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NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
Cat No. product name
TN1934 Mogroside IIA1 Mogroside IIA1 是从罗汉果的果实中分离得到的。Mogroside IIA1 是一种无糖甜味剂,比蔗糖更甜。 Mogroside IIA1 具有抗氧化、抗糖尿病和抗癌活性。
TN1021 Secologanic acid Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages.
TN2167 Rutaevin Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
TN1009 Epimagnolin B Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
T3S0364 L-Arginine 1. L-Arginine exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mell...
T0006 Methylene Blue trihydrate Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
T5681 ETHYL CAFFEATE In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-re...
T2791 Pectolinarin Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
TN1058 Pelargonidin chloride Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
TN1691 Glabrol Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
T1102 Mifepristone Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T3847 Asperuloside Asperuloside has anti-inflammatory activity.
TP2057L Camstatin acetate Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calm...
T0670 L-Arginine hydrochloride L-Arginine is a nitrogen donor for synthesis of nitric oxide.
T22419 S-Methylisothiourea sulfate S-Methylisothiourea sulfate is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].
TN1675 Gardenin B Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
T7030 Anemarsaponin B Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T7597 6-Biopterin 6-Biopterin is a natural product,is a NO synthase cofactor.
T3S0401 Piceatannol 3'-O-glucoside Piceatannol 3'-O-glucoside increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.
T1322 Bendazol Bendazol is always used as the drug for hypertension and cerebral Angiospasm.
T7461 2,4-Diamino-6-hydroxypyrimidine 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
T22724 Dimaprit dihydrochloride Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastri...
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
TN2144 Resveratroloside Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
TN1238 3,4-O-Isopropylidene-shikimic acid 3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experiment...
T3770 Taraxasterol Taraxasterol is compound with anti-inflammatory activity.
T6570 L-NAME hydrochloride L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human)...
TN1983 Neoisoastilbin Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T3S0870 Paederosidic acid methyl ester Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
TN1624 Ethyl cinnamate Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
T5684 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T5838 L-Canavanine sulfate L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
T3918 Ginsenoside Rb3 Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of...
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
TN1817 Kaempferol 3,7,4'-trimethyl ether Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines.
T6S1665 Irisflorentin 1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-...
T2S2335 Dehydroevodiamine Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibit...
T6888 Methylene Blue Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
TN1134 Euscaphic acid Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
T2980 Chondroitin sulfate Extracted from shark bone;Store the product in sealed, cool and dry condition
T1310 2-Thiouracil Deracil is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
T3779 Crocin II Crocin has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing ...
T21507 7-Ethoxyresorufin 7-Ethoxyresorufin (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
TN1413 Atranorin Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent ...
T7206 2-Iminobiotin 2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
T0358 Aminoguanidine hydrochloride Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
T1479 Isosorbide dinitrate Isosorbide dinitrate is a vasodilator used in the treatment of angina pectoris.
TN1102 Physalin L Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
TN2139 Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity.
Mogroside IIA1
TN1934
Mogroside IIA1 是从罗汉果的果实中分离得到的。Mogroside IIA1 是一种无糖甜味剂,比蔗糖更甜。 Mogroside IIA1 具有抗氧化、抗糖...
Secologanic acid
TN1021
Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages.
Rutaevin
TN2167
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
Epimagnolin B
TN1009
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
L-Arginine
T3S0364
1. L-Arginine exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mell...
Methylene Blue trihydrate
T0006
Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
ETHYL CAFFEATE
T5681
In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-r...
Pectolinarin
T2791
Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
Pelargonidin chloride
TN1058
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
Glabrol
TN1691
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
Hydrangenol
TN4234
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
Mifepristone
T1102
Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
Asperuloside
T3847
Asperuloside has anti-inflammatory activity.
Camstatin acetate
TP2057L
Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calm...
L-Arginine hydrochloride
T0670
L-Arginine is a nitrogen donor for synthesis of nitric oxide.
S-Methylisothiourea sulfate
T22419
S-Methylisothiourea sulfate is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].
Gardenin B
TN1675
Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
anemarsaponin B
T7030
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity...
6-Biopterin
T7597
6-Biopterin is a natural product,is a NO synthase cofactor.
Piceatannol 3'-O-glucoside
T3S0401
Piceatannol 3'-O-glucoside increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.
Bendazol
T1322
Bendazol is always used as the drug for hypertension and cerebral Angiospasm.
2,4-Diamino-6-hydroxypyrimidine
T7461
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
Dimaprit dihydrochloride
T22724
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastr...
Protosappanin A
TJS1779
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Resveratroloside
TN2144
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
3,4-O-Isopropylidene-shikimic acid
TN1238
3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experiment...
Taraxasterol
T3770
Taraxasterol is compound with anti-inflammatory activity.
L-NAME hydrochloride
T6570
L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human...
Neoisoastilbin
TN1983
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
Paederosidic acid methyl ester
T3S0870
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
Ethyl cinnamate
TN1624
Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
Ethyl 3,4-dihydroxybenzoate
T5684
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
L-Canavanine sulfate
T5838
L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
Ginsenoside Rb3
T3918
Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction ...
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
Kaempferol 3,7,4'-trimethyl ether
TN1817
Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines.
Irisflorentin
T6S1665
1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-...
Dehydroevodiamine
T2S2335
Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibit...
Methylene Blue
T6888
Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
Euscaphic acid
TN1134
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
Chondroitin sulfate
T2980
Extracted from shark bone;Store the product in sealed, cool and dry condition
2-Thiouracil
T1310
Deracil is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
Crocin II
T3779
Crocin has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing ...
7-Ethoxyresorufin
T21507
7-Ethoxyresorufin (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
Atranorin
TN1413
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent ...
2-Iminobiotin
T7206
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
Aminoguanidine hydrochloride
T0358
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
Isosorbide dinitrate
T1479
Isosorbide dinitrate is a vasodilator used in the treatment of angina pectoris.
Physalin L
TN1102
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
Regaloside B
TN2139
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity.
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