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Phospholipase

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.
Cat. No. Product name CAS No. Purity Chemical Structure
T67749 Fuzapladib 141283-87-6 98%
Fuzapladib (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesio...
T17239 VU0155069 1130067-06-9 98%
VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 4...
T9001 Desketoraloxifene 216570-81-9 98%
Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).
T11873 Lp-PLA2-IN-2 2071636-15-0 98%
Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
TN7075 Linocinnamarin 554-87-0 98%
Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
TN3139 5α-Hydroxycostic acid 132185-83-2 98%
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T11149 Ecopladib 381683-92-7 98%
Ecopladib with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.Ecopladib is a sub-micromolar inhibitor of cytosolic phos...
TP1299L1 Melittin Acetate 98%
Melittin Acetate is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the activity of the h...
T15949 Mahanimbine 21104-28-9 98%
Mahanimbine suppresses the progression of high-fat diet (HFD)-induced metabolic complications in mice. Mahanimbine is an orally active alkaloid from curry leaves...
T15948 MAFP 188404-10-6 98%
MAFP is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2.
T14829 Bromoenol lactone 88070-98-8 98%
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen...
T8968 ML299 1426916-00-8 98%
ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
TP1299 Melittin 20449-79-0 98%
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
TN4247 Ikshusterol 3-O-glucoside 112137-81-2 98%
Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
T9753 LEI110 2313525-90-3 98%
LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol h...
T21777 VU0359595 1246303-14-9 98%
VU0359595 is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD...
T15461 Halopemide 59831-65-1 98%
Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2). Halopemid is an antagonist of dopamine receptors. Halopemid can be used ...
T21907 PACOCF3 141022-99-3 98%
PACOCF3 is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
T10115 3-Nitrocoumarin 28448-04-6 98%
3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.
T13632 D-Erythro-dihydrosphingosine 764-22-7 98%
D-Erythro-dihydrosphingosine inhibits arachidonic acid release and cPLA2α activity.
Fuzapladib
T67749
Fuzapladib (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesio...
VU0155069
T17239
VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 4...
Desketoraloxifene
T9001
Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).
Lp-PLA2-IN-2
T11873
Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
Linocinnamarin
TN7075
Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
5α-Hydroxycostic acid
TN3139
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
Ecopladib
T11149
Ecopladib with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.Ecopladib is a sub-micromolar inhibitor of cytosolic phos...
Melittin Acetate
TP1299L1
Melittin Acetate is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the activity of the h...
Mahanimbine
T15949
Mahanimbine suppresses the progression of high-fat diet (HFD)-induced metabolic complications in mice. Mahanimbine is an orally active alkaloid from curry leaves...
MAFP
T15948
MAFP is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2.
Bromoenol lactone
T14829
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen...
ML299
T8968
ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
Melittin
TP1299
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
Ikshusterol 3-O-glucoside
TN4247
Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
LEI110
T9753
LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol h...
VU0359595
T21777
VU0359595 is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD...
Halopemide
T15461
Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2). Halopemid is an antagonist of dopamine receptors. Halopemid can be used ...
PACOCF3
T21907
PACOCF3 is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
3-Nitrocoumarin
T10115
3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.
D-Erythro-dihydrosphingosine
T13632
D-Erythro-dihydrosphingosine inhibits arachidonic acid release and cPLA2α activity.
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