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Neuroscience NMDAR

NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.
Cat No. product name
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0349 Riluzole Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC L...
T0802 Procaine hydrochloride
T0954 Anestan Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
T1186 Ifenprodil Tartrate Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T1308 Orphenadrine hydrochloride Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T1324 Phosphoserine Phosphoserine is the phosphoric acid ester of serine.
T1443 Memantine hydrochloride Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T1751 Eliprodil Eliprodil(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has ...
T1897 MDL 29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T1909 L-701324 L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T1946 Felbamate Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T2362 QNZ46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T3320 Dizocilpine Maleate (+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug ha...
T4171 PEAQX PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29,600 n...
T4225 Dextrorphan tartrate Dextrorphan D-tartrate is a noncompetitive NMDA glutamate receptor antagonist.
T6259 Dizocilpine MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
T6504 Flupirtine maleate Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal ...
T6608 NMDA N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
T6975 Sarcosine Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
T4096 Quinolinic acid Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T4979 Procyclidine hydrochloride Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T5385 Radiprodil Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic...
T4885 D-Aspartic acid D-Aspartic acid (D-Asp) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA ...
T4752 1-Aminocyclopropanecarboxylic acid 1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from s...
T5080 Spermidine hydrochloride Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
T5819 Rapastinel Trifluoroacetate Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
TQ0027 Transcrocetinate disodium Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
TQ0233 Traxoprodil Traxoprodil (CP101,606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
TQ0279 Ibotenic acid Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
T7778 Glypromate Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
T3486 3-MATIDA 3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
T7867 Flutriafol Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist 
T7870 TCN-201 TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T8394 (R)-Serine (R)-Serine is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
TN1420 Bacopaside I Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/P...
TN1432 Bacopasaponin C Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
T8351 UBP551 UBP551 is a potent and selective NMDA receptors modulator.
T16332 NKH477 NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 s...
T16473 Perzinfotel Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with ne...
T8626 4-oxo-1,4-dihydroquinoline-2-carboxylic acid 4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
TN5263 Xanthohumol Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Riluzole
T0349CAS 1744-22-5
Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC L...
Procaine hydrochloride
T0802CAS 51-05-8
Anestan
T0954CAS 151-67-7
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
Ifenprodil Tartrate
T1186CAS 23210-58-4
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
Orphenadrine hydrochloride
T1308CAS 341-69-5
Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Phosphoserine
T1324CAS 407-41-0
Phosphoserine is the phosphoric acid ester of serine.
Memantine hydrochloride
T1443CAS 41100-52-1
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Eliprodil
T1751CAS 119431-25-3
Eliprodil(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has ...
MDL 29951
T1897CAS 130798-51-5
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
L-701324
T1909CAS 142326-59-8
L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
Felbamate
T1946CAS 25451-15-4
Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
QNZ46
T2362CAS 1237744-13-6
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
Dizocilpine Maleate
T3320CAS 77086-22-7
(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug ha...
PEAQX
T4171CAS 459836-30-7
PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29,600 n...
Dextrorphan tartrate
T4225CAS 143-98-6
Dextrorphan D-tartrate is a noncompetitive NMDA glutamate receptor antagonist.
Dizocilpine
T6259CAS 77086-21-6
MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
Flupirtine maleate
T6504CAS 75507-68-5
Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal ...
NMDA
T6608CAS 6384-92-5
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
Sarcosine
T6975CAS 107-97-1
Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
Quinolinic acid
T4096CAS 89-00-9
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
Procyclidine hydrochloride
T4979CAS 1508-76-5
Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
Radiprodil
T5385CAS 496054-87-6
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic...
D-Aspartic acid
T4885CAS 1783-96-6
D-Aspartic acid (D-Asp) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA ...
1-Aminocyclopropanecarboxylic acid
T4752CAS 22059-21-8
1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from s...
Spermidine hydrochloride
T5080CAS 334-50-9
Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
Rapastinel Trifluoroacetate
T5819CAS 1435786-04-1
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
Transcrocetinate disodium
TQ0027CAS 591230-99-8
Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
Traxoprodil
TQ0233CAS 134234-12-1
Traxoprodil (CP101,606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
Ibotenic acid
TQ0279CAS 2552-55-8
Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
Glypromate
T7778CAS 32302-76-4
Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
3-MATIDA
T3486CAS 518357-51-2
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
Flutriafol
T7867CAS 76674-21-0
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist 
TCN-201
T7870CAS 852918-02-6
TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
(R)-Serine
T8394CAS 312-84-5
(R)-Serine is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
Bacopaside I
TN1420CAS 382148-47-2
Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/P...
Bacopasaponin C
TN1432CAS 178064-13-6
Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
UBP551
T8351CAS 89-35-0
UBP551 is a potent and selective NMDA receptors modulator.
NKH477
T16332CAS 138605-00-2
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 s...
Perzinfotel
T16473CAS 144912-63-0
Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with ne...
4-oxo-1,4-dihydroquinoline-2-carboxylic acid
T8626CAS 13593-94-7
4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
Xanthohumol
TN5263CAS 569-83-5
Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...