NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

Cat. No.	Product name	CAS No.	Purity
TN2641	15-Methoxypinusolidic acid	769928-72-5	98%
TN2641	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
T16473	Perzinfotel	144912-63-0	98%
T16473	Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with neu...
T8447	Ro 8-4304	195988-65-9	98%
T8447	Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
T16332	NKH477	138605-00-2	98%
T16332	NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 sh...
T3407	Rapastinel	117928-94-6	98%
T3407	Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T22542	1-Aminocyclobutanecarboxylic acid	22264-50-2	98%
T22542	1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T20571	Cis-PDA	46026-75-9	98%
T20571	cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
T7778	Glypromate	32302-76-4	98%
T7778	Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
T72662	NMDAR/TRPM4-IN-2	2243506-33-2	98%
T72662	NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T27606	Indantadol HCl	202914-18-9	98%
T27606	Indantadol HCl is a NMDA antagonist and nonselective MAO inhibitor.
T16451	PEAQX tetrasodium hydrate	T16451	98%
T16451	PEAQX tetrasodium hydrate is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base...
T25196	BZAD01	305339-41-7	98%
T25196	BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
T4096	Quinolinic acid	89-00-9	98%
T4096	Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T22733	DL-AP5	76326-31-3	98%
T22733	NMDA antagonist
T13854	Quininic acid	86-68-0	98%
T13854	Quinic acid is an organic acid extracted from the bark of Eucalyptus, Cinchona and other plants in the Asteraceae family.
T8459	DNQX disodium salt	1312992-24-7	98%
T8459	DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
T8450	TCN 213	556803-08-8	98%
T8450	TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T10930	D-AP5	79055-68-8	98%
T10930	D-AP5 is a NMDA receptor antagonist.
T0030L	Bupivacaine	38396-39-3	98%
T0030L	Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50...
T0954	Halothane	151-67-7	98%
T0954	Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...