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NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2641 15-Methoxypinusolidic acid 769928-72-5 98%
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
T8447 Ro 8-4304 195988-65-9 98%
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 569-83-5 98%
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
T16473 Perzinfotel 144912-63-0 98%
Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with neu...
T22654 Selfotel 110347-85-8 98%
NMDA receptor antagonist
T7778 Glypromate 32302-76-4 98%
Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
T16332 NKH477 138605-00-2 98%
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 sh...
T3407 Rapastinel 117928-94-6 98%
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T60237 L-Cysteine S-sulfate 1637-71-4 98%
L-Cysteine S-sulfate is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1].
T22900 L-701252 151057-13-5 98%
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral isch...
T22517 5,7-Dichlorokynurenic acid 131123-76-7 98%
NMDA receptor antagonist
T12234 NMDA-IN-1 700878-19-9 98%
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
T25196 BZAD01 305339-41-7 98%
BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
T3407L Rapastinel acetate 491872-39-0 98%
Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
TQ0279 Ibotenic acid 2552-55-8 98%
Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
T20571 Cis-PDA 46026-75-9 98%
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
T22733 DL-AP5 76326-31-3
NMDA antagonist
T4096 Quinolinic acid 89-00-9
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T22542 1-Aminocyclobutanecarboxylic acid 22264-50-2
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T7867 Flutriafol 76674-21-0 100%
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
15-Methoxypinusolidic acid
TN2641
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
Ro 8-4304
T8447
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
Perzinfotel
T16473
Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with neu...
Selfotel
T22654
NMDA receptor antagonist
Glypromate
T7778
Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
NKH477
T16332
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 sh...
Rapastinel
T3407
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
L-Cysteine S-sulfate
T60237
L-Cysteine S-sulfate is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1].
L-701252
T22900
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral isch...
5,7-Dichlorokynurenic acid
T22517
NMDA receptor antagonist
NMDA-IN-1
T12234
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
BZAD01
T25196
BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
Rapastinel acetate
T3407L
Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
Ibotenic acid
TQ0279
Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
cis-PDA
T20571
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
DL-AP5
T22733
NMDA antagonist
Quinolinic acid
T4096
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
1-Aminocyclobutanecarboxylic acid
T22542
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
Flutriafol
T7867
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
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