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Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.
Cat. No. Product name CAS No. Purity Chemical Structure
T11083 Dot1L-IN-4 T11083 98%
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
T11436 GNA002 1385035-79-9 98%
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
T2354 UNC 0631 1320288-19-4 98%
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
T1987 PFI-2 1627676-59-8 98%
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T12541 PRMT5-IN-1 2366149-83-7 98%
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
T28112 MS0124 1197196-63-6 98%
MS0124 is a highly selective G9A-like protein (GLP) inhibitor with an ic50 of 13±4 nM against GLP and 440±63 nM against G9a.
T12940 SMYD3-IN-1 2095160-79-3 98%
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
T16577 PRMT5-IN-2 1989620-04-3 98%
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
T15240 Tazemetostat trihydrochloride 1403255-00-4 98%
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
T11185 EML741 2328074-38-8 98%
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
T12939 SMYD2-IN-1 2023788-96-5 98%
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
T6810 CPI-360 1802175-06-9 98%
CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
T12428 PF-06726304 acetate 2080306-28-9 98%
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
T6292 3-Deazaneplanocin A 102052-95-9 98%
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
T27133 DCLX069 792946-69-1 98%
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
T11500 GSK3368715 1629013-22-4 98%
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
T3081L EPZ004777 hydrochloride 1380316-03-9 98%
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T10882 CPUY074020 902279-44-1 98%
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
T22342 GSK3368715 3HCl 2227587-26-8 98%
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
T10427 AZ505 ditrifluoroacetate 1035227-44-1 98%
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
Dot1L-IN-4
T11083
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
GNA002
T11436
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
UNC 0631
T2354
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
PFI-2
T1987
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
PRMT5-IN-1
T12541
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
MS0124
T28112
MS0124 is a highly selective G9A-like protein (GLP) inhibitor with an ic50 of 13±4 nM against GLP and 440±63 nM against G9a.
SMYD3-IN-1
T12940
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
PRMT5-IN-2
T16577
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
Tazemetostat trihydrochloride
T15240
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
EML741
T11185
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
SMYD2-IN-1
T12939
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
CPI-360
T6810
CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
PF-06726304 acetate
T12428
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
3-Deazaneplanocin A
T6292
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
DCLX069
T27133
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
GSK3368715
T11500
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
EPZ004777 hydrochloride
T3081L
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
CPUY074020
T10882
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
GSK3368715 3HCl
T22342
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
AZ505 ditrifluoroacetate
T10427
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
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