Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.

Cat. No.	Product name	CAS No.	Purity
T14703	Karenitecin	203923-89-1	98%
T14703	Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
T14953	Chloroquinoxaline sulfonamide	97919-22-7	98%
T14953	Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
TN4107	Ganoderic acid X	86377-53-9	98%
TN4107	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
T14945	CH-0793076	534605-78-2	98%
T14945	CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
T11090L1	Aldoxorubicin hydrochloride	1361563-03-2	98%
T11090L1	Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
TN5190	Tryprostatin A	171864-80-5	98%
TN5190	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
TN4422	Lauterine	28200-65-9	98%
TN4422	Lauterine is a DNA topoisomerase inhibitor.
T11090L	Aldoxorubicin	1361644-26-9	98%
T11090L	Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
T16726	Rebeccamycin	93908-02-2	98%
T16726	Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
TN1889	Lupalbigenin	76754-24-0	98%
TN1889	Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
T15054	Daun02	290304-24-4	98%
T15054	Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T6724	Voreloxin	175414-77-4	98%
T6724	Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
TQ0049	MC-DOXHZN hydrochloride	480998-12-7	98%
TQ0049	MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
TN4283	Isodiospyrin	20175-84-2	98%
TN4283	Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
TN2105	Proscillaridin A	466-06-8	98%
TN2105	Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
TN2953	3-Hydroxysarpagine	857297-90-6	98%
TN2953	Standard reference
TN1169	1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside	1415729-43-9	98%
TN1169	1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
T15200	Edotecarin	174402-32-5	98%
T15200	Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
T16286	Nelonemdaz	640290-67-1	98%
T16286	Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	125537-92-0	98%
TN5133	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...