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 a...
T6005	Z-DEVD-FMK	Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
T6013	Z-VAD(OMe)-FMK	Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor. It inhibits cleavage of PARP, preventing apoptosis when used at 10-50 μM.
T6090	Belnacasan	VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor.
T6191	Tasisulam	Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
T6826	Emricasan	Emricasan is an effective and irreversible pan-caspase inhibitor.
T7016	VR23	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM fo...
T7019	Z-IETD-FMK	Z-IETD-FMK is a selective caspase 8 inhibitor, which has cell permeable.

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