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NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.
Cat No. product name
T5385 Radiprodil Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
T9133 Caroverine hydrochloride Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that ...
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
T22674 Co 101244 hydrochloride NR2B-containing NMDA receptor antagonist
T8459 DNQX disodium salt DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
T16801 (RS)-(Tetrazol-5-yl)glycine (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC5...
T22654 Selfotel NMDA receptor antagonist
T7870 TCN 201 TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T24918 UBP710 UBP710 is an effective and selective NMDA receptor modulator.
T22517 5,7-Dichlorokynurenic acid NMDA receptor antagonist
T6608 NMDA N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
T22748 DQP 1105 NMDA receptor antagonist
T1909 L-701324 L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
T1443 Memantine hydrochloride Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T3407 Rapastinel Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T22542 1-Aminocyclobutanecarboxylic acid 1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
TQ0027 Transcrocetinate disodium Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
T10930 D-AP5 D-AP5 is a NMDA receptor antagonist.
T5819 Rapastinel Trifluoroacetate Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
T1324 O-Phospho-L-serine Phosphoserine is the phosphoric acid ester of serine.
T2362 QNZ46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
TQ0233 Traxoprodil Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
TN1432 Bacopasaponin C Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
T17293 ZL006 ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T12234 NMDA-IN-1 NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
T6504 Flupirtine maleate Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
T4096 Quinolinic acid Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T3320 Dizocilpine Maleate (+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
T22583 Arcaine sulfate NMDA antagonist
T4979 Procyclidine hydrochloride Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T4752 1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from se...
T6352 (-)-Dizocilpine maleate MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
T25196 BZAD01 BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
T20571 Cis-PDA cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
T1186 Ifenprodil Tartrate Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T0015 Mephenesin Mephenesin is a centrally acting muscle relaxant with a short duration of action.
T4171 PEAQX PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 n...
T1897 MDL-29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T1186L Ifenprodil Ifenprodil is an NMDA antagonist acting at the polyamine site; α2 adrenergic receptor ligand; α-Adrenergic central and peripheral vasodilator; Neuroprotective a...
T4885 (-)-Aspartic acid D-Aspartic acid (D-Asp) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA r...
T8447 Ro 8-4304 Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
T7867 Flutriafol Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
T12110 MRZ 2-514 MRZ 2-514 is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist(Ki of 33 μM).
T15684 L-689560 L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in ...
T8394 D-Serine (R)-Serine is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
T1751 Eliprodil Eliprodil(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has b...
T1946 Felbamate Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T6259 Dizocilpine MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
Radiprodil
T5385
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
Caroverine hydrochloride
T9133
Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that ...
Procaine hydrochloride
T0802
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
Co 101244 hydrochloride
T22674
NR2B-containing NMDA receptor antagonist
DNQX disodium salt
T8459
DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
(RS)-(Tetrazol-5-yl)glycine
T16801
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC5...
Selfotel
T22654
NMDA receptor antagonist
TCN 201
T7870
TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
UBP710
T24918
UBP710 is an effective and selective NMDA receptor modulator.
5,7-Dichlorokynurenic acid
T22517
NMDA receptor antagonist
NMDA
T6608
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
DQP 1105
T22748
NMDA receptor antagonist
L-701324
T1909
L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
Memantine hydrochloride
T1443
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Rapastinel
T3407
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
1-Aminocyclobutanecarboxylic acid
T22542
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
Transcrocetinate disodium
TQ0027
Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
D-AP5
T10930
D-AP5 is a NMDA receptor antagonist.
Rapastinel Trifluoroacetate
T5819
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
O-Phospho-L-serine
T1324
Phosphoserine is the phosphoric acid ester of serine.
QNZ46
T2362
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
Urethane
T0051
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Traxoprodil
TQ0233
Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
Bacopasaponin C
TN1432
Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
ZL006
T17293
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
NMDA-IN-1
T12234
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
Flupirtine maleate
T6504
Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
Quinolinic acid
T4096
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
Dizocilpine Maleate
T3320
(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
Arcaine sulfate
T22583
NMDA antagonist
Procyclidine hydrochloride
T4979
Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
1-Aminocyclopropane-1-carboxylic acid
T4752
1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from se...
(-)-Dizocilpine maleate
T6352
MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
BZAD01
T25196
BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
cis-PDA
T20571
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
Ifenprodil Tartrate
T1186
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
Mephenesin
T0015
Mephenesin is a centrally acting muscle relaxant with a short duration of action.
PEAQX
T4171
PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 n...
MDL-29951
T1897
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
Ifenprodil
T1186L
Ifenprodil is an NMDA antagonist acting at the polyamine site; α2 adrenergic receptor ligand; α-Adrenergic central and peripheral vasodilator; Neuroprotective...
(-)-Aspartic acid
T4885
D-Aspartic acid (D-Asp) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA r...
Ro 8-4304
T8447
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
Flutriafol
T7867
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
MRZ 2-514
T12110
MRZ 2-514 is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist(Ki of 33 μM).
L-689560
T15684
L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in ...
D-Serine
T8394
(R)-Serine is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
Eliprodil
T1751
Eliprodil(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has b...
Felbamate
T1946
Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
Dizocilpine
T6259
MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
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