T1237 |
Azathioprine |
Azathioprine, an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation. |
T1781 |
GW 9508 |
GW9508 is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. |
T1793 |
MBX2982 |
MBX-2982 is a selective, orally-available GPR119 agonist, used for the treatment of diabetes. |
T2036 |
GTPL5846 |
6-OAU(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105...
|
T2058 |
Palosuran |
Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor. |
T2088 |
APD 668 |
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively. |
T2351 |
TAK875 |
TAK875 is a potent, selective and orally bioavailable GPR40 agonist. |
T2351L |
TAK-875 Hemihydrate |
TAK-875 is a selective GPR40 agonist with EC50 of 14 nM, 400-fold more potent than oleic acid. |
T2396 |
Ramatroban |
Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. |
T2528 |
Latanoprost |
Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. |
T2664 |
Timapiprant |
OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM). |
T2701 |
GSK1292263 |
GSK1292263 is a GPR119 agonist and has been investigated for the treatment of DIABETES MELLITUS, TYPE 2. |
T3119 |
JNJ-63533054 |
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. |
T3171 |
GSK137647A |
GSK137647A is a selective FFA4 agonist. |
T3176 |
APD597 |
APD597 is a GPR119 agonist, used in the treatment of type 2 diabetes. |
T3433 |
TUG-891 |
TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty a...
|
T3520 |
Setipiprant |
Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced ...
|
T3965 |
Fevipiprant |
Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist. |
T6399 |
AZD1981 |
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors...
|
T6855 |
HA15 |
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells ...
|
T7010 |
VER155008 |
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fol...
|
T4312 |
GPR120 receptor agonist |
A potent and selective GPR120 receptor agonist. |
T4689 |
Palosuran hydrochloride 540769-28-6(free base) |
Palosuran is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM. |
T4626 |
TC-O 9311 |
TC-O 9311 is a potent GPR139 agonist. |
T5828 |
MS21570 |
MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice. |
T7261 |
Grp94 Inhibitor-1 |
Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM). |
T7127 |
DC260126 |
DC260126 is a small-molecule antagonist of FFA1 (GPR40) |
T7359 |
CAY10471 Racemate |
CAY 10471 is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, an...
|
T7482 |
3-chloro-5-hydroxybenzoic Acid |
3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 M) |
T7713 |
Benzyl nicotinate |
Benzyl Nicotinate is a agonist of GPR109A receptor and GPR109B receptor |
TQ0020 |
AMG 837 calcium hydrate |
AMG 837 calcium hydrate is a potent GPR40 agonist(EC50: 13 nM) with highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM). |
TQ0051 |
MK-7246 |
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM). |
TQ0108 |
MK-6892 |
MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM). |
TQ0241 |
TUG-770 |
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1). |
T1915 |
AM251 |
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
|
T8353 |
Pamoic acid |
Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity. |
TN2268 |
Tetrahydromagnolol |
Tetrahydromagnolol can activate cannabinoid (CB) receptors. |
T8329 |
AR 231453 |
AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function. |
T12216 |
NF-56-EJ40 |
NF-56-EJ40 is a high-affinity and highly selective antagonist of human SUCNR1 (GPR91) (IC50 of 25 nM). |
T12375 |
Setogepram sodium salt |
Setogepram sodium salt is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflammatory and anti-proli...
|
T10889 |
CRTh2 antagonist 2 |
CRTh2 antagonist selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia. |
T11044 |
Dihydromunduletone |
Dihydromunduletone (DHM) is a carotenoid derivative and selective strong adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonists, does...
|
T14200 |
AM-1638 |
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM). |
T14202 |
AM-4668 |
AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respe...
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T15283 |
Firuglipel |
Firuglipel is an orally available and selective agonist of GPR119. |
T15352 |
FTBMT |
FTBMT is a selective GPR52 agonist (EC50: 75 nM) and has antipsychotic and procognitive properties. |
T15364 |
G-1 |
G-1 is a nonsteroidal, high-affinity, and selective GPR30 agonist (Ki: 11 nM). |
T15388 |
GLPG0974 |
GLPG0974 is an antagonist of free fatty acid receptor-2 (IC50: 9 nM). |
T12883 |
Setogepram |
Setogepram is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84,with anti-inflammatory, anti-fibroticand anti-proliferative action...
|
T10691 |
CAY10595 |
CAY10595 is a potent antagonist of the CRTH2/DP2 receptor (Ki: 10 nM). |
T11452 |
GPR120 Agonist 1 |
GPR120 agonist 1 is an effective and selective GPR120 agonist with good anti-diabetes effect and safety, and is a candidate drug. |
T11458 |
GPR40/FFAR1 modulator 1 |
GPR40/FFAR1 modulator 1 is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1). |
T11460 |
GPR4 antagonist 1 |
GPR4 antagonist 1 is a GPR4 antagonist, with an IC50 of 189 nM. |
T11461 |
NE 52-QQ57 |
NE 52-QQ57 has anti-inflammatory activity. NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. |
T11462 |
GPR84 antagonist 8 |
GPR84 antagonist 8 is a selective GPR84 antagonist. |
T11560 |
hGPR91 antagonist 1 |
HGPR91 antagonist 1 is a potent and selective small molecule hGPR91 antagonist with an IC50 of 7 μM. |
T15432 |
GSK256073 |
GSK256073 is a selective and orally active GPR109A (G-protein coupled receptor 109A) agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-ca...
|
T15448 |
GW-1100 |
GW-1100 is a selective antagonist of GPR40 (pIC50: 6.9). GW1100 also plays the role of a GPR40 inverse agonist. |
T10084 |
CRTh2 antagonist 1 |
CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM). |
T10507 |
GPR40 Agonist 2 |
GPR40 Agonist 2 is a GPR40 agonist extracted from patent WO2009054479A1. It can be used in the research of diabetes. |
T15824 |
Lysergol |
Lysergol has been used as a hypotensive, psychotropic analgesic, and uterus- and intestine-stimulating drug. Lysergol is a clavinet alkaloid isolated from seeds...
|
TP2165 |
Urotensin II, mouse acetate |
Urotensin II, mouse acetate is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor. |
TP2166 |
Urotensin II, mouse TFA |
Urotensin II, mouse TFA is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor. |
T12778L |
RTI-13951-33 |
RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay). |
T5036 |
cangrelor tetrasodium |
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects. |