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Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.
Cat No. product name
TN1195 17-Hydroxy sprengerinin C 17-Hydroxy sprengerinin C 是从黄精的根茎中分离得到的一种糖苷化合物,具有更强的抗癌活性。17-Hydroxy sprengerinin C 降低 Blc-2 和 pro-caspase3 的表达并增加 Bax 的产生。
T9083 TC11 TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
T3384 Wedelolactone Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T8296 5,​7,​4'-​Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
T3519 Formosanin C Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems...
T3600 Licochalcone A Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
T2532 Tauroursodeoxycholate Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxy...
T6191 Tasisulam Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
T6761 Ossirene AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
T2122 Ixazomib MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC5...
T2881 Crustecdysone 20-Hydroxyecdysone is a steroid hormone that regulates the processes of molting or ecdysis in insects.
T8468 CIL62 CIL62 is a cell death inducer of caspase-3/7-independent. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death
T26193 SKLB-163 SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
TN1675 Gardenin B Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
T3914 Saikosaponin C Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T3907 Tenuigenin Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
T25049 Allethrin The allethrins are a group of related synthetic compounds utilized in insecticides.
T2698 Asperosaponin VI Akebia saponin D, the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone...
T2959 Ginsenoside Rh2 Ginsenoside Rh2, an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.
T2S2362 Dehydrocorydaline nitrate 1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
TN1891 Lupiwighteone Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T18909 Ac-DEVD-AMC Ac-DEVD-AMC is the Caspase-3 substrate.
TN1651 Furanodiene Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T16522 Phenoxodiol Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
T1772 MDK83190 Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
T6993 Tauroursodeoxycholate sodium Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
T9118 KEA1-97 Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspa...
T2A2481 Taurochenodeoxycholic Acid Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T11696 Ivachtin Ivachtin is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM.
T4085 Paris saponin VII Chonglou saponin VII shows inhibitory effects on cell proliferation.
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
T0282 Q-VD-OPH Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
TJA2398 Taurodeoxycholic acid sodium hydrate Taurohyodeoxycholic acid sodium salt, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
T5S2083 Puerarin 6''-O-Xyloside Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relate...
T5S2283 Sesamolin 1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 ac...
T10580 BOC-D-FMK Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).
T3S1227 Aristolactam I 1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may b...
T5S2076 Senkyunolide I 1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.
TN1405 Arnicolide D Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T5S1805 5,7-Dihydroxychromone 1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
T6826 Emricasan Emricasan is an effective and irreversible pan-caspase inhibitor.
T27242 EF24 EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity i...
T3779 Crocin II Crocin has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing ...
T4S2012 Dihydrosanguinarine Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity.
T5S2358 Dehydrocorydaline 1. Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. 2. Dehydrocorydaline stimulates p38 MAPK activa...
T4S0498 Glaucocalyxin A 1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases B...
T9113 Myristicin Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also h...
T7727 Se-Methylselenocysteine Se-Methylselenocysteine is a drug potentially for the treatment of solid tumors. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 exp...
TN1086 Dehydrotrametenolic acid Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
17-Hydroxy sprengerinin C
TN1195
17-Hydroxy sprengerinin C 是从黄精的根茎中分离得到的一种糖苷化合物,具有更强的抗癌活性。17-Hydroxy sprengerinin C 降低 Blc-2 和...
TC11
T9083
TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
Wedelolactone
T3384
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
5,​7,​4'-​Trimethoxyflavone
T8296
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
Formosanin C
T3519
Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems...
Licochalcone A
T3600
Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
Tauroursodeoxycholate
T2532
Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxy...
Tasisulam
T6191
Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
Ossirene
T6761
AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
Ixazomib
T2122
MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC...
Crustecdysone
T2881
20-Hydroxyecdysone is a steroid hormone that regulates the processes of molting or ecdysis in insects.
CIL62
T8468
CIL62 is a cell death inducer of caspase-3/7-independent. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death
SKLB-163
T26193
SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
Gardenin B
TN1675
Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
Saikosaponin C
T3914
Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
Tenuigenin
T3907
Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
Allethrin
T25049
The allethrins are a group of related synthetic compounds utilized in insecticides.
Asperosaponin VI
T2698
Akebia saponin D, the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone...
Ginsenoside Rh2
T2959
Ginsenoside Rh2, an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.
Dehydrocorydaline nitrate
T2S2362
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
Lupiwighteone
TN1891
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
Ac-DEVD-AMC
T18909
Ac-DEVD-AMC is the Caspase-3 substrate.
Furanodiene
TN1651
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
Phenoxodiol
T16522
Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
MDK83190
T1772
Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
Tauroursodeoxycholate sodium
T6993
Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
KEA1-97
T9118
Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and casp...
Taurochenodeoxycholic Acid
T2A2481
Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
Ivachtin
T11696
Ivachtin is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM.
Paris saponin VII
T4085
Chonglou saponin VII shows inhibitory effects on cell proliferation.
Terfenadine
T1266
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
Q-VD-OPH
T0282
Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
Taurodeoxycholic acid sodium hydrate
TJA2398
Taurohyodeoxycholic acid sodium salt, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
Puerarin 6''-O-Xyloside
T5S2083
Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relate...
Sesamolin
T5S2283
1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 ac...
BOC-D-FMK
T10580
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).
Aristolactam I
T3S1227
1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may b...
Senkyunolide I
T5S2076
1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.
Arnicolide D
TN1405
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
5,7-Dihydroxychromone
T5S1805
1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
Emricasan
T6826
Emricasan is an effective and irreversible pan-caspase inhibitor.
EF24
T27242
EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity i...
Crocin II
T3779
Crocin has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing ...
Dihydrosanguinarine
T4S2012
Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity.
Dehydrocorydaline
T5S2358
1. Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. 2. Dehydrocorydaline stimulates p38 MAPK activa...
Glaucocalyxin A
T4S0498
1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases ...
Myristicin
T9113
Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also h...
Se-Methylselenocysteine
T7727
Se-Methylselenocysteine is a drug potentially for the treatment of solid tumors. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 exp...
Dehydrotrametenolic acid
TN1086
Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
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