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Apoptosis Caspase

Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.
Cat No. Product Name
T0282 Q-VD-OPH Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
T1772 Apoptosis Activator 2 Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
T2503 PAC1 PAC-1 has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.
T3519 Polyphyllin B Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal system...
T3600 Licochalcone A Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
T3907 Senegenin Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
T3914 Saikosaponin C Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T6005 Z-DEVD-FMK Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
T6013 Z-VAD(OMe)-FMKHOT Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor. It inhibits cleavage of PARP, preventing apoptosis when used at 10-50 μM.
T6090 Belnacasan VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor.
T6191 Tasisulam Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
T6826 Emricasan Emricasan is an effective and irreversible pan-caspase inhibitor.
T7016 VR23 VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM fo...
T7019 Z-IETD-FMK Z-IETD-FMK is a selective caspase 8 inhibitor, which has cell permeable.
T3S0335 Soyasaponin Bb 1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-...
T3S1227 Aristololactam I 1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I ma...
T4S0498 Glaucocalyxin A 1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreas...
T4S1335 Daphnoretin 1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcom...
T5S2283 Sesamolin 1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 a...
T2A2481 Taurochenodeoxycholic Acid Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T5S1632 8-O-Acetylshanzhiside methyl ester 8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
T5574 Guggulsterone E&Z Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T5558 Chelidonic acid Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sh...
T4S2012 Dihydro Sanguinarine Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity.
T5S2083 Puerarin 6''-O-Xyloside Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relat...
TQ0146 Ac-DEVD-CHO Ac-DEVD-CHO is a selective Caspase-3 inhibitor (Ki: 230 pM).
T2122 Ixazomib MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (I...
TJA2398 Taurohyodeoxycholic acid sodium salt Taurohyodeoxycholic acid sodium salt, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
T8296 4',5,7-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
TN1466 Canthin-6-one Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflam...
TN1538 Curzerenone Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52).
TN1601 Effusol Effusol can induce caspase-3-mediated cytotoxicity in HT22 cells.
TN1814 Juncusol Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 ce...
TN2175 Salvianolic acid F The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentrati...
TN2191 Scutebarbatine A Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of casp...
TN2217 Sophoflavescenol Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , th...
TN1039 Tamarixetin Tamarixetin has vasodilator effects in rat isolated vessels. Tamarixetin has cytotoxic against leukemia cells and in particular P-glycoprotein- overexpressing K...
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TN1139 Dehydrocavidine Dehydrocorydaline has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as we...
TN1153 Polyporenic acid C Polyporenic acid C shows inhibitory activity against human collagenase.
TN1393 (-)-Anonaine (-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DN...
TN1532 Crenulatin Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L...
TN1677 Gartanin Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through...
TN1807 Isoverticine Isoverticine exhibits significant antitussive, expectorant and anti-inflammatory activities, it also displays significant cytotoxicity.
TN1837 Kuguaglycoside C Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
TN1875 Liriodenine Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can...
TN2002 Obovatol Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease tre...
TN2019 Orobol Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover, it has sensitization effect, it can produce produced cisplatin (DD...
TN2034 Paeoniflorigenone Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.
TN2040 Panaxynol Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
Q-VD-OPH
T0282CAS 1135695-98-5
Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
Apoptosis Activator 2
T1772CAS 79183-19-0
Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
PAC1
T2503CAS 315183-21-2
PAC-1 has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.
Polyphyllin B
T3519CAS 50773-42-7
Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal system...
Licochalcone A
T3600CAS 58749-22-7
Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
Senegenin
T3907CAS 2469-34-3
Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
Saikosaponin C
T3914CAS 20736-08-7
Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
Z-DEVD-FMK
T6005CAS 210344-95-9
Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
Z-VAD(OMe)-FMK HOT
T6013CAS 187389-52-2
Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor. It inhibits cleavage of PARP, preventing apoptosis when used at 10-50 μM.
Belnacasan
T6090CAS 273404-37-8
VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor.
Tasisulam
T6191CAS 519055-62-0
Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
Emricasan
T6826CAS 254750-02-2
Emricasan is an effective and irreversible pan-caspase inhibitor.
VR23
T7016CAS 1624602-30-7
VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM fo...
Z-IETD-FMK
T7019CAS 210344-98-2
Z-IETD-FMK is a selective caspase 8 inhibitor, which has cell permeable.
Soyasaponin Bb
T3S0335CAS 51330-27-9
1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-...
Aristololactam I
T3S1227CAS 13395-02-3
1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I ma...
Glaucocalyxin A
T4S0498CAS 79498-31-0
1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreas...
Daphnoretin
T4S1335CAS 2034-69-7
1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcom...
Sesamolin
T5S2283CAS 526-07-8
1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 a...
Taurochenodeoxycholic Acid
T2A2481CAS 516-35-8
Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
8-O-Acetylshanzhiside methyl ester
T5S1632CAS 57420-46-9
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
Guggulsterone E&Z
T5574CAS 95975-55-6
Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
Chelidonic acid
T5558CAS 99-32-1
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sh...
Dihydro Sanguinarine
T4S2012CAS 3606-45-9
Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity.
Puerarin 6''-O-Xyloside
T5S2083CAS 114240-18-5
Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relat...
Ac-DEVD-CHO
TQ0146CAS 169332-60-9
Ac-DEVD-CHO is a selective Caspase-3 inhibitor (Ki: 230 pM).
Ixazomib
T2122CAS 1072833-77-2
MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (I...
Taurohyodeoxycholic acid sodium salt
TJA2398CAS 110026-03-4
Taurohyodeoxycholic acid sodium salt, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
4',5,7-Trimethoxyflavone
T8296CAS 5631-70-9
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
Canthin-6-one
TN1466CAS 479-43-6
Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflam...
Curzerenone
TN1538CAS 20493-56-5
Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52).
Effusol
TN1601CAS 73166-28-6
Effusol can induce caspase-3-mediated cytotoxicity in HT22 cells.
Juncusol
TN1814CAS 62023-90-9
Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 ce...
Salvianolic acid F
TN2175CAS 158732-59-3
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentrati...
Scutebarbatine A
TN2191CAS 176520-13-1
Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of casp...
Sophoflavescenol
TN2217CAS 216450-65-6
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , th...
Tamarixetin
TN1039CAS 603-61-2
Tamarixetin has vasodilator effects in rat isolated vessels. Tamarixetin has cytotoxic against leukemia cells and in particular P-glycoprotein- overexpressing K...
Deoxypodophyllotoxin
TN1087CAS 19186-35-7
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
Dehydrocavidine
TN1139CAS 83218-34-2
Dehydrocorydaline has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as we...
Polyporenic acid C
TN1153CAS 465-18-9
Polyporenic acid C shows inhibitory activity against human collagenase.
(-)-Anonaine
TN1393CAS 1862-41-5
(-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DN...
Crenulatin
TN1532CAS 63026-02-8
Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L...
Gartanin
TN1677CAS 33390-42-0
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through...
Isoverticine
TN1807CAS 23496-43-7
Isoverticine exhibits significant antitussive, expectorant and anti-inflammatory activities, it also displays significant cytotoxicity.
Kuguaglycoside C
TN1837CAS 1041631-93-9
Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
Liriodenine
TN1875CAS 475-75-2
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can...
Obovatol
TN2002CAS 83864-78-2
Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease tre...
Orobol
TN2019CAS 480-23-9
Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover, it has sensitization effect, it can produce produced cisplatin (DD...
Paeoniflorigenone
TN2034CAS 80454-42-8
Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.
Panaxynol
TN2040CAS 81203-57-8
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.