ral

Zearalenone (F2 toxin) is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in cattle, pigs and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts.

β-Cyclocitral belongs to the class of organic compounds.

7-Methoxy-1-tetralone may have insecticidal activity.

2-methylpropanal oxime is an aldoxime derived from 2-methylpropanal. It derives from an isobutyraldehyde.

Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1).

2-Methylbutyraldehyde (2-Ethylpropanal) is a short-chain aldehyde compound and one of the burnt aroma substances in Atractylodes rhizome slices.

Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.

Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.

Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.

5-Hydroxymethylfurfural (2-Formyl-5-hydroxymethylfuran) is found from various carbohydrates.

Psoralen (Ficusin) is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.

Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.

Glyurallin A possesses an antigenotoxic effect against carcinogenic N-methyl-N-nitrosourea (MNU) for the first time, it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention.

8-(3-Ethoxy-2-hydroxy-3-methylbutyloxy)psoralen is a coumarin compound present in Heracleum pyrenaicum Lam.

Araloside V (Congmunoside V) comes from the roots of Aralia elata. It can be used to treat neurasthenia.

Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate( IC50 =49.5 μM). Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.

Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997). Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3 References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997).

Arisantetralone B is a natural product for research related to life sciences. The catalog number is TN6632 and the CAS number is 1161947-96-1.

Araloside C is a natural product from plants

Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.

8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen is a natural product of Psoralea, Fabaceae. The catalog number is TN3281 and the CAS number is 425680-98-4. 8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen can be used as a reference standard.

Araloside VII is a natural product

5,8-Dihydroxypsoralen is a natural product from Pueraria lobata (Willd.) Ohwi

Glyurallin B, a flavonoid derived from Glycyrrhiza inflata and Glycyrrhiza uralensis (licorice), exhibits ABTS+ radical scavenging activity and lipid peroxidation inhibition, with EC50 values of 11.9 ± 0.58 μM and 15.3 ± 1.26 μM, respectively [1].

Veratraldehyde (3,4-Dimethoxybenzaldehyde) has antifungal activity .It is found in Cymbopogon javanensis.

Glycyuralin E, a natural product, can be isolated from Glycyrrhiza uralensis [1].

Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line.It shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL).

Mevalonic acid 5-pyrophosphate (also known as 5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite involved in the mevalonate pathway.

Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cell growth (IC50: 6.41 µg/mL).

Walsuralactam A in the formula I, which is used as an active ingredient, and is used for treating and preventing the tumour.

3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter.

Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi

5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight.

Feralolide, a dihydroisocoumarin from the methanolic extract of aloe vera resin, functions as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 55 μg/mL and 52 μg/mL, respectively. It exhibits antioxidant properties, effectively inhibiting 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Research suggests feralolide's potential in studying cognitive disorders, including Alzheimer's disease, for its memory restoration and enhancement capabilities [1].

5-Methylfurfural (5-Methyl-2-furaldehyde) has been identified as one of the volatile flavor compounds in tamarind, Dutch Coffee, barrel-aged wines and deep fat-fried soybeans.

Trans-Psoralenoside exhibits hepatoprotective (liver-protective), nephroprotective (kidney-protective), antiulcer, and anticoagulant properties.

Glabralide C is a natural product from plants

Vibralactones D shows weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).

Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains.

8-[(6,7-Dihydroxy-3,7-dimethyloct-2-en-1-yl)oxy]psoralen is a natural product for research related to life sciences. The catalog number is TN6298 and the CAS number is 889112-17-8.

Isomurralonginol acetate is a natural product of Murraya, Rutaceae. The catalog number is TN4313 and the CAS number is 139115-59-6. Isomurralonginol acetate can be used as a reference standard.

Picralinal has anti-inflammatory and analgesic effects.

Uralsaponin D displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 μmol/L, it could significantly increase the cytotoxic activity after hydrolysis.

Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde), a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1.

Citral A monoterpene, obtained from the essential oil of lemongrass, which has anti-pain and anti-inflammatory properties.

Pomegralignan is a natural product for research related to life sciences. The catalog number is TN5430 and the CAS number is 1562492-32-3.

5-hydroxy-1-tetralone as the fluorescent labeling reagent.

Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism

Viteralone is a natural product for research related to life sciences. The catalog number is TN5241 and the CAS number is 87440-75-3.

4 ,5 -dehydroisopsoralidin is a natural product.