Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T11083	Dot1L-IN-4	T11083	98%
T11083	Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
T11436	GNA002	1385035-79-9	98%
T11436	GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
T2354	UNC 0631	1320288-19-4	98%
T2354	UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
T1987	PFI-2	1627676-59-8	98%
T1987	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T12541	PRMT5-IN-1	2366149-83-7	98%
T12541	PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
T28112	MS0124	1197196-63-6	98%
T28112	MS0124 is a highly selective G9A-like protein (GLP) inhibitor with an ic50 of 13±4 nM against GLP and 440±63 nM against G9a.
T12940	SMYD3-IN-1	2095160-79-3	98%
T12940	SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
T16577	PRMT5-IN-2	1989620-04-3	98%
T16577	PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
T15240	Tazemetostat trihydrochloride	1403255-00-4	98%
T15240	Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
T11185	EML741	2328074-38-8	98%
T11185	EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
T12939	SMYD2-IN-1	2023788-96-5	98%
T12939	SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
T6810	CPI-360	1802175-06-9	98%
T6810	CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
T12428	PF-06726304 acetate	2080306-28-9	98%
T12428	PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
T6292	3-Deazaneplanocin A	102052-95-9	98%
T6292	3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
T27133	DCLX069	792946-69-1	98%
T27133	DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
T11500	GSK3368715	1629013-22-4	98%
T11500	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
T3081L	EPZ004777 hydrochloride	1380316-03-9	98%
T3081L	EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T10882	CPUY074020	902279-44-1	98%
T10882	CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
T22342	GSK3368715 3HCl	2227587-26-8	98%
T22342	GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
T10427	AZ505 ditrifluoroacetate	1035227-44-1	98%
T10427	AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).