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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.

Filter Signaling PathwaysImmunology/InflammationNO Synthase

5,7,8-Trimethoxyflavone
TN199523050-38-6
5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) is a compound extracted from *Andrographis paniculata*, exhibiting anti-inflammatory activity and NO inhibition.
- $34
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FK-330 dihydrate
T68879682813-92-9In house
FK-330 dihydrate (FR-260330 dihydrate) is a novel and effective nitric oxide synthase inhibitor. It can prevent ischemia and reperfusion injury in rat liver transplantation.
- $397
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Glycyrrhisoflavone
TN1705116709-70-7
Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.
- $119
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Ergosta-7,22-dien-3-one
TN398332507-77-0
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis. It exhibits pro-inflammatory properties, stimulating nitric oxide production, inducing gene expression, and promoting the production of TLRs, cytokines, chemokines, and cellular adhesion molecules.
- $1,168
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Ginsenoside C-K
T381139262-14-1
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
- $110
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Hydrangenol
TN4234480-47-7In house
Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation.
- $139
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Andropanolide
TQ0073869807-57-8
Andropanolide is a dipterocarbon from Andrographis paniculata with anti-HIV, antimalarial and anticancer activities and inhibits Lipopolysaccharides (LPS)-stimulated overproduction of nitric oxide (NO) in RAW264.7 macrophages.
- $1,698
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Glabrol
TN169159870-65-4
5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.
- $97
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Prim-O-glucosylcimifugin
T380580681-45-4
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
- $55
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Asperuloside
T384714259-45-1
Asperuloside (Asperulosid) has anti-inflammatory activity.
- $55
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L-NAME hydrochloride
T657051298-62-5
L-NAME hydrochloride (L-NAME HCl), a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively.
- $46
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NG,NG-dimethyl-L-Arginine dihydrochloride
T21546220805-22-1
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
- $43
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Quercimeritrin
TN1041491-50-9
Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) has antibacterial activity, it shows promising activity against Staphylococcus aureus.
- $39
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5-O-Caffeoylshikimic acid
TN129573263-62-4
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.
- $116
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Mifepristone
T110284371-65-3
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
- $37
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L-Arginine
T3S036474-79-3
1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate lymphocyte proliferation through an interleukin-2-independent pathway. 4. A combination of oral L-citrulline and L-Arginine effectively and rapidly augments NO-dependent responses at the acute stage.
- $31
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1400W dihydrochloride
T3491214358-33-5
1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
- $43
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Moracin C
TN194969120-06-5In house
Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells.
- $198
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Taraxasterol
T37701059-14-9
Taraxasterol (Taraxasterin) is compound with anti-inflammatory activity.
- $71
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26-Deoxyactein
TN1222264624-38-6
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.
- $98
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Bavachromene
TN143441743-38-8
Bavachromene, an isoprenylated chalcone extractable from Fructus in the family Psoraceae, has estrogenic and antimicrobial activities, and concentration-dependent inhibition of Lipopolysaccharide (LPS)-activated NO and PGE2 production in microglia.
- $1,198
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S-Nitroso-N-acetyl-DL-penicillamine
T1280867776-06-1
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.
- $41
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Cyanidin 3-sambubioside chloride
TN110433012-73-6
Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride) is a plant-derived anthocyanin, an inhibitor of NO and H274Y mutations, and an inhibitor of influenza neuraminidase.Cyanidin 3- sambubioside chloride has anti-inflammatory properties. sambubioside chloride has antioxidant, antiangiogenic and antiviral activities and inhibits angiotensin-converting enzyme (ACE) activity, which can be used in the study of viral infections and cardiovascular diseases.
- $630
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Curvularin
T1362810140-70-2
Curvularin ((S)-Curvularin) is a quorum-sensing antagonist of Pseudomonas aeruginosa RhlR extractable from Curvularia lunata, a mycotoxin with anti-inflammatory activity, inhibition of cytokine-induced NO synthase, and inhibition of lipopolysaccharide-induced inflammation in antimyelocytes. study inflammation.
- $675
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Methylene Blue
T688861-73-4
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
- $30
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Grossamide
TN417180510-06-1
Grossamide (GSE) Grossamide is a lignan amide derived from thioguanosine.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor that inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.
- $978
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7-Ethoxyresorufin
T215075725-91-7
7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate and competitive inhibitor of cytochrome P450, particularly CYP1A1.
- $30
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AVE-9488
T30219291756-32-6
AVE-9488 is a novel endothelial NO synthase (eNOS) enhancer that upregulates eNOS expression, induces NO production, and may ameliorate portal hypertension.
- $293
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Gardenin B
TN16752798-20-1
Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
- $68
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Tat-NR2B9c
T13112500992-11-0
Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxidase in neurons, thereby blocking the production of superoxide, which reduces ischemic injury in the acute phase after stroke.
- $73
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Nitrosoglutathione
T1993057564-91-7
Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
- $48
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Isoquercetin
T5S0754482-35-9
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercetin is an inhibitor of Wnt/β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .
- $43
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DETA NONOate
T36033146724-94-9
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infected wounds.
- $30
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Regaloside B
TN2139114420-67-6
Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2).
- $63
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Catalposide
TN36096736-85-2
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties.
- $228
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Piceatannol 3'-O-glucoside
T3S040194356-26-0
Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.
- $64
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Chondroitin sulfate
T29809007-28-7
Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition
- $47
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Protosappanin A
TJS1779102036-28-2
Protosappanin A (PTA) has anti-oxidative nitrative activities on brain immune and neuroinflammation through regulation of CD14 TLR4-dependent IKK IÎºB NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.
- $89
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Hulupinic acid
TN42281891-42-5
Hulupinic acid is the main oxidation product of hop acid, which may inhibit the production of NO in macrophages RAW 264.7 cells.
- $143
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Anhydronotoptol
TN698588206-51-3
Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one), a natural compound extracted from the umbelliferae plant Qiangwu, is a potent inhibitor of nitric oxide production, inhibiting LPS-induced NO production in RAW 264.7 cells with an IC50 value of 36.6 μM.
- $340
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Asymmetric dimethylarginine
T768230315-93-6
Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide.
- $41
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Isoscoparin
TN180320013-23-4
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and treatment of obesity.
- $68
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Obtucarbamate A
TN20036935-99-5
Obtucarbamate A, isolated from *Disporum cantoniense*, exhibits antitussive activity and demonstrates a significant inhibitory effect against neuroinflammation with an IC50 value of 10.57 μM.
- $83
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Myristicin
T9113607-91-0
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin can induce Apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, Caspase-3 activation, PARP-cleavage and DNA fragmentation.
- $34
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Aminoguanidine hydrochloride
T03581937-19-5
Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
- $36
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MAHMA NONOate
T74030146724-86-9
MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
- $30
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Kaempferol 3,7,4'-trimethyl ether
TN181715486-34-7
Kaempferol 3,7,4'-trimethyl ether (Kaempferol 3,7,4'-trimethylether) demonstrates selective cytotoxic activities against nine tested cancer cell lines.
- $122
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NOC-5
T35969146724-82-5
NOC-5 is an NO donor that induces airway relaxation and concentration-dependently triggers 10 μM DAF-2 fluorescence.
- $110
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Methylene Blue trihydrate
T00067220-79-3
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
- $42
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anemarsaponin B
T7030139051-27-7
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B can inhibit PAF-induced rabbit platelet aggregation in vitro.
- $84
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