T38622 |
Bcl-xL antagonist 2
|
|
BCL
|
|
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL a... |
T6275 |
Obatoclax Mesylate
|
Obatoclax , GX15-070 |
BCL
,
Autophagy
,
Parasite
|
|
Obatoclax is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c r... |
T17018 |
TCPOBOP
|
|
BCL
|
|
TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCP... |
T39910 |
Desmorpholinyl Navitoclax-NH-Me
|
Desmorpholinyl ABT-263-NH-Me |
BCL
|
|
Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiq... |
T40412L |
BAD (103-127) (human) acetate
|
BAD (103-127) (human) acetate (331762-68-6 Free base) |
Others
|
|
BAD (103-107) (human) is a 25-mer Bad polypeptide from the BAD BH3 domain that antagonizes the effects of Bcl-xl. |
T7027 |
EURYCOMANONE
|
Pasakbumin A |
Others
|
|
Eurycomanone is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regula... |
T6S1653 |
Albiflorin
|
Alibiflorin |
Reactive Oxygen Species
|
|
1. Albiflorin has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action again... |
T6S1418 |
Praeruptorin C
|
|
Antioxidant
,
Calcium Channel
|
|
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C p... |
T5408 |
BI-3802
|
|
BCL
|
|
BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 value of ≤3 nM. ... |
T6778 |
BDA-366
|
|
BCL
|
|
BDA-366 is a potent Bcl2 antagonist, binding Bcl2-BH4 domain with high affinity and selectivity (Ki = 3.3 nM). BDA-366 i... |
T1979 |
AVN-944
|
VX-944 |
Dehydrogenase
|
|
AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. |
T16028 |
IMB-XH1
|
Mcl1-IN-2 |
BCL
,
Antibacterial
|
|
Mcl1-IN-2 is a myeloid cell factor 1 (Mcl-1) inhibitor. |
T39961 |
Bcl-2-IN-2
|
|
|
|
Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC 50 of 0.034 nM and also inhibits Bcl-xL with an IC 50 of... |
T11968 |
MCL-1/BCL-2-IN-1
|
|
BCL
|
|
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3... |
T6314 |
(R)-(-)-Gossypol
|
AT101 , R-(-)-gossypol acetic acid |
BCL
,
Autophagy
|
|
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and ... |
T38810 |
BM-1197
|
|
|
|
BM-1197 is a potent and selective inhibitor of dual Bcl-2/Bcl-xL , with IC 50 s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-x... |
T40230 |
Mcl-1 inhibitor 6
|
|
|
|
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a K d of 0.23 nM... |
T39909 |
XZ739
|
|
|
|
XZ739, a Cereblon -dependent PROTAC BCL-XL ( Bcl-2 family member) degrader with a DC 50 value of 2.5 nM in MOLT-4 cells ... |
T40135 |
PZ703b
|
|
|
|
PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition. |
T39135 |
S65487 hydrochloride
|
VOB560 hydrochloride |
|
|
S65487 (VOB560) hydrochloride is a potent and selective Bcl-2 inhibitor. S65487 hydrochloride is also active on BCL-2 mu... |