n-6

N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]- Thiourea is a cinchona alkaloid-derived bifunctional catalyst.

(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid is a potential SSTR4 agonist.

Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.

N-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) is utilized for N-terminal biotinylation.

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.

N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T64879 and the CAS number is 162012-67-1.

N-[5-[[[3-(6-Amino-4-methylpyridin-3-yl)-1-methyl-1H-indazol-5-yl]carbonyl]amino]-2-methylphenyl]-N′-methylterephthalamide had an IC50 value of 22 nM in a BD2 DEC-Tec assay.

(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide is a useful organic compound for research related to life sciences. The catalog number is T66342 and the CAS number is 863127-76-8.

N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T65343 and the CAS number is 231278-20-9.

N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide is a useful organic compound for research related to life sciences. The catalog number is T66071 and the CAS number is 799842-07-2.

N-[5-[[[3-(6-Amino-2-methylpyridin-3-yl)-1-methyl-1H-indazol-5-yl]carbonyl]amino]-2-methylphenyl]-N′-methylterephthalamide had an IC50 value of 94 nM in a BD2 DEC-Tec assay.

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T66550 and the CAS number is 314771-88-5.

N1-(tert-Butoxycarbonylmethyl)-6-[2-(N-Cbz-amino)ethoxy)]-phenoxazine is a PNA-related Derivative; Heterocyclic Compound - Fused polyheterocycle.

N-((2S,3R,4R,5S,6R)-2-(((2R,3S,4S,5R,6S)-3,5-Dihydroxy-2-(hydroxymethyl)-6-(((2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-5-hydroxy-6-(hydroxymethyl)-4-(((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)acetamide has a wide range of applications in life science related research.

N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine inhibits the PAICS protein, reducing the accumulation of SAICAR and SAICAr.

4-Fluoro-N-(6-nitrobenzo[d]thiazol-2-yl)benzamide is a Heterocyclic Compound and can be used in anticancer and antimicrobial studies.

tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate is a useful organic compound for research related to life sciences. The catalog number is T66277 and the CAS number is 289042-12-2.

N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T65584 and the CAS number is 147118-37-4.

5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole acts as a competitive inhibitor at the Qo site of the cytochrome bc1 complex (cytochrome c oxidoreductase) in Saccharomyces cerevisiae [1].

Canthin-6-one N-oxide has broad spectrum antifungal, leishmanicidal and trypanocidal activities.

N-6-Furfurylguanosine is a 2/6/8-modified purine nucleoside.

A natural compound from the herbs of Aristolochia debilis Sieb. et Zucc

9-Methoxycanthin-6-one-N-oxide shows cytotoxic activity against a panel of cell lines comprising a number of human cancer cell types.

(S)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide is a useful organic compound for research related to life sciences. The catalog number is T65667 and the CAS number is 106006-84-2.

6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin A is a useful organic compound for research related to life sciences and the catalog number is T64488.

N-((2R,3R,4R,5R)-5,6-Dihydroxy-1-oxo-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-2-yl)acetamide is a natural product for research related to life sciences. The catalog number is T65274 and the CAS number is 71208-06-5.

4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β [1-40] with a dissociation constant (KD) of 1.7 nM.

N-(5-(8-Amino-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-2-methylphenyl)methanesulfonamide hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64837.

2-Acetylamino-1-{3’-O-[(4,4’-dimethoxy triphenyl)methyl]-a-L-threo furanosyl}-6-(N,N-diphenylcarbamoyloxy)-9H-purine is a nucleoside analog and has a wide range of applications in life science related research.

N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64522.

N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T66148 and the CAS number is 289042-10-0.

tert-Butyl N-[6-(methylamino)hexyl]carbamate is a useful organic compound for research related to life sciences and the catalog number is T64467.

N1-Carboxymethyl-6-[2-(N,N'-bis-Cbz-guanidino) ethoxy]-phenoxazine is a PNA-related Derivative; Heterocyclic Compound - Fused polyheterocycle.

6-Acetonyl- N -methyl-dihydrodecarine has mosquito larvicidal activity against the malaria vector Anopheles gambiae.

Heterocyclic Compounds - Fused polyheterocycles; Drugs and Inhibitors; Anticancer agent

2’-C-Methyl nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleoside

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin/CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin/CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg/kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg/kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg/kg/day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

N6-Methyladenosine is a methylated adenine residue, glycoside is an endogenous uridine product of transfer RNA degradation. It is the most prevalent internal modification of messenger RNA present in all higher eukaryotes and can modify viral RNA with antiviral activity.

Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.

6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.

DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) is an α7-containing neuronal nicotinic receptor partial agonist and an antagonist at α4β2 and other nicotinic receptors.

Dacomitinib Intermediate 2 (N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine) has anticancer activity and can be used to study lung cancer.

AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).

n-acetylciprofloxacin (3-Quinolinecarboxylic acid, 7-(4-acetyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1) is inhibitor of H37Rv.

ZX-J-19J (N-(2,3-Diphenyl-6-quinoxalinyl)octanamide), an inhibitor of Cyclophilin J (CyPJ), demonstrates remarkable inhibition of tumor cell growth, comparable to cyclosporine A but much stronger than 5-fluorouracil.

N-Oleoyl Valine Ammonium salt is an N-acyl amide compound that is a TRPV3 antagonist and can be used to study inflammation.

CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.

C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM).

CCPA (2-chloro-N(6)cyclopentyladenosine) is a potent and selective agonist of adenosine A1 receptor