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Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Cat No. product name
T5030 Zofenopril calcium Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. ACE Zofenopril is a pro-drug designed to undergo metabolic...
T8347 Rifamycin S Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
T0877 Gallic acid Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T2S1865 Octyl gallate 1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Oct...
T6820 D-α-Hydroxyglutaric acid disodium Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.
T2S0618 β-Elemonic Acid 1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
T0498 Salsalate Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.
T12059L Mitoquinone mesylate Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
T5518 N-acetylcysteine amide N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
T5S1569 AKBA 1. 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
TN2167 Rutaevin Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
T6S1653 Albiflorin 1. Albiflorin has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoni...
T2864 Lycopene Lycopene is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, r...
T7717 Sodium 2-oxopropanoate Sodium pyruvate is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease.
T4902 ISOQUERCITRIN Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.
T0787 Butylhydroxyanisole Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydr...
T1717 Alpha-Mangostin Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
T2871 Quercitrin Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
T5363 Tempo TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
T6460 Cysteamine hydrochloride Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T8370 GSK5182 GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T1085L Glutathione oxidized A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
T16951 Sulcotrione Sulcotrione is a β-triketone herbicide. It also can inhibit hydroxyphenylpyruvate dioxygenase.
T9211 Mito-LND Mito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
T6699 Tempol Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
T2899 Liquiritin Liquiritin (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
T3429 Protopine Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
TN1058 Pelargonidin chloride Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T5736 1,3-Dicaffeoylquinic acid CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
T5098 Isochlorogenic acid A 3,5-Dicaffeoylquinic acid is a natural phenolic acid with antioxidant and anti-inflammatory activities .
TQ0288 Hexahydrocurcumin Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
T2992 Pinocembrin Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
T5728 OsMundacetone OsMundacetone is a natual product isolated from Rhizoma osmundae.
T3025 Asiaticoside Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burn...
T1439 Lacidipine Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does n...
T2587 Ecabet Sodium Ecabet sodium: a potential new agent in the management of distal colitis.
TN6735 Bigelovin Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pat...
T1660 Silibinin Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of si...
T2597 Norgestrel Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing ...
TN1141 Isodeoxyelephantopin Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
T0933 D-(+)-Glucono-1,5-lactone Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-g...
TN7108 Urolithin C Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T1648 α-Vitamin E (+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
T5A2461 Bufotalin 1. Bufotaline is a kind of poisonous secretions of toads.
T0418 Allylthiourea Allylthiourea, a metabolic inhibitor, specifically suppresses ammonia oxidation.
T15433 GSK2795039 GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
T2925 Schisandrin B Schisandrin B has an antioxidant effect on rodent liver and heart.
T3330 Trans-Trimethoxyresveratrol 3, 5, 4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin si...
Zofenopril calcium
T5030
Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. ACE Zofenopril is a pro-drug designed to undergo metabolic...
Rifamycin S
T8347
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
Gallic acid
T0877
Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
Octyl gallate
T2S1865
1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Oct...
D-α-Hydroxyglutaric acid disodium
T6820
Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.
β-Elemonic Acid
T2S0618
1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
Salsalate
T0498
Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.
Mitoquinone mesylate
T12059L
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
N-acetylcysteine amide
T5518
N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
AKBA
T5S1569
1. 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
Rutaevin
TN2167
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
Albiflorin
T6S1653
1. Albiflorin has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoni...
Lycopene
T2864
Lycopene is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, r...
Sodium 2-oxopropanoate
T7717
Sodium pyruvate is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease.
ISOQUERCITRIN
T4902
Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.
Butylhydroxyanisole
T0787
Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydr...
alpha-Mangostin
T1717
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
Quercitrin
T2871
Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
Tempo
T5363
TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
Cysteamine hydrochloride
T6460
Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.
Urolithin A
T7174
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
GSK5182
T8370
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
Glutathione oxidized
T1085L
A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
Sulcotrione
T16951
Sulcotrione is a β-triketone herbicide. It also can inhibit hydroxyphenylpyruvate dioxygenase.
Mito-LND
T9211
Mito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
Acetylcysteine
T0875
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
Tempol
T6699
Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
Liquiritin
T2899
Liquiritin (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
Protopine
T3429
Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
Pelargonidin chloride
TN1058
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
1,3-Dicaffeoylquinic acid
T5736
CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
Isochlorogenic acid A
T5098
3,5-Dicaffeoylquinic acid is a natural phenolic acid with antioxidant and anti-inflammatory activities .
Hexahydrocurcumin
TQ0288
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
Pinocembrin
T2992
Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
OsMundacetone
T5728
OsMundacetone is a natual product isolated from Rhizoma osmundae.
Asiaticoside
T3025
Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burn...
Lacidipine
T1439
Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does n...
Ecabet Sodium
T2587
Ecabet sodium: a potential new agent in the management of distal colitis.
Bigelovin
TN6735
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pa...
Silibinin
T1660
Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of si...
Norgestrel
T2597
Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing ...
Isodeoxyelephantopin
TN1141
Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
D-(+)-Glucono-1,5-lactone
T0933
Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-g...
Urolithin C
TN7108
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
α-Vitamin E
T1648
(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
Bufotalin
T5A2461
1. Bufotaline is a kind of poisonous secretions of toads.
Allylthiourea
T0418
Allylthiourea, a metabolic inhibitor, specifically suppresses ammonia oxidation.
GSK2795039
T15433
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
Schisandrin B
T2925
Schisandrin B has an antioxidant effect on rodent liver and heart.
trans-Trimethoxyresveratrol
T3330
3, 5, 4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin s...
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