Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat No.	product name
TN1195	17-Hydroxy sprengerinin C	17-Hydroxy sprengerinin C 是从黄精的根茎中分离得到的一种糖苷化合物，具有更强的抗癌活性。17-Hydroxy sprengerinin C 降低 Blc-2 和 pro-caspase3 的表达并增加 Bax 的产生。
T9083	TC11	TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
T3384	Wedelolactone	Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T8296	5,7,4'-Trimethoxyflavone	5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
T3519	Formosanin C	Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems...
T3600	Licochalcone A	Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
T2532	Tauroursodeoxycholate	Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxy...
T6191	Tasisulam	Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
T6761	Ossirene	AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one	Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
T2122	Ixazomib	MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC5...
T2881	Crustecdysone	20-Hydroxyecdysone is a steroid hormone that regulates the processes of molting or ecdysis in insects.
T8468	CIL62	CIL62 is a cell death inducer of caspase-3/7-independent. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death
T26193	SKLB-163	SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
TN1675	Gardenin B	Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
T3914	Saikosaponin C	Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T3907	Tenuigenin	Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
T25049	Allethrin	The allethrins are a group of related synthetic compounds utilized in insecticides.
T2698	Asperosaponin VI	Akebia saponin D, the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone...
T2959	Ginsenoside Rh2	Ginsenoside Rh2, an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.
T2S2362	Dehydrocorydaline nitrate	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
TN1891	Lupiwighteone	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T18909	Ac-DEVD-AMC	Ac-DEVD-AMC is the Caspase-3 substrate.
TN1651	Furanodiene	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T16522	Phenoxodiol	Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
T1772	MDK83190	Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
T6993	Tauroursodeoxycholate sodium	Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
T9118	KEA1-97	Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspa...
T2A2481	Taurochenodeoxycholic Acid	Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T11696	Ivachtin	Ivachtin is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM.
T4085	Paris saponin VII	Chonglou saponin VII shows inhibitory effects on cell proliferation.
T1266	Terfenadine	Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
T0282	Q-VD-OPH	Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
TJA2398	Taurodeoxycholic acid sodium hydrate	Taurohyodeoxycholic acid sodium salt, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
T5S2083	Puerarin 6''-O-Xyloside	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relate...
T5S2283	Sesamolin	1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 ac...
T10580	BOC-D-FMK	Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).
T3S1227	Aristolactam I	1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may b...
T5S2076	Senkyunolide I	1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.
TN1405	Arnicolide D	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T5S1805	5,7-Dihydroxychromone	1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
T6826	Emricasan	Emricasan is an effective and irreversible pan-caspase inhibitor.
T27242	EF24	EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity i...
T3779	Crocin II	Crocin has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing ...
T4S2012	Dihydrosanguinarine	Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity.
T5S2358	Dehydrocorydaline	1. Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. 2. Dehydrocorydaline stimulates p38 MAPK activa...
T4S0498	Glaucocalyxin A	1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases B...
T9113	Myristicin	Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also h...
T7727	Se-Methylselenocysteine	Se-Methylselenocysteine is a drug potentially for the treatment of solid tumors. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 exp...
TN1086	Dehydrotrametenolic acid	Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.