T0033 |
Miltefosine |
Miltefosine is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical ag...
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T0228 |
Methyl hesperidin |
Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin. |
T0465 |
Ellagic acid |
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
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T0610 |
Piceatannol |
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activ...
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T0979 |
Dequalinium chloride |
Dequalinium Chloride, a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may...
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T10549 |
Bisindolylmaleimide VIII acetate |
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 21...
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T10550 |
Bisindolylmaleimide X hydrochloride |
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM). |
T10555 |
BJE6-106 |
BJE6-106 (B106) is a potent, selective PKCδ inhibitor
(IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-d...
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T10888 |
CRT0066854 hydrochloride |
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 v...
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T10980 |
DCPLA-ME |
DCPLA-ME is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator. |
T12494 |
PKC-IN-1 |
PKC-IN-1 is a ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, ...
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T12496 |
PKC-theta inhibitor 1 |
PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM) |
T13314 |
VTX-27 |
VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ)(Kis of 0.08 nM and 16 nM for PKC θ and PKC δ). |
T13363 |
Y06137 |
Y06137 is a potent and selective inhibitor of BET, and used for treatment of castration-resistant prostate cancer (CRPC). Y06137 binds to the BRD4(1) bromodomai...
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T13384 |
Y-33075 |
Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. |
T13605 |
Cercosporin |
Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation waveleng...
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T13637 |
DCP-LA |
DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε. |
T14328 |
AS2521780 |
AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM). |
T14831 |
Bryostatin 1 |
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domai...
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T14943 |
CGP60474 |
CGP60474 is an inhibitor of VEGFR-2 (IC50: 84 nM) and an ATP-competitive inhibitor of PKC. |
T14989 |
CMPD101 |
CMPD101 is a membrane-permeable inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM) used for the study of heart failure. CMPD101 exhibits less selectively against GRK1...
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T15637 |
K-252b |
K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in...
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T15638 |
K-252c |
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 µM). K-252c also inhibits β-lactamase, chymo...
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T16276 |
NBD-556 |
NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding. |
T1648 |
Vitamin E |
(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties. |
T16526 |
Phorbol 12,13-dibutyrate |
Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter. |
T16671 |
PS315 |
PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a deriva...
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T16791 |
Rottlerin |
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
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T16848 |
SB-218078 |
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1...
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T17148 |
TPPB |
TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM). |
T17299 |
(-)-Indolactam V |
(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 ...
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T2356 |
Ro 3306 |
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinase...
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T2441 |
TAS-301 |
TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. |
T2757 |
Myricetrin |
Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects. |
T2851 |
Daphnetin |
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μ...
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T2S0501 |
Ilexgenin A |
Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib...
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T3050 |
ML-7 hydrochloride |
ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-mus...
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T3060 |
Fasudil hydrochloride |
Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively. |
T3211 |
Midostaurin |
PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endotheli...
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T3375 |
Verbascoside |
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities. |
T3419 |
Chelerythrine chloride |
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to...
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T3684 |
CP21R7 |
CP21R7 is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smoot...
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T3S1416 |
Decursin |
1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects ,...
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T4001 |
Euxanthone |
Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vaso...
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T4037 |
Phorbol |
Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C. |
T4391 |
Syk Inhibitor II (hydrochloride) |
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ cha...
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T5239 |
Cholesterol 3-Sulfate Sodium Salt |
Cholesterol sulfate is a sterol sulfate in human plasma. It is a component of cell membrane and has a regulatory function. It also activates multiple protein ki...
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T5600 |
LXS196 |
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respecti...
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T5771 |
Hypocrellin A |
Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted prese...
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T5796 |
Plantainoside D |
Plantainoside D shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vit...
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T5817 |
PKC-theta inhibitor |
PKC-theta inhibitor is a selective PKC-θinhibitor(IC50:12 nM). |
T5891 |
D-ERYTHRO-SPHINGOSINE |
D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator |
T5S2017 |
Ingenol |
1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to deve...
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T6167 |
SU9516 |
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively. |
T6223 |
U0126-EtOHHOT |
U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). |
T6278 |
SotrastaurinHOT |
Sotrastaurin is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ). |
T6280 |
Enzastaurin |
Enzastaurin (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε. |
T6285 |
GSK690693 |
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1. |
T6313 |
Go 6983 |
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively. |
T6513 |
Bisindolylmaleimide I |
GF109203X is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM. |
T6588 |
Mitoxantrone |
Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA re...
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T6605 |
NH125 |
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor. |
T6643 |
Ro 31-8220 Mesylate |
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T6680 |
Staurosporine |
Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM). |
T6932 |
PD168393 |
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin. |
T6S0052 |
Chelerythrine |
1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. ...
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T7501 |
Iso-H7 dihydrochloride |
Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7. |
T7604 |
Valrubicin |
Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity. |
T7659 |
Bisindolylmaleimide IV |
Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 µM) |
T7790 |
Bisindolylmaleimide V |
Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM) |
T7792 |
Hispidin |
Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties |
T8376 |
PKCβ inhibitor 1 |
PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKCß isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respective...
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TN1047 |
Ingenol mebutate |
Ingenol mebutate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activit...
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TN1136 |
Procyanidin A1 |
Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 c...
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TN1299 |
6,7,4'-Trihydroxyisoflavone |
6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer ac...
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TN1513 |
Clitorin |
Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential. |
TN1542 |
Cycloheterophyllin |
Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be ...
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TN2225 |
Soyasapogenol B |
Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2. |
TN2326 |
(Z)-Butylidenephthalide |
(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma. |
TN2799 |
20-Deoxyingenol 3-angelate |
20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant p...
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TN2844 |
(2R,3S)-Dihydrodehydroconiferyl alcohol |
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps suc...
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TN3160 |
6-Deoxyisojacareubin |
6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibit...
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TN3517 |
Bisacurone |
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppress...
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TN3655 |
Cimiside E |
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1...
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TN3694 |
Coniferaldehyde |
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
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TN4114 |
Gardenin A |
Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, b...
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TN4271 |
Isochamaejasmine |
Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the...
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TN4300 |
Isojacareubin |
Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the stand...
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TN4431 |
Leucosceptoside A |
Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosid...
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TQ0198 |
Phorbol 12-myristate 13-acetate |
Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator. |