NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.

Cat. No.	Product name	CAS No.	Purity
TN1949	Moracin C	69120-06-5	98%
TN1949	Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release ...
T77499	MSU-42011	2456434-36-7	98%
T77499	MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
TN3176	6-Methoxynaringenin	94942-49-1	98%
TN3176	6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.
TN2144	Resveratroloside	38963-95-0	98%
TN2144	Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
TN1109	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	168293-14-9	98%
TN1109	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
TN1058	Pelargonidin chloride	134-04-3	98%
TN1058	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T20232	Kazinol B	99624-27-8	98%
T20232	Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
TN4038	Eupatolide	6750-25-0	98%
TN4038	Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN2689	2',3,5,6',7-Pentahydroxyflavanone	80366-15-0	98%
TN2689	2',3,5,6',7-Pentahydroxyflavanone is a natural product isolated from the roots of Scutellaria baicalensis.
TN3983	Ergosta-7,22-dien-3-one	32507-77-0	98%
TN3983	Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory propertie...
TN1378	α-Viniferin	62218-13-7	98%
TN1378	α-Viniferin belongs to a class of organic compounds, also known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin h...
T7206	2-Iminobiotin	13395-35-2	98%
T7206	2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
TN1009	Epimagnolin B	1134188-26-3	98%
TN1009	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
T36512	PTIO	18390-00-6	98%
T36512	PTIO is a specific scavenger of NO. PTIO reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be used to examine nitric o...
TN3119	5-Hydroxy-7,8-dimethoxyflavanone	113981-49-0	98%
TN3119	5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
TN4160	Goniothalamin	17303-67-2	98%
TN4160	Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
TN5019	Siegeskaurolic acid	52645-97-3	98%
TN5019	Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN1102	Physalin L	113146-74-0	98%
TN1102	Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
TN1086	Dehydrotrametenolic acid	6879-05-6	98%
TN1086	Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
TN5387	Grasshopper ketone	41703-38-2	98%
TN5387	Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory e...