PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.

Cat No.	product name
T0033	Miltefosine	Miltefosine is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical ag...
T0228	Methyl hesperidin	Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
T0465	Ellagic acid	Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
T0610	Piceatannol	Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activ...
T0979	Dequalinium chloride	Dequalinium Chloride, a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may...
T10549	Bisindolylmaleimide VIII acetate	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 21...
T10550	Bisindolylmaleimide X hydrochloride	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
T10555	BJE6-106	BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-d...
T10888	CRT0066854 hydrochloride	CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 v...
T10980	DCPLA-ME	DCPLA-ME is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator.
T12494	PKC-IN-1	PKC-IN-1 is a ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, ...
T12496	PKC-theta inhibitor 1	PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)
T13314	VTX-27	VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ)(Kis of 0.08 nM and 16 nM for PKC θ and PKC δ).
T13363	Y06137	Y06137 is a potent and selective inhibitor of BET, and used for treatment of castration-resistant prostate cancer (CRPC). Y06137 binds to the BRD4(1) bromodomai...
T13384	Y-33075	Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
T13605	Cercosporin	Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation waveleng...
T13637	DCP-LA	DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.
T14328	AS2521780	AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
T14831	Bryostatin 1	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domai...
T14943	CGP60474	CGP60474 is an inhibitor of VEGFR-2 (IC50: 84 nM) and an ATP-competitive inhibitor of PKC.
T14989	CMPD101	CMPD101 is a membrane-permeable inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM) used for the study of heart failure. CMPD101 exhibits less selectively against GRK1...
T15637	K-252b	K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in...
T15638	K-252c	K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 µM). K-252c also inhibits β-lactamase, chymo...
T16276	NBD-556	NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.
T1648	Vitamin E	(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
T16526	Phorbol 12,13-dibutyrate	Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
T16671	PS315	PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a deriva...
T16791	Rottlerin	Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
T16848	SB-218078	SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1...
T17148	TPPB	TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
T17299	(-)-Indolactam V	(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 ...
T2356	Ro 3306	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinase...
T2441	TAS-301	TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.
T2757	Myricetrin	Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
T2851	Daphnetin	Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μ...
T2S0501	Ilexgenin A	Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib...
T3050	ML-7 hydrochloride	ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-mus...
T3060	Fasudil hydrochloride	Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T3211	Midostaurin	PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endotheli...
T3375	Verbascoside	Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T3419	Chelerythrine chloride	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to...
T3684	CP21R7	CP21R7 is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smoot...
T3S1416	Decursin	1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects ,...
T4001	Euxanthone	Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vaso...
T4037	Phorbol	Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.
T4391	Syk Inhibitor II (hydrochloride)	Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ cha...
T5239	Cholesterol 3-Sulfate Sodium Salt	Cholesterol sulfate is a sterol sulfate in human plasma. It is a component of cell membrane and has a regulatory function. It also activates multiple protein ki...
T5600	LXS196	LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respecti...
T5771	Hypocrellin A	Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted prese...
T5796	Plantainoside D	Plantainoside D shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vit...
T5817	PKC-theta inhibitor	PKC-theta inhibitor is a selective PKC-θinhibitor(IC50:12 nM).
T5891	D-ERYTHRO-SPHINGOSINE	D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
T5S2017	Ingenol	1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to deve...
T6167	SU9516	SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
T6223	U0126-EtOHHOT	U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
T6278	SotrastaurinHOT	Sotrastaurin is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).
T6280	Enzastaurin	Enzastaurin (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.
T6285	GSK690693	GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
T6313	Go 6983	Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
T6513	Bisindolylmaleimide I	GF109203X is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.
T6588	Mitoxantrone	Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA re...
T6605	NH125	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T6643	Ro 31-8220 Mesylate
T6680	Staurosporine	Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
T6932	PD168393	PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
T6S0052	Chelerythrine	1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. ...
T7501	Iso-H7 dihydrochloride	Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.
T7604	Valrubicin	Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
T7659	Bisindolylmaleimide IV	Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 µM)
T7790	Bisindolylmaleimide V	Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
T7792	Hispidin	Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties
T8376	PKCβ inhibitor 1	PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKCß isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respective...
TN1047	Ingenol mebutate	Ingenol mebutate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activit...
TN1136	Procyanidin A1	Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 c...
TN1299	6,7,4'-Trihydroxyisoflavone	6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer ac...
TN1513	Clitorin	Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.
TN1542	Cycloheterophyllin	Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be ...
TN2225	Soyasapogenol B	Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
TN2326	(Z)-Butylidenephthalide	(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
TN2799	20-Deoxyingenol 3-angelate	20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant p...
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps suc...
TN3160	6-Deoxyisojacareubin	6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibit...
TN3517	Bisacurone	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppress...
TN3655	Cimiside E	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1...
TN3694	Coniferaldehyde	Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
TN4114	Gardenin A	Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, b...
TN4271	Isochamaejasmine	Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the...
TN4300	Isojacareubin	Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the stand...
TN4431	Leucosceptoside A	Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosid...
TQ0198	Phorbol 12-myristate 13-acetate	Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.