T14703 |
Karenitecin
|
203923-89-1
|
98%
|
|
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
|
T14953 |
Chloroquinoxaline sulfonamide
|
97919-22-7
|
98%
|
|
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
|
TN4107 |
Ganoderic acid X
|
86377-53-9
|
98%
|
|
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
|
T14945 |
CH-0793076
|
534605-78-2
|
98%
|
|
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
|
T11090L1 |
Aldoxorubicin hydrochloride
|
1361563-03-2
|
98%
|
|
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
|
TN5190 |
Tryprostatin A
|
171864-80-5
|
98%
|
|
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
|
TN4422 |
Lauterine
|
28200-65-9
|
98%
|
|
Lauterine is a DNA topoisomerase inhibitor.
|
T11090L |
Aldoxorubicin
|
1361644-26-9
|
98%
|
|
Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
|
T16726 |
Rebeccamycin
|
93908-02-2
|
98%
|
|
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
|
TN1889 |
Lupalbigenin
|
76754-24-0
|
98%
|
|
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
|
T15054 |
Daun02
|
290304-24-4
|
98%
|
|
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
|
T6724 |
Voreloxin
|
175414-77-4
|
98%
|
|
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
|
TQ0049 |
MC-DOXHZN hydrochloride
|
480998-12-7
|
98%
|
|
MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
|
TN4283 |
Isodiospyrin
|
20175-84-2
|
98%
|
|
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
|
TN2105 |
Proscillaridin A
|
466-06-8
|
98%
|
|
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
|
TN2953 |
3-Hydroxysarpagine
|
857297-90-6
|
98%
|
|
Standard reference
|
TN1169 |
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside
|
1415729-43-9
|
98%
|
|
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
|
T15200 |
Edotecarin
|
174402-32-5
|
98%
|
|
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
|
T16286 |
Nelonemdaz
|
640290-67-1
|
98%
|
|
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
|
TN5133 |
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
|
125537-92-0
|
98%
|
|
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
|