12 o tiglylphorbol 13 –isobutyrate

The compound is extracted from Croton tiglium dried fruit.

Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

12-O-Methylinophyllum D is a natural product for research related to life sciences. The catalog number is TN5897 and the CAS number is 40883-10-1.

9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME (1 g/animal) enhances the antiviral IgA and IgG antibody responses induced by a nasal influenza hemagglutinin (HA) vaccine by 5.2- and 2-fold, respectively, in mice.4 1.Hamberg, M., and Hamberg, G.Peroxygenase-catalyzed fatty acid epoxidation in cereal seeds: Sequential oxidation of linoleic acid into 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acidPlant Physiol.110(3)807-815(1996) 2.Hong, S.S., and Oh, J.S.Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat branJ. Korean Soc. Appl. Biol. Chem.5569-74(2012) 3.Kim, C.S., Kwon, O.W., Kim, S.Y., et al.Five new oxylipins from Chaenomeles sinensisLipids49(11)1151-1159(2014) 4.Shirahata, T., Sunazuka, T., Yoshida, K., et al.Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acidsTetrahedron62(40)9483-9496(2006) 5.Fuchs, D., Tang, X., Johnsson, A.-K., et al.Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent processBiochim. Biophys. Acta Mol. Cell Biol. Lipids1865(4)158611(2020)

Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) is a natural product for research related to life sciences. The catalog number is TN6498 and the CAS number is 1309929-72-3.

13-O-Cinnamoylbaccatin III is a natural product from Taxus yunnanensis.

12-O-Methylinophyllum A is a natural product for research related to life sciences. The catalog number is TN5890 and the CAS number is 2131757-10-1.

8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell lines (IC50 = 3.50 microM for HT29

12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity, it is effective preventing gastric lesions. 12-O-Methylcarnosic acid can suppress melanin production with downregulation of Tyrosinase expression in HMV-II melanoma cells. 12-O-Methylcarnosic acid may have anti-diabetic activity, it is able to significantly activate peroxisome proliferator-activated receptor (PPAR)γ.

9.11(13)-Eremophiladien-12-oic acid is a useful organic compound for research related to life sciences. The catalog number is T124368 and the CAS number is 69905-01-7.

6-O-Isobutyrylhelenalin,Helenalin isobutyrate is a useful organic compound for research related to life sciences. The catalog number is T124696 and the CAS number is 53658-84-7.

8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate is a natural product for research related to life sciences. The catalog number is TN3293 and the CAS number is 883872-71-7.

12-Hydroxy-8(17),13-labdadien-16,15-olide is a natural product for research related to life sciences. The catalog number is TN2598 and the CAS number is 958885-86-4.

13-O-Deacetyltaxumairol Z is a natural product for research related to life sciences. The catalog number is TN2616 and the CAS number is 220935-39-7.

19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene is a natural product of Pinus, Pinaceae. The catalog number is TN6493 and the CAS number is 1011714-20-7. 19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene can be used as a reference standard.

12-O-Methylsordariol is a useful organic compound for research related to life sciences. The catalog number is T125463 and the CAS number is 1938054-84-2.

8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.

13-O-Ethylpiptocarphol is a natural product for research related to life sciences. The catalog number is TN2617 and the CAS number is 202522-40-5.

13-O-Acetylcorianin is a natural product of Coriaria, Coriariaceae. The catalog number is TN2614 and the CAS number is 108887-44-1. 13-O-Acetylcorianin can be used as a reference standard.

13-O-p-Coumaroylplumieride is a natural product for research related to life sciences. The catalog number is TN2618 and the CAS number is 80416-52-0.

3-O-Acetyl-13-deoxyphomenone is a useful organic compound for research related to life sciences. The catalog number is T125458 and the CAS number is 194241-10-6.

12-O-Acetylrosmarinine is a useful organic compound for research related to life sciences and the catalog number is T125966.

4,5-Dioxo-4,5-seco-11(13)-cadinen-12-oic acid is a useful organic compound for research related to life sciences and the catalog number is T125973.

3-Hydroxy-12-oleanene-27,28-dioic acid, 3-O-(6-Deo is a useful organic compound for research related to life sciences. The catalog number is T126383 and the CAS number is 111665-41-9.