NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.

Cat. No.	Product name	CAS No.	Purity
TN1058	Pelargonidin chloride	134-04-3	98%
TN1058	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T2S0765	Epibetulinic acid	38736-77-5	98%
T2S0765	Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
T7206	2-Iminobiotin	13395-35-2	98%
T7206	2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
TN1009	Epimagnolin B	1134188-26-3	98%
TN1009	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
TN1109	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	168293-14-9	98%
TN1109	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
TN2144	Resveratroloside	38963-95-0	98%
TN2144	Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
T7030	Anemarsaponin B	139051-27-7	98%
T7030	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
TN1102	Physalin L	113146-74-0	98%
TN1102	Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
TQ0301	Kuwanon A	62949-77-3	98%
TQ0301	Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.
TN1817	Kaempferol 3,7,4'-trimethyl ether	15486-34-7	98%
TN1817	Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines.
TP2057L	Camstatin acetate		98%
TP2057L	Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calm...
T25865	NG-Nitroarginine methyl ester	50903-99-6	98%
T25865	NG-Nitroarginine methyl ester is a non-selective nitric oxide synthase inhibitor. It has been utilized experimentally to induce hypertension.
TJS1779	Protosappanin A	102036-28-2	98%
TJS1779	Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammat...
TN1624	Ethyl cinnamate	103-36-6	98%
TN1624	Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
T19930	Nitrosoglutathione	57564-91-7	98%
T19930	GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins.
TN1983	Neoisoastilbin	54141-72-9
TN1983	Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T21507	7-Ethoxyresorufin	5725-91-7
T21507	7-Ethoxyresorufin (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
T21546	NG,NG-dimethyl-L-Arginine dihydrochloride	220805-22-1
T21546	NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to ...
T9376	Nitroarginine	2149-70-4
T9376	Nitroarginine is a competitive inhibitor of nitric oxide synthase which causes the selective reduction of blood flow to tumor cells[1].
T0358	Aminoguanidine hydrochloride	1937-19-5	100%
T0358	Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.