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Adenosine Receptor

The adenosine receptors are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand. There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3; each is encoded by a different gene.
Cat No. product name
T37793 A2B receptor antagonist 2 A2B receptor antagonist 2 是腺苷受体 A2B 的拮抗剂(rA1 的 Ki = 2.30 μM,rA2A 的 Ki = 6.8 μM,hA2B 的 3.44 μM)。
T5081 Adenine monohydrochloride hemihydrate Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfecte...
T12161 N6-Ethyladenosine N6-Ethyladenosine is an adenosine derivative, acts as an agonist of Adenosine receptor(hA1AR and hA3AR with Kis of 4.9 and 4.7 nM , respectively).
T0437 Inosine Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesi...
T29112 VPC171 VPC171 is a positive allosteric modulator (PAM) of the adenosine A1 receptor (A1R).
T14944 CGS 15943 CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Rec...
T1681 Aminophylline Aminophylline is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
T7736 2-Chloroadenosine 2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)...
T8551 Nitrobenzylthioinosine Nitrobenzylthioinosine is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.
T23201 PSB 1115 human A2B adenosine receptor antagonist
T23535 Xanthine amine congener Adenosine receptor antagonist
T6745 5-Iodotubercidin 5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphoryl...
T0665 Xanthine Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthin...
T22234 Alloxazine Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
T4668 ABT-702 dihydrochloride ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.
T0892 Diphylline Dyphylline is a xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline probably act...
T0362 Ticlopidine hydrochloride Ticlopidine hydrochloride is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
T7188 Piclidenoson Piclidenoson, a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
T0070 Pentoxifylline Pentoxifylline modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase a...
T5S1895 Norisoboldine 1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the...
T2205 Acefylline Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T1083L Theophylline monohydrate Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T27076 8-Cyclopentyl-1,3-dimethylxanthine 8-Cyclopentyl-1,3-dimethylxanthine is a potent antagonist of adenosine A1 receptor.
T16378 Ogerin Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and a...
T7340 5'-N-Ethylcarboxamidoadenosine NECA is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier mod...
T1825 Reversine Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).
T15418 GS-6201 GS-6201 is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors (Ki: 22 nM). GS-62...
T9516 Binodenoson Binodenoson is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adj...
TN2247 Swertisin Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, ...
T16980 Taminadenant Taminadenant is an adenosine receptor antagonist.
T9330 MIPS521 MIPS-521 is a positive allosteric modulator of the A1R.
T5940 Proxyphylline Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
T6115 Fostamatinib Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T21519 2-Chloro-N6-cyclopentyladenosine 2-Chloro-N6-cyclopentyladenosine is a potent and selective agonist of adenosine A1 receptor
T0480 Doxofylline Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown...
T4006 Pentostatin Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
T0853L Adenosine 5'-monophosphate monohydrate Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
T0625 Theobromine 3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
T1083 Theophylline Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
T21620 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is an adenosine receptor antagonist.
T22744 DPCPX DPCPX is an A1 adenosine receptor antagonist
T23336 SCH442416 SCH-442416 is an selective antagonist of adenosine A2A receptor. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 ...
T23347 SDZ WAG 994 A1 adenosine receptor agonist
T2373 Vipadenant Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
T2671 Regadenoson Regadenoson is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selecti...
T7183 CPI-444 CPI-444 is an antagonist of the adenosine A2A receptor.It reduces tumor area in mouse model of murine Her2/neu-expressing breast cancer.
T7021 ZM241385 ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
T7509 PD 117519 PD 117519 is an agonist of adenosine receptor
T7320 Tozadenant Tozadenant is an adenosine A2A receptor antagonist(Ki of 11.5 nM and 6 nM on human and rhesus,respectively)
T7683 Adenosine amine congener Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor,.
A2B receptor antagonist 2
T37793
A2B receptor antagonist 2 是腺苷受体 A2B 的拮抗剂(rA1 的 Ki = 2.30 μM,rA2A 的 Ki = 6.8 μM,hA2B 的 3.44 μM)。
Adenine monohydrochloride hemihydrate
T5081
Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfecte...
N6-Ethyladenosine
T12161
N6-Ethyladenosine is an adenosine derivative, acts as an agonist of Adenosine receptor(hA1AR and hA3AR with Kis of 4.9 and 4.7 nM , respectively).
Inosine
T0437
Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesi...
VPC171
T29112
VPC171 is a positive allosteric modulator (PAM) of the adenosine A1 receptor (A1R).
CGS 15943
T14944
CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Rec...
Aminophylline
T1681
Aminophylline is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
2-Chloroadenosine
T7736
2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)...
Nitrobenzylthioinosine
T8551
Nitrobenzylthioinosine is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.
PSB 1115
T23201
human A2B adenosine receptor antagonist
Xanthine amine congener
T23535
Adenosine receptor antagonist
5-Iodotubercidin
T6745
5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphoryl...
Xanthine
T0665
Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthin...
Alloxazine
T22234
Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
ABT-702 dihydrochloride
T4668
ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.
Diphylline
T0892
Dyphylline is a xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline probably act...
Ticlopidine hydrochloride
T0362
Ticlopidine hydrochloride is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Piclidenoson
T7188
Piclidenoson, a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
Pentoxifylline
T0070
Pentoxifylline modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase a...
Norisoboldine
T5S1895
1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the...
Acefylline
T2205
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
Theophylline monohydrate
T1083L
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
8-Cyclopentyl-1,3-dimethylxanthine
T27076
8-Cyclopentyl-1,3-dimethylxanthine is a potent antagonist of adenosine A1 receptor.
Ogerin
T16378
Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and a...
5'-N-Ethylcarboxamidoadenosine
T7340
NECA is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier mod...
Reversine
T1825
Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).
GS-6201
T15418
GS-6201 is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors (Ki: 22 nM). GS-62...
Binodenoson
T9516
Binodenoson is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adj...
Swertisin
TN2247
Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, ...
Taminadenant
T16980
Taminadenant is an adenosine receptor antagonist.
MIPS521
T9330
MIPS-521 is a positive allosteric modulator of the A1R.
Proxyphylline
T5940
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
Fostamatinib
T6115
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
2-Chloro-N6-cyclopentyladenosine
T21519
2-Chloro-N6-cyclopentyladenosine is a potent and selective agonist of adenosine A1 receptor
Doxofylline
T0480
Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown...
Pentostatin
T4006
Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
Adenosine 5'-monophosphate monohydrate
T0853L
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
Theobromine
T0625
3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
Theophylline
T1083
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
T21620
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is an adenosine receptor antagonist.
DPCPX
T22744
DPCPX is an A1 adenosine receptor antagonist
SCH442416
T23336
SCH-442416 is an selective antagonist of adenosine A2A receptor. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 ...
SDZ WAG 994
T23347
A1 adenosine receptor agonist
Vipadenant
T2373
Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
Regadenoson
T2671
Regadenoson is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selecti...
CPI-444
T7183
CPI-444 is an antagonist of the adenosine A2A receptor.It reduces tumor area in mouse model of murine Her2/neu-expressing breast cancer.
ZM241385
T7021
ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
PD 117519
T7509
PD 117519 is an agonist of adenosine receptor
Tozadenant
T7320
Tozadenant is an adenosine A2A receptor antagonist(Ki of 11.5 nM and 6 nM on human and rhesus,respectively)
Adenosine amine congener
T7683
Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor,.
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