iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.

Cat No.	product name
T5385	Radiprodil	Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
T9133	Caroverine hydrochloride	Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that ...
T8459	DNQX disodium salt	DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
T16801	(RS)-(Tetrazol-5-yl)glycine	(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC5...
T7591	Coluracetam	Coluracetam(MKC-231) is a Choline Uptake Enhancer.
T7355	IC87201	IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T7870	TCN 201	TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T7178	CNQX	CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
T3379	Decanoic Acid	Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
T6608	NMDA	N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
T6618	Orphenadrine Citrate	Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T1909	L-701324	L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T1443	Memantine hydrochloride	Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T0426	Piracetam	Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T3407	Rapastinel	Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T22542	1-Aminocyclobutanecarboxylic acid	1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T16402	Org-26576	Org-26576 is a positive allosteric modulator of the AMPA receptor.
T17179	Tulrampator	Tulrampator is an orally bioavailable positive AMPAR.
T3957	Farampator	Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
T1884	CX516	Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, ...
TQ0027	Transcrocetinate disodium	Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
T15623	JNJ-61432059	JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1...
T4S0171	Transcrocetin	1. Croceic acid is a singlet oxygen quencher.
T6871	L-Glutamic acid monosodium salt	L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
T12406	PEPA	PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
T10930	D-AP5	D-AP5 is a NMDA receptor antagonist.
T5819	Rapastinel Trifluoroacetate	Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
T7108	Omberacetam	Omberacetam is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other rel...
T2A2497	L-Glutamic acid	(S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
T7579	1-BCP	1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
T2362	QNZ46	QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T3026	(-)-Huperzine A	Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
TQ0233	Traxoprodil	Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T5522	NMDAR antagonist 1
T0324	Isoxsuprine hydrochloride	Isoxsuprine hydrochloride is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
T17293	ZL006	ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T23490	UBP310	GLUK5 kainate receptor antagonist
T6504	Flupirtine maleate	Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
T12187L	Naspm trihydrochloride	Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
T4096	Quinolinic acid	Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T3320	Dizocilpine Maleate	(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
T4979	Procyclidine hydrochloride	Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T6352	(-)-Dizocilpine maleate	MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
T16800	(RS)-AMPA	(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA ((±)-AMPA) is an effective and selective excitatory neurotransmitter L-glutamic acid agonist.
T20571	Cis-PDA	cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
T0333	Aniracetam	Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T1186	Ifenprodil Tartrate	Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T0015	Mephenesin	Mephenesin is a centrally acting muscle relaxant with a short duration of action.
T4171	PEAQX	PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 n...
T1897	MDL-29951	MDL-29951 is a novel glycine antagonist of NMDA receptor activation.