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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.
Cat No. product name
T5385 Radiprodil Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
T9133 Caroverine hydrochloride Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that ...
T8459 DNQX disodium salt DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
T16801 (RS)-(Tetrazol-5-yl)glycine (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC5...
T7591 Coluracetam Coluracetam(MKC-231) is a Choline Uptake Enhancer.
T7355 IC87201 IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T7870 TCN 201 TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T7178 CNQX CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
T3379 Decanoic Acid Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
T6608 NMDA N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
T6618 Orphenadrine Citrate Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T1909 L-701324 L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T1443 Memantine hydrochloride Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T0426 Piracetam Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T3407 Rapastinel Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T22542 1-Aminocyclobutanecarboxylic acid 1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T16402 Org-26576 Org-26576 is a positive allosteric modulator of the AMPA receptor.
T17179 Tulrampator Tulrampator is an orally bioavailable positive AMPAR.
T3957 Farampator Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
T1884 CX516 Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, ...
TQ0027 Transcrocetinate disodium Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
T15623 JNJ-61432059 JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1...
T4S0171 Transcrocetin 1. Croceic acid is a singlet oxygen quencher.
T6871 L-Glutamic acid monosodium salt L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
T12406 PEPA PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
T10930 D-AP5 D-AP5 is a NMDA receptor antagonist.
T5819 Rapastinel Trifluoroacetate Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
T7108 Omberacetam Omberacetam is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other rel...
T2A2497 L-Glutamic acid (S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
T7579 1-BCP 1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
T2362 QNZ46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T3026 (-)-Huperzine A Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
TQ0233 Traxoprodil Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T5522 NMDAR antagonist 1
T0324 Isoxsuprine hydrochloride Isoxsuprine hydrochloride is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
T17293 ZL006 ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T23490 UBP310 GLUK5 kainate receptor antagonist
T6504 Flupirtine maleate Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
T12187L Naspm trihydrochloride Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
T4096 Quinolinic acid Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T3320 Dizocilpine Maleate (+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
T4979 Procyclidine hydrochloride Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T6352 (-)-Dizocilpine maleate MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
T16800 (RS)-AMPA (RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA ((±)-AMPA) is an effective and selective excitatory neurotransmitter L-glutamic acid agonist.
T20571 Cis-PDA cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T1186 Ifenprodil Tartrate Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T0015 Mephenesin Mephenesin is a centrally acting muscle relaxant with a short duration of action.
T4171 PEAQX PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 n...
T1897 MDL-29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
Radiprodil
T5385
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
Caroverine hydrochloride
T9133
Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that ...
DNQX disodium salt
T8459
DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
(RS)-(Tetrazol-5-yl)glycine
T16801
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC5...
Coluracetam
T7591
Coluracetam(MKC-231) is a Choline Uptake Enhancer.
IC87201
T7355
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
TCN 201
T7870
TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
CNQX
T7178
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
Decanoic Acid
T3379
Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
NMDA
T6608
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
Orphenadrine Citrate
T6618
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
L-701324
T1909
L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
Memantine hydrochloride
T1443
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Piracetam
T0426
Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
Rapastinel
T3407
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
1-Aminocyclobutanecarboxylic acid
T22542
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
Org-26576
T16402
Org-26576 is a positive allosteric modulator of the AMPA receptor.
Tulrampator
T17179
Tulrampator is an orally bioavailable positive AMPAR.
Farampator
T3957
Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
CX516
T1884
Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, ...
Transcrocetinate disodium
TQ0027
Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
JNJ-61432059
T15623
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA...
Transcrocetin
T4S0171
1. Croceic acid is a singlet oxygen quencher.
L-Glutamic acid monosodium salt
T6871
L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
PEPA
T12406
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
D-AP5
T10930
D-AP5 is a NMDA receptor antagonist.
Rapastinel Trifluoroacetate
T5819
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
Omberacetam
T7108
Omberacetam is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other rel...
L-Glutamic acid
T2A2497
(S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
1-BCP
T7579
1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
QNZ46
T2362
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
(-)-Huperzine A
T3026
Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
Traxoprodil
TQ0233
Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
NMDAR antagonist 1
T5522
Isoxsuprine hydrochloride
T0324
Isoxsuprine hydrochloride is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
ZL006
T17293
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
UBP310
T23490
GLUK5 kainate receptor antagonist
Flupirtine maleate
T6504
Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
Naspm trihydrochloride
T12187L
Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
Quinolinic acid
T4096
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
Dizocilpine Maleate
T3320
(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
Procyclidine hydrochloride
T4979
Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
(-)-Dizocilpine maleate
T6352
MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
(RS)-AMPA
T16800
(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA ((±)-AMPA) is an effective and selective excitatory neurotransmitter L-glutamic acid agonist.
cis-PDA
T20571
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
Aniracetam
T0333
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
Ifenprodil Tartrate
T1186
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
Mephenesin
T0015
Mephenesin is a centrally acting muscle relaxant with a short duration of action.
PEAQX
T4171
PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 n...
MDL-29951
T1897
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
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