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Phospholipase

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.
Cat No. product name
TN1419 Rhamnetin Rhamnetin是一种槲皮素衍生物,在芫荽中被发现,具有抗氧化和抗炎活性。Rhamnetin可抑制分泌型磷脂酶 A2。
T15782 Lp-PLA2-IN-1 Lp-PLA2 -IN-1 suppresses Lp-PLA2 activity processes for their preparation. Lp-PLA2 -IN-1also inhibits to compositions containing them and to their use in the tre...
T4019 Cambinol Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-,...
T0942 Quinacrine dihydrochloride Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T3616 Carbazochrome Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a ...
T0757 Omeprazole Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
T8155 Maltoheptaose Maltoheptaose is an activator of phosphorylase B for the preparation of heptulose-2-phosphate.
T8236 RHC 80267 RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
T3439 ML348 ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
T6243 U-73122 U73122, an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
TN4893 Rapanone Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
T16108 ML349 ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).
T10017 1-Linoleoyl Glycerol 1-Linoleoyl Glycerol is a fatty acid glycerol that has been isolated from Saururus chinensis roots.
T0674 Lansoprazole Lansoprazole is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug...
T0188 Fluticasone (propionate) Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
T3580 FIPI FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reor...
T5454 N-(p-amylcinnamoyl) Anthranilic Acid N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
T4511 ST271 ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
T3990 AA26-9 AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
T0693 Niflumic acid Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
TMO2790 1-Naphthaleneacetic acid 1-Naphthaleneacetic Acid, is widely used in agriculture for various purposes. It is a synthetic plant hormone in the auxin family and is an ingredient in many co...
T4S0590 Columbin 1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC...
T0950 Neomycin sulfate Neomycin is a broad spectrum aminoglycoside antibiotic whose current use is limited to oral and topical administration.
TN7075 Linocinnamarin Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
T0944 Levamisole hydrochloride Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by ...
T0458 Indomethacin Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
T2282 RPI-1 RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
TCS1554 Trans-Benzylideneacetone trans-4-Phenyl-3-buten-2-one is used in various synthetic preparations.
T3417 Amentoflavone Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in t...
T21651 Lansoprazole sodium Lansoprazole sodium is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and...
T5580 1-Naphthaleneacetic acid potassium salt 1-Naphthaleneacetate is used as a plant Growth Regulator that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viabil...
T9753 LEI110 LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol h...
T21606L Anti-Inflammatory Peptide 1 Acetate Anti-Inflammatory Peptide 1 Acetate (C45H82N12O14S2) possesses a potent anti-inflammatory activity in vivo and is a strong inhibitor of phospholipase A2 (PLA2), ...
T2938 (E/Z)-Polydatin (E/Z)-Polydatin, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensi...
T2907 Tanshinone I Tanshinone I, an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.
T21969 ML-095 hydrochloride ML095 hydrochloride is a specific placental alkaline phosphatase inhibitor. It inhibits PLAP, TNAP and IAP with IC50 of 2.1, >100 and 53 μM, respectively.
T2044 Varespladib Varespladib, a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and ...
T8531 M-3M3FBS m-3M3FBS is a phospholipase C (PLC) activator.
T9001 Desketoraloxifene Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).
T8966 ML-298 ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).
T8968 ML299 ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
T7280 CAY10594 CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK ...
T13206 Tris(2,4-di-tert-butylphenyl)phosphate Tris(2,4-di-tert-butylphenyl)phosphate is a natural compound isolated from Vitex negundo L. with anti-inflammatory activity.
T11873 Lp-PLA2-IN-2 Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
T11149 Ecopladib Ecopladib with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.Ecopladib is a sub-micromolar inhibitor of cytosolic phos...
TN3139 5α-Hydroxycostic acid 5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TN4247 Ikshusterol 3-O-glucoside Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
TP1299L Melittin TFA(20449-79-0(free base)) Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the ac...
TP1299 Melittin Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
TQ0105 CAY10650 CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).
Rhamnetin
TN1419
Rhamnetin是一种槲皮素衍生物,在芫荽中被发现,具有抗氧化和抗炎活性。Rhamnetin可抑制分泌型磷脂酶 A2。
Lp-PLA2-IN-1
T15782
Lp-PLA2 -IN-1 suppresses Lp-PLA2 activity processes for their preparation. Lp-PLA2 -IN-1also inhibits to compositions containing them and to their use in the tre...
Cambinol
T4019
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
Quinacrine dihydrochloride
T0942
Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
Carbazochrome
T3616
Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a ...
Omeprazole
T0757
Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
Maltoheptaose
T8155
Maltoheptaose is an activator of phosphorylase B for the preparation of heptulose-2-phosphate.
RHC 80267
T8236
RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
ML348
T3439
ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
U-73122
T6243
U73122, an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
Rapanone
TN4893
Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
ML349
T16108
ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).
1-Linoleoyl Glycerol
T10017
1-Linoleoyl Glycerol is a fatty acid glycerol that has been isolated from Saururus chinensis roots.
Lansoprazole
T0674
Lansoprazole is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug...
Fluticasone (propionate)
T0188
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
FIPI
T3580
FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reor...
N-(p-amylcinnamoyl) Anthranilic Acid
T5454
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
ST271
T4511
ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
AA26-9
T3990
AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
Niflumic acid
T0693
Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
1-Naphthaleneacetic acid
TMO2790
1-Naphthaleneacetic Acid, is widely used in agriculture for various purposes. It is a synthetic plant hormone in the auxin family and is an ingredient in many co...
Columbin
T4S0590
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC...
Neomycin sulfate
T0950
Neomycin is a broad spectrum aminoglycoside antibiotic whose current use is limited to oral and topical administration.
Linocinnamarin
TN7075
Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
Levamisole hydrochloride
T0944
Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by ...
Indomethacin
T0458
Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
RPI-1
T2282
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
trans-Benzylideneacetone
TCS1554
trans-4-Phenyl-3-buten-2-one is used in various synthetic preparations.
Amentoflavone
T3417
Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in t...
Lansoprazole sodium
T21651
Lansoprazole sodium is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and...
1-Naphthaleneacetic acid potassium salt
T5580
1-Naphthaleneacetate is used as a plant Growth Regulator that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viabil...
LEI110
T9753
LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol h...
Anti-Inflammatory Peptide 1 Acetate
T21606L
Anti-Inflammatory Peptide 1 Acetate (C45H82N12O14S2) possesses a potent anti-inflammatory activity in vivo and is a strong inhibitor of phospholipase A2 (PLA2),...
(E/Z)-Polydatin
T2938
(E/Z)-Polydatin, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensi...
Tanshinone I
T2907
Tanshinone I, an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.
ML-095 hydrochloride
T21969
ML095 hydrochloride is a specific placental alkaline phosphatase inhibitor. It inhibits PLAP, TNAP and IAP with IC50 of 2.1, >100 and 53 μM, respectively.
Varespladib
T2044
Varespladib, a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and ...
m-3M3FBS
T8531
m-3M3FBS is a phospholipase C (PLC) activator.
Desketoraloxifene
T9001
Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).
ML-298
T8966
ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).
ML299
T8968
ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
CAY10594
T7280
CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK...
Tris(2,4-di-tert-butylphenyl)phosphate
T13206
Tris(2,4-di-tert-butylphenyl)phosphate is a natural compound isolated from Vitex negundo L. with anti-inflammatory activity.
Lp-PLA2-IN-2
T11873
Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
Ecopladib
T11149
Ecopladib with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.Ecopladib is a sub-micromolar inhibitor of cytosolic ph...
5α-Hydroxycostic acid
TN3139
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
Ikshusterol 3-O-glucoside
TN4247
Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
Melittin TFA(20449-79-0(free base))
TP1299L
Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the ac...
Melittin
TP1299
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
CAY10650
TQ0105
CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).
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