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DNA Damage/DNA Repair Topoisomerase

Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Cat No. product name
T0125 Epirubicin hydrochloride Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
T0132 EtoposideHOT Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50: 60.3 μM).
T0158 Mitoxantrone hydrochloride Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
T0250 Ciprofloxacin hydrochloride Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T0274 Cinoxacin Cinoxacin, an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.
T0331 Moxifloxacin hydrochloride Moxifloxacin is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens. Moxifloxacin has been l...
T0425 Pefloxacin Mesylate Pefloxacin mesylate is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
T0425L Pefloxacin Mesylate Dihydrate Pefloxacin mesylate dehydrate, an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
T0486 Irinotecan hydrochloride trihydrate Irinotecan HCl-trihydrate keeps DNA from unwinding by inhibiting topoisomerase 1.
T0486L Irinotecan Hydrochloride Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active m...
T0717 Enoxacin Sesquihydrate Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T0717L Enoxacin Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T0902 Ofloxacin Ofloxacin is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzy...
T0909 Nalidixic acid Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA ...
T0909L Nalidixic acid sodium salt Nalidixic acid sodium salt is an antimicrobial agent with a limited bacteriocidal spectrum.
T0974 Albamycinsodium Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
T1020 Doxorubicin hydrochlorideHOT Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
T1060 Flumequine Flumequine is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II...
T1095 Sparfloxacin Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T1121 Podophyllotoxin Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
T1123 (S)-(+)-Camptothecin (S)-(+)-Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I), isolated from Camptotheca acuminata.
T1174 Topotecan hydrochloride Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer.
T1206 Amsacrine Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specific...
T1293 Gatifloxacin Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase...
T1294 Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T1306 Norfloxacin Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
T1444 Lomefloxacin Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
T1451 Levofloxacin Hemihydrate Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
T1492 Gemifloxacin mesylate Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin M...
T1521 Hydroxy Camptothecine Hydroxy Camptothecine is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzy...
T1523 Teniposide Teniposide, a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
T1620 Pazufloxacin Mesylate Pazufloxacin (INN) is a fluoroquinolone antibiotic.
T1625 Lomefloxacin hydrochloride Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inh...
T1640 Ciprofloxacin Ciprofloxacin, a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram...
T1703 SN-38 SN-38 is an active metabolite of CPT-11.
T2160 Suramin Sodium Salt Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gr...
T2764 10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T2830 Betulinic acid Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretro...
T2937 4'-Demethylepipodophyllotoxin 4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
T3117 Marbofloxacin Marbofloxacin is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.
T3181 SW044248 SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
T3186 NU2058 NU2058 is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
T3339 Sophoridine Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and e...
T3481 Bimolane Bimolane is a topoisomerase II inhibitor.
T4047 Bisantrene Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA sin...
T6228 Irinotecan Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the acti...
T6336 Amonafide Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA ...
T6567 Levofloxacin Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abd...
T6588 Mitoxantrone Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA re...
T6628 Pirarubicin Pirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as...
Epirubicin hydrochloride
T0125CAS 56390-09-1
Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
Etoposide HOT
T0132CAS 33419-42-0
Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50: 60.3 μM).
Mitoxantrone hydrochloride
T0158CAS 70476-82-3
Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
Ciprofloxacin hydrochloride
T0250CAS 93107-08-5
Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.
Cinoxacin
T0274CAS 28657-80-9
Cinoxacin, an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.
Moxifloxacin hydrochloride
T0331CAS 186826-86-8
Moxifloxacin is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens. Moxifloxacin has been l...
Pefloxacin Mesylate
T0425CAS 70458-95-6
Pefloxacin mesylate is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Pefloxacin Mesylate Dihydrate
T0425LCAS 149676-40-4
Pefloxacin mesylate dehydrate, an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
Irinotecan hydrochloride trihydrate
T0486CAS 136572-09-3
Irinotecan HCl-trihydrate keeps DNA from unwinding by inhibiting topoisomerase 1.
Irinotecan Hydrochloride
T0486LCAS 100286-90-6
Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active m...
Enoxacin Sesquihydrate
T0717CAS 84294-96-2
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
Enoxacin
T0717LCAS 74011-58-8
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Ofloxacin
T0902CAS 82419-36-1
Ofloxacin is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzy...
Nalidixic acid
T0909CAS 389-08-2
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA ...
Nalidixic acid sodium salt
T0909LCAS 3374-05-8
Nalidixic acid sodium salt is an antimicrobial agent with a limited bacteriocidal spectrum.
Albamycinsodium
T0974CAS 1476-53-5
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
Doxorubicin hydrochloride HOT
T1020CAS 25316-40-9
Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
Flumequine
T1060CAS 42835-25-6
Flumequine is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II...
Sparfloxacin
T1095CAS 110871-86-8
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
Podophyllotoxin
T1121CAS 518-28-5
Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
(S)-(+)-Camptothecin
T1123CAS 7689-03-4
(S)-(+)-Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I), isolated from Camptotheca acuminata.
Topotecan hydrochloride
T1174CAS 119413-54-6
Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer.
Amsacrine
T1206CAS 51264-14-3
Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specific...
Gatifloxacin
T1293CAS 112811-59-3
Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase...
Fleroxacin
T1294CAS 79660-72-3
Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
Norfloxacin
T1306CAS 70458-96-7
Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Lomefloxacin
T1444CAS 98079-51-7
Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
Levofloxacin Hemihydrate
T1451CAS 138199-71-0
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
Gemifloxacin mesylate
T1492CAS 210353-53-0
Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin M...
Hydroxy Camptothecine
T1521CAS 64439-81-2
Hydroxy Camptothecine is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzy...
Teniposide
T1523CAS 29767-20-2
Teniposide, a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
Pazufloxacin Mesylate
T1620CAS 163680-77-1
Pazufloxacin (INN) is a fluoroquinolone antibiotic.
Lomefloxacin hydrochloride
T1625CAS 98079-52-8
Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inh...
Ciprofloxacin
T1640CAS 85721-33-1
Ciprofloxacin, a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram...
SN-38
T1703CAS 86639-52-3
SN-38 is an active metabolite of CPT-11.
Suramin Sodium Salt
T2160CAS 129-46-4
Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gr...
10-Hydroxycamptothecin
T2764CAS 19685-09-7
10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
Betulinic acid
T2830CAS 472-15-1
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretro...
4'-Demethylepipodophyllotoxin
T2937CAS 6559-91-7
4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
Marbofloxacin
T3117CAS 115550-35-1
Marbofloxacin is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.
SW044248
T3181CAS 522650-83-5
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
NU2058
T3186CAS 161058-83-9
NU2058 is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
Sophoridine
T3339CAS 6882-68-4
Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and e...
Bimolane
T3481CAS 74550-97-3
Bimolane is a topoisomerase II inhibitor.
Bisantrene
T4047CAS 78186-34-2
Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA sin...
Irinotecan
T6228CAS 97682-44-5
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the acti...
Amonafide
T6336CAS 69408-81-7
Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA ...
Levofloxacin
T6567CAS 100986-85-4
Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abd...
Mitoxantrone
T6588CAS 65271-80-9
Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA re...
Pirarubicin
T6628CAS 72496-41-4
Pirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as...