Search Result

Search Results for " jak "

Targets

JAK JAK

189

Compounds

Natural Products

123

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T11710	JAK-IN-5		JAK
	JAK-IN-5 is a JAK inhibitor.		JAK
T13571	JAK-IN-10		JAK
	JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.		JAK
T12549	JAK-IN-11	R-348	JAK
	JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.		JAK
T27650	JAK3i	JAK-3i,JAK 3i	JAK
	JAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cel...		JAK
T61494	JAK-IN-21		Tyrosine Kinases , JAK
	JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.		Tyrosine Kinases , JAK
T78607	JAK-STAT-IN-1		JAK , STAT
	JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.		JAK , STAT
T3080	Pyridone 6	Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I	Tyrosine Kinases , JAK
	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...		Tyrosine Kinases , JAK
T11710L	JAK-IN-5 hydrochloride	JAK-IN-5 hydrochloride(2096999-92-5 Free base)	JAK
	JAK-IN-5 hydrochloride is a JAK inhibitor [1].		JAK
T39400	JAK-IN-15
	JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).
T9764	JAK-IN-14
	JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC 50 of <5 μM. JAK-IN-14 is more than 8-fold selective for JAK1 than JAK2 and JAK3 [1].
T11705	JAK-IN-4		Others
	JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.		Others
T11704	JAK-IN-3		CCR
	JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.		CCR
T11703	JAK-IN-1		Others
	JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.		Others
T38436	JAK-2/3-IN-1
	JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.
T2460	JAK 3 inhibitor IV	ZM 39923 hydrochloride,Jak3 inhibitor IV	EGFR , Others , JAK
	JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.		EGFR , Others , JAK
T82018	JAK-IN-33		JAK
	JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].		JAK
T73250	JAK-IN-17
	JAK-IN-17 is a potent inhibitor of JAK . JAK-IN-17 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases.
T63658	JAK-IN-18
	JAK-IN-18 is a potent inhibitor of JAK and can be used to study a variety of diseases, particularly eye, skin and respiratory diseases.
T73330	JAK-IN-24
	JAK-IN-24, a JAK inhibitor, exhibits IC50 values of 0.534 nM and 24 nM in the presence of 4 μM and 1 mM ATP, respectively. Additionally, it effectively inhibits STAT5 phosphorylation induced by PBMC IL-15 with an IC50 of...
T78175	JAK-IN-25		JAK
	JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-1...		JAK
T62556	JAK-IN-23
	JAK-IN-23 is an orally active dual JAK/STAT and NF-κB inhibitor that inhibits J AK1 (IC50: 8.9 nM), J AK2 (IC50: 15 nM), and J AK3 (IC50: 46.2 nM). JAK-IN-23 exhibits strong anti-inflammatory effects and can reduce the r...
T63026	JAK-IN-19
	JAK-IN-19 is a potent inhibitor of JAK, with pIC50 values of 7.2 and 7.7 for PBMC IFNγ and HLF Eotaxin, respectively. The pIC50 values for VEGFR2 and Aurora B are 7.0 and 5.8 respectively).
T79882	JAK-IN-31		JAK
	JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2, indicating potent activity across these targets. It is utilized in c...		JAK
T79110	JAK-IN-27		JAK
	JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nM for TYK2, 7.7 nM for JAK1, and 629.6 nM for JAK3. Moreover, JA...		JAK
T82017	JAK-IN-34		JAK
	JAK-IN-34 (compound 11n) is a potent inhibitor of Janus kinases (JAKs), demonstrating IC50 values of 0.40 nM for JAK1, 0.83 nM for JAK2, 2.10 nM for JAK3, and 1.95 nM for TYK2. It effectively reduces joint swelling w...		JAK
T79235	JAK-IN-30		JAK
	JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50) values of 2 nM for JAK2, 15 nM for JAK1, 18 nM for JAK3, an...		JAK
TP1269	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)	Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.
T79222	JAK-IN-29		JAK
	JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].		JAK
T79116	JAK-IN-28		JAK
	JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].		JAK
T63581	JAK-IN-20
	JAK-IN-20 is a potent, orally active, broad-based JAK inhibitor, capable of acting on JAK1 (IC50: 7 nM), JAK2 (IC50: 5 nM), and JAK3 (IC50: 14 nM).JAK-IN-20 has excellent pharmacokinetic and anti-inflammatory activity in...
T78189	JAK-IN-26		JAK
	JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in suppressing IFN-α2B-induced STAT3 phosphorylation in Jurkat cells wit...		JAK
T78708	JAK/HDAC-IN-2		JAK
	JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations. This compound exhibits proapoptotic properties, inhibits histone deace...		JAK
T63086	SYK/JAK-IN-1
	SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.
T79807	JAK kinase-IN-1		JAK
	JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32 nM, 27 nM, and 3473 nM, respectively [1].		JAK
T60895	JAK-2/3-IN-3
	JAK-2-/3-IN-3 (compound ST4j) can be used in lymph derived diseases and leukemia research. JAK-2-/3-IN-3 inhibits JAK2 autophosphorylation and induces apoptosis in a time- and dose-dependent manner. JAK-2-/3-IN-3 is a po...
T61323	JAK-2/3-IN-2
	JAK-2/3-IN-2 (Compound 3h) is a potent dual inhibitor of JAK2 and JAK3. It exhibits inhibitory activity with IC50 values of 23.85 nM and 18.9 nM against JAK2 and JAK3, respectively [1].
T79768	HDAC/JAK/BRD4-IN-1		Epigenetic Reader Domain
	HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4. This compound not only inhibits cell proliferation but also induces apoptosis in MDA-MB-231 cells and demonstrates in vivo an...		Epigenetic Reader Domain
T5492	JAK3-IN-6		JAK
	JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM		JAK
T38624	Fosifidancitinib		JAK
	Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.		JAK
T10009	JAK3-IN-7		JAK
	JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ...		JAK
T35899	JAK1-IN-8	JAK1-IN-8	JAK
	JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).		JAK
T40443	JAK2-IN-6	JAK2-IN-6	JAK
	JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathway...		JAK
T35900	JAK2-IN-7	JAK2-IN-7	JAK
	JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and select...		JAK
T3069	AZD-1480		JAK
	AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...		JAK
T11706	Londamocitinib	AZD4604	JAK
	Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.		JAK
T4210	SAR-20347	SAR20347	Tyrosine Kinases , JAK
	SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).		Tyrosine Kinases , JAK
T6790	BMS-911543	BMS911543	Tyrosine Kinases , Histone Methyltransferase , JAK
	BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.		Tyrosine Kinases , Histone Methyltransferase , JAK
T5091	FM-381	FM381	JAK
	FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.		JAK
T6122	CEP-33779	CEP33779	JAK
	CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.		JAK
T2156	WP1066		Apoptosis , JAK , STAT
	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Bra...		Apoptosis , JAK , STAT

Compounds

Synonym: JAK-3i,JAK 3i

Target: Tyrosine Kinases, JAK

Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I

Target: Tyrosine Kinases, JAK

JAK-IN-5 hydrochloride

T11710L

Synonym: JAK-IN-5 hydrochloride(2096999-92-5 Free base)

Synonym: ZM 39923 hydrochloride,Jak3 inhibitor IV

Target: EGFR, Others, JAK

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

TP1269

Synonym: Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9

Target: Epigenetic Reader Domain

Target: Tyrosine Kinases, JAK

BMS-911543

T6790

Synonym: BMS911543

Target: Tyrosine Kinases, Histone Methyltransferase, JAK

Target: Apoptosis, JAK, STAT

Cat No.	Product Name	Synonyms	Targets
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...
T6S1966	Curculigoside	Curculigoside A	Antioxidant , NF-κB , JAK , STAT
	1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord...		Antioxidant , NF-κB , JAK , STAT
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
TQ0196	Cucurbitacin I	NSC-521777,JSI-124,Elatericin B	JAK , STAT
	Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.		JAK , STAT
T4S1499	Ginsenoside Rk1		Apoptosis , Others , NF-κB , PI3K , JAK
	Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB. It also h...		Apoptosis , Others , NF-κB , PI3K , JAK
T16324	Nimbolide		Apoptosis , NF-κB , CDK
	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene ...		Apoptosis , NF-κB , CDK
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T5S1897	Linderalactone		Apoptosis , Others , JAK
	1. Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.		Apoptosis , Others , JAK
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T19934	Dehydrocrenatidine	TOP 3,TOP-3,O-Methylpicrasidine I,TOP3,Kumujian G	Apoptosis , JAK
	Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.		Apoptosis , JAK
TN4774	Physalin A		ERK , BCL , p38 MAPK , NF-κB , Androgen Receptor , ROS , JAK , JNK , STAT , p53 , Autophagy
	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and dow...
TN1567	Delphinidin chloride		Estrogen Receptor/ERR , VEGFR
	Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...		Estrogen Receptor/ERR , VEGFR
TN3364	Agrimonolide		Apoptosis , Dehydrogenase , p38 MAPK , ROS , JAK
	Agrimonolide, a compound derived from isocoumarins and found mainly in the herb Agrimonia pilosa Ledeb, has significant biological activity. agrimonolide exerts anti-inflammatory effects by inhibiting lipopolysaccharide ...		Apoptosis , Dehydrogenase , p38 MAPK , ROS , JAK

Natural Products

Brevilin A

T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Protosappanin A

TJS1779

Synonym: PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Curculigoside

T6S1966

Synonym: Curculigoside A

Target: Antioxidant, NF-κB, JAK, STAT

Atractylenolide I

T5S0167

Synonym:

Target: IL Receptor, TNF, TLR, JAK, STAT

Cucurbitacin I

TQ0196

Synonym: NSC-521777,JSI-124,Elatericin B

Target: Apoptosis, Others, NF-κB, PI3K, JAK

Nimbolide

T16324

Synonym:

Target: Apoptosis, NF-κB, CDK

Target: Apoptosis, Others, JAK

Ganoderic acid A

T6S1141

Synonym:

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Dehydrocrenatidine

T19934

Synonym: TOP 3,TOP-3,O-Methylpicrasidine I,TOP3,Kumujian G

Target: Apoptosis, JAK

Physalin A

TN4774

Synonym:

Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy

Delphinidin chloride

TN1567

Synonym:

Target: Estrogen Receptor/ERR, VEGFR

Agrimonolide

TN3364

Synonym:

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02273	JAK1 Protein, Human, Recombinant (His)	Human	Yeast
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but ...
TMPH-02272	JAK1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but ...
TMPH-02961	JAK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but ...
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cyto...
TMPJ-00059	IL-7 Protein, Human, Recombinant (His)	Human	Human Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions...
TMPY-02647	IFNAR1 Protein, Human, Recombinant (His)	Human	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-04632	IL-15 Protein, Human, Recombinant	Human	E. coli
	The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common h...
TMPY-03532	LIF Protein, Human, Recombinant (His)	Human	HEK293
	Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone met...
TMPY-05274	IL-23R Protein, Human, Recombinant (His)	Human	HEK293
	IL23R, also known as the IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK, and dendritic cells. Isofo...
TMPY-04278	LIF Protein, Mouse, Recombinant	Mouse	HEK293
	Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone met...
TMPY-04104	LIF Protein, Human, Recombinant	Human	HEK293
	Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone met...
TMPY-00136	IL-29 Protein, Human, Recombinant	Human	HEK293
	Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL...
TMPY-01701	IL-12RB1 Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I tra...
TMPY-05242	CRLF2/TSLPR Protein, Human, Recombinant (His)	Human	HEK293
	Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to contribute to oncogenesis and unfavorable outcome in ALL....
TMPY-01872	IL-28B Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda...
TMPY-01053	Prolactin Receptor Protein, Human, Recombinant (His)	Human	HEK293
	Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective recept...
TMPY-05748	CD45 Protein, Human, Recombinant (aa 26-577, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05308	CD45 Protein, Human, Recombinant (aa 1-529, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05480	IL-21R Protein, Human, Recombinant (hFc)	Human	HEK293
	Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamil...
TMPY-00418	IL-21R Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamil...
TMPY-01934	IL-21R Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamil...
TMPY-01845	IL-10 Protein, Human, Recombinant (His)	Human	HEK293
	IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by mono...
TMPY-05064	IL-10 Protein, Mouse, Recombinant	Mouse	E. coli
	IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by mono...
TMPY-03547	IL-10 Protein, Human, Recombinant	Human	E. coli
	IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by mono...
TMPY-01410	IL-3R alpha/CD123 Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-03644	CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-03776	CD25/IL2R alpha Protein, Cynomolgus, Recombinant	Cynomolgus	HEK293
	CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-01103	CD25/IL2R alpha Protein, Human, Recombinant (His)	Human	HEK293
	CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-05584	CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-05090	CD25/IL2R alpha Protein, Rat, Recombinant (His)	Rat	Baculovirus-Insect Cells
	CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-01923	CD25/IL2R alpha Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-05644	CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated	Rhesus	HEK293
	CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPK-00343	IFNAR1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPK-00326	IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPK-00342	IFNAR1 Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293
	IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPK-00325	IFNAR1 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPU-00003	STAT2 Protein, Human, Recombinant (His)	Human	E. coli
	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading...
TMPH-00779	IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)	Guinea pig	E. coli
	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 b...
TMPK-00353	IL-23R Protein, Human, Recombinant (aa 24-355, His)	Human	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00575	IL-23R Protein, Canine, Recombinant (His)	Canine	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPJ-00076	IL-28B Protein, Human, Recombinant	Human	Human Cells
	Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to pla...
TMPK-01094	IL-23R Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00474	IL-22RA1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component o...
TMPK-00652	IL-23R Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPJ-00326	CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated	Human	Human Cells
	Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 recepto...
TMPY-03829	IFNAR1 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-01489	IFNAR1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPH-02456	IL-12B Protein, Mesocricetus auratus, Recombinant (His & Myc)	Mesocricetus auratus	E. coli
	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.; Associates with IL23A...
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JAK1 Protein, Human, Recombinant (His)

TMPH-02273

Species: Human

Expression System: Yeast

JAK1 Protein, Human, Recombinant (E. coli, His)

TMPH-02272

Species: Human

Expression System: E. coli

JAK1 Protein, Mouse, Recombinant (His)

TMPH-02961

Species: Mouse

Expression System: E. coli

JAK2 Protein, Human, Recombinant (His)

TMPH-02274

Species: Human

Expression System: E. coli

IL-7 Protein, Human, Recombinant (His)

TMPJ-00059

Species: Human

Expression System: Human Cells

IFNAR1 Protein, Human, Recombinant (His)

TMPY-02647

Species: Human

Expression System: HEK293

IL-15 Protein, Human, Recombinant

TMPY-04632

Species: Human

Expression System: E. coli

LIF Protein, Human, Recombinant (His)

TMPY-03532

Species: Human

Expression System: HEK293

IL-23R Protein, Human, Recombinant (His)

TMPY-05274

Species: Human

Expression System: HEK293

LIF Protein, Mouse, Recombinant

TMPY-04278

Species: Mouse

Expression System: HEK293

LIF Protein, Human, Recombinant

TMPY-04104

Species: Human

Expression System: HEK293

IL-29 Protein, Human, Recombinant

TMPY-00136

Species: Human

Expression System: HEK293

IL-12RB1 Protein, Human, Recombinant (His)

TMPY-01701

Species: Human

Expression System: HEK293

CRLF2/TSLPR Protein, Human, Recombinant (His)

TMPY-05242

Species: Human

Expression System: HEK293

IL-28B Protein, Human, Recombinant (His)

TMPY-01872

Species: Human

Expression System: HEK293

Prolactin Receptor Protein, Human, Recombinant (His)

TMPY-01053

Species: Human

Expression System: HEK293

CD45 Protein, Human, Recombinant (aa 26-577, His)

TMPY-05748

Species: Human

Expression System: HEK293

CD45 Protein, Human, Recombinant (aa 1-529, His)

TMPY-05308

Species: Human

Expression System: HEK293

IL-21R Protein, Human, Recombinant (hFc)

TMPY-05480

Species: Human

Expression System: HEK293

IL-21R Protein, Mouse, Recombinant (His)

TMPY-00418

Species: Mouse

Expression System: HEK293

IL-21R Protein, Human, Recombinant (His)

TMPY-01934

Species: Human

Expression System: HEK293

IL-10 Protein, Human, Recombinant (His)

TMPY-01845

Species: Human

Expression System: HEK293

IL-10 Protein, Mouse, Recombinant

TMPY-05064

Species: Mouse

Expression System: E. coli

IL-10 Protein, Human, Recombinant

TMPY-03547

Species: Human

Expression System: E. coli

IL-3R alpha/CD123 Protein, Human, Recombinant (His)

TMPY-01410

Species: Human

Expression System: HEK293

CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His)

TMPY-03644

Species: Cynomolgus

Expression System: HEK293

CD25/IL2R alpha Protein, Cynomolgus, Recombinant

TMPY-03776

Species: Cynomolgus

Expression System: HEK293

CD25/IL2R alpha Protein, Human, Recombinant (His)

TMPY-01103

Species: Human

Expression System: HEK293

CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-05584

Species: Human

Expression System: HEK293

CD25/IL2R alpha Protein, Rat, Recombinant (His)

TMPY-05090

Species: Rat

Expression System: Baculovirus-Insect Cells

CD25/IL2R alpha Protein, Mouse, Recombinant (His)

TMPY-01923

Species: Mouse

Expression System: HEK293

CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated

TMPY-05644

Species: Rhesus

Expression System: HEK293

IFNAR1 Protein, Mouse, Recombinant (hFc)

TMPK-00343

Species: Mouse

Expression System: HEK293

IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00326

Species: Human

Expression System: HEK293

IL-22RA1 Protein, Mouse, Recombinant (hFc)

TMPK-01071

Species: Mouse

Expression System: HEK293

IFNAR1 Protein, Mouse, Recombinant (His & Avi)

TMPK-00342

Species: Mouse

Expression System: HEK293

IL-22RA1 Protein, Human, Recombinant (hFc)

TMPK-01105

Species: Human

Expression System: HEK293

IFNAR1 Protein, Human, Recombinant (His & Avi)

TMPK-00325

Species: Human

Expression System: HEK293

STAT2 Protein, Human, Recombinant (His)

TMPU-00003

Species: Human

Expression System: E. coli

IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)

TMPH-00779

Species: Guinea pig

Expression System: E. coli

IL-23R Protein, Human, Recombinant (aa 24-355, His)

TMPK-00353

Species: Human

Expression System: HEK293

IL-23R Protein, Canine, Recombinant (His)

TMPK-00575

Species: Canine

Expression System: HEK293

IL-28B Protein, Human, Recombinant

TMPJ-00076

Species: Human

Expression System: Human Cells

IL-23R Protein, Mouse, Recombinant (His)

TMPK-01094

Species: Mouse

Expression System: HEK293

IL-22RA1 Protein, Cynomolgus, Recombinant (His)

TMPK-00474

Species: Cynomolgus

Expression System: HEK293

IL-23R Protein, Cynomolgus, Recombinant (His)

TMPK-00652

Species: Cynomolgus

Expression System: HEK293

CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated

TMPJ-00326

Species: Human

Expression System: Human Cells

IFNAR1 Protein, Rhesus, Recombinant (hFc)

TMPY-03829

Species: Rhesus

Expression System: HEK293

IFNAR1 Protein, Mouse, Recombinant (His)

TMPY-01489

Species: Mouse

Expression System: HEK293

IL-12B Protein, Mesocricetus auratus, Recombinant (His & Myc)

TMPH-02456

Species: Mesocricetus auratus

Expression System: E. coli

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Cat No.	Product Name
L3700	JAK-STAT Compound Library	256 compounds
	A unique collection of 256 JAK/STAT signaling targeted compounds for high throughput and high content screening;
L3400	Clinical Compound Library	3480 compounds
	A unique collection of 3480 compounds in clinical trial phases for high throughput screening (HTS) and high content screening (HCS);
L3600	Cytokine Inhibitor Library	613 compounds
	A unique collection of 613 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
L2192	Anti-Pancreatic Cancer Compound Library	2267 compounds
	A unique collection of 2267 pancreatic cancer related compounds can be used in HTS and HCS;
L1610	FDA-Approved Kinase Inhibitor Library	266 compounds
	A unique collection of 266 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L1600	Kinase Inhibitor Library	2720 compounds
	A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;