T67749 |
Fuzapladib
|
141283-87-6
|
98%
|
|
Fuzapladib (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesio...
|
T17239 |
VU0155069
|
1130067-06-9
|
98%
|
|
VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 4...
|
T9001 |
Desketoraloxifene
|
216570-81-9
|
98%
|
|
Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).
|
T11873 |
Lp-PLA2-IN-2
|
2071636-15-0
|
98%
|
|
Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
|
TN7075 |
Linocinnamarin
|
554-87-0
|
98%
|
|
Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
|
TN3139 |
5α-Hydroxycostic acid
|
132185-83-2
|
98%
|
|
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
|
T11149 |
Ecopladib
|
381683-92-7
|
98%
|
|
Ecopladib with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.Ecopladib is a sub-micromolar inhibitor of cytosolic phos...
|
TP1299L1 |
Melittin Acetate
|
|
98%
|
|
Melittin Acetate is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the activity of the h...
|
T15949 |
Mahanimbine
|
21104-28-9
|
98%
|
|
Mahanimbine suppresses the progression of high-fat diet (HFD)-induced metabolic complications in mice. Mahanimbine is an orally active alkaloid from curry leaves...
|
T15948 |
MAFP
|
188404-10-6
|
98%
|
|
MAFP is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2.
|
T14829 |
Bromoenol lactone
|
88070-98-8
|
98%
|
|
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen...
|
T8968 |
ML299
|
1426916-00-8
|
98%
|
|
ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
|
TP1299 |
Melittin
|
20449-79-0
|
98%
|
|
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
|
TN4247 |
Ikshusterol 3-O-glucoside
|
112137-81-2
|
98%
|
|
Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
|
T9753 |
LEI110
|
2313525-90-3
|
98%
|
|
LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol h...
|
T21777 |
VU0359595
|
1246303-14-9
|
98%
|
|
VU0359595 is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD...
|
T15461 |
Halopemide
|
59831-65-1
|
98%
|
|
Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2). Halopemid is an antagonist of dopamine receptors. Halopemid can be used ...
|
T21907 |
PACOCF3
|
141022-99-3
|
98%
|
|
PACOCF3 is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
|
T10115 |
3-Nitrocoumarin
|
28448-04-6
|
98%
|
|
3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.
|
T13632 |
D-Erythro-dihydrosphingosine
|
764-22-7
|
98%
|
|
D-Erythro-dihydrosphingosine inhibits arachidonic acid release and cPLA2α activity.
|