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NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1949 Moracin C 69120-06-5 98%
Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release ...
T77499 MSU-42011 2456434-36-7 98%
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
TN3176 6-Methoxynaringenin 94942-49-1 98%
6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.
TN2144 Resveratroloside 38963-95-0 98%
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9 98%
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
TN1058 Pelargonidin chloride 134-04-3 98%
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T20232 Kazinol B 99624-27-8 98%
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
TN4038 Eupatolide 6750-25-0 98%
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN2689 2',3,5,6',7-Pentahydroxyflavanone 80366-15-0 98%
2',3,5,6',7-Pentahydroxyflavanone is a natural product isolated from the roots of Scutellaria baicalensis.
TN3983 Ergosta-7,22-dien-3-one 32507-77-0 98%
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory propertie...
TN1378 α-Viniferin 62218-13-7 98%
α-Viniferin belongs to a class of organic compounds, also known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin h...
T7206 2-Iminobiotin 13395-35-2 98%
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
TN1009 Epimagnolin B 1134188-26-3 98%
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
T36512 PTIO 18390-00-6 98%
PTIO is a specific scavenger of NO. PTIO reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be used to examine nitric o...
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 113981-49-0 98%
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
TN4160 Goniothalamin 17303-67-2 98%
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
TN5019 Siegeskaurolic acid 52645-97-3 98%
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN1102 Physalin L 113146-74-0 98%
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
TN1086 Dehydrotrametenolic acid 6879-05-6 98%
Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
TN5387 Grasshopper ketone 41703-38-2 98%
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory e...
Moracin C
TN1949
Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release ...
MSU-42011
T77499
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
6-Methoxynaringenin
TN3176
6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.
Resveratroloside
TN2144
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
Pelargonidin chloride
TN1058
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
Kazinol B
T20232
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
2',3,5,6',7-Pentahydroxyflavanone
TN2689
2',3,5,6',7-Pentahydroxyflavanone is a natural product isolated from the roots of Scutellaria baicalensis.
Ergosta-7,22-dien-3-one
TN3983
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory propertie...
α-Viniferin
TN1378
α-Viniferin belongs to a class of organic compounds, also known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin h...
2-Iminobiotin
T7206
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
Epimagnolin B
TN1009
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
PTIO
T36512
PTIO is a specific scavenger of NO. PTIO reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be used to examine nitric o...
5-Hydroxy-7,8-dimethoxyflavanone
TN3119
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
Goniothalamin
TN4160
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
Siegeskaurolic acid
TN5019
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
Physalin L
TN1102
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
Dehydrotrametenolic acid
TN1086
Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
Grasshopper ketone
TN5387
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory e...
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