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PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
Cat No. product name
T9605 Sangivamycin Sangivamycin 是蛋白激酶 C (PKC) 的有效抑制剂 (Ki = 10 μM)。 Sangivamycin 对多种人类癌症细胞具有抗增殖活性。
T35827L PKCε Inhibitor Peptide acetate PKCε Inhibitor Peptide acetate 是一种特异性 PKCε 抑制剂,含有其特定受体活化 C 激酶 (RACK) 的位点。 PKCε Inhibitor Peptide acetate 抑制 PKCε 的转运,但不抑制 αPKC,βPKC 和 δPKC 的转运。
T6515 Go6976 Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and ...
T14072 A-443654 A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
TQ0198 Phorbol 12-myristate 13-acetate Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
T3S1416 Decursin 1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , ...
T2851 Daphnetin Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), ...
T4950 1,2-Dipalmitoyl-sn-glycerol 1,2-Dipalmitoyl-sn-glycerol is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.
T4391 Syk Inhibitor II (hydrochloride) Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...
T8376 PKCβ inhibitor 1 PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).
T0979 Dequalinium chloride Dequalinium Chloride, a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may ...
T26019 R59949 R 59949 is used as a Diacylglycerol kinase (DGK) inhibitor.
T3375 Verbascoside Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T1648 α-Vitamin E (+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
T3211 Midostaurin PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelia...
T7648 HA-100 HA-100 is an inhibitor of protein kinase
T0610 Piceatannol Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...
T11665 Ionomycin calcium lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase ...
T7790 Bisindolylmaleimide V Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
T7885 Afuresertib hydrochloride Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T6285 GSK-690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
T6605 NH125 NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T6280 Enzastaurin Enzastaurin (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.
T5239 Cholesteryl sulfate sodium Cholesterol sulfate is a sterol sulfate in human plasma. It is a component of cell membrane and has a regulatory function. It also activates multiple protein kin...
T6680 Staurosporine Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
T3050 ML-7 hydrochloride ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-musc...
T20168 Aurothiomalate sodium Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor...
T3060 Fasudil hydrochloride Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T6932 PD168393 PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
T7792 Hispidin Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties
T4444 A-674563 HCl (552325-73-2(free base)) A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
T6S0052 Chelerythrine 1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. C...
T1606 Fasudil Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T14069 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T0158 Mitoxantrone dihydrochloride Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
T0033 Miltefosine Miltefosine is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agen...
T13384L Y-33075 dihydrochloride Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T1911 Afuresertib Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T12148 N-Desmethyltamoxifen hydrochloride N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.
T7659 Bisindolylmaleimide IV Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)
T3419 Chelerythrine chloride Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ...
T2356 Ro-3306 RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
T6167 SU9516 SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
TN1299 Desmethylglycitein 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer acti...
T7604 Valrubicin Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
T5891 D-ERYTHRO-SPHINGOSINE D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
T5771 Hypocrellin A Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presen...
T4S1335 Daphnoretin 1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma...
T16791 Rottlerin Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-...
Sangivamycin
T9605
Sangivamycin 是蛋白激酶 C (PKC) 的有效抑制剂 (Ki = 10 μM)。 Sangivamycin 对多种人类癌症细胞具有抗增殖活性。
PKCε Inhibitor Peptide acetate
T35827L
PKCε Inhibitor Peptide acetate 是一种特异性 PKCε 抑制剂,含有其特定受体活化 C 激酶 (RACK) 的位点。 PKCε Inhibitor Peptide acetate 抑...
Go6976
T6515
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 an...
A-443654
T14072
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
Phorbol 12-myristate 13-acetate
TQ0198
Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
Decursin
T3S1416
1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , ...
Daphnetin
T2851
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM...
1,2-Dipalmitoyl-sn-glycerol
T4950
1,2-Dipalmitoyl-sn-glycerol is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.
Syk Inhibitor II (hydrochloride)
T4391
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chai...
PKCβ inhibitor 1
T8376
PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively)...
Dequalinium chloride
T0979
Dequalinium Chloride, a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may ...
R59949
T26019
R 59949 is used as a Diacylglycerol kinase (DGK) inhibitor.
Verbascoside
T3375
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
α-Vitamin E
T1648
(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
Midostaurin
T3211
PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelia...
HA-100
T7648
HA-100 is an inhibitor of protein kinase
Piceatannol
T0610
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activa...
Ionomycin calcium
T11665
lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase ...
Bisindolylmaleimide V
T7790
Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
Afuresertib hydrochloride
T7885
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
GSK-690693
T6285
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
NH125
T6605
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
Ellagic acid
T0465
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
Enzastaurin
T6280
Enzastaurin (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.
Cholesteryl sulfate sodium
T5239
Cholesterol sulfate is a sterol sulfate in human plasma. It is a component of cell membrane and has a regulatory function. It also activates multiple protein kin...
Staurosporine
T6680
Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
ML-7 hydrochloride
T3050
ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-musc...
Aurothiomalate sodium
T20168
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor...
Fasudil hydrochloride
T3060
Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
PD168393
T6932
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
Hispidin
T7792
Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties
A-674563 HCl (552325-73-2(free base))
T4444
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
Chelerythrine
T6S0052
1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. C...
Fasudil
T1606
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
A-3 hydrochloride
T14069
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
Mitoxantrone dihydrochloride
T0158
Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
Miltefosine
T0033
Miltefosine is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agen...
Y-33075 dihydrochloride
T13384L
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
Afuresertib
T1911
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
N-Desmethyltamoxifen hydrochloride
T12148
N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.
Bisindolylmaleimide IV
T7659
Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)
Chelerythrine chloride
T3419
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ...
Ro-3306
T2356
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
SU9516
T6167
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
Desmethylglycitein
TN1299
6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer act...
Valrubicin
T7604
Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
D-ERYTHRO-SPHINGOSINE
T5891
D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
Hypocrellin A
T5771
Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presen...
Daphnoretin
T4S1335
1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma...
Rottlerin
T16791
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,...
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