Androgen Receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.

Cat. No.	Product name	CAS No.	Purity
T19449	N-desmethyl Enzalutamide D6	T19449	98%
T19449	N-desmethyl Enzalutamide D6 is a deuterium labeled N-desmethyl Enzalutamide.
TMA1012	Ganoderiol F	114567-47-4	98%
TMA1012	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
T14843	Bifluranol	34633-34-6	98%
T14843	Bifluranol is an anti-androgen.
T14675	BMS-564929	627530-84-1	98%
T14675	BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
TN4774	Physalin A	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T10946	D4-abiraterone	154229-21-7	98%
T10946	D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abira...
T15816	LY341495	201943-63-7	98%
T15816	LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).
T15749	LGD-2226	328947-93-9	98%
T15749	LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle...
TN1061	Ganoderol B	104700-96-1	98%
TN1061	Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate ...
TN1663	Ganoderic acid DM	173075-45-1	98%
TN1663	Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
T20625	Prochloraz	67747-09-5	98%
T20625	Prochloraz, a broad-spectrum contact imidazole fungicide, is used against several diseases in wheat, barley, and oleaginous plants but also for the treatment of ...
TN1067	Galloylpaeoniflorin	122965-41-7	98%
TN1067	6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
T39695	ARD-2128	2222111-87-5	98%
T39695	ARD-2128 is a highly potent, orally bioavailable PROTAC degrader of androgen receptor (AR). ARD-2128 effectively reduces AR protein, suppresses AR-regulated gene...
T8860	DSRM-3716	58142-99-7	98%
T8860	Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a...
T24943	VPC-14228	19983-28-9	98%
T24943	VPC-14228 is a specific AR-DBD inhibitor that acts by inhibiting both Y594A and Q592A mutants.
T67818	BMS-641988		98%
T67818	BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.
T2991	3,3'-Diindolylmethane	1968-05-4	98%
T2991	DIM (3, 3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.
T8117	Metenolone acetate	434-05-9	98%
T8117	Methenolone acetate is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.
T75129	Luxdegalutamide	2750830-09-0	98%
T75129	Luxdegalutamide is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades the wild-type and...
T6400	AZD3514	1240299-33-5	98%
T6400	AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.