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SARS-CoV

Severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1) is a strain of virus that causes severe acute respiratory syndrome (SARS). It is an enveloped, positive-sense, single-stranded RNA virus which infects the epithelial cells within the lungs. The virus enters the host cell by binding to the ACE2 receptor. It infects humans, bats, and palm civets.
Cat No. product name
T40660 Kansuinine B Kansuinine B 抑制由 IL-6 诱导的 Stat3 活化。 Kansuinine B 具有抗病毒活性,可用于 COVID-19 研究。
T40276 GS-621763 GS-621763, a prodrug of GS-441524, exhibits antiviral activity against SARS-CoV-2 pathogenesis.
T0194 Chloroquine phosphate Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T7766 Remdesivir Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
T11464 GRL0617 GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).
T1803 GNF-5 GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic propertie...
T8676 FOY 251 FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.
T1076 Dexamethasone Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
T6040 Aloxistatin Aloxistatin is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibito...
T9341 Bemnifosbuvir Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.
T3319 Scutellarein Scutellarein reduces inflammatory responses by inhibiting Src kinase activity.
T0100L Atazanavir Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T2392 Nafamostat mesylate Nafamostat mesylate, a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic de...
T1303 Auranofin Auranofin is an antirheumatic agent, is used to treat rheumatoid arthritis, improves arthritis symptoms including painful or tender and swollen joints and mornin...
TQ0180 Chebulagic acid Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
T6025 Danoprevir Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).
T15445 Proxalutamide Proxalutamide is a potent antagonist of the androgen receptor (AR).
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
T9458 PF-00835231 PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-0083523...
T8689 Chloroquine Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and...
T6230 Imatinib matinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit (IC50: 600/100/100 nM).
T4686 Simeprevir Simeprevir is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.
T4547 Grazoprevir MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.0...
T6738 Z-FA-FMK Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
T5539 GS-443902 GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T0134 Imiquimod Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
T4988 Boceprevir Boceprevir is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-...
T5126 Glecaprevir Glecaprevir is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).
T9287 Hydroxychloroquine Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a med...
T0211L Azelastine hydrochloride Azelastine Hydrochloride is a phthalazinone derivative with antihistaminergic activity.
T2160 Suramin Sodium Salt Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
T6200 Ledipasvir Ledipasvir is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein In...
T9351 Nirmatrelvir PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
TP1016L Aviptadil Acetate Avitadil acetate induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for resear...
T0828 Bromhexine hydrochloride Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
T1307 Carmofur Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
TQ0302 Thapsigargin Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
T2869 Emodin Emodin is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated b...
T2391 Camostat mesylate Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
T1623 Lopinavir Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding t...
T1817 GNF-2 GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.
T9331 Bemnifosbuvir hemisulfate Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.
T0211 Azelastine Azelastine is a phthalazine derivative, and is an histamine antagonist and mast cell stabilizer.
T5863 Indinavir sulfate Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
T3089 6-Thioguanine Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T6986 Sivelestat Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
T6388 Amprenavir Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
T9672 GRL-0496 GRL-0496 is a potent inhibitor with an enzyme inhibitory activity against SARS-CoV 3CLpro with an IC50 of 30 nM and antiviral potency with an EC50 value of 6.9 μ...
T3921 Punicalagin Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown t...
T3S1447 Arteannuin B 1. Arteannuin B has potent antimalarial activity.
Kansuinine B
T40660
Kansuinine B 抑制由 IL-6 诱导的 Stat3 活化。 Kansuinine B 具有抗病毒活性,可用于 COVID-19 研究。
GS-621763
T40276
GS-621763, a prodrug of GS-441524, exhibits antiviral activity against SARS-CoV-2 pathogenesis.
Chloroquine phosphate
T0194
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
Remdesivir
T7766
Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
GRL0617
T11464
GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).
GNF-5
T1803
GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properti...
FOY 251
T8676
FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.
Dexamethasone
T1076
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
Aloxistatin
T6040
Aloxistatin is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibito...
Bemnifosbuvir
T9341
Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.
Scutellarein
T3319
Scutellarein reduces inflammatory responses by inhibiting Src kinase activity.
Atazanavir
T0100L
Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
Nafamostat mesylate
T2392
Nafamostat mesylate, a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic de...
Auranofin
T1303
Auranofin is an antirheumatic agent, is used to treat rheumatoid arthritis, improves arthritis symptoms including painful or tender and swollen joints and mornin...
Chebulagic acid
TQ0180
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
Danoprevir
T6025
Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).
Proxalutamide
T15445
Proxalutamide is a potent antagonist of the androgen receptor (AR).
Hydroxychloroquine sulfate
T0951
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
PF-00835231
T9458
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-0083523...
Chloroquine
T8689
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and...
Imatinib
T6230
matinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit (IC50: 600/100/100 nM).
Simeprevir
T4686
Simeprevir is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.
Grazoprevir
T4547
MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.0...
Z-FA-FMK
T6738
Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
Imiquimod
T0134
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
Boceprevir
T4988
Boceprevir is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-...
Glecaprevir
T5126
Glecaprevir is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).
Hydroxychloroquine
T9287
Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a med...
Azelastine hydrochloride
T0211L
Azelastine Hydrochloride is a phthalazinone derivative with antihistaminergic activity.
Suramin Sodium Salt
T2160
Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
Ledipasvir
T6200
Ledipasvir is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein In...
Nirmatrelvir
T9351
PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
Aviptadil Acetate
TP1016L
Avitadil acetate induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for resear...
Bromhexine hydrochloride
T0828
Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
Carmofur
T1307
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
Thapsigargin
TQ0302
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
Emodin
T2869
Emodin is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated b...
Camostat mesylate
T2391
Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
Lopinavir
T1623
Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding t...
GNF-2
T1817
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.
Bemnifosbuvir hemisulfate
T9331
Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.
Azelastine
T0211
Azelastine is a phthalazine derivative, and is an histamine antagonist and mast cell stabilizer.
Indinavir sulfate
T5863
Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
6-Thioguanine
T3089
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Sivelestat
T6986
Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
Amprenavir
T6388
Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
GRL-0496
T9672
Punicalagin
T3921
Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown t...
Arteannuin B
T3S1447
1. Arteannuin B has potent antimalarial activity.
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