TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat No.	product name
T14848	C 87	C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合，有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM)，并有效阻断 TNF-α 触发的信号传导活动。
T4S0227	Sinensetin	Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lip...
TC0036	Lup-20(29)-en-3-yl acetate	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
T2S0843	Negletein	1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action...
T6S0653	Linarin	1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver i...
T2923	Apremilast	Apremilast (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
T7889	C25-140	C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
T2384	Pomalidomide	Pomalidomide inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
T0304	Methylthiouracil	Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T0875	Acetylcysteine	Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
T5768	Bruceine B	Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysacchar...
TN1660	Ganoderic acid C1	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T2S0731	Trilobatin	Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopol...
T0694	Pranlukast	Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
T5S2129	Sciadopitysin	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
T1738	Taxifolin	Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
TN2082	Pinostrobin	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
T2794	Astilbin	Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T6591	Nodinitib-1	Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T2720	Ginsenoside Rc	Ginsenoside Rc is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β.
T2065	Bioymifi	Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
T1813	VGX-1027	VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
T3332	Isosteviol	Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...
T9901	Adalimumab	Adalimumab anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
T5785	MALTOTETRAOSE	MALTOTETRAOSE are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of...
T2893	Muscone	Muscone is an organic compound that is the primary contributor to the odor of musk.
TJS1779	Protosappanin A	Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammat...
TN1132	Procyanidin A2	Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 ...
T6S1538	Neochlorogenic acid	(E)-Neochlorogenic Acid is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
T3770	Taraxasterol	Taraxasterol is compound with anti-inflammatory activity.
T2A2481	Taurochenodeoxycholic Acid	Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T2932	Ginsenoside Rh1	Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
TN1742	Homovanillyl alcohol	Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
TN1983	Neoisoastilbin	Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T0122	Bergenin	Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T4423	LY 303511 hydrochloride	LY303511 (NV-128)is a potent mTOR inhibitor
T6S0630	Hypaconitine	Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T2993	Cordycepin	Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
T0429	Glucosamine	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T2205	Acefylline	Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T6S2140	β-Anhydroicaritin	1. Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. Anhydroicaritin phytosomes can inhibit enhanced bone turnover...
T0213	Thalidomide	沙利度胺是谷氨酸（α-邻苯二甲酰亚胺-戊二酰亚胺）的合成衍生物，具有致畸、免疫调节、抗炎和抗血管生成特性，可以作为分子胶来增强底物。
TN1291	7,3',4'-Tri-O-methylluteolin	5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC val...
TQ0181	Resatorvid	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
T1125	Shikonin	Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...
T7001	TIC10	TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and...
TN1373	α-Humulene	Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects,...
T22922	Lenalidomide hemihydrate	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
TN1507	Clematichinenoside AR	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associate...
T4S0998	Trifolirhizin	Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirh...