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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Cat. No. Product name CAS No. Purity Chemical Structure
T14703 Karenitecin 203923-89-1 98%
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
T14953 Chloroquinoxaline sulfonamide 97919-22-7 98%
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
TN4107 Ganoderic acid X 86377-53-9 98%
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
T14945 CH-0793076 534605-78-2 98%
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
T11090L1 Aldoxorubicin hydrochloride 1361563-03-2 98%
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
TN5190 Tryprostatin A 171864-80-5 98%
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
TN4422 Lauterine 28200-65-9 98%
Lauterine is a DNA topoisomerase inhibitor.
T11090L Aldoxorubicin 1361644-26-9 98%
Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
T16726 Rebeccamycin 93908-02-2 98%
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
TN1889 Lupalbigenin 76754-24-0 98%
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
T15054 Daun02 290304-24-4 98%
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T6724 Voreloxin 175414-77-4 98%
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
TQ0049 MC-DOXHZN hydrochloride 480998-12-7 98%
MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
TN4283 Isodiospyrin 20175-84-2 98%
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
TN2105 Proscillaridin A 466-06-8 98%
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
TN2953 3-Hydroxysarpagine 857297-90-6 98%
Standard reference
TN1169 1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside 1415729-43-9 98%
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
T15200 Edotecarin 174402-32-5 98%
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
T16286 Nelonemdaz 640290-67-1 98%
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 125537-92-0 98%
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
Karenitecin
T14703
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Chloroquinoxaline sulfonamide
T14953
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
CH-0793076
T14945
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
Aldoxorubicin hydrochloride
T11090L1
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
Tryprostatin A
TN5190
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
Lauterine
TN4422
Lauterine is a DNA topoisomerase inhibitor.
Aldoxorubicin
T11090L
Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
Rebeccamycin
T16726
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
Lupalbigenin
TN1889
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
Daun02
T15054
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
Voreloxin
T6724
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
MC-DOXHZN hydrochloride
TQ0049
MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
Isodiospyrin
TN4283
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
Proscillaridin A
TN2105
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
3-Hydroxysarpagine
TN2953
Standard reference
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside
TN1169
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
Edotecarin
T15200
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Nelonemdaz
T16286
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
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