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Search Result

Search Results for " lipoxygenase "

Targets

Lipoxygenase Apoptosis Others Lipoxygenase

189

Compounds

43

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8794 4-MMPB 15-Lipoxygenase Inhibitor 1 Apoptosis , Others , Lipoxygenase
15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB (15-Lipoxygenase Inhibitor 1) has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxyg...
T10151 5-Lipoxygenase-In-1 Lipoxygenase
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.
T76164 Lipoxygenase, general
Lipoxygenase (LOX), a dioxygenase, plays a crucial role in biochemistry by catalyzing the transformation of polyunsaturated fatty acids, including linoleic and arachidonic acids, into their respective hydroperoxides [1].
T75122 5-Lipoxygenase-IN-3
5-Lipoxygenase-IN-3 (Compound 14), with an IC50 of less than 1 μM, serves as an inhibitor of 5-Lipoxygenase. This compound is utilized in the research of inflammatory diseases, cancer, stroke, and Alzheimer's disease [1]...
T8950 CAY10698 Lipoxygenase
CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).
T8356 FPL 62064 Lipoxygenase , COX
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).
T2367 SKF-86002 SKF86002 p38 MAPK , TNF
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
T4347 ML355 Lipoxygenase
ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
T6243 U-73122 U73122 Phospholipase , Ferroptosis , Lipoxygenase
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
T6568 Licofelone ML-3000 Apoptosis , Lipoxygenase , COX
Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity ass...
T16503 PF-4191834 PF-04191834 Lipoxygenase
PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the ...
T21902 ML351 Lipoxygenase
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
T7540 2,5-Di-tert-butylhydroquinone BHQ Calcium Channel , Lipoxygenase , COX
2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
T21746 Terameprocol tetramethyl Nordihydroguaiaretic Acid,EM-1421 HIV Protease
Terameprocol (EM-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol sh...
T10098 PGS-IN-1 KME-4 Lipoxygenase , Prostaglandin Receptor
PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
T22398 Phenidone 1-phenyl-3-pyrazolidinone Lipoxygenase , COX
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg...
T0477 Zileuton Abbott 64077,A 64077 Ferroptosis , Lipoxygenase , COX
Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca...
T6576 Malotilate Malotilatum,NKK 105,Kantec Lipoxygenase
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.
T5200 Indirubin-3'-monoxime Indirubin-3'-oxime GSK-3 , Lipoxygenase , CDK
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).
T7724 Tepoxalin RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485 Lipoxygenase , COX
Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxyge...
T19679 Benoxaprofen NSC 299582,LY-90459,Benoxaphen. Compound 90459 COX
Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.
T27026 CJ-13,610 CJ 13610,CJ-13610 Lipoxygenase
CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.
T24488 MLS000545091 MLS-000545091,MLS 000545091
MLS000545091 is a potent and selective human epithelial 15-lipoxygenase-2 mixed-type inhibitor.
T12784 RWJ 63556 RWJ-63556 Lipoxygenase , COX
RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
T61211 5-LOX-IN-1 Lipoxygenase
5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research.
T22054 BW 755C Lipoxygenase
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.
T17191 Bunaprolast U66858 Lipoxygenase , LTR
Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase and TXB2 release.
T22358 Etalocib LY293111,VML295 Apoptosis , Leukotriene Receptor , LTR
Etalocib (LY293111) is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-l...
T16817 S-2474 Lipoxygenase , COX
S-2474, an inhibitor of COX-2 and 5-lipoxygenase, has anti-inflammatory and neuroprotective activities and inhibits Abeta (25 - 35) and Abeta (1 - 40) induced cell death.
T27244 Efletirizine UCB 28754,UCB-28754,UCB28754 Lipoxygenase , Histamine Receptor
Efletirizine (UCB-28754) is a histamine receptor antagonist with inhibitory effects on the enzyme 5-lipoxygenase (5-LO), and is useful in the topical treatment of allergic diseases.
T70188 ER-34122 Lipoxygenase
ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor, exhibits potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model.
T9023 Atuliflapon AZD5718 FLAP
Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.
T25737 Linetastine TMK 688,TMK-688,TMK688 Lipoxygenase , LTR , Histamine Receptor
Linetastine (TMK-688) is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of asthma, atherosclerosis, and peptic ulcers.
TQ0159 U-73343 U 73343 Phospholipase
U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor...
T22502 2-TEDC Lipoxygenase
2-TEDC is a potent lipoxygenase (LOX) inhibitor with inhibitory effects on 5-LOX, 12-LOX, and 15-LOX with IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively.2-TEDC can be used in the study of atherosclerosis.
T77288 KKII5 Lipoxygenase
KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers of some compounds to receive electrons.
T68155 Tebufelone Prostaglandin Receptor , LTR
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticul...
T6893 MK-886 MK886,L 663536 Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T10208 A-69412 N-1-(Fur-3-ylethyl)-N-hydroxyurea Lipoxygenase
A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other inflammatory and allergic...
T11487 Fiboflapon GSK2190915,AM-803 FLAP
Fiboflapon (GSK2190915) is an orally available and effective 5-lipoxygenase-activating protein (FLAP) inhibitor that binds FLAP with a titer of 2.9 nM and inhibition of LTB4 in human blood with an IC50 of 76 nM.
T67908 ThioLox Lipoxygenase
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has anti-inflammatory and neuroprotective effects, and has a st...
T9878 Croconazole Lipoxygenase , LTR
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraeno...
T7530 PD146176 NSC168807 Ferroptosis , Lipoxygenase , Autophagy
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology...
T68173 ZD-2138 Ici-D2138 Lipoxygenase
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolat...
T8844 Diflapolin Others , FLAP , Epoxide Hydrolase
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
T16087 Quiflapon MK-591 Apoptosis , FLAP
Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotr...
T68037L CBS-1114 HCl N-Phenylbenzamidrazone hydrochloride,cbs-1114 HCl(46721-85-1 Free base) Lipoxygenase
CBS-1114 HCl (N-Phenylbenzamidrazone hydrochloride) is a 5-lipoxygenase inhibitor and an anti-inflammatory compound in a good eye-permeable model.CBS-1114 HCl maintains and improves cardiac function, attenuates cardiac d...
T4657 WHI-P97 JAK
WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ...
T1482 Ciclopirox HOE296b ATPase , Ferroptosis , Antibacterial , Autophagy , Antifungal
Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spect...
T77528 5-LOX-IN-2 Apoptosis , Lipoxygenase
5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apopt...

Compounds

4-MMPB
T8794
Synonym: 15-Lipoxygenase Inhibitor 1
Target: Apoptosis, Others, Lipoxygenase
5-Lipoxygenase-In-1
T10151
Synonym:
Target: Lipoxygenase
Lipoxygenase, general
T76164
Synonym:
Target:
5-Lipoxygenase-IN-3
T75122
Synonym:
Target:
CAY10698
T8950
Synonym:
Target: Lipoxygenase
FPL 62064
T8356
Synonym:
Target: Lipoxygenase, COX
SKF-86002
T2367
Synonym: SKF86002
Target: p38 MAPK, TNF
ML355
T4347
Synonym:
Target: Lipoxygenase
U-73122
T6243
Synonym: U73122
Target: Phospholipase, Ferroptosis, Lipoxygenase
Licofelone
T6568
Synonym: ML-3000
Target: Apoptosis, Lipoxygenase, COX
PF-4191834
T16503
Synonym: PF-04191834
Target: Lipoxygenase
ML351
T21902
Synonym:
Target: Lipoxygenase
2,5-Di-tert-butylhydroquinone
T7540
Synonym: BHQ
Target: Calcium Channel, Lipoxygenase, COX
Terameprocol
T21746
Synonym: tetramethyl Nordihydroguaiaretic Acid,EM-1421
Target: HIV Protease
PGS-IN-1
T10098
Synonym: KME-4
Target: Lipoxygenase, Prostaglandin Receptor
Phenidone
T22398
Synonym: 1-phenyl-3-pyrazolidinone
Target: Lipoxygenase, COX
Zileuton
T0477
Synonym: Abbott 64077,A 64077
Target: Ferroptosis, Lipoxygenase, COX
Malotilate
T6576
Synonym: Malotilatum,NKK 105,Kantec
Target: Lipoxygenase
Indirubin-3'-monoxime
T5200
Synonym: Indirubin-3'-oxime
Target: GSK-3, Lipoxygenase, CDK
Tepoxalin
T7724
Synonym: RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485
Target: Lipoxygenase, COX
Benoxaprofen
T19679
Synonym: NSC 299582,LY-90459,Benoxaphen. Compound 90459
Target: COX
CJ-13,610
T27026
Synonym: CJ 13610,CJ-13610
Target: Lipoxygenase
MLS000545091
T24488
Synonym: MLS-000545091,MLS 000545091
Target:
RWJ 63556
T12784
Synonym: RWJ-63556
Target: Lipoxygenase, COX
5-LOX-IN-1
T61211
Synonym:
Target: Lipoxygenase
BW 755C
T22054
Synonym:
Target: Lipoxygenase
Bunaprolast
T17191
Synonym: U66858
Target: Lipoxygenase, LTR
Etalocib
T22358
Synonym: LY293111,VML295
Target: Apoptosis, Leukotriene Receptor, LTR
S-2474
T16817
Synonym:
Target: Lipoxygenase, COX
Efletirizine
T27244
Synonym: UCB 28754,UCB-28754,UCB28754
Target: Lipoxygenase, Histamine Receptor
ER-34122
T70188
Synonym:
Target: Lipoxygenase
Atuliflapon
T9023
Synonym: AZD5718
Target: FLAP
Linetastine
T25737
Synonym: TMK 688,TMK-688,TMK688
Target: Lipoxygenase, LTR, Histamine Receptor
U-73343
TQ0159
Synonym: U 73343
Target: Phospholipase
2-TEDC
T22502
Synonym:
Target: Lipoxygenase
KKII5
T77288
Synonym:
Target: Lipoxygenase
Tebufelone
T68155
Synonym:
Target: Prostaglandin Receptor, LTR
MK-886
T6893
Synonym: MK886,L 663536
Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP
A-69412
T10208
Synonym: N-1-(Fur-3-ylethyl)-N-hydroxyurea
Target: Lipoxygenase
Fiboflapon
T11487
Synonym: GSK2190915,AM-803
Target: FLAP
ThioLox
T67908
Synonym:
Target: Lipoxygenase
Croconazole
T9878
Synonym:
Target: Lipoxygenase, LTR
PD146176
T7530
Synonym: NSC168807
Target: Ferroptosis, Lipoxygenase, Autophagy
ZD-2138
T68173
Synonym: Ici-D2138
Target: Lipoxygenase
Diflapolin
T8844
Synonym:
Target: Others, FLAP, Epoxide Hydrolase
Quiflapon
T16087
Synonym: MK-591
Target: Apoptosis, FLAP
CBS-1114 HCl
T68037L
Synonym: N-Phenylbenzamidrazone hydrochloride,cbs-1114 HCl(46721-85-1 Free base)
Target: Lipoxygenase
WHI-P97
T4657
Synonym:
Target: JAK
Ciclopirox
T1482
Synonym: HOE296b
Target: ATPase, Ferroptosis, Antibacterial, Autophagy, Antifungal
5-LOX-IN-2
T77528
Synonym:
Target: Apoptosis, Lipoxygenase
1 2 3 4
Cat No. Product Name Synonyms Targets
T3S0153 Xanthatin Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr...
T8260 4',5-Dihydroxyflavone Lipoxygenase , Glucosidase
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
T2807 Caffeic Acid Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.
TQ0180 Chebulagic acid SARS-CoV , Influenza Virus , Lipoxygenase , COX
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
T8002 3-Hydroxycoumarin Lipoxygenase
3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors
TN2330 Phenethyl ferulate Caffeic Acid 3-Methyl Phenethyl Ester Lipoxygenase , COX
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a...
TN5634 Aureusidin Auresudidin,Auresidin Antioxidant , Reactive Oxygen Species , Lipoxygenase
Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.
T6S0413 Pectolinarigenin Pectolinaringenin Others , Lipoxygenase , COX
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ...
T5714 5-O-Demethylnobiletin 5-DEMETHYLNOBILETIN Leukotriene Receptor , Lipoxygenase
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.
T9512 Linoleyl alcohol CIS,CIS-9,12-OCTADECADIENOL Others
Linoleyl alcohol (CIS,CIS-9,12-OCTADECADIENOL), fatty alcohol, is a structural analog of Linoleic acid with no a-carboxyl group[1].
TJS2190 Nordihydroguaiaretic acid NDGA,Dihydronorguaiaretic Acid Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibito...
T3399 Psoralidin Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T5759 S-(+)-Marmesin (+)-Marmesin,(S)-Marmesin,marmesin Lipoxygenase , COX
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T3384 Wedelolactone IKK Inhibitor II Apoptosis , NF-κB , Lipoxygenase , Caspase
Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
TN1097 β-Boswellic acid Beta-boswellic acid Lipoxygenase , DNA/RNA Synthesis
β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
TN1255 3-O-Acetyl-11-hydroxy-beta-boswellic acid Lipoxygenase
3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
TN1182 11-​Keto-​beta-​boswellic acid 11-Keto-beta-boswellic acid Leukotriene Receptor , NF-κB , Lipoxygenase
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas...
TN2068 Picrinine Lipoxygenase
Picrinine is an akuammiline alkaloid extracted from the leaves of Alstonia scholaris. It exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase.
T3879 Silychristin Silicristin Lipoxygenase
Silychristin (Silicristin) is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.
T6389 Anacardic Acid 6-pentadecylsalicylic Acid,Hydroginkgolic acid Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland...
TJS0315 4-Methyldaphnetin 7,8-Dihydroxy-4-methylcoumarin,DHMC Apoptosis , Lipoxygenase
4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydr...
T5214 Cholesteryl linoleate CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester Others , Endogenous Metabolite
Cholesteryl linoleate (Linoleic Acid cholesteryl ester) is a cholesterol ester found in LDL. Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via...
TN1308 6-Hydroxyflavanone Others , Lipoxygenase , COX , GABA Receptor
6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r...
T4137 4,7-DIHYDROXYCOUMARIN Others
4,7-DIHYDROXYCOUMARIN is a naturally occurring coumarin derivative found in a variety of plants, including parsley and chamomile. It has been found to inhibit the activity of several enzymes, including cytochrome P450, c...
T6S1699 Shogaol [6]-Shogaol,6-Shogaol Lipoxygenase , Autophagy
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f...
T37974 (S)-Coriolic acid 13(S)-HODE Lipoxygenase , Mitochondrial Metabolism , PPAR
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation i...
T24869 Texasin IR2,IR 2,IR-2
Texasin is a selective inhibitor of human leukocyte 5-lipoxygenase.
TN5196 Turmeronol A Others
Turmeronol A and turmeronol B are inhibitors of soybean lipoxygenase, they inhibited soybean lipoxygenase at the IC50 values of 16 uM and 9 uM, respectively.
T10821 Cirsiliol Lipoxygenase
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
TN5159 Trachelosiaside Others
Trachelosiaside shows moderate activity against lipoxygenase.
TN4331 Isotachioside Lipoxygenase
Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
TN4032 Eugenol benzoate Others
Eugenol benzoate, a potent lipoxygenase inhibitor, has antioxidant activity.
TQ0262 Dihomo-γ-linolenic acid Diroleuton,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989 Others
Ro 12-1989 can be converted into prostaglandin E1 (PGE1). Ro 12-1989 competes with arachidonic acid for COX and lipoxygenase, inhibiting the production of arachidonic acid's eicosanoids.
TN2688 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone Antioxidant , Lipoxygenase
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is a natural product obtained from Parinari hypochrysea (Chrysobalanaceae). 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is an antioxidant and lipoxygenase inhibitor. dime...
TN1813 Jujuboside D Others
Jujuboside D shows lipoxygenase-inhibiting activity.
TN5017 Sideritoflavone Opioid Receptor , Prostaglandin Receptor
Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
T13764 Lycopodine Lipoxygenase , Caspase
Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refr...
T60692 Masoprocol
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active inhibitor of lipoxygenase. Masoprocol exhibits antihyperglycemic activity that has the potential for the type II diabetes research. In vivo, Masop...
TN4088 Futoenone PAFR
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neol...
TN6458 Acetylshikonin
Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acety...
T36560 (±)9-HpODE
(±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid. It shows antimicrobial activity against various fungal and bacterial pathogens and th...
T73776 13-Hydroxyoctadecadienoic acid
13-Hydroxyoctadecadienoic acid (13-HODE), an endogenous metabolite produced by the lipoxygenase pathway of Linoleic acid, promotes prostacyclin synthesis by facilitating the release of arachidonic acid (AA) from phosphol...
T37272 9(S),12(S),13(S)-TriHOME
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble ...

Natural Products

Xanthatin
T3S0153
Synonym:
Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial
4',5-Dihydroxyflavone
T8260
Synonym:
Target: Lipoxygenase, Glucosidase
Caffeic Acid
T2807
Synonym:
Target: Lipoxygenase, Endogenous Metabolite, TRP/TRPV Channel
Chebulagic acid
TQ0180
Synonym:
Target: SARS-CoV, Influenza Virus, Lipoxygenase, COX
3-Hydroxycoumarin
T8002
Synonym:
Target: Lipoxygenase
Phenethyl ferulate
TN2330
Synonym: Caffeic Acid 3-Methyl Phenethyl Ester
Target: Lipoxygenase, COX
Aureusidin
TN5634
Synonym: Auresudidin,Auresidin
Target: Antioxidant, Reactive Oxygen Species, Lipoxygenase
Pectolinarigenin
T6S0413
Synonym: Pectolinaringenin
Target: Others, Lipoxygenase, COX
5-O-Demethylnobiletin
T5714
Synonym: 5-DEMETHYLNOBILETIN
Target: Leukotriene Receptor, Lipoxygenase
Linoleyl alcohol
T9512
Synonym: CIS,CIS-9,12-OCTADECADIENOL
Target: Others
Nordihydroguaiaretic acid
TJS2190
Synonym: NDGA,Dihydronorguaiaretic Acid
Target: Antioxidant, Ferroptosis, Lipoxygenase, Autophagy
Psoralidin
T3399
Synonym:
Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial
S-(+)-Marmesin
T5759
Synonym: (+)-Marmesin,(S)-Marmesin,marmesin
Target: Lipoxygenase, COX
Wedelolactone
T3384
Synonym: IKK Inhibitor II
Target: Apoptosis, NF-κB, Lipoxygenase, Caspase
β-Boswellic acid
TN1097
Synonym: Beta-boswellic acid
Target: Lipoxygenase, DNA/RNA Synthesis
3-O-Acetyl-11-hydroxy-beta-boswellic acid
TN1255
Synonym:
Target: Lipoxygenase
11-​Keto-​beta-​boswellic acid
TN1182
Synonym: 11-Keto-beta-boswellic acid
Target: Leukotriene Receptor, NF-κB, Lipoxygenase
Picrinine
TN2068
Synonym:
Target: Lipoxygenase
Silychristin
T3879
Synonym: Silicristin
Target: Lipoxygenase
Anacardic Acid
T6389
Synonym: 6-pentadecylsalicylic Acid,Hydroginkgolic acid
Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial
4-Methyldaphnetin
TJS0315
Synonym: 7,8-Dihydroxy-4-methylcoumarin,DHMC
Target: Apoptosis, Lipoxygenase
Cholesteryl linoleate
T5214
Synonym: CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester
Target: Others, Endogenous Metabolite
6-Hydroxyflavanone
TN1308
Synonym:
Target: Others, Lipoxygenase, COX, GABA Receptor
4,7-DIHYDROXYCOUMARIN
T4137
Synonym:
Target: Others
Shogaol
T6S1699
Synonym: [6]-Shogaol,6-Shogaol
Target: Lipoxygenase, Autophagy
(S)-Coriolic acid
T37974
Synonym: 13(S)-HODE
Target: Lipoxygenase, Mitochondrial Metabolism, PPAR
Texasin
T24869
Synonym: IR2,IR 2,IR-2
Target:
Turmeronol A
TN5196
Synonym:
Target: Others
Cirsiliol
T10821
Synonym:
Target: Lipoxygenase
Trachelosiaside
TN5159
Synonym:
Target: Others
Isotachioside
TN4331
Synonym:
Target: Lipoxygenase
Eugenol benzoate
TN4032
Synonym:
Target: Others
Dihomo-γ-linolenic acid
TQ0262
Synonym: Diroleuton,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989
Target: Others
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
TN2688
Synonym:
Target: Antioxidant, Lipoxygenase
Jujuboside D
TN1813
Synonym:
Target: Others
Sideritoflavone
TN5017
Synonym:
Target: Opioid Receptor, Prostaglandin Receptor
Lycopodine
T13764
Synonym:
Target: Lipoxygenase, Caspase
Masoprocol
T60692
Synonym:
Target:
Futoenone
TN4088
Synonym:
Target: PAFR
Acetylshikonin
TN6458
Synonym:
Target:
(±)9-HpODE
T36560
Synonym:
Target:
13-Hydroxyoctadecadienoic acid
T73776
Synonym:
Target:
9(S),12(S),13(S)-TriHOME
T37272
Synonym:
Target:

Recombinant Proteins

Species：
Human (4)
Expression System：
Baculovirus-Insect Cells (3)
E. coli (1)
Tag：
His (1)
His,GST (1)
N-terminal 6xHis-tagged (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-03553 15 Lipoxygenase 2 Protein, Human, Recombinant Human Baculovirus-Insect Cells
ALOX15B is a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. ALOX15B converts arachidonic acid exclusively to 15S-hydroperoxy...
TMPY-03462 15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
ALOX15B is a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. ALOX15B converts arachidonic acid exclusively to 15S-hydroperoxy...
TMPH-00955 ALOX12 Protein, Human, Recombinant (His) Human E. coli
ALOX12 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-01481 FLAP Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk fo...
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