Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat No.	Product Name
T0282	Q-VD-OPH	Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
T1772	Apoptosis Activator 2	Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
T2503	PAC1	PAC-1 has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.
T3519	Polyphyllin B	Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal system...
T3600	Licochalcone A	Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
T3907	Senegenin	Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
T3914	Saikosaponin C	Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T6005	Z-DEVD-FMK	Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
T6013	Z-VAD(OMe)-FMKHOT	Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor. It inhibits cleavage of PARP, preventing apoptosis when used at 10-50 μM.
T6090	Belnacasan	VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor.
T6191	Tasisulam	Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
T6826	Emricasan	Emricasan is an effective and irreversible pan-caspase inhibitor.
T7016	VR23	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM fo...
T7019	Z-IETD-FMK	Z-IETD-FMK is a selective caspase 8 inhibitor, which has cell permeable.
T3S0335	Soyasaponin Bb	1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-...
T3S1227	Aristololactam I	1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I ma...
T4S0498	Glaucocalyxin A	1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreas...
T4S1335	Daphnoretin	1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcom...
T5S2283	Sesamolin	1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 a...
T2A2481	Taurochenodeoxycholic Acid	Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T5S1632	8-O-Acetylshanzhiside methyl ester	8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
T5574	Guggulsterone E&Z	Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T5558	Chelidonic acid	Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sh...
T4S2012	Dihydro Sanguinarine	Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity.
T5S2083	Puerarin 6''-O-Xyloside	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relat...
TQ0146	Ac-DEVD-CHO	Ac-DEVD-CHO is a selective Caspase-3 inhibitor (Ki: 230 pM).
T2122	Ixazomib	MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (I...
TJA2398	Taurohyodeoxycholic acid sodium salt	Taurohyodeoxycholic acid sodium salt, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
T8296	4',5,7-Trimethoxyflavone	5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
TN1466	Canthin-6-one	Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflam...
TN1538	Curzerenone	Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52).
TN1601	Effusol	Effusol can induce caspase-3-mediated cytotoxicity in HT22 cells.
TN1814	Juncusol	Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 ce...
TN2175	Salvianolic acid F	The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentrati...
TN2191	Scutebarbatine A	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of casp...
TN2217	Sophoflavescenol	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , th...
TN1039	Tamarixetin	Tamarixetin has vasodilator effects in rat isolated vessels. Tamarixetin has cytotoxic against leukemia cells and in particular P-glycoprotein- overexpressing K...
TN1087	Deoxypodophyllotoxin	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TN1139	Dehydrocavidine	Dehydrocorydaline has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as we...
TN1153	Polyporenic acid C	Polyporenic acid C shows inhibitory activity against human collagenase.
TN1393	(-)-Anonaine	(-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DN...
TN1532	Crenulatin	Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L...
TN1677	Gartanin	Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through...
TN1807	Isoverticine	Isoverticine exhibits significant antitussive, expectorant and anti-inflammatory activities, it also displays significant cytotoxicity.
TN1837	Kuguaglycoside C	Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
TN1875	Liriodenine	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can...
TN2002	Obovatol	Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease tre...
TN2019	Orobol	Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover, it has sensitization effect, it can produce produced cisplatin (DD...
TN2034	Paeoniflorigenone	Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.
TN2040	Panaxynol	Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.