Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No.	Product name	CAS No.	Purity
T67927	BAY-069	2639638-66-5	98%
T67927	BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at...
T8306	Epiberberine chloride	889665-86-5	98%
T8306	Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
T63918	α-Tocopherol phosphate disodium	60934-46-5	98%
T63918	α-Tocopherol phosphate disodium shows potent antioxidant properties. α-Tocopherol phosphate disodium protects against long-wave UVA1-induced cell death. α-Tocoph...
T41242	Uric acid sodium	1198-77-2	98%
T41242	Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric a...
TN1058	Pelargonidin chloride	134-04-3	98%
TN1058	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T4902	ISOQUERCITRIN	21637-25-2	98%
T4902	Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.
T12059L	Mitoquinone mesylate	845959-50-4	98%
T12059L	Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
T38155	N-Acetyl-D-cysteine	26117-28-2	98%
T38155	N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway[1]...
T17155	Trabectedin	114899-77-3	98%
T17155	Trabectedin a tetrahydroisoquinoline alkaloid. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbon...
TN1403	Arjunolic acid	465-00-9	98%
TN1403	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
T16747	Riboflavin Tetrabutyrate	752-56-7	98%
T16747	Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.
T5852	Canthaxanthin	514-78-3	98%
T5852	Canthaxanthin is a red-orange carotenoid that belongs to the xanthophyll group. This naturally occurring pigment is present in bacteria, algae and some fungi.
T11580	Heme Oxygenase-1-IN-1	1093058-52-6	98%
T11580	HO-1-IN-1 is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).
T37688	Cyfluthrin	68359-37-5	98%
T37688	Cyfluthrin is a pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1,2It slowly activates rat recombinant Nav1.8 channels, delays inac...
T10492	BD-AcAc 2	1208313-97-6	98%
T10492	BD-AcAc 2 is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrat...
TN7108	Urolithin C	165393-06-6	98%
TN7108	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T20578	Maclurin	519-34-6	98%
T20578	Maclurin is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and ...
T36404L	PRLX-93936 HCL	1094210-96-4	98%
T36404L	PRLX-93936 hcl is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
T7703	PK11007	874146-69-7
T7703	PK11007 is an anti-p53 drug.
T8193	α-Thujone	546-80-5
T8193	Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.