Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product name	CAS No.	Purity
T13764	Lycopodine	466-61-5	98%
T13764	Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive comp...
T16998	Tauroursodeoxycholate dihydrate	117609-50-4	98%
T16998	Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decrea...
TN4166	Griffipavixanthone	219649-95-3	98%
TN4166	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN1466	Canthin-6-one	479-43-6	98%
TN1466	Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflamm...
TN2977	3-O-trans-p-Coumaroyltormentic acid	121064-78-6	98%
TN2977	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in ...
TN3922	Effusanin E	76470-15-0	98%
TN3922	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
TN2040	Panaxynol	81203-57-8	98%
TN2040	Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TN4087	Furowanin A	911004-72-3	98%
TN4087	Furowanin A shows significant cytotoxicity against HL-60 cells, it induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis.
TN3618	Cedrin	75513-81-4	98%
TN3618	Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TMA0153	Safflor Yellow A	85532-77-0	98%
TMA0153	Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
T11701	J22352	2252395-44-9	98%
T11701	J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and...
TN2034	Paeoniflorigenone	80454-42-8	98%
TN2034	Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.
TN2691	2',3'-Dehydrosalannol	97411-50-2	98%
TN2691	2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits ca...
TN5033	Skullcapflavone I	41060-16-6	98%
TN5033	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
T10548	Biotin-VAD-FMK	1135688-15-1	98%
T10548	Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates.
T38563	Raptinal	1176-09-6	98%
T38563	Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
TP2161	Z-WEHD-FMK	210345-00-9	98%
TP2161	Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
TN2191	Scutebarbatine A	176520-13-1	98%
TN2191	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspa...
T5526	Glycoborinine	233279-39-5	98%
T5526	Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
TQ0146	Ac-DEVD-CHO	169332-60-9	98%
TQ0146	Ac-DEVD-CHO is a selective Caspase-3 inhibitor (Ki: 230 pM).