13epi12oxo phytodienoic acid

Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.

Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-, a lanosterane-type compound, can be isolated from Tu-Jin-Pi, the root bark of Pseudolarix kaempferi [1].

1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in part, by the induction of apoptosis. It shows cytotoxic against OVCAR-3 and HeLa cancer cell line

2,3-Dihydroxy-olean-12-en-28-oic acids show a low cytotoxicity towards several human tumor cell lines.

The compound is extracted from Croton tiglium dried fruit.

11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN6271 and the CAS number is 75911-16-9.

13-Hydroxy-8,11,13-podocarpatrien-18-oic acid is a natural product for research related to life sciences. The catalog number is TN2612 and the CAS number is 61597-83-9.

2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively.

12-Oxograndiflorenic acid is a natural product that can be extracted from Anemone and Porphyra and is cytotoxic to some cells.

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o

3-Oxo-7-hydroxychol-4-enoic acid, an endogenous metabolite, is potentially a significant prognostic marker for adverse outcomes in hepatobiliary disease [1].

3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.

3α-Acetoxyurs-5:12-dien-24-oic acid, a natural compound, is isolatable from Boswellia sacra Fluckiger [1].

(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid, a phytotoxin recently identified in Alternaria alternata ssp. tenuissima isolates, is associated with fruit spots on apples.

3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid is a natural product for research related to life sciences. The catalog number is TN2853 and the CAS number is 261768-88-1.

2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.

6,19-Dihydroxyurs-12-en-3-oxo-28-oic acid is a natural product for research related to life sciences. The catalog number is TN3143 and the CAS number is 194027-11-7.

2α,3α,24-Trihydroxyolean-12-en-28-oic acid, a triterpenoid phytoalexin, isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia), shows antifungal activity against the fungus mentioned.

13-Oxo-ODE is an octadecadienoic acid isolated from moxa and Artemisia argyi leaves [1].

ent-6,11-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3951 and the CAS number is 81263-97-0.

3,22-Dihydroxyolean-12-en-29-oic acid is a natural product for research related to life sciences. The catalog number is TN2860 and the CAS number is 808769-54-2.

2α,3β,24-Trihydroxyurs-12-en-28-oic acid, a natural product, is isolated from Salvia palaestina [1].

Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) is a natural product for research related to life sciences. The catalog number is TN6498 and the CAS number is 1309929-72-3.

3-Hydroxy-12-oleanene-23,28-dioic acid is a natural product for research related to life sciences. The catalog number is TN2937 and the CAS number is 226562-47-6.

9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME (1 g/animal) enhances the antiviral IgA and IgG antibody responses induced by a nasal influenza hemagglutinin (HA) vaccine by 5.2- and 2-fold, respectively, in mice.4 1.Hamberg, M., and Hamberg, G.Peroxygenase-catalyzed fatty acid epoxidation in cereal seeds: Sequential oxidation of linoleic acid into 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acidPlant Physiol.110(3)807-815(1996) 2.Hong, S.S., and Oh, J.S.Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat branJ. Korean Soc. Appl. Biol. Chem.5569-74(2012) 3.Kim, C.S., Kwon, O.W., Kim, S.Y., et al.Five new oxylipins from Chaenomeles sinensisLipids49(11)1151-1159(2014) 4.Shirahata, T., Sunazuka, T., Yoshida, K., et al.Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acidsTetrahedron62(40)9483-9496(2006) 5.Fuchs, D., Tang, X., Johnsson, A.-K., et al.Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent processBiochim. Biophys. Acta Mol. Cell Biol. Lipids1865(4)158611(2020)

12-Hydroxyganoderic acid D is a natural product

22-Hydroxy-3-oxo-12-ursen-30-oic acid is a natural product for research related to life sciences. The catalog number is TN2812 and the CAS number is 173991-81-6.

LeDSF3 is a regulator of the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes and anti-tumor agent. LeDSF3 down-regulates p-AKT and activates caspase-3.

12-Hydroxydodecanoic acid (12-hydroxylauric acid) is the substrate of the human glutathione-dependent formaldehyde dehydrogenase.

'(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid, a saponin isolated from Rubus ellipticus var. obcordatus, inhibits α-Glucosidase with an IC 50 of 1.68 mM [1].'

9-Oxo-2,7-bisaboladien-15-oic acid is a natural product for research related to life sciences. The catalog number is TN3328 and the CAS number is 93888-59-6.

3,4-seco-Olean-12-en-4-ol-3,28-dioic acid is a natural product from Ligularia intermedia.

12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1].

12-Hydroxy-6-epi-albrassitriol is a natural product for research related to life sciences. The catalog number is TN2597 and the CAS number is 178330-78-4.

19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide is a natural product for research related to life sciences. The catalog number is TN2661 and the CAS number is 919120-78-8.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3955 and the CAS number is 81263-96-9.

12-Hydroxyabietic acid is a natural product of Pinus, Pinaceae. The catalog number is TN5570 and the CAS number is 3484-61-5. 12-Hydroxyabietic acid can be used as a reference standard.

12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity, it is effective preventing gastric lesions. 12-O-Methylcarnosic acid can suppress melanin production with downregulation of Tyrosinase expression in HMV-II melanoma cells. 12-O-Methylcarnosic acid may have anti-diabetic activity, it is able to significantly activate peroxisome proliferator-activated receptor (PPAR)γ.

ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3953 and the CAS number is 81264-00-8.

28-Hydroxy-3-oxoolean-12-en-29-oic acid is a natural product for research related to life sciences. The catalog number is TMA1182 and the CAS number is 381691-22-1.

13-Oxo-9E,11E-octadecadienoic acid, a potent PPARα activator derived from tomato juice and an isomer of 9-oxo-ODA, exhibits the ability to decrease plasma and hepatic triglyceride levels in obese diabetic mice[1].

3alpha-Acetoxy-20-oxo-29-norlupane-23,28-dioic acid is a natural product for research related to life sciences. The catalog number is TN2989 and the CAS number is 262272-76-4.

13-Oxopodocarp-8(14)-en-18-oic acid is a natural product for research related to life sciences. The catalog number is TN2619 and the CAS number is 63976-69-2.

11β,13-Dihydrotaraxinic acid is a natural product for research related to life sciences. The catalog number is TN6254 and the CAS number is 1274668-83-5.

8'-Oxo-6-hydroxydihydrophaseic acid is a natural product from Illicium dunnianum.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3956 and the CAS number is 77658-39-0.

13-Hydroxyoctadecadienoic acid (13-HODE), an endogenous metabolite produced by the lipoxygenase pathway of Linoleic acid, promotes prostacyclin synthesis by facilitating the release of arachidonic acid (AA) from phospholipids [1].

ent-14,15-Dinor-13-oxolabda-8(17),11-dien-18-oic acid is a natural product of Chloranthus, Chloranthaceae. The catalog number is TN3934 and the CAS number is 875585-30-1. ent-14,15-Dinor-13-oxolabda-8(17),11-dien-18-oic acid can be used as a reference standard.

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM).