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Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.
Cat No. product name
TJS2190 Nordihydroguaiaretic acid Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) ...
T1644 Dopamine hydrochloride Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine b...
T0877 Gallic acid Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T4414 Eprenetapopt PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
T0093L Sorafenib Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-4/B-Raf).
T1487 Fluvastatin sodium Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
T6235 Lapatinib Ditosylate Lapatinib is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
T0078 Lapatinib Lapatinib is a dual inhibitor of Lapatinib is a dual ErbB2/EGFR (IC50: 9.2/10.8 nM) inhibitor
T0787 Butylhydroxyanisole Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydr...
T6500 Ferrostatin-1 Ferrostatin-1 is a potent ferroptosis inhibitor (EC50: 60 nM).
T8922 SRS11-92 SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1
T0191 Linagliptin Linagliptin is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
TQ0120 CDDO-Im CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
T1622 Rosiglitazone maleate Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
T0477 Zileuton Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...
T7092 NADPH tetrasodium salt NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various ...
T0334 Rosiglitazone Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare...
T6871 L-Glutamic acid monosodium salt L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
T0326 DL-Glutamine DL-Glutamine, a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processes. It is synthesized from glutamic ...
TQ0211 Brusatol Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
T1648 α-Vitamin E (+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
T6821 Dp44mT Dp44mT, a effective iron chelator, has selective antitumor activity.
T0392 Artemisinin Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organis...
T2A2497 L-Glutamic acid (S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
T6243 U-73122 U73122, an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
T1457 Deferasirox Deferasirox is an oral iron chelating agent used to treat chronic iron overload.
T6192 Alogliptin Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
T1085 L-Glutathione reduced Glutathione is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved...
T5515 Hemin Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
T6099 Setanaxib GKT137831 is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
T7708 DL-Buthionine-(S,R)-sulfoximine D,L-Buthionine-(S,R)-sulfoximine is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.
T1710 Trolox Troloxa is a vitamin E analogue, used in reducing oxidative stress or damage.
T3637 Pifithrin-β hydrobromide Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in mod...
T1885 Siramesine hydrochloride Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
T5371 L-BUTHIONINE-(S,R)-SULFOXIMINE L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cell...
T3109 SP600125 SP600125 is a JNK1/2/3 inhibitor (IC50: 40/40/90 nM) and 10-fold higher selectivity than MKK4, 25-fold higher selectivity than MKK3, MKK6, PKCα, and PKB.
T0672 Pravastatin sodium Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T1114 Ciclopirox olamine Ciclopirox Olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
T6165 Bardoxolone Methyl Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T3646 RSL3 RSL3 is a VDAC-independent ferroptosis activator with selectivity for tumor cells bearing oncogenic RAS. RSL3 is the inhibitor of the glutathione peroxidase 4, w...
THS1455 DihydroarteMisinic acid Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to ...
T2796 Coenzyme Q10 Coenzyme Q10 (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
T2O2733 L-Cystine Not considered one of the 20 amino acids, Cystine is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It function...
T7530 PD146176 PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive im...
T0214 Pioglitazone Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare i...
T0423 Ethylenediaminetetraacetic acid trisodium salt Edetate Trisodiumis used to bind metal ions in the chelation therapy.
T6468 D-glutamine D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T2401 Alogliptin Benzoate Alogliptin Benzoate(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may...
T0687 Simvastatin Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
Nordihydroguaiaretic acid
TJS2190
Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) ...
Dopamine hydrochloride
T1644
Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine b...
Gallic acid
T0877
Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
Eprenetapopt
T4414
PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
Sorafenib
T0093L
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-4/B-Raf).
Fluvastatin sodium
T1487
Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
Lapatinib Ditosylate
T6235
Lapatinib is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
Lapatinib
T0078
Lapatinib is a dual inhibitor of Lapatinib is a dual ErbB2/EGFR (IC50: 9.2/10.8 nM) inhibitor
Butylhydroxyanisole
T0787
Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydr...
Ferrostatin-1
T6500
Ferrostatin-1 is a potent ferroptosis inhibitor (EC50: 60 nM).
SRS11-92
T8922
SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1
Linagliptin
T0191
Linagliptin is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
Acetylcysteine
T0875
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
CDDO-Im
TQ0120
CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
Rosiglitazone maleate
T1622
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
Zileuton
T0477
Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...
NADPH tetrasodium salt
T7092
NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various ...
Rosiglitazone
T0334
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare...
L-Glutamic acid monosodium salt
T6871
L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
DL-Glutamine
T0326
DL-Glutamine, a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processes. It is synthesized from glutamic ...
Brusatol
TQ0211
Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
α-Vitamin E
T1648
(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
Dp44mT
T6821
Dp44mT, a effective iron chelator, has selective antitumor activity.
Artemisinin
T0392
Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organis...
L-Glutamic acid
T2A2497
(S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
U-73122
T6243
U73122, an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
Deferasirox
T1457
Deferasirox is an oral iron chelating agent used to treat chronic iron overload.
Alogliptin
T6192
Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
L-Glutathione reduced
T1085
Glutathione is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved...
Hemin
T5515
Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
Setanaxib
T6099
GKT137831 is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
DL-Buthionine-(S,R)-sulfoximine
T7708
D,L-Buthionine-(S,R)-sulfoximine is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.
Trolox
T1710
Troloxa is a vitamin E analogue, used in reducing oxidative stress or damage.
Pifithrin-β hydrobromide
T3637
Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in mo...
Siramesine hydrochloride
T1885
Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
L-BUTHIONINE-(S,R)-SULFOXIMINE
T5371
L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in ce...
SP600125
T3109
SP600125 is a JNK1/2/3 inhibitor (IC50: 40/40/90 nM) and 10-fold higher selectivity than MKK4, 25-fold higher selectivity than MKK3, MKK6, PKCα, and PKB.
Pravastatin sodium
T0672
Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
Ciclopirox olamine
T1114
Ciclopirox Olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
Bardoxolone Methyl
T6165
Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
RSL3
T3646
RSL3 is a VDAC-independent ferroptosis activator with selectivity for tumor cells bearing oncogenic RAS. RSL3 is the inhibitor of the glutathione peroxidase 4, w...
DihydroarteMisinic acid
THS1455
Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to ...
Coenzyme Q10
T2796
Coenzyme Q10 (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
L-Cystine
T2O2733
Not considered one of the 20 amino acids, Cystine is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It function...
PD146176
T7530
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive i...
Pioglitazone
T0214
Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare i...
Ethylenediaminetetraacetic acid trisodium salt
T0423
Edetate Trisodiumis used to bind metal ions in the chelation therapy.
D-glutamine
T6468
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
Alogliptin Benzoate
T2401
Alogliptin Benzoate(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may...
Simvastatin
T0687
Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
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