T11083 |
Dot1L-IN-4
|
T11083
|
98%
|
|
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
|
T11436 |
GNA002
|
1385035-79-9
|
98%
|
|
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
|
T2354 |
UNC 0631
|
1320288-19-4
|
98%
|
|
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
|
T1987 |
PFI-2
|
1627676-59-8
|
98%
|
|
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
|
T12541 |
PRMT5-IN-1
|
2366149-83-7
|
98%
|
|
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
|
T28112 |
MS0124
|
1197196-63-6
|
98%
|
|
MS0124 is a highly selective G9A-like protein (GLP) inhibitor with an ic50 of 13±4 nM against GLP and 440±63 nM against G9a.
|
T12940 |
SMYD3-IN-1
|
2095160-79-3
|
98%
|
|
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
|
T16577 |
PRMT5-IN-2
|
1989620-04-3
|
98%
|
|
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
|
T15240 |
Tazemetostat trihydrochloride
|
1403255-00-4
|
98%
|
|
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
|
T11185 |
EML741
|
2328074-38-8
|
98%
|
|
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
|
T12939 |
SMYD2-IN-1
|
2023788-96-5
|
98%
|
|
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
|
T6810 |
CPI-360
|
1802175-06-9
|
98%
|
|
CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
|
T12428 |
PF-06726304 acetate
|
2080306-28-9
|
98%
|
|
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
|
T6292 |
3-Deazaneplanocin A
|
102052-95-9
|
98%
|
|
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
|
T27133 |
DCLX069
|
792946-69-1
|
98%
|
|
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
|
T11500 |
GSK3368715
|
1629013-22-4
|
98%
|
|
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
|
T3081L |
EPZ004777 hydrochloride
|
1380316-03-9
|
98%
|
|
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
|
T10882 |
CPUY074020
|
902279-44-1
|
98%
|
|
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
|
T22342 |
GSK3368715 3HCl
|
2227587-26-8
|
98%
|
|
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
|
T10427 |
AZ505 ditrifluoroacetate
|
1035227-44-1
|
98%
|
|
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
|