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Apoptosis TNF

TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Cat No. Product Name
T0122 Bengenin Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T0213 Thalidomide Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic...
T0429 Glucosamine Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to r...
T0694 Pranlukast Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
T1265 Amrinone Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
T1642 LenalidomideHOT Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
T1738 Taxifolin Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
T1813 VGX-1027 VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
T1847 Necrostatin-1HOT Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T2048 LY-364947 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T2065 Bioymifi Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
T2205 Theophylline-7-acetic acid Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in th...
T2384 PomalidomideHOT Pomalidomide inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
T2993 Cordycepin Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
T3280 Disodium clodronate tetrahydrate Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification.
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
T3537 GSK583 GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T3561 CPI-1189 REN-1189 is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.
T3790 Hederacoside D Hederacoside D is a bioactive saponins from Hedera helix.
T3805 Cimifugin beta-D-glucopyranoside Prim-O-glucosylcimifugin can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
T3997 WEHI-345 WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
T4074 GSK872 GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activ...
T4319 Hispidol Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with ...
T6204 QNZ QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
T6591 ML130 Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T6852 GSK481 GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
T5S0167 Atractylenolide I 1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome,liver and kidney functions by reducti...
T6S0653 Linarin 1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver...
T2S2264 Linalool 1. Linalool, a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was ...
T5S2129 Sciadopitysin Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin s...
T2A2481 Taurochenodeoxycholic Acid Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T4637 R-7050 R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
T5S1632 8-O-Acetylshanzhiside methyl ester 8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
T3S1641 Esculentoside H Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
T4S0998 Trifolirhizin Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolir...
T2S0731 Trilobatin Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopo...
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
T9921 Infliximab Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.
T4S0217 HOMOPLANTAGININ Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows po...
T5054 GSK963 (Racemate) GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T5660 Menthone Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor n...
T5768 bruceine B Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccha...
T5785 MALTOTETRAOSE MALTOTETRAOSE are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression ...
T5788 XYLOBIOSE XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabol...
T5779 MOSLOFLAVONE MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
T6815 HS1371 HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T7397 GSK547 GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
T7151 GSK2982772 GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T7795 RIPA-56 RIPA-56 is an inhibitor of RIP1 
T2367 SKF-86002 SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
Bengenin
T0122CAS 477-90-7
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Thalidomide
T0213CAS 50-35-1
Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic...
Glucosamine
T0429CAS 3416-24-8
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to r...
Pranlukast
T0694CAS 103177-37-3
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
Amrinone
T1265CAS 60719-84-8
Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
Lenalidomide HOT
T1642CAS 191732-72-6
Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
Taxifolin
T1738CAS 480-18-2
Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
VGX-1027
T1813CAS 6501-72-0
VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
Necrostatin-1 HOT
T1847CAS 4311-88-0
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
LY-364947
T2048CAS 396129-53-6
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
Bioymifi
T2065CAS 1420071-30-2
Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
Theophylline-7-acetic acid
T2205CAS 652-37-9
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in th...
Pomalidomide HOT
T2384CAS 19171-19-8
Pomalidomide inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
Cordycepin
T2993CAS 73-03-0
Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
Disodium clodronate tetrahydrate
T3280CAS 88416-50-6
Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification.
Isosteviol
T3332CAS 27975-19-5
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
GSK583
T3537CAS 1346547-00-9
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
CPI-1189
T3561CAS 183619-38-7
REN-1189 is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.
Hederacoside D
T3790CAS 760961-03-3
Hederacoside D is a bioactive saponins from Hedera helix.
Cimifugin beta-D-glucopyranoside
T3805CAS 80681-45-4
Prim-O-glucosylcimifugin can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
WEHI-345
T3997CAS 1354825-58-3
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
GSK872
T4074CAS 1346546-69-7
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activ...
Hispidol
T4319CAS 5786-54-9
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with ...
QNZ
T6204CAS 545380-34-5
QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
ML130
T6591CAS 799264-47-4
Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
GSK481
T6852CAS 1622849-58-4
GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
Atractylenolide I
T5S0167CAS 73069-13-3
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome,liver and kidney functions by reducti...
Linarin
T6S0653CAS 480-36-4
1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver...
Linalool
T2S2264CAS 78-70-6
1. Linalool, a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was ...
Sciadopitysin
T5S2129CAS 521-34-6
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin s...
Taurochenodeoxycholic Acid
T2A2481CAS 516-35-8
Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
R-7050
T4637CAS 303997-35-5
R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
8-O-Acetylshanzhiside methyl ester
T5S1632CAS 57420-46-9
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
Esculentoside H
T3S1641CAS 66656-92-6
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
Trifolirhizin
T4S0998CAS 6807-83-6
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolir...
Trilobatin
T2S0731CAS 4192-90-9
Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopo...
Acetylcysteine
T0875CAS 616-91-1
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
Infliximab
T9921CAS 170277-31-3
Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.
HOMOPLANTAGININ
T4S0217CAS 17680-84-1
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows po...
GSK963 (Racemate)
T5054CAS 2049868-46-2
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
Menthone
T5660CAS 10458-14-7
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor n...
bruceine B
T5768CAS 25514-29-8
Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccha...
MALTOTETRAOSE
T5785CAS 34612-38-9
MALTOTETRAOSE are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression ...
XYLOBIOSE
T5788CAS 6860-47-5
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabol...
MOSLOFLAVONE
T5779CAS 740-33-0
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
HS1371
T6815CAS 2158197-70-5
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
GSK547
T7397CAS 2226735-55-1
GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
GSK2982772
T7151CAS 1622848-92-3
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
RIPA-56
T7795CAS 1956370-21-0
RIPA-56 is an inhibitor of RIP1 
SKF-86002
T2367CAS 72873-74-6
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).