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NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2641 15-Methoxypinusolidic acid 769928-72-5 98%
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
T16473 Perzinfotel 144912-63-0 98%
Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with neu...
T8447 Ro 8-4304 195988-65-9 98%
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
T16332 NKH477 138605-00-2 98%
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 sh...
T3407 Rapastinel 117928-94-6 98%
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T22542 1-Aminocyclobutanecarboxylic acid 22264-50-2 98%
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T20571 Cis-PDA 46026-75-9 98%
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
T7778 Glypromate 32302-76-4 98%
Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
T72662 NMDAR/TRPM4-IN-2 2243506-33-2 98%
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T27606 Indantadol HCl 202914-18-9 98%
Indantadol HCl is a NMDA antagonist and nonselective MAO inhibitor.
T16451 PEAQX tetrasodium hydrate T16451 98%
PEAQX tetrasodium hydrate is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base...
T25196 BZAD01 305339-41-7 98%
BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
T4096 Quinolinic acid 89-00-9 98%
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T22733 DL-AP5 76326-31-3 98%
NMDA antagonist
T13854 Quininic acid 86-68-0 98%
Quinic acid is an organic acid extracted from the bark of Eucalyptus, Cinchona and other plants in the Asteraceae family.
T8459 DNQX disodium salt 1312992-24-7 98%
DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
T8450 TCN 213 556803-08-8 98%
TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T10930 D-AP5 79055-68-8 98%
D-AP5 is a NMDA receptor antagonist.
T0030L Bupivacaine 38396-39-3 98%
Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50...
T0954 Halothane 151-67-7 98%
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...
15-Methoxypinusolidic acid
TN2641
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
Perzinfotel
T16473
Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with neu...
Ro 8-4304
T8447
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
NKH477
T16332
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 sh...
Rapastinel
T3407
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
1-Aminocyclobutanecarboxylic acid
T22542
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
cis-PDA
T20571
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
Glypromate
T7778
Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
NMDAR/TRPM4-IN-2
T72662
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
Indantadol HCl
T27606
Indantadol HCl is a NMDA antagonist and nonselective MAO inhibitor.
PEAQX tetrasodium hydrate
T16451
PEAQX tetrasodium hydrate is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base...
BZAD01
T25196
BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
Quinolinic acid
T4096
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
DL-AP5
T22733
NMDA antagonist
Quininic acid
T13854
Quinic acid is an organic acid extracted from the bark of Eucalyptus, Cinchona and other plants in the Asteraceae family.
DNQX disodium salt
T8459
DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
TCN 213
T8450
TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
D-AP5
T10930
D-AP5 is a NMDA receptor antagonist.
Bupivacaine
T0030L
Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50...
Halothane
T0954
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...
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