TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN5019	Siegeskaurolic acid	52645-97-3	98%
TN5019	Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
T2434	LY 303511	154447-38-8	98%
T2434	LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
T11442	GNE684	T11442	98%
T11442	GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean K i app values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, ...
TN4164	Grandifloroside	61186-24-1	98%
TN4164	Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, sug...
TN1960	Mussaenoside	64421-27-8	98%
TN1960	Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN5147	Tilifodiolide	126724-95-6	98%
TN5147	Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
T10350	Apremilast-d5	1258597-47-5	98%
T10350	Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α rele...
TN3325	9-O-Feruloyl-5,5'-dimethoxylariciresinol	166322-14-1	98%
TN3325	(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
TN4635	Neoechinulin A	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
TN1996	Nothofagin	11023-94-2	98%
TN1996	Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
TN4374	Kaerophyllin	75590-33-9	98%
TN4374	Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
TN4675	Nortrachelogenin	34444-37-6	98%
TN4675	Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
T14381	AZD7624	1095004-78-6	98%
T14381	AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
TN3708	Coronarin D	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
TN3245	7-O-Methylmorroniside	119943-46-3	98%
TN3245	7-O-Methylmorroniside exhibits anti-inflammatory activity.
TN4409	Lansiumarin C	205115-75-9	98%
TN4409	Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
TN4490	Manassantin B	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
TN4986	Selinidin	19427-82-8	98%
TN4986	Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
TN2149	Reynosin	28254-53-7	98%
TN2149	Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...